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WO1998030198A1 - Composition pour ameliorer l'etat de la peau ou des cheveux - Google Patents

Composition pour ameliorer l'etat de la peau ou des cheveux Download PDF

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Publication number
WO1998030198A1
WO1998030198A1 PCT/US1997/000154 US9700154W WO9830198A1 WO 1998030198 A1 WO1998030198 A1 WO 1998030198A1 US 9700154 W US9700154 W US 9700154W WO 9830198 A1 WO9830198 A1 WO 9830198A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
composition
composition according
enhancer
hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/000154
Other languages
English (en)
Inventor
Dean Hsieh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hsieh Phyllis
Conrex Pharmaceutical Corp
Original Assignee
Hsieh Phyllis
Conrex Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hsieh Phyllis, Conrex Pharmaceutical Corp filed Critical Hsieh Phyllis
Priority to BR9714464A priority Critical patent/BR9714464A/pt
Priority to PCT/US1997/000154 priority patent/WO1998030198A1/fr
Priority to JP53514398A priority patent/JP2002514203A/ja
Priority to CA002275971A priority patent/CA2275971C/fr
Priority to EP97903746A priority patent/EP0964672A4/fr
Priority to KR10-1999-7006000A priority patent/KR100521787B1/ko
Priority to IL13066397A priority patent/IL130663A/xx
Priority to AU18238/97A priority patent/AU731269B2/en
Publication of WO1998030198A1 publication Critical patent/WO1998030198A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Definitions

  • This invention relates to means for improving a physiologic condition of the body. More particularly, this invention relates to a composition which is effective in enhancing the qualities of skin or hair.
  • the present invention relates to the provision of an improved composition for enhancing the qualities of skin or hair.
  • composition which is effective in enhancing the qualities of skin or hair and which comprises: (A) a skin- treating or hair-treating compound; (B) an enhancer, as described below; (C) a carrier; and optionally (D) a cosmetic additive.
  • the composition of the present invention comprises a skin- or hair-treating compound, an enhancer, a carrier, and optionally a cosmetic additive.
  • skin-treating compound means a material which is effective in enhancing one or more properties of skin as evidenced by statistically significant differences between the quality of untreated skin and skin treated with said material, at the 95% level of confidence, using standard methods of evaluation which are known to persons skilled in the art.
  • Examples of skin characteristics or properties that are capable of being improved by a skin-treating compound include: (A) smoothness of the skin; (B) thickness of the epidermal layer of the skin; (C) increase in the cellular density of the skin; (D) reduction in the depth of interossei; (E) elasticity of the skin; and (F) texture of the skin.
  • Methods for evaluating in an objective way skin properties of the aforementioned type are well known to persons skilled in the art. They include, for example, the use of clinical assessments, photographic assessments, silastic castings, ultra-sound evaluation, histological examination, punch biopsies, and tape stripping.
  • Examples of classes of materials for use as skin- treating compounds in the practice of the present invention include nutrients, modifiers, rejuvinators, hormones, regulators, immunomodulators, moisturizers, and stimulators.
  • Examples of skin-treating materials for use in the practice of the present invention include: nutrients - vitamins, amino acids, and carbohydrates; modifiers - melanin and antioxidants; rejuvinators - growth factors and human growth hormones; hormones - estrogens, progesterones and other steroids, and growth hormones; regulators - peptides, proteins, and anti-sense variations; immunomodulators - beta 1, 3-glucan and farnesol; moisturizers - vegetable oils, beeswax, and other waxes, lanolins, fatty acid esters, mineral oils, and other hydrophobic materials; and stimulators - tocopheryl nicotinate, retinoids, and alpha- hydroxy acids.
  • a plurality of skin-treating compounds can be used in the composition.
  • the minimum percent improvement which is imparted by the skin-treating compound (s) to the skin and which constitutes a statistically significant difference will vary depending on the skin property being evaluated, as well as on sample size and distribution. For example, in evaluating epidermal thickness, an improvement of 10 % or greater is considered by persons skilled in the art as a statistically significant difference. On the other hand, in evaluating elasticity of skin, an improvement of at least about 30 % would be considered by persons skilled in the art as constituting a statistically significant difference.
  • the skin-treating compound (s) is used in conjunction with an enhancer which is a compound within the scope of Formula I below.
  • A is a group having the structure
  • X and Y are defined; m and n are integers having a value of from 1 to 20 and the sum of + n is not greater than 25; p is an integer having a value of 0 or 1; q is an integer having a value of 0 or 1; r is an integer having a value of 0 or 1; and R is hydrogen or an alkyl group having from 1 to 6 carbon atoms and may be straight chained or branched; with the proviso that when p, q and r have a value of 0 and Y is oxygen, m + n is at least 11.
  • R is alkyl
  • it can be, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec - butyl, amyl, hexyl, and the like.
  • a plurality of enhancers can be used.
  • the enchancers for use in the practice of this invention are non-toxic and are compatible with skin/hair treating compounds which comprise the composition of this invention. Additional improvements in the qualities of the skin are achieved by the use of the enhancer (s) in combination with the skin-treating compound. Such improvements are identified and evaluated by use of the same type of methodologies referred to hereinabove in connection with the skin-treating compound (s) .
  • the enhancer is a cyclic lactone compound wherein both X and Y are oxygen, q is 1 and r is 0, a cyclic diester (compounds wherein both X and Y are oxygen and both q and r are 1) , and a cyclic ketone (compounds wherein both q and r are 0 and Y is oxygen) .
  • m+n is preferably at least 3.
  • m+n is preferably from 11 to 15 and p is preferably 0.
  • Particularly preferred enhancers for use of the practice of the present invention include macrocylcic ketones and lactones of Formula I above.
  • a highly preferred enhancer is cyclopentadecanolide.
  • the skin-treating compound or a mixture of skin-treating compounds should be used in an amount which is effective in improving the quality of the skin.
  • the minimum amount (s) needed to achieve the improvement will vary depending on the particular skin-treating compound or mixture of skin-treating compounds that are used. Generally speaking, it is believed that the skin-treating compound (s) will comprise at least about 0.01 wt.% of the composition. Typically, the skin- treating compound(s) will comprise about 0.1 to about 10 wt.% of the composition. Preferably, the skin-treating compound (s) will comprise about 0.5 to about 3 wt.% of the composition.
  • the enhancer or a mixture of enhancers can be used in an amount at least effective to impart additional improvements to the skin, that is, improvements beyond those provided by the skin-treating compound. It is believed that, for most applications, the enhancer will comprise about 0.1 to about 30 wt.% of the composition, with a preferred range of enhancer being about 0.5 to about 10 wt.%, and a particularly preferred range comprising about 2 to about 5 wt.% of the composition.
  • the skin-improving composition of the present invention will generally include also a carrier in which the other ingredients comprising the composition are either dissolved or dispersed in the form of solid particles or liquid droplets.
  • a carrier in which the other ingredients comprising the composition are either dissolved or dispersed in the form of solid particles or liquid droplets.
  • Any suitable material can be used as the carrier, for example, materials which are suitable for use in pharmaceutical and cosmetic compositions.
  • carriers include water, alcohol, glycerine, sorbitol, propylene glycol, vegetable- and animal-derived oils, waxes, acids, alcohols, esters, ethers, amides, ethoxylates and propoxylates, ethylene and propylene glycol ethers, mineral oils and waxes, silicone oils and waxes, and surfactants.
  • the carrier can comprise one or more compounds.
  • the carrier will comprise about 10 to about 95 wt.% of the composition.
  • the composition will include also one or more compounds which impart other desired properties to the composition.
  • Such compounds will typically comprise materials of the type that are used as additives in cosmetic compositions. Examples of such materials are fragrances, colorants, including pigments or dyes, preservatives, thickening agents, pH controlling agents, stabilizers, surfactants, and emulsifiers.
  • the form of the composition can be liquid, semi-solid, or solid.
  • the composition can be formulated so that it can be dispersed from an aerosol container. For convenience and ease of application, the use of the composition in a cream or lotion form is recommended.
  • the skin-improving composition can be applied to the skin as often as needed to achieve the desired improvements.
  • the frequency of application will vary depending on the nature of the composition and the involved skin condition. In general, the application of the composition twice a day (for example, in the morning and the evening) will be suitable for treating many conditions and can be continued for as long as is required to obtain the desired results, for example, weeks or months or indefinitely. For some conditions, the composition can be applied every two or three days. In treating the skin of the hands, consideration should be given to applying the composition after every washing.
  • Compositions for treating hair are also within the scope of the present invention.
  • Such compositions can comprise hair-treating compounds, for example, materials which function as hair conditioners and compounds which improve the manageability of hair.
  • Such compositions can comprise a hair-treating compound and the enhancer of Formula I above, as well as other ingredients, and in amounts as described above in connection with the skin-improving composition.
  • the enhancer of the present invention can be used to advantage in any type of skin-enhancing composition which includes one or more skin- treating compounds that do not readily or easily penetrate the skin epithelial barrier.
  • Such compositions are well known to those skilled in the art.
  • An exemplary class of such compositions is an anti-oxidant composition.
  • Such compositions typically comprise a variety of natural nutrients, including, for example, vitamins, which function to rejuvenate the skin, retard the signs of aging of the skin and maintain the vitality of skin cells.
  • Retin A a material whose anti-wrinkle property has been well documented, it was determined that the performance of the composition of the present invention was equal to that of Retin A in terms of effecting an increase in epithelial thickness, but without the side effects experienced with Retin A.
  • Examples 1 to 3 below are illustrative of anti-oxidant compositions which promote the natural repair process and retard aging of the skin by providing skin cells with beneficial natural nutrients.
  • the enhancer used in the compositions is cyclopentadecanolide. It is believed that the enhancer functions to aid in the delivery of the nutrients effectively to the skin cells for their nourishment. This results in rejuvenation of the skin, imparting to the skin a radiant and youthful appearance.
  • the principal variations among the compositions are related to differences in viscosity and concentrations of ingredients.
  • Panthenol (Pantothenyl Alcohol) 1.00
  • compositions of Examples 1 to 3 are formulated into a substantially homogeneous composition with standard mixing, stirring, or shearing equipment, including high shear, as well as motionless or other mixers, for example, at room temperature - 90°C, to form a creamy emulsion or lotion with a smooth feeling.
  • the resultant compositions can be packaged, as appropriate, in plastic or aluminum tubes, glass or plastic jars, or glass or plastic bottles.
  • the compositions evidence gross physical stability even under drastic conditions, for example, at 60°C for 3 months.
  • Example 2 The hand and body cream of Example 2 is evaluated for effectiveness in tests involving humans (15 Caucasians, aged 50 years and older) .
  • the test subjects use the composition of Example 2 or a placebo cream, according to the blind code, for the first 2 months and then all subjects use the composition of Example 2.
  • the test compositions are rubbed into the hands daily at night before the test subjects retire.
  • the following techniques are used to evaluate the performance of the composition on the back of the hand: (A) photographs; (B) silastic castings; (C) ultrasound B-mode scans; (D) biopsies for histological examination; and (E) ballistometry.
  • the overall effects observed as a result of the use in the evaluations of the composition of Example 2 are summarized hereafter.
  • composition of Example 2 On the basis of photographic assessments (A) above, a comparison of the subjects shows a gradual improvement in the appearance of the dorsal surface of the hands as a result of the use of the composition of Example 2. Study of the photographs reveal that there is a decrease in the number of lines, a decrease in the depth of the interossei, and a general improvement in the smoothness of the skin. Use of composition of Example 2 appears to improve both the quality of the stratum corneum and the hydration of the epidermis and dermis. Improvement in the interossei depth, as manifested by a decrease in the depth, would indicate a dermal improvement .
  • Silastic castings of (B) above are evaluated and compared by two independent scorers. Changes in the skin's topography are rated according to the following scale: positive response; no response or no change; and negative response or worsening. These results are then averaged. At 30 days, there is no significant difference in the skin's topography. At 90 days, the silastic castings show that 60% of the subjects exhibited a positive response in the skin's topography, and at 180 days, 73% of the subjects have a positive response.
  • epidermal thickness increases by 19% over the course of the study, with a 50% increase being found in epidermal thickness in some subjects.
  • Granular layer increases in all subjects to at least double in thickness. This increase is estimated by the number of granular cells.
  • Stratum corneum appearance is markedly different in most subjects. From a compacted initial appearance, the stratum corneum assumes a basket weave pattern that is associated with a younger epidermis. Dermal evaluation is difficult to assess in that no special stains are used. Overall most subjects will show an increase in cellularity of the dermis. This finding would be consistent with a restructuring process of the dermis.
  • sunscreen compositions typically contain a plurality of sunscreen agents which are compounds that function to protect the skin by virtue of their ability to absorb various wavelengths of potentially harmful ultraviolet radiation.
  • Sunscreen compositions should have a combination of properties including, for example: (A) the fundamental ability to absorb the involved radiation; (B) the ability to continue to absorb the radiation over a prolonged period of time; and (C) the ability to resist removal upon exposure to water and/or perspiration. It is known that various sunscreen agents penetrate the skin relatively rapidly, with subsequent loss to lower skin layers (dermis) and eventually to systemic circulation.
  • the sunscreen agent (s) in the composition of the present invention is retained at higher concentrations for longer periods of time in the epidermis. It is believed that concentrating the sunscreen agent in the epidermis helps to provide a natural resistance to removal by exposure to physical contact and to water, including perspiration. The extent of this "retaining" effectiveness is dependent on the particular sunscreen agent (s) and carrier used and the concentration of the enhancer.
  • the enhancer used in each of the compositions of Examples 4 and 5 is cyclopentadecanolide.
  • Benzophenone-3 (Oxybenzone) 3.00% w/w
  • the present invention provides an effective means for improving the delivery to the body of a variety of types of materials which have beneficial effects on the body.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition et son utilisation pour améliorer l'état de la peau ou des cheveux, ladite composition comprenant: (A) un composé de traitement de la peau ou un composé de traitement capillaire; (B) un activateur de formule (I), dans laquelle X et Y représentent oxygène, soufre ou un groupe imino de structure =N-R, à condition que, lorsque Y représente le groupe imino, X soit un groupe imino, et lorsque X représente soufre, X représente soufre ou un groupe imino; A représente un groupe de structure (a), dans laquelle X et Y ont la signification mentionnée ci-dessus; m et n sont des nombres entiers compris entre 1 et 20 et la somme m + n est inférieure à 25; p est un nombre entier valant 0 ou 1; q est un nombre entier valant 0 ou 1; r est un nombre entier valant 0 ou 1; et R représente hydrogène ou un groupe alkyle comportant 1 à 6 atomes de carbones, à chaîne linéaire ou ramifiée; à condition que, lorsque p, q et r valent 0 et Y représente oxygène, la somme m + n soit au moins égale à 11; (C) un support; et éventuellement (D) un additif cosmétique.
PCT/US1997/000154 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux Ceased WO1998030198A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR9714464A BR9714464A (pt) 1997-01-09 1997-01-09 Composição para melhorar a pele ou cabelo
PCT/US1997/000154 WO1998030198A1 (fr) 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux
JP53514398A JP2002514203A (ja) 1997-01-09 1997-01-09 皮膚又は毛髪の増進用組成物
CA002275971A CA2275971C (fr) 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux
EP97903746A EP0964672A4 (fr) 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux
KR10-1999-7006000A KR100521787B1 (ko) 1997-01-09 1997-01-09 피부 또는 머리카락을 개선하기 위한 조성물
IL13066397A IL130663A (en) 1997-01-09 1997-01-09 Cosmetic composition for enhancing skin or hair
AU18238/97A AU731269B2 (en) 1997-01-09 1997-01-09 Composition for enhancing skin or hair

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/000154 WO1998030198A1 (fr) 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux

Publications (1)

Publication Number Publication Date
WO1998030198A1 true WO1998030198A1 (fr) 1998-07-16

Family

ID=22260188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/000154 Ceased WO1998030198A1 (fr) 1997-01-09 1997-01-09 Composition pour ameliorer l'etat de la peau ou des cheveux

Country Status (7)

Country Link
EP (1) EP0964672A4 (fr)
JP (1) JP2002514203A (fr)
KR (1) KR100521787B1 (fr)
AU (1) AU731269B2 (fr)
CA (1) CA2275971C (fr)
IL (1) IL130663A (fr)
WO (1) WO1998030198A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
WO2005051341A3 (fr) * 2003-11-21 2005-07-21 Gillette Co Composition cosmetique topique
US9125816B2 (en) 2000-08-30 2015-09-08 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248831A (en) * 1991-06-28 1993-09-28 Haarmann & Reimer Gmbh Ethers of 1-hydroxy-hex-5-en-2-one, processes for their preparation and their use as odoriferous substances

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3690626C2 (de) * 1985-12-04 1997-05-15 Dean Hsieh Arzneimittel, enthaltend neben einer wirksamen Arzneistoffmenge ein Lacton oder cyclisches Keton
AU618517B2 (en) * 1986-12-23 1992-01-02 Eugene J. Van Scott Additives enhancing topical actions of therapeutic agents
JPH05310543A (ja) * 1992-05-08 1993-11-22 Kao Corp 染毛剤組成物
WO1996012467A1 (fr) * 1994-10-20 1996-05-02 The Procter & Gamble Company Compositions de soins personnels et/ou compositions cosmetiques contenant un parfum persistant
US5540853A (en) * 1994-10-20 1996-07-30 The Procter & Gamble Company Personal treatment compositions and/or cosmetic compositions containing enduring perfume
JPH08259444A (ja) * 1995-03-24 1996-10-08 Earth Chem Corp Ltd 殺菌効力増強剤及びそれを配合した口腔用組成物
KR19990036357A (ko) * 1996-06-11 1999-05-25 코다 타다아키 항균제 및 그것을 사용한 화장품 및 의료품

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248831A (en) * 1991-06-28 1993-09-28 Haarmann & Reimer Gmbh Ethers of 1-hydroxy-hex-5-en-2-one, processes for their preparation and their use as odoriferous substances

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
US9125816B2 (en) 2000-08-30 2015-09-08 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism
US9132089B2 (en) 2000-08-30 2015-09-15 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism
WO2005051341A3 (fr) * 2003-11-21 2005-07-21 Gillette Co Composition cosmetique topique

Also Published As

Publication number Publication date
CA2275971A1 (fr) 1998-07-16
IL130663A (en) 2005-12-18
AU1823897A (en) 1998-08-03
KR20000069832A (ko) 2000-11-25
JP2002514203A (ja) 2002-05-14
EP0964672A4 (fr) 2001-03-21
CA2275971C (fr) 2008-04-29
AU731269B2 (en) 2001-03-29
EP0964672A1 (fr) 1999-12-22
KR100521787B1 (ko) 2005-10-14
IL130663A0 (en) 2000-06-01

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