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WO1998043604A1 - Composition antisudorale en bille transparente a base aqueuse - Google Patents

Composition antisudorale en bille transparente a base aqueuse Download PDF

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Publication number
WO1998043604A1
WO1998043604A1 PCT/US1998/005642 US9805642W WO9843604A1 WO 1998043604 A1 WO1998043604 A1 WO 1998043604A1 US 9805642 W US9805642 W US 9805642W WO 9843604 A1 WO9843604 A1 WO 9843604A1
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WO
WIPO (PCT)
Prior art keywords
composition
composition according
antiperspirant
aqueous
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/005642
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English (en)
Inventor
Maria Esther Avendano Munguia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Colgate Palmolive Co
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Priority to AU65777/98A priority Critical patent/AU6577798A/en
Publication of WO1998043604A1 publication Critical patent/WO1998043604A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A61K2800/874—Roll-on

Definitions

  • the present invention is directed to a composition for reducing body malodor, containing antiperspirant and/or deodorant active material, to be dispensed from a roll-on dispenser.
  • a composition for reducing body malodor containing antiperspirant and/or deodorant active material
  • One example of the present invention is directed to a transparent antiperspirant composition to be dispensed from a roll-on dispenser.
  • Antiperspirant products are well known in the art. Antiperspirant products have appeared in the marketplace in varied dosage forms, such as sticks, soft solids, soft gels, roll-ons, aerosols and creams. Generally, these dosage forms include a solution of the active ingredient in a suitable solvent, a suspension of the active ingredient in a non-solvent, or a multi-phasic dispersion or emulsion in which a solution of the active ingredient is dispersed in some continuous phase or in which the solubilized active ingredient constitutes a continuous phase .
  • the antiperspirant composition for example, liquid composition containing antiperspirant active material
  • a reservoir having a suitable roll-on applicator above the liquid level
  • the roll-on applicator being rotatably mounted in the package discharge orifice whereby antiperspirant liquid discharged onto the roll-on applicator may be selectively applied to a desired area (for example, to the axillary region of a human body, by rubbing the roll-on (ball) applicator on the axillary region of the human body) .
  • U.S. Patent No. 3,932,609 to Rosenstreich, et al . discloses an antiperspirant liquid composition particularly suitable for use as an antiperspirant roll-on composition, the composition being a liquid containing an aluminum astringent material, a small but effective amount of a quaternary ammonium salt and a select amount of water-dispersible fumed silica in an aqueous medium.
  • This patent discloses that the presence of a select amount of fumed silica and a small but effective amount of a quaternary ammonium salt in the liquid medium stabilizes the composition, and upon application thereof allows application of a substantially uniform coating.
  • U.S. Patent No. 5,135,741 to Park discloses an antiperspirant composition of the lotion type for applying to the skin from a roll-on dispenser, containing an antiperspirant agent in the form of fine particles suspended in an anhydrous normally liquid medium by means of a suspending agent, the suspending agent including a hydrophobic clay, and the liquid medium consisting of ethanol or isopropanol or a mixture thereof and one or more liquids less volatile than ethanol or isopropanol, such less volatile liquid including a non- polar and water-immiscible liquid.
  • U.S. Patent No. 5,135,741 to Park requires ethanol or isopropanol or mixtures thereof. These monohydric alcohols can cause a stinging sensation, and can be irritating, when applied to human skin.
  • compositions including clear (transparent) antiperspirant compositions dispensed by a roll-on dispenser.
  • Such compositions have increased consumer appeal, being perceived by the consumer, for example, as having greater purity than compositions which are not clear or transparent.
  • U.S. Patent No. 3,932,609 to Rosenstreich, et al. or U.S. Patent No. 5,135,741 to Park disclose that their compositions are clear or transparent.
  • the disclosed compositions in these patents require a particulate material.
  • U.S. Patent No. 5,393,518 to Yamass discloses an optically clear liquid antiperspirant product, capable of being dispensed from a roll-on type dispenser, which is an emulsion that includes an aqueous phase with an antiperspirant active ingredient in solution therein, an oil phase making up at least about 30% of the product and a stabilizing agent, the stabilizing agent having a substantial solubility in the aqueous and oil phases and stabilizing the emulsion in a temperature range from about 0° to about 45°C.
  • the stabilizing agent preferably includes a polyalkoxylated alcohol and a lower alcohol such as ethanol, methanol or propanol that solubilizes the polyalkoxylated alcohol.
  • the oil phase preferably includes one or a combination of polyether-substituted water-in-oil silicone emulsifiers such as cyclomethicone and dimethicone copolyol, dimethicone and cyclomethicone.
  • the aqueous phase includes one or a combination of polar species such as water and propylene glycol and an antiperspirant active ingredient in solution. The refractive indices of the aqueous and oil phases are substantially matched, in order to provide clarity.
  • U.S. Patent No. 5,487,887 to Benfatto discloses a clear antiperspirant roll-on composition which is an oil-in-water emulsion containing antiperspirant active material; water; PEG-7 glycerol cocoate; an emollient, preferably isopropyl myristate; and cyclomethicone.
  • the antiperspirant composition should preferably also include an organic non-resinous thickener, such as PEG-150 pentaerythritol tetrastearate; an oil-in- water emulsifying system including Poloxomer 217, glycereth-7-benzoate and a nonionic surfactant for high temperature stability such as octoxynol-9 or lauric diethanolamide; a soluble electrolyte as a viscosity control agent and to enhance clarity, preferably sodium chloride; a humectant for low temperature stability, such as dipropylene glycol; and optional ingredients such as perfumes, fillers, etc.
  • an organic non-resinous thickener such as PEG-150 pentaerythritol tetrastearate
  • an oil-in- water emulsifying system including Poloxomer 217, glycereth-7-benzoate and a nonionic surfactant for high temperature stability such as
  • a transparent composition to reduce body malodor which composition will preferably contain antiperspirant active material, and will be dispensed from a roll-on dispenser, wherein transparency is achieved without the need for microemulsions and/or for refractive index matching, and wherein the composition does not contain alcohol. It is also desired to provide an aqueous-based transparent composition which contains antiperspirant active material, reduces body malodor, is dispensed from a roll-on dispenser, and achieves the cost advantages of aqueous roll- ons .
  • a transparent, aqueous-based antiperspirant composition which (a) can be dispensed from a roll-on dispenser, (b) achieves transparency without the need of a microemulsion and/or refractive index matching, and (c) does not require monohydric alcohols (such as ethanol) in the formulation.
  • the present invention provides a cosmetic composition, especially a transparent cosmetic composition, for underarm use (such as deodorants and antiperspirants) which is capable of reducing body malodor, can be dispensed from a roll-on dispenser, and does not require refractive index matching and/or a microemulsion to achieve transparency.
  • a cosmetic composition especially a transparent cosmetic composition, for underarm use (such as deodorants and antiperspirants) which is capable of reducing body malodor, can be dispensed from a roll-on dispenser, and does not require refractive index matching and/or a microemulsion to achieve transparency.
  • the invention also provides such transparent composition packaged in a roll- on dispenser and a method of using such composition and such packaged composition.
  • the compositions of this invention comprise:
  • At least one active agent that is an antiperspirant and/or deodorant material for example, an antiperspirant active metal salt or salts
  • an antiperspirant active metal salt or salts for example, an antiperspirant active metal salt or salts
  • aqueous based does not require refractive index matching and/or a microemulsion in order to achieve transparency in the final product; and (iii) is present in the final product in a solution.
  • an antiperspirant composition Preferably if an antiperspirant composition is formed it also contains an antibacterial (antimicrobial) agent and perfume (fragrance), as deodorant active agents.
  • compositions of the present invention can also contain other ingredients such as chelants, fillers, coloring agents etc.
  • compositions made according to the present invention need not contain monohydric alcohol (for example, ethanol) , in order to obtain a transparent antiperspirant composition.
  • monohydric alcohol for example, ethanol
  • the compositions according to the present invention are preferably made as solution; however, those skilled in the art will recognize that appropriate use of thickeners could form gels and creams.
  • Transparency is achieved by direct solubility of the ingredients in, for example, the water and a glycol such as propylene glycol. This avoids multiple phases, and avoids a need for refractive index matching of the multiple phases and/or formation of microemulsions, to achieve transparency.
  • the compositions according to the present invention are a liquid solution, which have a sufficient viscosity such that they can be packaged in a roll-on dispensing package known in the art, and applied as conventionally done utilizing roll-on dispensers.
  • compositions according to the present invention are aqueous- based (that is, contain water), providing cost advantages.
  • compositions of this invention are packaged in a conventional roll-on dispenser and used by applying these compositions using a roll- on dispenser as done conventionally (for example, by rubbing the roller ball of the roll-on dispenser against the skin, in axillary regions of the human body, in order to apply the compositions.
  • transparent aqueous antiperspirant compositions to be dispensed from a roll-on dispenser, can be achieved.
  • the compositions are a solution of the ingredients, rather than a composition containing multiple phases (such as an emulsion) , thereby avoiding a need for refractive index matching and/or microemulsions to achieve transparency.
  • the compositions of the invention combine the aesthetics of transparency with the cost advantages of an aqueous roll-on antiperspirant DETAILED DESCRIPTION OF THE INVENTION
  • solutions which form the base of the present invention are aqueous solutions comprising (a) a solvent selected from the group consisting of propylene glycol, dipropylene glycol, tripropylene glycol and mixtures of two or all of the foregoing, with a particular solvent being propylene glycol;
  • a surfactant selected from the group consisting of silicone glycol copolymers, particularly a polymer of dimethylsiloxane known as dimethicone copolyol.
  • the emollient moisturizer are the ethylene oxide polymers of polyethylene glycol especially a polymer of ethylene oxide that conforms generally to the formula H(OCH 2 CH 2 ) p OH, where p has an average value of 12 (also known as PEG-12) and dimethicone copolyol; (c) a thickener selected from the group consisting of water soluble cellulosic polymers such as hydroxy C1-C3 alkyl celluloses and hydroxy C1-C3 alkyl (methyl) celluloses for example, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose and carboxymethylcellulose, especially hydroxypropyl methylcellulose and hydroxyethylcellulose.
  • a thickener selected from the group consisting of water soluble cellulosic polymers such as hydroxy C1-C3 alkyl celluloses and hydroxy C1-C3 alkyl (methyl) celluloses for example, hydroxyethylcellulose,
  • ingredients include fragrances; fragrance solubilizers (for example, an ethoxylated alkyl phenol that conforms generally to the formula C 8 H ⁇ 7 C6H4 (OCH 2 CH 2 ) r OH where r has an average value of 13 (also called octoxynol-13) , the polyethylene glycol ether of lauryl alcohol that conforms to the formula CH 3 (CH 2 ) 1 0CH2 (OCH 2 CH 2 ) z OH where z has an average value of 23 (also called laureth-23) and the polyoxypropylene, polyoxyethylene ether of cetyl alcohol that conforms generally to the formula CH 3 (CH 2 )i 4 CH 2 (OCH(CH 3 )CH 2 ) x (OCH 2 CH2)yOH where x has an average value of 5 and y has an average value of 20 (also called PPG-5-ceteth-20) ) ; chelants such as ethylenediaminetetraacetic
  • a particular embodiment is an antiperspirant comprising the following formulation (in percent by weight) : Hydroxypropyl methylcellulose 1.0-3.0
  • Triclosan (IRGAZAN DP-300) 0.02-0.05
  • hydroxypropyl methylcellulose is used with 10.0 percent propylene glycol, .02 percent Triclosan, 32.0 percent aluminum chlorohydrate (50% solution), 0.7-2.0 percent octoxynol-13, 1.0 percent fragrance and the remainder water up to 100 percent.
  • One embodiment of the present invention contemplates a transparent aqueous-based composition, for reduction of body malodor (for example, a transparent aqueous-based antiperspirant composition) , to be dispensed by a roll-on dispenser, containing at least an antiperspirant active material in solution, wherein the solution comprises propylene glycol as the solvent; and PEG-12 as the emollient/moisturizer; and wherein the thickener is selected from the group consisting of at least one hydroxyalkyl cellulose selected from the group consisting of hydroxyethyl cellulose and hydroxypropyl methylcellulose (preferably hydroxypropyl methylcellulose) and water.
  • compositions according to the present invention can be deodorant compositions.
  • underarm compositions Collectively antiperspirant compositions and deodorant compositions are referred to herein as underarm compositions.
  • compositions are described as including or comprising specific components or materials, or where methods are described as including or comprising specific steps, it is contemplated that the compositions of the present invention can also consist essentially of, or consist of, the recited components or materials, and that the methods of the present invention can also consist essentially of, or consist of, the recited steps.
  • a feature of the present invention is that a clear or transparent antiperspirant composition can be provided.
  • the term clear or transparent that is, clarity
  • a clear antiperspirant composition for example, a liquid composition according to the present invention
  • a translucent composition although allowing light to pass through, causes the light to be so scattered that it would be impossible to see clearly objects behind the composition (for example, where the composition is packaged in a transparent container) .
  • Opaque compositions do not allow a substantial amount of light to pass therethrough. Thus, there is a difference among transparent (clear), translucent and opaque compositions.
  • compositions are denoted by their name in the CTFA International Cosmetic Ingredient Dictionary (4th Ed. 1991) , the contents of which are incorporated herein by reference in their entirety.
  • the composition also includes at least one deodorant active ingredient selected from (but not limited to) antibacterial (antimicrobial) agents and fragrance.
  • the compositions further include PPG-5-ceteth-20, dimethicone copolyol, and ethylenediaminetetraacetic acid (EDTA) .
  • deodorant active materials and “antiperspirant active” materials are discussed. Both types of materials contribute to reduction of body (for example, axillary) malodor.
  • reduction of body malodor is meant that, generally, there is less body malodor after application of the composition to a person's skin, as compared to body malodor of the person without application of the composition.
  • Such reduction can be due to a masking of the malodor, absorption and/or chemical reaction of the malodorous material, reduction of levels of the bacteria producing the malodorous materials, for example, from perspiration, reduction of perspiration, etc.
  • the antiperspirant materials when utilized in appropriate amounts, primarily act to reduce body malodor by reducing production of perspiration; the antiperspirant materials can also have a deodorant function, for example, as an antimicrobial (antibacterial) agent.
  • the deodorant active materials do not substantially reduce the production of perspiration, but reduce malodor in other ways, for example, as fragrances masking the malodor or reducing the malodor intensity, as odor absorbents, as antimicrobial (antibacterial) agents, as agents chemically reacting with malodorous materials, etc.
  • Suitable antiperspirant active materials can be utilized in the composition of the present invention.
  • Suitable materials which may be mentioned by way of example include aluminum chlorohydrate, aluminum chloride, aluminum sesquichlorohydrate, aluminum-zirconium hydroxychlorides, complexes or adducts of the above-mentioned active ingredients with one or more glycols, such as propylene glycol, dipropylene glycol tripropylene glycol and combinations thereof.
  • Known aluminum-zirconium salts in combination with neutral amino acids such as glycine (for example, aluminum-zirconium tetrachlorohydrex Gly) , can also be used.
  • any of the Category I active antiperspirant ingredients listed in the Food and Drug Administration's Monograph On Antiperspirant Drug Products For Over-The-Counter Human Use (October 10, 1973), which is incorporated by reference in its entirety herein, can be used.
  • Some of these include aluminum chlorohydrate, aluminum zirconium octachlorohydrate, aluminum zirconium octachlorohydrex glycine, aluminum zirconium pentachlorohydrate, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium tetrachlorohydrate, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium trichlorohydrate, aluminum zirconium trichlorohydrex glycine, with aluminum chlorohydrate and aluminum zirconium tetrachlorohydrex glycine being the more preferred antiperspirant ingredients.
  • any new drug such as aluminum nitratohydrate and its combination with zirconyl hydroxychlorides and nitrates, or aluminum-stannous chlorohydrates, can be incorporated as an antiperspirant active ingredient in compositions, including antiperspirant compositions, according to the present invention.
  • the amount of active component used will vary with the particular active ingredient incorporated. It is important that the active antiperspirant material be dissolved in the compositions of the present invention.
  • the active antiperspirant material utilized in the compositions of the present invention can be pre-dissolved in water or in another solvent (for example, in propylene glycol, dipropylene glycol and/or tripropylene glycol) , and incorporated in the present compositions while in such solution.
  • the active antiperspirant material should be included in an amount from at least about 10% by weight, of the total weight of the composition, and preferably in the range of 15 - 20 percent in order to have an antiperspirant effect (that is, achieve reduction of perspiration flow).
  • the antiperspirant active material can be utilized in lesser amounts providing an antibacterial (antimicrobial) effect.
  • the relative amounts of antiperspirant active ingredient and deodorant ingredient can be in the range of at least about 15 percent for the antiperspirant and in the range of at least about 8. percent for the deodorant.
  • the antiperspirant active can be used in an amount of 15 percent in combination with a deodorant in an amount of 0.02 to 0.05 percent based on the total weight of the underarm composition.
  • glycol such as propylene glycol, dipropylene glycol and/or tripropylene glycol acts, in combination with the water, as a solvent for the present composition.
  • glycol such as propylene glycol and water are essential components of compositions of the present invention.
  • Emollients such as PEG-12 are used in the compositions of the invention as noted above.
  • the hydroxypropyl methylcellulose is a propylene glycol ether of methylcellulose (methylcellulose being the methyl ether of cellulose) ; it is a thickening agent in the present compositions, so as to provide compositions of desired viscosity (for example, sufficient viscosity to be dispensed from a roll-on dispenser) .
  • Hydroxyethyl cellulose is the ethylene glycol ether of cellulose and may also be used.
  • desirable viscosities for roll-on compositions see, for example, U.S. Patent No. 5,393,518 to Kwass and No. 5,487,887 to Benfatto, the contents of each of which have been incorporated herein by reference in their entirety.
  • Viscosities useful in the compositions of this invention include those in the range of 1000 to 4000 centipoise (CPS) , with a range of 1500 to 3000 CPS being preferred.
  • deodorant active materials can be incorporated in the compositions of the present invention, so as to incorporate deodorant active materials for reducing body malodor. It is believed that optionally fragrances can be incorporated into the compositions as well as known antibacterial (antimicrobial) agents, such as (but not limited to) Triclosan (a substituted organic ether that conforms generally to the formula C ⁇ HCl 3 0 2 ) can be incorporated in the compositions of the present invention.
  • Triclosan a substituted organic ether that conforms generally to the formula C ⁇ HCl 3 0 2
  • compositions according to the present invention can also include PPG-5-ceteth-20 , dimethicone copolyol and/or ⁇ DTA.
  • a material such as octoxynol 13 as a fragrance solubilizer.
  • Dimethicone copolyol is a polymer of dimethylsiloxane with polyoxyethylene and/or polyoxypropylene side chains.
  • Antiperspirant Active Material in Solution (50%) 30.0 - 35.0
  • compositions according to the present invention can be made by mixing the various components together at, for example, elevated temperature (for example 85 to 90 degrees C) so as to form a solution (water and propylene glycol, for example, being solvents in the solution) , and then pouring the resulting solution into packages (for example, bottles) to be closed off with conventional roll-on applicators (conventional ball or elongated ball applicators or some other type of roll-on applicators) .
  • elevated temperature for example 85 to 90 degrees C
  • a solution water and propylene glycol, for example, being solvents in the solution
  • packages for example, bottles
  • a suitable vessel is provided with an agitator and heating source. Water is placed in the vessel and heated to about 85-90 degrees C. Hydroxypropyl methylcellulose is added while agitating the mixture to allow thorough dispersion.
  • a Triclosan (such as IRGAZAN DP- 300 sold by CIBA-GEIGY, Greensboro, North Carolina) may be added as described below.
  • a moisturizer/emollient such as PEG-12 is added and the mixing is continued until the mixture is homogeneous.
  • a selected amount of an aluminum chlorohydrate solution (such as from 30 -35 percent (particularly 32 percent) of a 50% solution) is added with mixing and the mixture is cooled to 55-60 degrees C.
  • a perfume premix such as the one described below is then added and the mixture is cooled to 10-20 degrees C, preferably 15-20 degrees C, and most preferably, 15 degrees C. This cooling step has been found preferable to obtain the best transparency and the optimum viscosity.
  • other ingredients can be added such as EDTA as a chelant up to an amount of 0- 0.3 and, more particularly, in an amount of at least 0.02-0.05 percent.
  • water can be placed in the vessel and heated to about 70-75 degrees C. Hydroxypropyl methylcellulose is added and dispersed with agitation.
  • deterpenated fragrance is mixed with octoxynol-13. The mixture of the main vessel is cooled to 50-55 degrees C.
  • EDTA and dimethicone copolyol can be added in an amount of 0.02-0.3 percent EDTA and 0.1-3 percent dimethicone copolymer.
  • compositions according to the present invention are used in the same manner as conventional roll-on compositions, dispensed from, for example, dispensing packages having a roll-on applicator.
  • a cap covering the roll-on applicator is removed, the portion of the applicator ball facing the composition is wetted by the composition (for example, by inverting the package) and the roll-on applicator (for example, ball or elongated ball) is rubbed on the skin, so as to deposit the active material (for example, antiperspirant and/or deodorant active material) on the skin.
  • the active material for example, antiperspirant and/or deodorant active material
  • the applicator ball is rubbed against the axillary regions of the human body, so as to deposit the antiperspirant active material and, if present, deodorant active material, on the skin in the axillary regions .
  • a transparent aqueous- based antiperspirant composition to be dispensed using a roll-on dispenser, is achieved.
  • the composition combines the aesthetics of transparency with cost advantages of an aqueous roll-on antiperspirant.
  • the composition is a solution, avoiding the need of refractory index matching and/or forming microemulsions in order to achieve transparency.
  • the composition according to the present invention need not contain monohydric alcohol (such as ethanol) , making the present composition non-stinging and non-irritating when applied to the skin.
  • IRGAZAN Premix means a mixture made by dissolving a selected amount of IRGAZAN brand Triclosan in a selected amount of propylene glycol with agitation. For Examples 2-4, 10.00% by weight (based on the total mixture of the final product made) and 0.02% Triclosan were used.
  • Perfume Premix means a mixture of a selected amount of a perfume with octoxynol 13. For Examples 2-4, 1.00% by weight (based on the total weight of the final product) perfume and 2.00% by weight of octoxynol were mixed with agitation and used. PPG 5 ceteth 20 can be used instead of octoxynol 13 depending on the type of fragrance used.
  • EXAMPLE 1 Batch Process In a suitable vessel provided with an agitator and heating source water ( selected amount) is placed. The water is heated to about 85-90 degrees C. Hydroxypropyl methyl cellulose or hydroxyethyl cellulose (selected amount) is added while agitating the mixture to allow thorough dispersion. IRGAZAN Premix and PEG-12 (2%) are added and the mixing is continued until the mixture is homogeneous. A 50% aluminum chlorohydrate solution (selected amount) is added with mixing and the mixture is cooled to 55-60 degrees C. The Perfume Premix is then added and the mixture is cooled to 15 degrees C. This cooling step has been found preferable to obtain the best transparency and the optimum viscosity. PPG 5-ceteth-20 can be used instead of octoxynol 13 in the Perfume Premix depending on the type of fragrance used.
  • EDTA and dimethicone copolyol can be added in an amount of 0.02-0.3 percent EDTA and 0.1-3 percent dimethicone copolyol.
  • Example 1 The method described in Example 1 was used with the following amounts of material:
  • Example 0.02% EDTA was also added. This was done by adding EDTA to the water at 85-90 degrees C before the addition of hydroxypropyl methyl cellulose.
  • the final product had a good transparency and a white color.
  • the viscosity of the product was 2,350 CPS and the pH was 3.98.
  • EXAMPLE 4 The method described in Example 2 was repeated except that 51.98% of water was used instead of 51.88%, and 1.00% of hydroxyethyl cellulose was used instead of hydroxypropyl methylcellulose.
  • the final composition had a good transparency. The color was a little yellowish but still acceptable.
  • the viscosity was 3100 CPS and the pH was 3.96. While several embodiments in accordance with the present invention have been shown and described, it is understood that the same is not limited thereto, but is susceptible to numerous changes and modifications as known to one having ordinary skill in the art. It is intended to cover such modifications which are within the spirit and scope of the invention.

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Abstract

L'invention concerne une composition aqueuse pour aisselles telle qu'un antisudoral pouvant être délivrée par un distributeur à bille, ladite composition étant transparente et ne contenant pas d'alcool monohydrique. La composition est en forme de solution, la transparence étant produite par une solubilité directe, sans nécessité de micrémulsions ou de mise en correspondance d'indices de réfraction de phases différentes. La composition comprend au moins une solution d'une matière active antisudorale; du propylèneglycol; PEG-12; octoxynol-13; hydroxypropylméthylcellulose; et de l'eau. De préférence, la composition comprend également un agent antibactérien (par exemple Triclosan) et un parfum; et éventuellement, la composition comprend aussi PPG-5-ceteth-20, un copolyol de diméthicone, et un acide éthylènediaminetetraacétique.
PCT/US1998/005642 1997-03-27 1998-03-24 Composition antisudorale en bille transparente a base aqueuse Ceased WO1998043604A1 (fr)

Priority Applications (1)

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AU65777/98A AU6577798A (en) 1997-03-27 1998-03-24 Transparent aqueous-based roll-on antiperspirant composition

Applications Claiming Priority (2)

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US82715197A 1997-03-27 1997-03-27
US08/827,151 1997-03-27

Publications (1)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001052804A1 (fr) * 2000-01-18 2001-07-26 Unilever Plc Produits anti-transpirants antimicrobiens
GB2378653A (en) * 2001-07-26 2003-02-19 Revlon Consumer Prod Corp An acidic aqueous-based solid antiperspirant composition containing a polysaccharide and a gel degradation inhibitor
US6632420B1 (en) 2000-09-28 2003-10-14 The Gillette Company Personal care product
WO2007031137A1 (fr) * 2005-07-30 2007-03-22 Unilever Plc Compositions de pulverisation
GB2431580A (en) * 2005-10-28 2007-05-02 Unilever Plc Deodorant composition containing polyethylene glycol humectant
WO2007071474A1 (fr) * 2005-12-16 2007-06-28 Beiersdorf Ag Action longue duree amelioree d'antitranspirants
US20170209357A1 (en) * 2014-07-10 2017-07-27 L'oreal Cosmetic use of spiculisporic acid as a deodorant active agent

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US4383988A (en) * 1978-04-28 1983-05-17 Anheuser-Busch, Incorporated Gelled antiperspirant
WO1996026709A2 (fr) * 1995-03-02 1996-09-06 The Gillette Company Baton antisudorifique transparent contenant du dibenzylidene alditol
US5575990A (en) * 1993-10-28 1996-11-19 Bristol-Myers Squibb Company Antiperspirant roll-on compositions
WO1997006777A1 (fr) * 1995-08-18 1997-02-27 Colgate-Palmolive Company Composition de gel cosmetique transparente
US5650143A (en) * 1996-05-30 1997-07-22 Church & Dwight Co., Inc. Deodorant cosmetic stick composition
WO1997031618A1 (fr) * 1996-02-06 1997-09-04 The Gillette Company Procede de fabrication en une phase pour un antitranspirant en batonnet transparent a base de dibenzylidene alditol

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383988A (en) * 1978-04-28 1983-05-17 Anheuser-Busch, Incorporated Gelled antiperspirant
US5575990A (en) * 1993-10-28 1996-11-19 Bristol-Myers Squibb Company Antiperspirant roll-on compositions
WO1996026709A2 (fr) * 1995-03-02 1996-09-06 The Gillette Company Baton antisudorifique transparent contenant du dibenzylidene alditol
WO1997006777A1 (fr) * 1995-08-18 1997-02-27 Colgate-Palmolive Company Composition de gel cosmetique transparente
WO1997031618A1 (fr) * 1996-02-06 1997-09-04 The Gillette Company Procede de fabrication en une phase pour un antitranspirant en batonnet transparent a base de dibenzylidene alditol
US5650143A (en) * 1996-05-30 1997-07-22 Church & Dwight Co., Inc. Deodorant cosmetic stick composition

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001052804A1 (fr) * 2000-01-18 2001-07-26 Unilever Plc Produits anti-transpirants antimicrobiens
US6893630B2 (en) 2000-01-18 2005-05-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Anti-microbial antiperspirant products
US6632420B1 (en) 2000-09-28 2003-10-14 The Gillette Company Personal care product
GB2378653A (en) * 2001-07-26 2003-02-19 Revlon Consumer Prod Corp An acidic aqueous-based solid antiperspirant composition containing a polysaccharide and a gel degradation inhibitor
US6749841B2 (en) 2001-07-26 2004-06-15 Revlon Consumer Products Corporation Stabilized aqueous acidic antiperspirant compositions and related methods
GB2378653B (en) * 2001-07-26 2004-09-01 Revlon Consumer Prod Corp Stabilized aqueous acidic antipersperiant compositions and related methods
WO2007031137A1 (fr) * 2005-07-30 2007-03-22 Unilever Plc Compositions de pulverisation
US8518384B2 (en) 2005-07-30 2013-08-27 Conopco Inc. Spray compositions
GB2431580A (en) * 2005-10-28 2007-05-02 Unilever Plc Deodorant composition containing polyethylene glycol humectant
AU2006308228B2 (en) * 2005-10-28 2010-05-20 Unilever Global Ip Limited Antiperspirant or deodorant compositions
WO2007071474A1 (fr) * 2005-12-16 2007-06-28 Beiersdorf Ag Action longue duree amelioree d'antitranspirants
US20170209357A1 (en) * 2014-07-10 2017-07-27 L'oreal Cosmetic use of spiculisporic acid as a deodorant active agent
US10966913B2 (en) * 2014-07-10 2021-04-06 L'oreal Cosmetic use of spiculisporic acid as a deodorant active agent

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