[go: up one dir, main page]

WO1998051363A1 - Spray forming device - Google Patents

Spray forming device Download PDF

Info

Publication number
WO1998051363A1
WO1998051363A1 PCT/GB1998/001341 GB9801341W WO9851363A1 WO 1998051363 A1 WO1998051363 A1 WO 1998051363A1 GB 9801341 W GB9801341 W GB 9801341W WO 9851363 A1 WO9851363 A1 WO 9851363A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
port means
mixing chamber
carrier gas
spray
Prior art date
Application number
PCT/GB1998/001341
Other languages
French (fr)
Inventor
Iain Michael Jocelyn Mackenzie
Original Assignee
Isis Innovation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation Limited filed Critical Isis Innovation Limited
Publication of WO1998051363A1 publication Critical patent/WO1998051363A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0463—Tracheal tubes combined with suction tubes, catheters or the like; Outside connections

Definitions

  • the present invention relates to a spray forming device.
  • a number of devices for administering drugs to patients in the form of sprays are known, for example, pressurised spray bottles.
  • a spray forming device for producing a spray in the form of an atomised agent dispersed within a carrier gas, the device comprising a mixing chamber having a releasable gas port means for attachment to a supply of pressurised carrier gas; a releasable agent port means for attachment to a supply of the agent to be dispersed; and an outlet nozzle.
  • the agent is preferably in the form of a liquid.
  • such a device When in use, such a device preferably forms a part of a complete spray application system which further includes a means for supplying agent to the device, which means is connected to the device via the agent port means, and a source of pressurised carrier gas, which source is connected to the device via the gas port means.
  • the spray forming device of the present invention may be disposed of separately from the source of pressurised carrier gas and the means for supplying agent to the device.
  • the spray forming device further comprises a one-way valve associated with the agent port means, which valve acts to prevent the flow of gas from the mixing chamber towards the supply of agent via the agent port means.
  • the valve takes the form of a flexible sleeve mounted in the mixing chamber such that a part of its outer surface lies against, and thus closes, an inlet from the agent port means.
  • a one-way valve in this manner has the advantage of enabling a very simple unit, such as a common syringe, to be used as the means for supplying agent to the device.
  • a unit such as a syringe as the means for supplying agent to the device gives rise to the significant advantage that a physician using the device has complete control over the composition of the agent and exactly how much is administered to the patient.
  • the device may be used with any desired solution or mixture of solutions.
  • the use of a unit such as a syringe also has the advantage of rendering the operation of the spray forming device very straightforward such that no great manual dexterity is required on the part of an operator.
  • the nozzle is elongate having a length of between 0.5cm and 10cm and an internal diameter of between 0.1 mm and 5mm. Such a nozzle gives rise to a fine, well directed spray from the nozzle tip regardless of the skill of the operator of the device.
  • a method of forming a spray in the form of an atomised agent dispersed within a carrier gas comprising the steps of providing a device comprising a mixing chamber having a releasable gas port means, a releasable agent port means and an outlet nozzle; releasably attaching a pressurised source of carrier gas to the gas port means; releasably attaching a means for supplying agent to the device, to the agent port means; and simultaneously supplying carrier gas and agent to the mixing chamber via the first and second inlets respectively.
  • the carrier gas used is preferably a respirable gas such as medical oxygen or air and is preferably supplied to the mixing chamber at a rate of 1 to 2 litres per minute.
  • the advantage of such an arrangement is that the spray application system may be operated in synchrony with the patient's inspiration.
  • the agent is typically a drug, anaesthetic or similar for administration to a patient or animal.
  • the device may be used to administer both local and general anaesthetics.
  • Figure 2 is a cross sectional side view of the spray forming device of Figure 1 .
  • the spray forming device 10 comprises a housing 11 within which is formed a mixing chamber 12 having a first inlet 14 and an associated releasable gas port means 15 for attachment to a supply (not shown) of pressurised carrier gas such as medical oxygen or air.
  • the carrier gas flows into the mixing chamber 12 in the direction indicated by arrow A1 in Figure 2.
  • a second inlet 24 to the mixing chamber 12 has an associated releasable agent port means 25 for attachment to a supply (not shown) of agent.
  • An O-ring valve 30 is formed at the second inlet 24 and acts to allow flow through the valve only in the direction indicated by arrow A2 in Figure 2.
  • the O-ring valve 30 essentially comprises a flexible cylinder (for example one made of rubber), which, because of its position in front of the inlet 24, prevents the flow of fluid past the valve 30 into the inlet 24. None- the-less, when pressure is applied from the inlet 24, the cylinder deforms inwardly sufficiently to permit the flow of fluid from the inlet 24 to the mixing chamber 12 between the housing 11 and the outer surface of the valve 30.
  • the nozzle 40 extends away from the mixing chamber 12 and is preferably formed integrally with the housing 11.
  • the nozzle is preferably elongate, as shown, having a length of between 0.5cm and 10cm and an internal diameter of between 0.1mm and 5mm.
  • the device 10 shown in Figures 1 and 2 is formed from a conventional narrow gauge intravenous cannula with an injection port 25 (e.g. 20 or 22G Venflon®).
  • an injection port 25 e.g. 20 or 22G Venflon®
  • the device could, of course, be custom made which would reduce costs.
  • a carrier gas in the form of medical air or oxygen is supplied from a pressurised canister thereof (not shown) to the device 10 via medical "green bubble tubing" (not shown) which is releasably attached to the gas port means 15.
  • a syringe or part thereof may be releasably attached to the gas port means 15, and the tubing may be releasably attached to the syringe.
  • the gas is supplied to the device 10 at a rate of about 1 to 2 litres per minute.
  • a syringe (not shown) containing an agent (e.g. anaesthetic) in the form of a solution or mixture of solutions, is releasably attached to the agent port means 25.
  • agent e.g. anaesthetic
  • the agent is injected around the valve 30 into the mixing chamber 12. Meanwhile, the flow of the pressurised carrier gas through the centre of the valve 30 causes the carrier gas at the downstream side of valve to be turbulent. As a result of the turbulence the agent is essentially atomised and substantially evenly dispersed throughout the carrier gas.
  • the spray thus formed travels along the nozzle 40 to its tip, from which it emerges as a fine, well directed spray.
  • the device When all of the required agent has been administered, the device

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Nozzles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A spray forming device primarily intended for administering drugs to patients, said device comprising a mixing chamber (12) having an inlet (14) for carrier gas and an inlet (24) for (usually liquid) agents. A one-way valve in the form of a cylindrical sleeve (30) of rubber is formed in the mixing chamber (12) and normally covers the inlet (24). Supply of agent, for example, from a syringe is of sufficient pressure to deform the sleeve (30) to allow the agent into the mixing chamber (12) where it is atomised within the carrier gas and dispensed through a nozzle (40).

Description

"SPRAY FORMING DEVICE"
The present invention relates to a spray forming device. A number of devices for administering drugs to patients in the form of sprays are known, for example, pressurised spray bottles. There are, however, a number of disadvantages associated with currently available spray forming devices.
One disadvantage of such devices is that they are generally sold as complete spray application systems formed as units which already incorporate a particular single agent solution which may not subsequently be altered. Thus it is not possible for a physician to customise currently available spray forming devices to administer a non-standard solution or mixture of solutions. Furthermore, such devices are not intended to be disposed of after each use. This gives rise to a risk of cross-infection between patients exposed to the devices.
According to a first aspect of the present invention, there is provided a spray forming device for producing a spray in the form of an atomised agent dispersed within a carrier gas, the device comprising a mixing chamber having a releasable gas port means for attachment to a supply of pressurised carrier gas; a releasable agent port means for attachment to a supply of the agent to be dispersed; and an outlet nozzle. The agent is preferably in the form of a liquid. When in use, such a device preferably forms a part of a complete spray application system which further includes a means for supplying agent to the device, which means is connected to the device via the agent port means, and a source of pressurised carrier gas, which source is connected to the device via the gas port means.
Such a system has a significant advantage over known spray application systems which is that the spray forming device of the present invention may be disposed of separately from the source of pressurised carrier gas and the means for supplying agent to the device. Thus that part of the system which is likely to come into contact with patients may be economically disposed of after each use of the system. This eliminates the risk of cross-infection between patients. Preferably, the spray forming device further comprises a one-way valve associated with the agent port means, which valve acts to prevent the flow of gas from the mixing chamber towards the supply of agent via the agent port means. Preferably the valve takes the form of a flexible sleeve mounted in the mixing chamber such that a part of its outer surface lies against, and thus closes, an inlet from the agent port means. The use of a one-way valve in this manner has the advantage of enabling a very simple unit, such as a common syringe, to be used as the means for supplying agent to the device. The use of a unit such as a syringe as the means for supplying agent to the device gives rise to the significant advantage that a physician using the device has complete control over the composition of the agent and exactly how much is administered to the patient. Thus the device may be used with any desired solution or mixture of solutions.
The use of a unit such as a syringe also has the advantage of rendering the operation of the spray forming device very straightforward such that no great manual dexterity is required on the part of an operator. Preferably the nozzle is elongate having a length of between 0.5cm and 10cm and an internal diameter of between 0.1 mm and 5mm. Such a nozzle gives rise to a fine, well directed spray from the nozzle tip regardless of the skill of the operator of the device.
According to a second aspect of the present invention, there is provided a method of forming a spray in the form of an atomised agent dispersed within a carrier gas, the method comprising the steps of providing a device comprising a mixing chamber having a releasable gas port means, a releasable agent port means and an outlet nozzle; releasably attaching a pressurised source of carrier gas to the gas port means; releasably attaching a means for supplying agent to the device, to the agent port means; and simultaneously supplying carrier gas and agent to the mixing chamber via the first and second inlets respectively. The carrier gas used is preferably a respirable gas such as medical oxygen or air and is preferably supplied to the mixing chamber at a rate of 1 to 2 litres per minute. The advantage of such an arrangement is that the spray application system may be operated in synchrony with the patient's inspiration. The agent is typically a drug, anaesthetic or similar for administration to a patient or animal. The device may be used to administer both local and general anaesthetics.
In order that the present invention may be better understood an embodiment thereof will now be described by way of example only and with reference to the accompanying drawings in which:- Figure 1 is a partially cross sectional diagrammatic view from below of a spray forming device according to the present invention; and
Figure 2 is a cross sectional side view of the spray forming device of Figure 1 .
The spray forming device 10 comprises a housing 11 within which is formed a mixing chamber 12 having a first inlet 14 and an associated releasable gas port means 15 for attachment to a supply (not shown) of pressurised carrier gas such as medical oxygen or air. The carrier gas flows into the mixing chamber 12 in the direction indicated by arrow A1 in Figure 2. A second inlet 24 to the mixing chamber 12 has an associated releasable agent port means 25 for attachment to a supply (not shown) of agent. An O-ring valve 30 is formed at the second inlet 24 and acts to allow flow through the valve only in the direction indicated by arrow A2 in Figure 2. The O-ring valve 30 essentially comprises a flexible cylinder (for example one made of rubber), which, because of its position in front of the inlet 24, prevents the flow of fluid past the valve 30 into the inlet 24. None- the-less, when pressure is applied from the inlet 24, the cylinder deforms inwardly sufficiently to permit the flow of fluid from the inlet 24 to the mixing chamber 12 between the housing 11 and the outer surface of the valve 30. The nozzle 40 extends away from the mixing chamber 12 and is preferably formed integrally with the housing 11. The nozzle is preferably elongate, as shown, having a length of between 0.5cm and 10cm and an internal diameter of between 0.1mm and 5mm. The device 10 shown in Figures 1 and 2 is formed from a conventional narrow gauge intravenous cannula with an injection port 25 (e.g. 20 or 22G Venflon®). However, the device could, of course, be custom made which would reduce costs. As an example of the spray forming device described above, a carrier gas in the form of medical air or oxygen is supplied from a pressurised canister thereof (not shown) to the device 10 via medical "green bubble tubing" (not shown) which is releasably attached to the gas port means 15. Alternatively, a syringe or part thereof may be releasably attached to the gas port means 15, and the tubing may be releasably attached to the syringe. The gas is supplied to the device 10 at a rate of about 1 to 2 litres per minute.
Simultaneously, a syringe (not shown) containing an agent (e.g. anaesthetic) in the form of a solution or mixture of solutions, is releasably attached to the agent port means 25. The agent is injected around the valve 30 into the mixing chamber 12. Meanwhile, the flow of the pressurised carrier gas through the centre of the valve 30 causes the carrier gas at the downstream side of valve to be turbulent. As a result of the turbulence the agent is essentially atomised and substantially evenly dispersed throughout the carrier gas. The spray thus formed travels along the nozzle 40 to its tip, from which it emerges as a fine, well directed spray.
When all of the required agent has been administered, the device
10 is disposed of and a new device 10 may be used on the next patient. This eliminates the risk of cross-infection between patients as a result of the continued use of a single spray forming device.

Claims

1. A spray forming device for producing a spray in the form of an atomised agent dispersed within a carrier gas, the device comprising a mixing chamber having a releasable gas port means for attachment to a supply of pressurised carrier gas; a releasable agent port means for attachment to a supply of the agent to be dispersed; and an outlet nozzle.
2. A spray forming device as claimed in claim 1 , further comprising a one-way valve associated with the agent port means, which valve acts to prevent the flow of gas from the mixing chamber towards the supply of agent via the agent port means.
3. A spray forming device as claimed in claim 2 wherein said valve takes the form of a flexible sleeve mounted in the mixing chamber such that a part of its outer surface lies against, and thus closes, an inlet from the agent port means.
4. A spray forming device as claimed in claim 3 wherein the mixing chamber has at least a section which is cylindrical in shape, wherein said agent port means is situated in said section, and wherein said flexible sleeve is of cylindrical shape and fits closely within the said section of the mixing chamber, covering the agent port means.
5. A spray forming device as claimed in either one of claims 3 or 4 wherein said sleeve is made of rubber.
6. A spray forming device as claimed in any one of the preceding claims wherein the outlet nozzle is elongate and has a length of between 0.5cm and 10cm and an internal diameter of between 0.1mm and 5mm.
7. A spray application system comprising a spray forming device as claimed in any one of the preceding claims, means for supplying agent to the device, which means is connected to the device via the agent port means, and a source of pressurised carrier gas, which source is connected to the device via the gas port means.
8. A spray application system as claimed in claim 7 wherein said means for supplying agent comprises a syringe.
9. A method of forming a. spray in the form of an atomised agent dispersed within a carrier gas, the method comprising the steps of providing a device comprising a mixing chamber having a releasable gas port means, a releasable agent port means and an outlet nozzle; releasably attaching a pressurised source of carrier gas to the gas port means; releasably attaching a means for supplying agent to the device, to the agent port means; and simultaneously supplying carrier gas and agent to the mixing chamber via the first and second inlets respectively.
10. A method as claimed in claim 9 wherein the carrier gas is a respirable gas such as medical oxygen or air.
11. A method as claimed in either one of claims 9 or 10 wherein the carrier gas is supplied to the mixing chamber at a rate of 1 to 2 litres per minute.
12. A method as claimed in any one of claims 9 to 11 which is carried out in synchrony with a patient's inspiration.
13. A method as claimed in any one of claims 9 to 12 wherein the agent is a drug or anaesthetic.
PCT/GB1998/001341 1997-05-13 1998-05-11 Spray forming device WO1998051363A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9709692.9 1997-05-13
GBGB9709692.9A GB9709692D0 (en) 1997-05-13 1997-05-13 Spray forming device

Publications (1)

Publication Number Publication Date
WO1998051363A1 true WO1998051363A1 (en) 1998-11-19

Family

ID=10812235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001341 WO1998051363A1 (en) 1997-05-13 1998-05-11 Spray forming device

Country Status (2)

Country Link
GB (1) GB9709692D0 (en)
WO (1) WO1998051363A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0843565A4 (en) * 1995-05-12 2002-10-16 Genentech Inc Coarse spray delivery of functional biologic materials

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416567A (en) * 1964-02-20 1968-12-17 Viggo Ab Syringe valve
US4537188A (en) * 1982-01-26 1985-08-27 Senki Medical Instrument Mfg. Co., Ltd. Gas jet device for use in respirators
US5233979A (en) * 1990-10-22 1993-08-10 Ballard Medical Products Methods and apparatus for a micro-tracheal catheter hub assembly
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
EP0642838A2 (en) * 1993-09-09 1995-03-15 Acheson Industries Deutschland Spray element

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416567A (en) * 1964-02-20 1968-12-17 Viggo Ab Syringe valve
US4537188A (en) * 1982-01-26 1985-08-27 Senki Medical Instrument Mfg. Co., Ltd. Gas jet device for use in respirators
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
US5233979A (en) * 1990-10-22 1993-08-10 Ballard Medical Products Methods and apparatus for a micro-tracheal catheter hub assembly
EP0642838A2 (en) * 1993-09-09 1995-03-15 Acheson Industries Deutschland Spray element

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0843565A4 (en) * 1995-05-12 2002-10-16 Genentech Inc Coarse spray delivery of functional biologic materials

Also Published As

Publication number Publication date
GB9709692D0 (en) 1997-07-02

Similar Documents

Publication Publication Date Title
EP2678055B1 (en) A device for administering therapeutic substances using a high velocity liquid-gas stream
CN210250131U (en) Device for applying liquid therapeutic substances to tissue
US5297543A (en) Medication inhaler mixer
EP0983103B1 (en) Device for administering a medicinal aerosol via the lungs
US2535844A (en) Aspirator for administering medicine
JP6156799B2 (en) Anesthetic inhalation assist device and its attachment
EP0692273B1 (en) Nebulizing catheter system and method of manufacture
US6085742A (en) Intrapulmonary delivery device
US8146587B2 (en) Method for nasal irrigation and drug delivery
US20040084049A1 (en) Nebulizing catheter system and methods of use and manufacture
US8042536B1 (en) Nebulizer apparatus
JPS5825466B2 (en) Liquid volume control method in medical sprayer and medical sprayer
JPH10500035A (en) Resuscitator
US6237597B1 (en) Endotracheal medication port adapter
WO2008056986A1 (en) System for artificial respiration of persons
US20190232031A1 (en) Methods and systems for bathing nose and sinus passages
AU2003270242A1 (en) Drug nebulizer usable with a diagnostic or therapeutic instrument, such as a bronchoscope
JP3500151B2 (en) The endotracheal tube where the aerosol is diverted and supplied at Murphy Eye
CA2908781C (en) Cpap flow driver for using nebulizer with cpap apparatus
JP3652216B2 (en) Chemical spray tube
WO1998051363A1 (en) Spray forming device
EP1364671B1 (en) Breathing device with nebuliser
JPH0454971A (en) Aerosol drug administration method
CN211068508U (en) Medical local atomizing medicine feeder
CN218552854U (en) Clinical anesthesia is with supplying medicine anesthesia device

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA GB JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: CA

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998548909

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase