WO1998006411A2 - Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale - Google Patents
Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale Download PDFInfo
- Publication number
- WO1998006411A2 WO1998006411A2 PCT/IT1997/000201 IT9700201W WO9806411A2 WO 1998006411 A2 WO1998006411 A2 WO 1998006411A2 IT 9700201 W IT9700201 W IT 9700201W WO 9806411 A2 WO9806411 A2 WO 9806411A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diarrhoea
- lactobacillus
- treatment
- acute
- preparation
- Prior art date
Links
- 241000186660 Lactobacillus Species 0.000 title claims abstract description 15
- 229940039696 lactobacillus Drugs 0.000 title claims abstract description 14
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 39
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 230000001154 acute effect Effects 0.000 claims description 11
- 235000013305 food Nutrition 0.000 claims description 7
- 206010020751 Hypersensitivity Diseases 0.000 claims description 5
- 230000007815 allergy Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 230000001332 colony forming effect Effects 0.000 claims description 2
- 208000004262 Food Hypersensitivity Diseases 0.000 abstract description 6
- 235000020932 food allergy Nutrition 0.000 abstract description 6
- 208000011580 syndromic disease Diseases 0.000 abstract description 6
- 206010016946 Food allergy Diseases 0.000 abstract description 5
- 238000004904 shortening Methods 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 208000005577 Gastroenteritis Diseases 0.000 description 9
- 241000702670 Rotavirus Species 0.000 description 6
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000004916 vomit Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000020247 cow milk Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 244000000021 enteric pathogen Species 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 241000607534 Aeromonas Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 241000223935 Cryptosporidium Species 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000224466 Giardia Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010022678 Intestinal infections Diseases 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 201000010859 Milk allergy Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- QFKWSRIUZIYLCK-UHFFFAOYSA-J copper;disodium;hydrogen carbonate;2-hydroxypropane-1,2,3-tricarboxylic acid;hydroxide;sulfate Chemical compound [OH-].[Na+].[Na+].[Cu+2].OC([O-])=O.[O-]S([O-])(=O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O QFKWSRIUZIYLCK-UHFFFAOYSA-J 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000003870 intestinal permeability Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 206010036784 proctocolitis Diseases 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
Definitions
- the present invention seeks to provide a formulation responsive to such requirements.
- Lactobacillus casei subspecies rhamnosius (so-called also Lactobacillus GG initially isolated from the intestinal bacterial flora of a man) , administered both in the form of powder and yoghurt produced by the fermentation of the milk with said enzyme, is capable of shortening by about 2 days the duration of the diarrhoea in little patients with gastroenteritis by rotavirus which is considered as the most common etiologic agent of acute infant's diarrhoea in the world.
- enteric pathogens Rotavirus and Adenoviru ⁇ of the enteric type (40-41) , Giardia and Cryptosporidium, Salmonella, Shigella, Campylobacter, Yersinia, Aeromonas, E. Coli pathogens (ETEC, EPEC, EHEC, EIEC, EAggEC, searched by specific DNA probes) .
- enteric pathogens Rotavirus and Adenoviru ⁇ of the enteric type (40-41) , Giardia and Cryptosporidium, Salmonella, Shigella, Campylobacter, Yersinia, Aeromonas, E. Coli pathogens (ETEC, EPEC, EHEC, EIEC, EAggEC, searched by specific DNA probes) .
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'administration précoce de Lactobacillus GG pendant la phase de réhydratation permet de raccourcir la durée de la diarrhée, de prévenir le syndrome d'allergie alimentaire s'ensuivant chez le patient, et de stimuler une augmentation rapide du poids. Pour ce faire, on a produit une préparation à administrer par voie buccale et constituée d'une solution de réhydration orale de type commercial, tel que Dicodral 60, dans laquelle est contenue une dose efficace de ferments Lactobacillus GG à la fois vivants et inactivés.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97935765A EP0918531A2 (fr) | 1996-08-09 | 1997-08-04 | Utilisation de lactobacillus gg dans la solution de rehydratation |
| AU38639/97A AU3863997A (en) | 1996-08-09 | 1997-08-04 | Treatment of the acute infant's diarrhoea and prevention of allergic reactions to foods swallowed in the following phase by administering lactobacillus gg in the oral rehydrating solution |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000571A IT1284877B1 (it) | 1996-08-09 | 1996-08-09 | Trattamento delle diarree acute del bambino e prevenzione della sensibilizzazione allergica verso alimenti introdotti nella fase |
| ITRM96A000571 | 1996-08-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998006411A2 true WO1998006411A2 (fr) | 1998-02-19 |
| WO1998006411A3 WO1998006411A3 (fr) | 1998-05-07 |
Family
ID=11404390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IT1997/000201 WO1998006411A2 (fr) | 1996-08-09 | 1997-08-04 | Traitement de la diarrhee infantile aigue et prevention des reactions allergiques a des aliments ingeres dans la phase suivant l'administration de lactobacillus gg dans la solution de rehydratation orale |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0918531A2 (fr) |
| AU (1) | AU3863997A (fr) |
| IT (1) | IT1284877B1 (fr) |
| WO (1) | WO1998006411A2 (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1034787A1 (fr) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Souches de lactobacillus capables de prévenir la diarrhée causée des bactéries pathogènes |
| EP1034788A1 (fr) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Souches de bacteries lactiques capables de prevenir la diarrhée |
| WO2000053202A1 (fr) * | 1999-03-11 | 2000-09-14 | Societe Des Produits Nestle S.A. | Souches de lactobacille pouvant prevenir la diarrhee provoquee par des bacteries pathogenes et des rotavirus |
| WO2001095741A1 (fr) * | 2000-06-13 | 2001-12-20 | Unilever N.V. | Produit alimentaire contenant du lactobacille non-viable |
| US7183108B1 (en) | 1998-11-18 | 2007-02-27 | Compagnie Gervais Danone | Selection and uses of lactic acid bacteria strains modulating non-specific immunity |
| ES2277550A1 (es) * | 2005-12-21 | 2007-07-01 | Laboratorios Casen-Fleet, S.L. | Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes. |
| WO2012062781A1 (fr) * | 2010-11-11 | 2012-05-18 | Nestec S.A. | Micro-organismes probiotiques ne se répliquant pas et protégeant les enfants des infections gastro-intestinales |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839281A (en) * | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
| AU624067B2 (en) * | 1986-12-12 | 1992-06-04 | Biorem C.C. | Preparation suitable for use in the treatment of enteric disorders |
| AU7687091A (en) * | 1990-04-09 | 1991-10-30 | Medicis Corporation | Antidiarrheal composition and method |
| US5413785A (en) * | 1993-01-27 | 1995-05-09 | New England Deaconess Hospital Corp. | Methodology employing lactobacillus GG for reduction of plasma endotoxin levels circulating in-vivo |
| WO1994018997A1 (fr) * | 1993-02-24 | 1994-09-01 | Valio Ltd. | Procede d'amelioration de la reponse immunitaire aux vaccins oraux |
-
1996
- 1996-08-09 IT IT96RM000571A patent/IT1284877B1/it active IP Right Grant
-
1997
- 1997-08-04 EP EP97935765A patent/EP0918531A2/fr not_active Withdrawn
- 1997-08-04 WO PCT/IT1997/000201 patent/WO1998006411A2/fr not_active Application Discontinuation
- 1997-08-04 AU AU38639/97A patent/AU3863997A/en not_active Abandoned
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7183108B1 (en) | 1998-11-18 | 2007-02-27 | Compagnie Gervais Danone | Selection and uses of lactic acid bacteria strains modulating non-specific immunity |
| US6835376B1 (en) | 1999-03-11 | 2004-12-28 | Nestec S.A. | Lactobacillus paracasei strain for preventing diarrhea caused by pathogenic bacteria |
| US6887465B1 (en) | 1999-03-11 | 2005-05-03 | Nestec S.A. | Lactobacillus strains capable of preventing diarrhoea caused by pathogenic bacteria and rotaviruses |
| WO2000053200A1 (fr) * | 1999-03-11 | 2000-09-14 | Societe Des Produits Nestle S.A. | Souches de lactobacille empechant la diarrhee causee par des bacteries pathogenes |
| WO2000053201A1 (fr) * | 1999-03-11 | 2000-09-14 | Societe Des Produits Nestle S.A. | Souches de bacteries d'acide lactique a capacite antidiarrheique |
| EP1034788A1 (fr) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Souches de bacteries lactiques capables de prevenir la diarrhée |
| EP1415656A1 (fr) * | 1999-03-11 | 2004-05-06 | Société des Produits Nestlé S.A. | Souches de Lactobacillus pouvant prévenir la diarrhée causée par les rotavirus |
| US7029669B1 (en) | 1999-03-11 | 2006-04-18 | Nestec S. A. | Lactic acid bacteria strains capable of preventing diarrhoea |
| EP1034787A1 (fr) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Souches de lactobacillus capables de prévenir la diarrhée causée des bactéries pathogènes |
| WO2000053202A1 (fr) * | 1999-03-11 | 2000-09-14 | Societe Des Produits Nestle S.A. | Souches de lactobacille pouvant prevenir la diarrhee provoquee par des bacteries pathogenes et des rotavirus |
| AU779804B2 (en) * | 1999-03-11 | 2005-02-10 | Societe Des Produits Nestle S.A. | Lactic acid bacteria strains capable of preventing diarrhoea |
| AU779789B2 (en) * | 1999-03-11 | 2005-02-10 | Societe Des Produits Nestle S.A. | Lactobacillus strains capable of preventing diarrhoea caused by pathogenic bacteria and rotaviruses |
| AU2001269015B2 (en) * | 2000-06-13 | 2004-10-14 | Unilever Plc | Non-viable lactobacillus containing food product |
| WO2001095741A1 (fr) * | 2000-06-13 | 2001-12-20 | Unilever N.V. | Produit alimentaire contenant du lactobacille non-viable |
| ES2277550A1 (es) * | 2005-12-21 | 2007-07-01 | Laboratorios Casen-Fleet, S.L. | Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes. |
| ES2277550B1 (es) * | 2005-12-21 | 2008-06-16 | Laboratorios Casen-Fleet, S.L. | Kit farmaceutico para la preparacion de una sal de hidratacion con un probiotico para bebes. |
| WO2012062781A1 (fr) * | 2010-11-11 | 2012-05-18 | Nestec S.A. | Micro-organismes probiotiques ne se répliquant pas et protégeant les enfants des infections gastro-intestinales |
| EP2455094A1 (fr) * | 2010-11-11 | 2012-05-23 | Nestec S.A. | Micro-organismes probiotiques sans réplication pour protéger les enfants contre les infections gastro-intestinales |
| US9345728B2 (en) | 2010-11-11 | 2016-05-24 | Nestec S.A. | Non-replicating probiotic micro-organisms protect children against gastrointestinal infections |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0918531A2 (fr) | 1999-06-02 |
| WO1998006411A3 (fr) | 1998-05-07 |
| ITRM960571A0 (fr) | 1996-08-09 |
| IT1284877B1 (it) | 1998-05-22 |
| ITRM960571A1 (it) | 1998-02-09 |
| AU3863997A (en) | 1998-03-06 |
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