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WO1998058842A1 - Procede de sterilisation de fournitures medicales - Google Patents

Procede de sterilisation de fournitures medicales Download PDF

Info

Publication number
WO1998058842A1
WO1998058842A1 PCT/JP1998/002735 JP9802735W WO9858842A1 WO 1998058842 A1 WO1998058842 A1 WO 1998058842A1 JP 9802735 W JP9802735 W JP 9802735W WO 9858842 A1 WO9858842 A1 WO 9858842A1
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
medical device
packaging material
package
oxygen concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1998/002735
Other languages
English (en)
Japanese (ja)
Inventor
Akira Otsuka
Kiyoshi Uno
Hidetoshi Hatayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Gas Chemical Co Inc
Gambro KK
Original Assignee
Mitsubishi Gas Chemical Co Inc
Gambro KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Gas Chemical Co Inc, Gambro KK filed Critical Mitsubishi Gas Chemical Co Inc
Priority to AU80360/98A priority Critical patent/AU8036098A/en
Publication of WO1998058842A1 publication Critical patent/WO1998058842A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation

Definitions

  • the present invention relates to a method for sterilizing a medical device package and a medical device package sterilized by the method. More specifically, for example, by encapsulating both a medical device and a delayed-acting oxygen scavenger in an oxygen-impermeable material, medical devices that prevent the formation of by-products due to oxidation after radiation sterilization
  • the present invention relates to a method for sterilizing a tool package.
  • radiation sterilization methods such as gamma linear sterilization are widely used as sterilization methods for medical device packages.
  • disposable medical devices such as artificial dialysis machines are sterilized by radiation after being enclosed in packaging materials and delivered to users in that state in order to maintain sterility until just before use.
  • the acetate group constituting the membrane is used. Oxidation produces aldehydes, such as acetoaldehyde and formaldehyde, which may have an adverse effect on patients who are users.
  • the main material of the dialysis machine is plastic, and the strength may decrease due to the oxidization over time due to oxygen excited during radiation sterilization.
  • gamma linear sterilization is a method that can achieve excellent sterilization effects in the presence of oxygen, although it is possible even in the absence of oxygen.
  • an artificial dialyzer is placed in a gas-permeable sterilization bag, which is sterilized by gamma, and then put into an aluminum packaging material while keeping the sterilization bag while maintaining the sterility.
  • the nozzle is inserted into the aluminum packaging material, the air in the packaging material is evacuated by a vacuum pump, and nitrogen gas is injected. This process is performed twice in order to reduce the amount of oxygen removed. After that, the nozzle is pulled out, sealed, and shipped. In this way, the gas permeable The air in the packaging material is replaced with nitrogen gas to remove oxygen without compromising the sterility of the sterilization bag.
  • Japanese Patent Publication No. 5-509496 discloses a method in which a hollow fiber type blood processor and an oxygen scavenger are both sealed in a container made of a gas impermeable material and irradiated with radiation for sterilization.
  • the radiation include gamma rays (Claim 2)
  • examples of the blood processor include a blood processor using a regenerated cellulose hollow fiber membrane (Claim 5).
  • oxygen in the container is absorbed by the oxygen scavenger, and is in an oxygen-free state during sterilization (column 4, line 10, line 15). This publication does not mention that the absence of oxygen during sterilization reduces the sterilization effect.
  • the sterilization effect is obtained by the formation of oxygen radicals during gamma ray irradiation, and that oxygen radicals are obtained by influencing and killing bacteria. It was found that the sterilization effect was obtained even at low oxygen levels. That is, there was no substantial change in the sterilization effect if the oxygen concentration was above 0.1%, preferably above 0.2%, more preferably 1% or above.
  • oxygen radicals formed during sterilization can affect the material of dialysis machines, especially in the case of dialysis machines made from regenerated cellulose, and may generate aldehydes.
  • the present inventors have also found that performing sterilization under a reduced oxygen concentration can suppress the generation of unwanted by-products while maintaining the sterilization effect. That is, when the reduced oxygen concentration is lower than 4-5%, preferably lower than 2%, and more preferably 1% or lower, excellent production conditions are obtained.
  • the present inventors have reached the present invention, and the effects of the present invention can be explained by harmful substances such as aldehydes generated by irradiation for sterilization. That is, according to the sterilization in the reduced oxygen atmosphere of the present invention, almost no such harmful products were generated.
  • radiation sterilization may initiate a reaction that will later produce harmful products under the influence of oxygen.
  • the first object of the present invention is to provide a medical device and an oxygen absorber in an oxygen-impermeable packaging material.
  • a step of performing radiation sterilization on the package while maintaining the atmosphere in the package at a reduced oxygen concentration; maintaining the sterilized state of the package after the radiation sterilization A method of sterilizing a medical device package, further comprising a step of reducing the oxygen concentration with a deoxidizer. Products manufactured in this manner are harmful due to the reduced oxygen atmosphere during sterilization while maintaining the efficiency of sterilization by radiation sterilization, and the reduced oxygen concentration during subsequent storage. It was possible to suppress the generation of by-products, and thus to avoid an increase in irradiation dose.
  • the reduced oxygen concentration is above 0.1%, preferably above 0.2%, more preferably at or above 1%. Further, the reduced oxygen concentration is below 5%, preferably below 4%, more preferably below 2%, even more preferably 1% or below. Furthermore, the reduced oxygen concentration after sterilization is below 0.1%.
  • the method comprises sealing the package under a reduced oxygen concentration atmosphere, and encapsulating the oxygen scavenger in a sealed packaging material having opening means such as breaking means; and Can be carried out by radiation sterilization under a reduced oxygen concentration, then breaking the breaking means and exposing the oxygen absorber to the atmosphere inside the package to further reduce the oxygen concentration.
  • the breaking means may be one that breaks under the influence of radiation sterilization.
  • a preferred method of the present invention is a method in which the oxygen scavenger is sealed in a sustained-release packaging material, whereby the oxygen concentration of the package can be reduced at a constant rate at a certain rate.
  • the package is illuminated when reduced to the desired value.
  • This method provides very favorable manufacturing conditions and provides an improved method with very limited manufacturing steps.
  • the invention also relates to a product made by the method described above.
  • FIG. 1 is a diagram showing an embodiment of the medical device package according to the present invention from above
  • FIG. 2 is a diagram showing an embodiment of the medical device package according to the present invention from the side
  • FIG. 4 is a side view of another embodiment of the medical device package according to the present invention.
  • the medical device and the delayed-acting oxygen scavenger packaging material are both enclosed in a packaging material made of an oxygen-impermeable material.
  • the above-mentioned delayed-acting oxygen scavenger packaging material is a gas-permeable packaging material in which a relatively small air permeability can be obtained stably, in which the oxygen scavenger is stored, and the medical device packaging for radiation sterilization.
  • the body has an oxygen concentration above 0.1%, preferably above 0.2%, more preferably at or above 1%, and below 5%, preferably below 4%. More preferably, the oxygen concentration is controlled to be less than 2%, more preferably 1% or less, and the oxygen concentration after 2 weeks of radiation sterilization is controlled to be less than 0.1%.
  • Radiation sterilization is usually performed within 3 to 7 days after the completion of the production of medical devices.
  • the oxygen concentration in the packaging material is described assuming that radiation sterilization is performed 5 days after the completion of production. This was adopted as a criterion to indicate the degree of delayed action of the oxygen scavenger package and does not mean that radiation sterilization should be performed 5 days after encapsulation.
  • the oxygen concentration can be realized, for example, by controlling the air permeability of the material constituting the packaging material, and various types of resin films made of synthetic polymers or natural polymers, woven fabrics conventionally used in the field of laminates
  • One material having desired air permeability may be selected from nonwoven fabrics and the like, or these materials may be appropriately combined to form a laminate to obtain desired air permeability.
  • a ventilation hole may be provided in some or each layer of the laminate to obtain a desired air permeability. The thickness of each layer is appropriately set.
  • the inner layer perforated plastic film 6 (hereinafter referred to as the inner layer film), because of its low breathability and low danger of the oxygen scavenger leaking out of the packaging material.
  • a cross-sectional breathable sheet 7 and an outer layer plastic film 8 (hereinafter, referred to as an outer layer film) are laminated in this order from the inside of the packaging material containing the oxygen scavenger. Ventilate through the exposed section of the air-permeable sheet at the end section of the packaging material, or reduce the porosity of the outer film to the inner film. It is preferable that a laminated body having a structure in which ventilation is further provided by providing a ventilation hole to control the ventilation is used for at least a part of the packaging material.
  • the porosity (the ratio of the open area to the total area of the outer layer film) is preferably less than 1%.
  • the porosity of the inner layer film is not particularly limited, but is usually 1 to 10%.
  • the oxygen scavenger packaging material is used to reduce the oxygen in the various sizes of packaged goods to which it is applied within two weeks after radiation sterilization within a certain period of deoxidation required to obtain good preservability.
  • the oxygen absorber, the size of the packaging material used for packaging the oxygen absorber, and the air permeability must be changed according to the amount of oxygen present in the article package when the oxygen absorber is enclosed.
  • the air permeability suitable for the delayed-acting oxygen absorber packaging material used in the medical device package of the present invention is as follows: the moisture permeability of the oxygen absorber packaging material is P (mg / 24 Hrs) as a measure of air permeability; Assuming that the amount of oxygen present in the package at the time of packaging is V (ml), the value K represented by the following relational expression is preferably 10 or less, more preferably 8 or less.
  • the moisture permeability P of the oxygen scavenger packaging material was determined by filling a sample filled with anhydrous calcium chloride in place of the oxygen scavenger packaging material (oxygen scavenger) at 25 ° C or lower and 75% RH. Determined by storing within a desiccated overnight humidified condition and measuring the weight gain per sample 24 hours later.
  • Materials for the inner layer film and the outer layer film include polymers of olefins such as ethylene, propylene, butene, pentene, and hexene, vinyl chloride, vinylidene chloride, vinyl acetate, vinyl alcohol, acrylate, and methacrylate. And polymers of vinyl compounds such as acrylonitrile and styrene, polymers of diolefins such as butadiene and isoprene and copolymers thereof, polyamides and polyesters. Of these, polyester, polyamide, and polyolefin are preferred for the outer layer film, and polymers of polyolefin or vinyl compound having a lower melting point than the outer layer film are preferred for the inner layer film so that bag making by heat welding is easy.
  • olefins such as ethylene, propylene, butene, pentene, and hexene
  • vinyl chloride vinylidene chloride
  • vinyl acetate vinyl alcohol
  • acrylate acrylate
  • polyester is more preferably used for the outer layer film
  • polyethylene is more preferably used for the inner layer film.
  • the cross-sectional breathable sheet is a laminate-like sheet that has air permeability in the plane direction at least inside the thickness thereof, and is preferably made of paper or nonwoven fabric, and is printed on the inner surface or outer surface of the outer layer film.
  • a layer may be provided, and a reinforcing layer or the like may be provided at an arbitrary position.
  • the laminate shall be folded or laminated with the perforated plastic film inside, sealed with an oxygen scavenger, and sealed to form a three-sided or four-sided sealed bag.
  • a deoxygenating agent may be sealed in the laminated body, and a non-breathable plastic film may be stacked and sealed to form a four-side seal bag.
  • the sealing may be performed using an adhesive, but it is preferable to heat seal the plastic film as a sealant.
  • oxygen scavenger those mainly containing iron powder, which can use various compounds conventionally used in this field, are preferable.
  • an auxiliary such as a water donor impregnated with water on a porous carrier, activated carbon, or silica may be appropriately selected and added to the oxygen scavenger.
  • any material conventionally used in the field of laminates for example, a metal foil, a metal deposition film, a metal oxide deposition film, a glass deposition film, a vinylidene chloride synthetic resin, Those containing at least one layer of a vinylidene acetate-based synthetic resin, an acrylonitrile-based synthetic resin, or the like can be used.
  • the outer layer is made of nylon
  • the intermediate layer is a laminate of EVOH (ethylene vinyl acetate polymer, saponified)
  • the inner layer is a laminate of polyethylene
  • the outer layer is nylon
  • the intermediate layer is A laminate of polyvinyl alcohol, an inner layer of polyethylene; an outer layer of polyester, an intermediate layer of aluminum foil, and an inner layer of polyethylene are preferred.
  • an artificial dialyzer which has conventionally been considered unsuitable for radiation sterilization, particularly a regenerated cellulose membrane of a hollow fiber membrane type, particularly a cellulose acetate membrane Suitable for use are artificial dialysers that use dialysis and medical devices that are susceptible to adverse effects such as deterioration due to oxygen.
  • Radiation sterilization is used as a sterilization method. Among them, gamma ray sterilization is preferable from the viewpoint of cost.
  • FIGS. 1 and 2 are views showing one embodiment of the medical device package according to the present invention at different angles.
  • the main body of the medical device 1 is sealed together with the oxygen-absorbing material 2 in an oxygen-impermeable material.
  • an oxygen-impermeable laminate sheet (Pairflex FA29I trade name, manufactured by Kureha Chemical Co., Ltd.) used on the bottom side 5 of the packaging material is drawn out of the roll, heated by a heater, and air-heated. And pressed into a mold to form a concave shape with a medical device enclosure as shown in FIG.
  • the oxygen scavenger packaging material 2 (Ageless Z—300 PK gas, moisture permeability of the package 3 O mg / 24 Hr, trade name, product of Mitsubishi Gas Chemical Co., Ltd., manufactured by Mitsubishi Gas Chemical Co., Ltd.) is automatically loaded by the automatic feeding machine. Put in the center of part 5.
  • the medical device is placed on top of it, and the oxygen-impermeable laminate sheet (Boblon, trade name, product of Kureha Chemical Co., Ltd.) used for the packaging material top 3 is pulled out of the roll and the packaging material bottom It is overlapped with the part 5, and the periphery is sealed and sealed by heat sealing (the amount of oxygen at the time of sealing is about 120 ml).
  • the oxygen concentration in the packaging material of the oxygen-impermeable material of the medical device package of this example was 1% at the time of radiation sterilization, and 0.1% or less two weeks after the sterilization.
  • each of the above three test samples is primed and washed with 150 ml of distilled water only on the blood side. Thereafter, 500 ml of distilled water at 37 ° C is circulated at 6:00 at a flow rate of 400 ml / min only on the blood side. This extract is used as a specimen.
  • the measurement is performed by reversed-phase high-performance liquid chromatography using acetoaldehyde and formaldehyde as hydrazone derivatives, a column packed with octyl groups in the stationary phase, and acetonitrile / water as the mobile phase.
  • the packaging material made of an oxygen-impermeable material
  • the oxygen present in the packaging material at the time of sealing is absorbed by the enclosed slow-acting oxygen absorber packaging material at the same time, and the interior of the packaging material is almost completely oxygen-free until the packaging material is opened immediately before use. Can be kept.
  • FIG. 4 is a view showing another embodiment of the medical device package according to the present invention.
  • the oxygen scavenger packaging material 2 ′ has a breaking pin 9 as an opening means.
  • the outer film is impervious to oxygen and breaks the breaking pin 9 until the interior of the oxygen absorber 2 ′ is exposed to the oxygen atmosphere inside the package consisting of the package top 3 and package bottom 5. The oxygen cannot enter the oxygen scavenger 2 '.
  • the by-product from a medical device by time-dependent oxidation for example, the production

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Packages (AREA)

Abstract

L'invention porte sur un procédé de stérilisation consistant à: placer des fournitures médicales dans un emballage imperméable à l'oxygène, stériliser l'emballage par irradiation tout en maintenant à l'intérieur une faible concentration d'oxygène, puis à l'issue de l'irradiation, à réduire encore la concentration d'oxygène au moyen d'un désoxydant qui maintient l'emballage dans des conditions stériles. Avec ce procédé, la concentration d'oxygène portée à un niveau réduit pendant la stérilisation maintient lors du stockage le niveau de stérilisation acquis par l'irradiation et la faible concentration en oxygène. On peut ainsi inhiber la formation de sous-produits nocifs et prévoir des fournitures médicales très sûres.
PCT/JP1998/002735 1997-06-20 1998-06-19 Procede de sterilisation de fournitures medicales Ceased WO1998058842A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80360/98A AU8036098A (en) 1997-06-20 1998-06-19 Method for sterilizing packages of medical supplies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16402697 1997-06-20
JP9/164026 1997-06-20

Publications (1)

Publication Number Publication Date
WO1998058842A1 true WO1998058842A1 (fr) 1998-12-30

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PCT/JP1998/002735 Ceased WO1998058842A1 (fr) 1997-06-20 1998-06-19 Procede de sterilisation de fournitures medicales

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AU (1) AU8036098A (fr)
WO (1) WO1998058842A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002000699A (ja) * 2000-06-23 2002-01-08 Jms Co Ltd 医療用具のための包装材料
JP2003245526A (ja) * 2001-12-19 2003-09-02 Toray Ind Inc 中空糸膜およびその製造方法、中空糸膜モジュールおよびその製造方法
WO2006016575A1 (fr) * 2004-08-10 2006-02-16 Toyo Boseki Kabushiki Kaisha Membrane de type fibre creuse, hautement perméable à l'eau, pour purifier le sang et procédé pour fabriquer cette membrane
WO2006041125A1 (fr) * 2004-10-15 2006-04-20 Nipro Corporation Procédé de stérilisation d’hémopurificateur et paquet hémopurificateur
EP1518564A3 (fr) * 2003-09-24 2006-10-04 Nipro Corporation Dispositif à fibres creuses pour traitement du sang et méthode pour l'emballer et le stériliser
WO2006104082A1 (fr) * 2005-03-28 2006-10-05 Toyo Boseki Kabushiki Kaisha Module emballe destine a la purification du sang et procede de sterilisation de celui-ci
JP2010017712A (ja) * 2001-12-19 2010-01-28 Toray Ind Inc 中空糸膜および中空糸膜モジュール
US7837042B2 (en) 2004-08-10 2010-11-23 Nipro Corporation Polysulfone type selectively permeable hollow fiber membrane module and process for manufacturing the same
US8319195B2 (en) 2003-06-12 2012-11-27 Safe Haven, Inc. Methods and apparatus for sterilization of air and objects
EP1834655A4 (fr) * 2004-12-22 2014-12-17 Nipro Corp Boitier de purificateur sanguin et son procede de fabrication
US9050410B2 (en) 2004-10-15 2015-06-09 Nipro Corporation Blood purifier and blood purifier package
WO2015194668A1 (fr) * 2014-06-20 2015-12-23 旭化成メディカル株式会社 Colonne d'élimination de neutrophiles
JP2016007235A (ja) * 2014-06-20 2016-01-18 旭化成メディカル株式会社 放射線が照射された体外循環用顆粒球除去器包装体
JP2017023681A (ja) * 2015-07-17 2017-02-02 アイオン株式会社 ポリビニルアセタール樹脂多孔質体の滅菌方法及び滅菌用包装体
JP2017137062A (ja) * 2016-02-01 2017-08-10 株式会社常盤産業 袋体および包装体
JP2017159026A (ja) * 2016-02-05 2017-09-14 ビー．ブラウン アビタム アーゲーＢ． Ｂｒａｕｎ Ａｖｉｔｕｍ Ａｇ フィルタモジュールのパッケージングユニット
JP2017164486A (ja) * 2016-02-05 2017-09-21 ビー．ブラウン アビタム アーゲーＢ． Ｂｒａｕｎ Ａｖｉｔｕｍ Ａｇ フィルタモジュール包装ユニット
EP3184446A4 (fr) * 2014-08-22 2018-03-21 Terumo Kabushiki Kaisha Procédé de fabrication d'instrument médical conditionné
WO2018181793A1 (fr) 2017-03-29 2018-10-04 共同印刷株式会社 Film absorbant l'oxygène, corps d'emballage stratifié et corps d'emballage utilisant le film absorbant l'oxygène, et procédé de traitement de contenus à l'aide du corps d'emballage

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6326010B2 (fr) * 1980-10-17 1988-05-27 Dainippon Printing Co Ltd
JPH01267130A (ja) * 1988-04-13 1989-10-25 Toppan Printing Co Ltd 包装材料の殺菌方法
JPH0318371A (ja) * 1989-06-15 1991-01-25 Nippon Medical Supply Corp 医療用具の放射線滅菌方法
JPH0349807B2 (fr) * 1982-03-10 1991-07-30 Unitika Ltd
JPH0550946B2 (fr) * 1986-03-03 1993-07-30 Nisso Kk

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6326010B2 (fr) * 1980-10-17 1988-05-27 Dainippon Printing Co Ltd
JPH0349807B2 (fr) * 1982-03-10 1991-07-30 Unitika Ltd
JPH0550946B2 (fr) * 1986-03-03 1993-07-30 Nisso Kk
JPH01267130A (ja) * 1988-04-13 1989-10-25 Toppan Printing Co Ltd 包装材料の殺菌方法
JPH0318371A (ja) * 1989-06-15 1991-01-25 Nippon Medical Supply Corp 医療用具の放射線滅菌方法

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002000699A (ja) * 2000-06-23 2002-01-08 Jms Co Ltd 医療用具のための包装材料
JP2010017712A (ja) * 2001-12-19 2010-01-28 Toray Ind Inc 中空糸膜および中空糸膜モジュール
JP2003245526A (ja) * 2001-12-19 2003-09-02 Toray Ind Inc 中空糸膜およびその製造方法、中空糸膜モジュールおよびその製造方法
US8319195B2 (en) 2003-06-12 2012-11-27 Safe Haven, Inc. Methods and apparatus for sterilization of air and objects
EP1518564A3 (fr) * 2003-09-24 2006-10-04 Nipro Corporation Dispositif à fibres creuses pour traitement du sang et méthode pour l'emballer et le stériliser
AU2004212619B2 (en) * 2003-09-24 2009-12-17 Nipro Corporation Hollow fiber blood-processing device and method for packaging and sterilizing such devices
US8211362B2 (en) 2003-09-24 2012-07-03 Nipro Corporation Packaged blood purification device
US7837042B2 (en) 2004-08-10 2010-11-23 Nipro Corporation Polysulfone type selectively permeable hollow fiber membrane module and process for manufacturing the same
JP4848278B2 (ja) * 2004-08-10 2011-12-28 東洋紡績株式会社 高透水性中空糸膜型血液浄化器及びその製造方法
WO2006016575A1 (fr) * 2004-08-10 2006-02-16 Toyo Boseki Kabushiki Kaisha Membrane de type fibre creuse, hautement perméable à l'eau, pour purifier le sang et procédé pour fabriquer cette membrane
JP2006110164A (ja) * 2004-10-15 2006-04-27 Toyobo Co Ltd 血液浄化器の滅菌方法および血液浄化器包装体
US10137234B2 (en) 2004-10-15 2018-11-27 Nipro Corporation Method for sterilizing blood purifier and blood purifier package
WO2006041125A1 (fr) * 2004-10-15 2006-04-20 Nipro Corporation Procédé de stérilisation d’hémopurificateur et paquet hémopurificateur
US9987409B2 (en) 2004-10-15 2018-06-05 Nipro Corporation Blood purifier and blood purifier package
US9050410B2 (en) 2004-10-15 2015-06-09 Nipro Corporation Blood purifier and blood purifier package
US9056280B2 (en) 2004-10-15 2015-06-16 Nipro Corporation Method for sterilizing blood purifier and blood purifier package
US9067178B2 (en) 2004-12-22 2015-06-30 Nipro Corporation Blood purifier package and process for manufacturing the same
EP1834655A4 (fr) * 2004-12-22 2014-12-17 Nipro Corp Boitier de purificateur sanguin et son procede de fabrication
EP2962712A1 (fr) 2004-12-22 2016-01-06 Nipro Corporation Boitier de purificateur sanguin et son procede de fabrication
EP3437670A1 (fr) 2004-12-22 2019-02-06 Nipro Corporation Boitier de purificateur sanguin et son procede de fabrication
US9987408B2 (en) 2004-12-22 2018-06-05 Nipro Corporation Blood purifier package and process for manufacturing the same
WO2006104082A1 (fr) * 2005-03-28 2006-10-05 Toyo Boseki Kabushiki Kaisha Module emballe destine a la purification du sang et procede de sterilisation de celui-ci
JPWO2015194668A1 (ja) * 2014-06-20 2017-04-20 旭化成メディカル株式会社 好中球除去カラム
WO2015194668A1 (fr) * 2014-06-20 2015-12-23 旭化成メディカル株式会社 Colonne d'élimination de neutrophiles
JP2016007235A (ja) * 2014-06-20 2016-01-18 旭化成メディカル株式会社 放射線が照射された体外循環用顆粒球除去器包装体
EP3184446A4 (fr) * 2014-08-22 2018-03-21 Terumo Kabushiki Kaisha Procédé de fabrication d'instrument médical conditionné
JP2017023681A (ja) * 2015-07-17 2017-02-02 アイオン株式会社 ポリビニルアセタール樹脂多孔質体の滅菌方法及び滅菌用包装体
JP2017137062A (ja) * 2016-02-01 2017-08-10 株式会社常盤産業 袋体および包装体
JP2017159026A (ja) * 2016-02-05 2017-09-14 ビー．ブラウン アビタム アーゲーＢ． Ｂｒａｕｎ Ａｖｉｔｕｍ Ａｇ フィルタモジュールのパッケージングユニット
JP2017164486A (ja) * 2016-02-05 2017-09-21 ビー．ブラウン アビタム アーゲーＢ． Ｂｒａｕｎ Ａｖｉｔｕｍ Ａｇ フィルタモジュール包装ユニット
JP7009065B2 (ja) 2016-02-05 2022-01-25 ビー．ブラウン アビタム アーゲー フィルタモジュール包装ユニット
WO2018181793A1 (fr) 2017-03-29 2018-10-04 共同印刷株式会社 Film absorbant l'oxygène, corps d'emballage stratifié et corps d'emballage utilisant le film absorbant l'oxygène, et procédé de traitement de contenus à l'aide du corps d'emballage
JPWO2018181793A1 (ja) * 2017-03-29 2019-12-12 共同印刷株式会社 酸素吸収性フィルム、これを用いた包装用積層体及び包装体、並びに包装体を用いた内容物処理方法
EP3603965A4 (fr) * 2017-03-29 2020-11-25 Kyodo Printing Co., Ltd. Film absorbant l'oxygène, corps d'emballage stratifié et corps d'emballage utilisant le film absorbant l'oxygène, et procédé de traitement de contenus à l'aide du corps d'emballage

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