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WO1997021720B1 - Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles - Google Patents

Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles

Info

Publication number
WO1997021720B1
WO1997021720B1 PCT/US1996/020780 US9620780W WO9721720B1 WO 1997021720 B1 WO1997021720 B1 WO 1997021720B1 US 9620780 W US9620780 W US 9620780W WO 9721720 B1 WO9721720 B1 WO 9721720B1
Authority
WO
WIPO (PCT)
Prior art keywords
group
chr
compound
hydrogen
hydroxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/020780
Other languages
English (en)
Other versions
WO1997021720A3 (fr
WO1997021720A2 (fr
Filing date
Publication date
Priority to IL158857A priority Critical patent/IL158857A/en
Priority to JP52230497A priority patent/JP4146897B2/ja
Priority to EA199800449A priority patent/EA009176B1/ru
Priority to EP96945103A priority patent/EP0973791B1/fr
Priority to DK96945103T priority patent/DK0973791T3/da
Priority to CA002347346A priority patent/CA2347346C/fr
Priority to DE69637140T priority patent/DE69637140T2/de
Priority to AU13551/97A priority patent/AU719260B2/en
Priority to HU9900493A priority patent/HU222453B1/hu
Priority to IL12463196A priority patent/IL124631A/en
Priority to CA002347345A priority patent/CA2347345C/fr
Priority to CA 2240388 priority patent/CA2240388A1/fr
Application filed filed Critical
Priority to KR10-2004-7011499A priority patent/KR100523146B1/ko
Priority claimed from US08/763,910 external-priority patent/US5981744A/en
Publication of WO1997021720A2 publication Critical patent/WO1997021720A2/fr
Publication of WO1997021720A3 publication Critical patent/WO1997021720A3/fr
Publication of WO1997021720B1 publication Critical patent/WO1997021720B1/fr
Anticipated expiration legal-status Critical
Priority to IL175299A priority patent/IL175299A0/en
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne de multiples procédés de réaction nouveaux, de nouvelles phase de procédés et de nouveaux intermédiaires pour la synthèse de l'époxymexrénone et d'autres composés de formule (I). Dans cette formule (I), -A-A- représente le groupe -CHR4-CHR5- ou -CR?4=CR5-; R3, R4 et R5¿ sont choisis séparément dans le groupe constitué d'hydrogène, d'halo, d'hydroxy, d'alkyle inférieur, d'alcoxy inférieur, d'hydroxyalkyle, d'alcoxyalkyle, d'hydroxycarbonyle, de cyano et d'aryloxy; R1 représente un radical alcoxycarbonyle ou hydroxycarbonyle à orientation alpha, -B-B- représente le groupe -CHR6-CHR7- ou un groupe à orientation alpha ou bêta de formule (III), dans lequel R6 et R7 sont choisis séparément dans le groupe constitué d'hydrogène, d'halo, d'alcoxy inférieur, d'acyle, d'hydroxyalkyle, d'alcoxyalkyle, d'hydroxycarbonyle, d'alkyle, d'alcoxycarbonyle, d'acyloxyalkyle, de cyano, d'aryloxy et R8 et R9 sont choisis séparément dans le groupe constitué d'hydrogène, d'halo, d'alcoxy inférieur, d'acyle, d'hydroxyalkyle, d'alcoxyalkyle, d'hydroxycarbonyle, d'alkyle, d'alcoxycarbonyle, d'acyloxyalkyle, de cyano, d'aryloxy, ou R8 et R9 comprennent conjointement avec R6 ou R7 une structure cyclique carbocyclique ou hétérocyclique fusionnée au cycle D pentacyclique.
PCT/US1996/020780 1995-12-11 1996-12-11 Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles Ceased WO1997021720A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA002347345A CA2347345C (fr) 1995-12-11 1996-12-11 Procedes de preparation de steroides 7 alpha-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles
EA199800449A EA009176B1 (ru) 1995-12-11 1996-12-11 Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям
EP96945103A EP0973791B1 (fr) 1995-12-11 1996-12-11 Procede pour la preparation d'un composé époxy
DK96945103T DK0973791T3 (da) 1995-12-11 1996-12-11 Fremgangsmåde til fremstilling af en epoxyforbindelse
CA002347346A CA2347346C (fr) 1995-12-11 1996-12-11 Procedes de preparation de steroides 7 alpha-carboxylyl 9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles
DE69637140T DE69637140T2 (de) 1995-12-11 1996-12-11 Verfahren zur herstellung einer epoxy-verbindung
AU13551/97A AU719260B2 (en) 1995-12-11 1996-12-11 Process for preparation of 7 alpha-carboxyl 9, 11-epoxy steroids and intermediates useful therein
HU9900493A HU222453B1 (hu) 1995-12-11 1996-12-11 Általános eljárás olefines kettős kötés epoxidálására
IL12463196A IL124631A (en) 1995-12-11 1996-12-11 Processes for preparations of steroids and intermediates useful therein
IL158857A IL158857A (en) 1995-12-11 1996-12-11 Processes for preparation of steroids and intermediates useful therein
JP52230497A JP4146897B2 (ja) 1995-12-11 1996-12-11 ７―アルファ―カルボキシル―９，１１―エポキシステロイド化合物の製造方法およびこの方法に有用な中間体ならびにオレフィン二重結合の一般的エポキシ化方法
CA 2240388 CA2240388A1 (fr) 1995-12-11 1996-12-11 Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles
KR10-2004-7011499A KR100523146B1 (ko) 1995-12-11 1996-12-11 7α-카르복실 9,11-에폭시 스테로이드의 제조방법 및 여기에 유용한 중간체 및 올레핀계 이중결합의 에폭시화를 위한 일반방법
IL175299A IL175299A0 (en) 1995-12-11 2006-04-27 Steroids, processes for their preparation and intermediates useful therein

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US845595P 1995-12-11 1995-12-11
US60/008,455 1995-12-11
US08/763,910 US5981744A (en) 1995-12-11 1996-12-11 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Publications (3)

Publication Number Publication Date
WO1997021720A2 WO1997021720A2 (fr) 1997-06-19
WO1997021720A3 WO1997021720A3 (fr) 1997-10-30
WO1997021720B1 true WO1997021720B1 (fr) 1997-12-31

Family

ID=26678218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/020780 Ceased WO1997021720A2 (fr) 1995-12-11 1996-12-11 Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles

Country Status (12)

Country Link
US (13) US5981744A (fr)
EP (1) EP0973791B1 (fr)
JP (2) JP4146897B2 (fr)
CN (1) CN100384866C (fr)
AT (1) ATE365171T1 (fr)
DE (1) DE69637140T2 (fr)
DK (1) DK0973791T3 (fr)
EA (1) EA009176B1 (fr)
ES (1) ES2287943T3 (fr)
IL (2) IL124631A (fr)
PT (1) PT973791E (fr)
WO (1) WO1997021720A2 (fr)

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