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WO1998051363A1 - Pulverisateur - Google Patents

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Publication number
WO1998051363A1
WO1998051363A1 PCT/GB1998/001341 GB9801341W WO9851363A1 WO 1998051363 A1 WO1998051363 A1 WO 1998051363A1 GB 9801341 W GB9801341 W GB 9801341W WO 9851363 A1 WO9851363 A1 WO 9851363A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
port means
mixing chamber
carrier gas
spray
Prior art date
Application number
PCT/GB1998/001341
Other languages
English (en)
Inventor
Iain Michael Jocelyn Mackenzie
Original Assignee
Isis Innovation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation Limited filed Critical Isis Innovation Limited
Publication of WO1998051363A1 publication Critical patent/WO1998051363A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0463—Tracheal tubes combined with suction tubes, catheters or the like; Outside connections

Definitions

  • the present invention relates to a spray forming device.
  • a number of devices for administering drugs to patients in the form of sprays are known, for example, pressurised spray bottles.
  • a spray forming device for producing a spray in the form of an atomised agent dispersed within a carrier gas, the device comprising a mixing chamber having a releasable gas port means for attachment to a supply of pressurised carrier gas; a releasable agent port means for attachment to a supply of the agent to be dispersed; and an outlet nozzle.
  • the agent is preferably in the form of a liquid.
  • such a device When in use, such a device preferably forms a part of a complete spray application system which further includes a means for supplying agent to the device, which means is connected to the device via the agent port means, and a source of pressurised carrier gas, which source is connected to the device via the gas port means.
  • the spray forming device of the present invention may be disposed of separately from the source of pressurised carrier gas and the means for supplying agent to the device.
  • the spray forming device further comprises a one-way valve associated with the agent port means, which valve acts to prevent the flow of gas from the mixing chamber towards the supply of agent via the agent port means.
  • the valve takes the form of a flexible sleeve mounted in the mixing chamber such that a part of its outer surface lies against, and thus closes, an inlet from the agent port means.
  • a one-way valve in this manner has the advantage of enabling a very simple unit, such as a common syringe, to be used as the means for supplying agent to the device.
  • a unit such as a syringe as the means for supplying agent to the device gives rise to the significant advantage that a physician using the device has complete control over the composition of the agent and exactly how much is administered to the patient.
  • the device may be used with any desired solution or mixture of solutions.
  • the use of a unit such as a syringe also has the advantage of rendering the operation of the spray forming device very straightforward such that no great manual dexterity is required on the part of an operator.
  • the nozzle is elongate having a length of between 0.5cm and 10cm and an internal diameter of between 0.1 mm and 5mm. Such a nozzle gives rise to a fine, well directed spray from the nozzle tip regardless of the skill of the operator of the device.
  • a method of forming a spray in the form of an atomised agent dispersed within a carrier gas comprising the steps of providing a device comprising a mixing chamber having a releasable gas port means, a releasable agent port means and an outlet nozzle; releasably attaching a pressurised source of carrier gas to the gas port means; releasably attaching a means for supplying agent to the device, to the agent port means; and simultaneously supplying carrier gas and agent to the mixing chamber via the first and second inlets respectively.
  • the carrier gas used is preferably a respirable gas such as medical oxygen or air and is preferably supplied to the mixing chamber at a rate of 1 to 2 litres per minute.
  • the advantage of such an arrangement is that the spray application system may be operated in synchrony with the patient's inspiration.
  • the agent is typically a drug, anaesthetic or similar for administration to a patient or animal.
  • the device may be used to administer both local and general anaesthetics.
  • Figure 2 is a cross sectional side view of the spray forming device of Figure 1 .
  • the spray forming device 10 comprises a housing 11 within which is formed a mixing chamber 12 having a first inlet 14 and an associated releasable gas port means 15 for attachment to a supply (not shown) of pressurised carrier gas such as medical oxygen or air.
  • the carrier gas flows into the mixing chamber 12 in the direction indicated by arrow A1 in Figure 2.
  • a second inlet 24 to the mixing chamber 12 has an associated releasable agent port means 25 for attachment to a supply (not shown) of agent.
  • An O-ring valve 30 is formed at the second inlet 24 and acts to allow flow through the valve only in the direction indicated by arrow A2 in Figure 2.
  • the O-ring valve 30 essentially comprises a flexible cylinder (for example one made of rubber), which, because of its position in front of the inlet 24, prevents the flow of fluid past the valve 30 into the inlet 24. None- the-less, when pressure is applied from the inlet 24, the cylinder deforms inwardly sufficiently to permit the flow of fluid from the inlet 24 to the mixing chamber 12 between the housing 11 and the outer surface of the valve 30.
  • the nozzle 40 extends away from the mixing chamber 12 and is preferably formed integrally with the housing 11.
  • the nozzle is preferably elongate, as shown, having a length of between 0.5cm and 10cm and an internal diameter of between 0.1mm and 5mm.
  • the device 10 shown in Figures 1 and 2 is formed from a conventional narrow gauge intravenous cannula with an injection port 25 (e.g. 20 or 22G Venflon®).
  • an injection port 25 e.g. 20 or 22G Venflon®
  • the device could, of course, be custom made which would reduce costs.
  • a carrier gas in the form of medical air or oxygen is supplied from a pressurised canister thereof (not shown) to the device 10 via medical "green bubble tubing" (not shown) which is releasably attached to the gas port means 15.
  • a syringe or part thereof may be releasably attached to the gas port means 15, and the tubing may be releasably attached to the syringe.
  • the gas is supplied to the device 10 at a rate of about 1 to 2 litres per minute.
  • a syringe (not shown) containing an agent (e.g. anaesthetic) in the form of a solution or mixture of solutions, is releasably attached to the agent port means 25.
  • agent e.g. anaesthetic
  • the agent is injected around the valve 30 into the mixing chamber 12. Meanwhile, the flow of the pressurised carrier gas through the centre of the valve 30 causes the carrier gas at the downstream side of valve to be turbulent. As a result of the turbulence the agent is essentially atomised and substantially evenly dispersed throughout the carrier gas.
  • the spray thus formed travels along the nozzle 40 to its tip, from which it emerges as a fine, well directed spray.
  • the device When all of the required agent has been administered, the device

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Pulvérisateur conçu en premier lieu pour administrer des médicaments à des malades et comprenant une chambre de mélange (12) comportant une entrée (14) pour un gaz porteur et une entrée (24) pour des agents généralement liquides. Un clapet unidirectionnel sous forme d'un manchon cylindrique (30) en caoutchouc est situé dans la chambre de mélange (12) et recouvre normalement l'entrée (12). L'apport d'un agent, par exemple, depuis une seringue s'effectue avec une pression suffisante pour déformer le clapet (30) et permettre à cet agent de pénétrer dans la chambre de mélange (12) dans laquelle il est atomisé dans le gaz porteur et distribué par un ajutage (40).
PCT/GB1998/001341 1997-05-13 1998-05-11 Pulverisateur WO1998051363A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9709692.9 1997-05-13
GBGB9709692.9A GB9709692D0 (en) 1997-05-13 1997-05-13 Spray forming device

Publications (1)

Publication Number Publication Date
WO1998051363A1 true WO1998051363A1 (fr) 1998-11-19

Family

ID=10812235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001341 WO1998051363A1 (fr) 1997-05-13 1998-05-11 Pulverisateur

Country Status (2)

Country Link
GB (1) GB9709692D0 (fr)
WO (1) WO1998051363A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0843565A4 (fr) * 1995-05-12 2002-10-16 Genentech Inc Administration d'un aerosol constitue de particules de grandes dimensions, contenant un produit a usage biologique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416567A (en) * 1964-02-20 1968-12-17 Viggo Ab Syringe valve
US4537188A (en) * 1982-01-26 1985-08-27 Senki Medical Instrument Mfg. Co., Ltd. Gas jet device for use in respirators
US5233979A (en) * 1990-10-22 1993-08-10 Ballard Medical Products Methods and apparatus for a micro-tracheal catheter hub assembly
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
EP0642838A2 (fr) * 1993-09-09 1995-03-15 Acheson Industries Deutschland Organe de pulvérisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416567A (en) * 1964-02-20 1968-12-17 Viggo Ab Syringe valve
US4537188A (en) * 1982-01-26 1985-08-27 Senki Medical Instrument Mfg. Co., Ltd. Gas jet device for use in respirators
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
US5233979A (en) * 1990-10-22 1993-08-10 Ballard Medical Products Methods and apparatus for a micro-tracheal catheter hub assembly
EP0642838A2 (fr) * 1993-09-09 1995-03-15 Acheson Industries Deutschland Organe de pulvérisation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0843565A4 (fr) * 1995-05-12 2002-10-16 Genentech Inc Administration d'un aerosol constitue de particules de grandes dimensions, contenant un produit a usage biologique

Also Published As

Publication number Publication date
GB9709692D0 (en) 1997-07-02

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