MXPA99006422A - Composition for enhancing skin or hair - Google Patents

Abstract

A composition and its use for enhancing the qualities of skin or hair, the composition comprising:(A)a skin-treating compound or a hair-treating compound;(B) an enhancer having structure (I) wherein:X and Y are oxygen, sulfur, or an imino group of the structure=N-R, with the proviso that when Y is the imino group, X is an imino group and when Y is sulfur, X is sulfur or an imino group;A is a group having the structure (a) wherein X and Y are defined;m and n are integers having a value of from 1 to 20 and the sum of m + n is not greater than 25;p is an integer having a value of 0 or 1;q is an integer having a value of 0 or 1;r is an integer having a value of 0 or 1;and R is hydrogen or an alkyl group having from 1 to 6 carbon atoms and may be straight chained or branched;with the proviso that when p, q and r have a value of 0 and Y is oxygen, m + n is at least 11;(C) a carrier;and optionally (D) a cosmetic additive.

Description

COMPOSITION TO IMPROVE SKIN OR HAIR FIELD OF THE INVENTION This invention relates to means for improving the physiological condition of the body. Very particularly, this invention relates to a composition that is effective in improving the qualities of the skin and hair. It is known that there are several types of materials that are effective in improving various properties of the skin, for example, properties such as skin smoothness and skin texture. Examples of such materials are vitamins, antioxidant growth factors and steroids. In the same way it is known that there are several types of materials that are effective in improving various hair properties, including, for example, materials that function as hair conditioners and materials that function to improve the manageability of hair. The present invention relates to the provision of an improved composition for improving the qualities of the skin or hair.

BRIEF DESCRIPTION OF THE INVENTION In accordance with the present invention, there is provided a composition which is effective for improving the qualities of the skin and hair and which comprises: (A) a compound for the treatment of the skin or a compound for the treatment of hair; (B) an improver, as described below; (C) a carrier; and optionally (D) a cosmetic additive. Another aspect of the present invention is the provision of a method for improving one or more properties of the skin or hair that comprises applying to the skin or hair a composition of the present invention. In a preferred form, the composition is applied to the body part in the form of a cream or lotion. Numerous benefits provided by the present invention will be clear in the examples set forth below.

BRIEF DESCRIPTION OF THE INVENTION As set forth above, the composition of the present invention comprises a compound for the treatment of the skin or hair, an enhancer, a carrier, and optionally a cosmetic additive. The term "skin treatment compound" means a material that is effective to improve one or more skin properties as a test for statistically significant differences between the quality of the untreated skin and the skin treated with said material, to a 95% confidence level, using standard evaluation methods that are known to those skilled in the art. Examples of skin characteristics or properties that are capable of being improved by a compound for treating the skin include: (A) skin smoothness; (B) thickness of the epidermal layer of the skin; (C) increase in the cellular density of the skin; (D) reduction in interosseous depth; (E) skin elasticity; (F) skin texture. Methods for objectively evaluating skin properties of the aforementioned type are well known to those skilled in the art. These include, for example, the use of clinical evaluations, photographic evaluations, silastic castings, ultrasound evaluation, histological examination, punch biopsies and tape detachment. Examples of classes of materials to be used as skin treatment compounds in the practice of the present invention include nutrients, modifiers, rejuvenators, hormones, regulators, immunomodulators, humectants, and stimulators. Examples of materials for the treatment of the skin for use in the practice of the present invention include: nutrients - vitamins, amino acids, and carbohydrates; modifiers - melanin and antioxidants; rejuvenating - growth factors and human growth hormones; hormones - estrogens, progesterones and other steroids, and growth hormones; regulators - peptides, proteins, and anti-sensations variations; Immunomodulators - beta 1,3-glucan and famesol; humectants - vegetable oils, beeswax, and other waxes, lanolins, fatty acid esters, mineral oils, and other hydrophobic materials; and stimulants - tocopheryl nicotinate, retinoids, and alpha hydroxy acids. A large number of compounds can be used for the treatment of the skin in the composition.

The minimum percentage of improvement that is imparted by the compound (s) for skin skin treatment and that constitutes a statistically significant difference, as mentioned above, will vary depending on the property of the skin to be evaluated, as well as the size and distribution of the sample. For example, in evaluating epidermal thickness, an improvement of 10% or greater is considered by statisticians to be a statistically significant difference. On the other hand, when evaluating the elasticity of the skin, an improvement of at least 30% should be considered by those skilled in the art as constituting a statistically significant difference. The compound (s) for the treatment of the skin is used together with an improver which is a compound within the scope of Formula I which is presented below.

Formula Where: X and Y are oxygen, sulfur or an imino group of structure = N-R, with the proviso that when Y is the minimum group, X is an imino group and when Y is sulfur, X is sulfur or an imino group; A is a group that has the structure Y - c - x where X and Y are defined; m and n are integers that have a value 'from 1 to 20 and the sum of m + n is not greater than 25; p is an integer having a value of 0 or 1; q is an integer that has a value of 0 or 1; r is an integer that has a value of 0 or 1; and R is hydrogen or an alkyl group having 1 to 6 carbon atoms and can be straight or branched chain; with the proviso that when p, q and p have the value of 0 and Y is oxygen, m + n is at least 11. When R is alkyl it may be, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, amyl, hexyl, and the like. A large number of breeders can be used. The enhancers that are used in the practice of this invention are non-toxic and are compatible with the skin / hair treatment compounds comprising the composition of this invention. Additional improvements in the qualities of the skin are achieved with the use of the improver (s) in combination with the compound for the treatment of the skin. Said improvements are identified and evaluated by the use of the same type of methodologies mentioned above with respect to the compound (s) for the treatment of the skin. Preferably the builder is a compound, cyclic lactone wherein X and Y are oxygen, q is 1 and r is 0, a cyclic diester (compounds wherein X and Y are oxygen and both q and r are 1), and a cyclic ketone (compounds where both q and r are 0 and Y is oxygen). When the enhancer is a cyclic diester, m + n is preferably at least 3. When the enhancer is a cyclic ketone, m + n is preferably 11 to 15 and p is preferably 0. Particularly preferred improvers for the use of the practice of the present invention include macrocyclic ketones and 'lactones of Formula I above. A highly preferred improver is cyclopentadecanolide. The compound for the treatment of the skin or a mixture of the compounds for the treatment of the skin should be used in an amount that is effective in improving the quality of the skin. The minimum amount (s) that is needed to achieve the improvement will vary depending on the compound for the particular skin treatment or the mixture of the skin treatment compounds that are used. Generally speaking, it is believed that the compound (s) for the treatment of the skin will comprise at least about 0.01. % by weight of the composition. Typically, the compound (s) for the treatment of the skin will comprise from about 0.1 to about 10% by weight of the composition. Preferably, the compound (s) for the treatment of the skin will comprise from about 0.5 to about 3% by weight of the composition. The breeder or breeder mix can be used in an at least effective amount to provide additional skin improvements, ie, improvement beyond those provided by the compound for the treatment of the skin. It is believed, that for most applications, the improver will comprise from about 0.1 to about 30% by weight of the composition, with a preferred scale of the improver about 0.5 to about 10% by weight, and a particularly preferred scale that comprises about 2 to about 5% by weight of the composition. The composition for improving the skin of the present invention will generally also include a vehicle in which the other ingredients comprising the composition are also dissolved or dispersed in the form of solid particles or liquid drops. Any suitable material can be used as a carrier, for example, materials that are suitable for use in pharmaceutical and cosmetic compositions. Examples of carriers include water, alcohol, glycerin, sorbitol, propylene glycol, oils derived from plants and animals, waxes, acids, alcohols, esters, ether, amides, ethoxylates, and propoxylates, ethylene and propylene glycol ethers, mineral oils and waxes, silicone and waxes, and surfactants. The carrier may comprise one or more compounds. Generally speaking, the carrier will comprise about 10 to about 95% by weight of the composition. Optionally, but typically, the composition will also include one or more compounds that give other desired properties to the composition. Such compounds will typically comprise materials of the type that are used as additives in cosmetic compositions. Examples of such materials are fragrances, colorants, including pigments or dyes, preservatives, thickening agents, pH controlling agents, stabilizers, surfactants and emulsifiers. The form of the composition can be liquid, semi-solid, or solid. The composition can be formulated so that it can be dispersed from an aerosol container. For comfort and ease of application, the use of the composition in the form of a cream or lotion is recommended. The improved skin composition can be applied to the skin as frequently as needed to achieve the desired improvements. The frequency of application will vary depending on the nature of the composition and the condition of the skin to be treated. In general, the application of the composition twice a day (for example in the morning and at night) will be adequate to treat many conditions and may continue to do so for as long as required to obtain the desired results, for example, weeks or months or indefinitely. For some circumstances, the composition can be applied every two or three days. To treat the skin of the hands, considerations must be given to apply the composition after each wash. Compositions for treating hair are also within the scope of the present invention. Said compositions can comprise hair treatment compounds, for example, materials that function as hair conditioners and compounds that improve the manageability of hair. Said compositions may comprise a hair treatment compound and the enhancer of Formula I above, as other ingredients, and in amounts as described above with respect to the composition for improving the skin. It should also be appreciated that the enhancer of the present invention can be usefully used in any type of skin improvement composition that includes one or more skin treatment compounds that do not promptly or easily penetrate the epithelial barrier of the skin. skin. Such compositions are well known to those skilled in the art. An illustrative class of said compositions is an antioxidant composition. Said compositions typically comprise a variety of natural nutrients, including, for example, vitamins, which work to rejuvenate the skin, slow the signs of aging in the skin and maintain the vitality of skin cells. In a comparative in vivo study comprising the use of an antioxidant composition within the scope of the present invention and Retin A, a material whose anti-wrinkle property has been well documented, it was determined that the performance of the composition of the present invention was equal to that of Retin A in terms of effectiveness and increase in epithelial thickness, but without the side effects experienced with Retin A. Examples 1 to 3 below are illustrative of the antioxidant compositions that promote the natural repair procedure and the delay in the aging of the skin by providing skin cells with beneficial natural nutrients. The improver used in the compositions is cyclopentadecanolide. It is believed that the enhancer works to assist in the effective release of nutrients to skin cells for nutrition. This results in the rejuvenation of the skin, giving the skin a radiant and youthful appearance. The main variations between the compositions are related to the differences in viscosity and concentrations of the ingredients. These differences illustrate that the compositions can be custom-made for the convenience and effectiveness of the application - for example, for repetitive use during the day, especially after the body or parts of the body, such as hands, are washed or clean, or for the application at night before sleep.

EXAMPLE 1 LOTION FOR HANDS AND BODY Vitamin A Palmitate 0.38% w / w Magnesium Ascorbyl Phosphate 0.75 Vitamin E acetate 0.38 Alpha-bisabolol 0.38 Panthenol (pantotenyl alcohol) 0.25 Disodium edetate 0.10 Sodium citrate 0.60 Trolamine (Triethanolamine) 1.70 Diethanolamine methoxycinnamate (DEA methoxycinnamate) 2.00 Concentrate of Aloe Vera gel 1.00 Beeswax, white 0.50 Mineral oil, clear 4.00 Cetyl palmitate 1.00 Soy starral 1.00 Cetyl alcohol 2.00 Stearic acid 3.00, Carbomer 934 0.10 Copolymer of poly (Vinylpyrrolidone) / 1-eicosene 1.00 Methylparaben 0.20 Propylparaben 0.10 Imidazolidinylurea (Imidurea) 0.30 Hydroxytoluene butylated (BHT) 0.20 Cyclopentadecanolide 4.00 Fragrance CS Water is Total 100.00% p / p EXAMPLE 2 CREAM FOR HANDS AND BODY Vitamin A Palmitate 0.50 p / p Magnesium Ascorbyl Phosphate 0.75% Vitamin E Acetate 1.50 Alpha-bisabolol 1.00 Panthenol (pantotenyl alcohol) 1.00 Disodium edetate 0.10 Sodium citrate 0.60 Trolamine (Triethanolamine) 0.50 Diethanolamine methoxycinnamate '(DEA methoxycinnamate) 2.00 Aloe Vera Gel Concentrate 1.00 Escualane 3.00 Cetyl Esters 2.00 Stearyl Alcohol 4.00 PEG-40 Stearate 4.00 Glyceryl Monostearate 3.00 Methylparaben 0.20 Propylparaben 0.10 Imidazolidinylurea (Imidurea) 0.30 Butylated Hydroxytoluene (BHT) 0.20 Silicone Oils 5.50 Cyclopentadecanolide 4.00 Fragrance CS Water CS Total 100.00% p / p EXAMPLE 3 NIGHT CREAM Vitamin A palmitate 0.375% w / w Ascorbyl magnesium phosphate 3.000 Vitamin E acetate .500 Alfa-bisabolol 1.000 Panthenol (pantotenyl alcohol) 1,000 Disodium edetate 0.100 Sodium citrate 0.600 Trolamine (Triethanolamine) 0.500 Diethanolamine methoxycinnamate (DEA methoxycinnamate) 2,000 Aloe Vera gel concentrate 1,000 Escualan 3,000 Cetyl esters 2,000 Mineral oil, clear 4,000 Stearyl alcohol 4,000 PEG-40 stearate 2,500 Glyceryl monostearate 4,500 Methylparaben 0.200 Propylparaben 0.100 Imidazolidinylurea (Imidurea) 0.300 Butylated hydroxytoluene (BHT) 0.200 Silicone oils 5.000 Cilopentadecanolide 4.000 Fragrance CS Water CS Total 100.00% p / p The ingredients of the compositions of Examples 1 to 3 were formulated in a substantially homogeneous composition with standard mixing, stirring or shear application equipment, including high shear mixers as well as non-moving mixers or other mixers, for example, at a temperature that varies from room temperature to 90 ° C, to form a creamy emulsion or lotion with a soft feel. The resulting compositions can be packaged, suitably, in plastic or aluminum tubes, glass or plastic jars, or glass or plastic bottles. The compositions show evident physical stability even under drastic conditions, for example, at 60 ° C for three months. The hand and body cream of Example 2 is evaluated for effectiveness in tests involving humans (15 Caucasians, 50 years or older). The subjects tested used the composition of Example 2 or a placebo cream, in accordance with the blind code, for the first 2 months and subsequently all subjects tested used the composition of Example 2. The test compositions are rubbed in the hands daily in the night before the subjects under test withdrew. The following techniques were used to evaluate the performance of the composition in the back of the hand. (A) photographs; (B) silastic recesses; (C) ultrasound mode B scanners; (D) biopsies for histological examination; and (E) ballistometry. All the effects observed as a result of the use of the composition evaluations of Example 2 are summarized in the following. Based on the above photographic evaluations (A), a comparison of the subjects under test shows a gradual improvement in the appearance of the dorsal surface of the hands as a result of the use of the composition of Example 2. The study of the photographs reveals that there is a decrease in the number of lines, a decrease in interosseous depth, and a general improvement in the smoothness of the skin. The use of the composition of Example 2 appears to improve both the stratum corneum quality and the hydration of the epidermis and dermis. The improvement in interosseous depth as manifested by the decrease in depth, will indicate a dermal improvement. The silastic castings of (B) above were evaluated and compared by two independent evaluators. The changes in the topography of the skin were evaluated according to the following scale: positive response; no response or no change; and negative response or worsening. Later these results were averaged. At 30 days there is no important difference in the topography of the skin. At 90 days, the castings showed that 60% of the subjects tested showed a positive response in the topography of the skin, and at 180 days, 73% of the subjects tested had a positive response. Based on the ultrasound evaluation of (C) above, the total effects that occur from the use of composition Example 2 can be summarized by means of three observations. (1) the epidermis in most of the subjects under test became thick and better hydrated; (2) the papillary dermis increase in density; (3) the reticular dermis increase in density. The course in time of events showed a gradual increase in thickness and density until three or four months. After this period, the increase reached a stable stage or declined slightly. These findings suggest an initial proliferative effect of the product on the epidermis followed by a dermal restructuring. From the histological examination of (D) above, the painted sections are examined and evaluated for the following parameters: (1) epidermal thickness; (2) size of the granular layer; (3) appearance of the stratum corneum; and (4) appearance of the dermis. The epidermal thickness increased by 19% during the study, with an increase of 50% found in the epidermal thickness in some subjects under test. The granular layer is increased in all subjects tested at least twice as thick. This increase in estimate by the number of granular cells. The appearance of the stratum corneum is markedly different in most subjects tested. From a compact initial appearance, the stratum corneum adopts a radiating ligament pattern that is related to a young epidermis. The dermal evaluation is difficult to evaluate since no special dyes are used. Overall, most subjects tested will show an increase in cellular character of the dermis. This discovery may be consistent with a procedure for restructuring the dermis. Based on a ballistic evaluation of (E) above, 10 subjects tested have a positive response and 4 subjects tested do not have a significant change. A subject under test has a negative response. This test measures the dermal changes (not epidermal changes) and suggests that some restructuring of the dermis occurs. Based on the data obtained in the evaluation of the use of the composition of Example 2, conclusions can be made regarding the use of the composition of Example 2: (1) the product is effective to increase the epidermal thickness; (2) the product is effective to produce smoothness, well-structured corneal extract; (3) the product increases epidermal proliferation; (4) the product increases the elasticity of the skin; (5) the product helps restore the dermal structure and (6) the product is effective in restoring the aging of the hands to give them a more youthful appearance. The following two examples are illustrative of the use of the improver of the present invention in sunscreen compositions. Such compositions typically contain a large amount of sunscreen agents which are compounds that function to protect the skin by virtue of their ability to absorb various wavelengths of potentially harmful ultraviolet radiation. The sunscreen compositions have to have a combination of properties including, for example: (A) the fundamental ability to absorb the radiation in question; (B) the ability to continue absorbing radiation for a prolonged period; and (C) the ability to resist removal by exposure to water and / or perspiration. It is known that several sunscreen agents penetrate the skin relatively quickly, with subsequent loss to the lower layers of the skin (dermis) and finally to the systemic circulation. In the development of the present invention, it has been observed that the sunscreen agent (s) in the composition of the present invention is retained at high concentrations for long periods in the epidermis. It is believed that concentrating the sunscreen agent in the epidermis helps provide natural resistance to removal by exposure to physical contact and water, including perspiration. The extent of this "retention" effectiveness depends on the particular agent (s) of sunscreen and carrier used and the concentration of the improver. The improver used in each composition of Example 4 and 5 is cyclopentadecanolide.

EXAMPLE 4 LOTION WITH SOLAR FILTER Benzophenone-3 (Oxybenzone) 3.0% w / w Diethanolamine methoxycinnamate (DEA methoxycinnamate) 3.0 Cyclopentadecanoiido 4.0 Silicone oil 5.0 Glycerium monostearate 5.0 PEG-40 stearate 1.0 Sodium lauryl sulfate 0.5 Stearyl alcohol 7.1 Cetyl esters 5.0 Propylparaben 0.2 Butylated hydroxytoluene ( BHT) 0.2 Diethylene glycol monomethyl ether 30.0 Water CS Total 100.0% p / p EXAMPLE 5 LOTION WITH SOLAR FILTER Benzophenone-3 (Oxybenzone) 3.00% w / w Diethanolamine methoxycinnamate (DEA Methoxycinnamate) 3.00 Cyclopentadecanolide 4.00 Silicone oil 1.00 Glycerin (Glycerol) 5.00 Propylene glycol 5.00 Carbomer 941 0.25 Squalene 3.00 Stearic acid 1.50 Cetyl esters 0.50 Cetyl alcohol 0.50 Glyceryl monostearate 3.00 PEG-40 stearate 1.50 Trolamine (Triethanolamine) 0.50 Methylparaben 0.20 Propylparaben 0.10 Imidazolidinylurea (Imidurea) 0.30 Fragrance CS Water CS Total 100.00% w / w It should be noted that the present invention provides effective means to improve the body's distribution of a variety of types of materials that have beneficial effects on the body.

Claims (18)

NOVELTY OF THE INVENTION CLAIMS

1. - A composition that is effective to improve the qualities of the skin or hair and that comprises: (A) a compound for the treatment of 'skin or a compound for hair treatment; (B) an improver that has the

Formula I where: X and Y are oxygen, sulfur or an imino group of structure = N-R, with the proviso that when Y is the imino group, X is a minimum group and when Y is sulfur, X is sulfur or an imino group; A is a group that has the structure - c - x where X and Y are defined; m and n are integers that have a value from 1 to 20 and the sum of m + n is not greater than 25; p is an integer having a value of 0 or 1; q is an integer that has a value of 0 or 1; r is an integer that has a value of 0 or 1; and R is hydrogen or an alkyl group having 1 to 6 carbon atoms and can be straight or branched chain; with the proviso that when p, q and r have the value of 0 and Y is oxygen, m + n is at least 11; (C) a carrier; and optionally (D) a cosmetic additive. 2. A composition according to claim 1, further characterized in that the amount of said compound in said composition is at least about 0.01% by weight.

3. A composition according to claim 1, further characterized in that it comprises from about 0.1 to about 10% by weight of said compound and about 0.1 to about 30% by weight of said improver.

4. A composition according to claim 3, further characterized in that it comprises from about 0.5 to about 3% by weight of said compound and from about 0.5 to about 10% by weight of said improver.

5. A composition according to claim 3, further characterized in that it comprises from about 2 to about 5% by weight of said improver.

6. A composition according to claim 2, further characterized in that it is an antioxidant composition and wherein said compound includes an antioxidant material.

7. A composition according to claim 1, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

8. - A composition according to claim 2, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

9. A composition according to claim 3, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

10. A composition according to claim 4, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

11. A composition according to claim 5, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

12. A composition according to claim 6, further characterized in that said enhancer is essentially composed of cyclopentadecanolide.

13. A composition according to claim 1, further characterized in that it includes said compound for the treatment of the skin.

14. A composition according to claim 7, further characterized in that it includes said compound for the treatment of the skin.

15. - A composition according to claim 13, further characterized in that the compound for the treatment of the skin includes a sunscreen agent.

16. A method for improving a property of the skin or hair that comprises applying, in addition, a composition of claim 1.

17. A method according to claim 16, further characterized in that it includes applying a composition of conformity to the skin. with claim 1 and include a compound for the treatment of the skin.

18. A method according to claim 16, further characterized in that it includes applying to the hair a composition according to claim 1 and including a compound for the treatment of the hair. SUMMARY OF THE INVENTION A composition and its use for improving the qualities of the skin or hair, the composition comprising: a compound for the treatment of the skin or a compound for the treatment of hair; an improver that has a structure (I) where: X and Y are oxygen, sulfur or an imino group of the structure = N-R, with the proviso that when Y is the imino group, X is an imino group and when Y is sulfur, X is sulfur or an imino group; A is a group that has the structure (a) - C-X where X and Y are defined; m and n are integers that have a value from 1 to 20 and the sum of m + n is not greater than 25; p is an integer having a value of 0 or 1; q is an integer that has a value of 0 or 1; r is an integer that has a value of 0 or 1; and R is hydrogen or an alkyl group having 1 to 6 carbon atoms and can be straight or branched chain; with the proviso that when p, q and r have a value of 0 and Y is oxygen, m + n is at least 11; a carrier; and optionally a cosmetic additive. PM / mmr * sll * amm P99 / 896F