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WO1998023260A3 - Non-ionic surfactant vesicles as a delivery agent for nucleic acid - Google Patents

Non-ionic surfactant vesicles as a delivery agent for nucleic acid Download PDF

Info

Publication number
WO1998023260A3
WO1998023260A3 PCT/GB1997/003235 GB9703235W WO9823260A3 WO 1998023260 A3 WO1998023260 A3 WO 1998023260A3 GB 9703235 W GB9703235 W GB 9703235W WO 9823260 A3 WO9823260 A3 WO 9823260A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
ionic surfactant
delivery agent
surfactant vesicles
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1997/003235
Other languages
French (fr)
Other versions
WO1998023260A2 (en
Inventor
Katharine Christine Carter
Alexander Balfour Mullen
Alan James Baillie
John Douglas Ansell
William Gerard Murphy
Kay Samuel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Edinburgh
University of Strathclyde
Common Services Agency for Scottish Health Service
Original Assignee
University of Edinburgh
University of Strathclyde
Common Services Agency for Scottish Health Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Edinburgh, University of Strathclyde, Common Services Agency for Scottish Health Service filed Critical University of Edinburgh
Priority to JP52442098A priority Critical patent/JP2001510459A/en
Priority to EP97945945A priority patent/EP0946148A2/en
Publication of WO1998023260A2 publication Critical patent/WO1998023260A2/en
Publication of WO1998023260A3 publication Critical patent/WO1998023260A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides an aqueous formulation (especially an injectable formulation) comprising a polynucleotide and a carrier component suspended in an aqueous delivery vehicle. The formulation though not exclusively comprises DNA or RNA in combination with vesicles comprised of non-ionic surfactants.
PCT/GB1997/003235 1996-11-26 1997-11-26 Non-ionic surfactant vesicles as a delivery agent for nucleic acid Ceased WO1998023260A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP52442098A JP2001510459A (en) 1996-11-26 1997-11-26 Nonionic surfactant vesicles as nucleic acid release agents
EP97945945A EP0946148A2 (en) 1996-11-26 1997-11-26 Non-ionic surfactant vesicles as a delivery agent for nucleic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9624536.0A GB9624536D0 (en) 1996-11-26 1996-11-26 Non-ionic surfactant vesicles as a delivery agent for nucleic acid
GB9624536.0 1996-11-26

Publications (2)

Publication Number Publication Date
WO1998023260A2 WO1998023260A2 (en) 1998-06-04
WO1998023260A3 true WO1998023260A3 (en) 1998-08-27

Family

ID=10803479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/003235 Ceased WO1998023260A2 (en) 1996-11-26 1997-11-26 Non-ionic surfactant vesicles as a delivery agent for nucleic acid

Country Status (4)

Country Link
EP (1) EP0946148A2 (en)
JP (1) JP2001510459A (en)
GB (1) GB9624536D0 (en)
WO (1) WO1998023260A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2802422B1 (en) * 1999-12-21 2002-08-09 Capsulis MIXED STRUCTURES RESULTING FROM THE INCORPORATION OF A BIOLOGICAL MACROMOLECULE, PARTICULARLY DNA, IN A STRUCTURED PHASE OF AMPHIPHILES AND VESICLES OBTAINED FROM THESE STRUCTURES
WO2009156706A1 (en) * 2008-06-27 2009-12-30 University Of Strathclyde Pulmonary drug delivery with vesicles comprising non-ionic surfactants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016437A1 (en) * 1993-12-17 1995-06-22 Micro-Pak, Inc. Method of transmitting a biologically active material to a cell
WO1996004890A1 (en) * 1994-08-10 1996-02-22 University Of Strathclyde Vesicle formulation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016437A1 (en) * 1993-12-17 1995-06-22 Micro-Pak, Inc. Method of transmitting a biologically active material to a cell
WO1996004890A1 (en) * 1994-08-10 1996-02-22 University Of Strathclyde Vesicle formulation

Also Published As

Publication number Publication date
WO1998023260A2 (en) 1998-06-04
JP2001510459A (en) 2001-07-31
EP0946148A2 (en) 1999-10-06
GB9624536D0 (en) 1997-01-15

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