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WO1997008312B1 - Chevauchement du gene pms2 par le gene $i(jtv1) d'origine humaine - Google Patents

Chevauchement du gene pms2 par le gene $i(jtv1) d'origine humaine

Info

Publication number
WO1997008312B1
WO1997008312B1 PCT/US1996/013598 US9613598W WO9708312B1 WO 1997008312 B1 WO1997008312 B1 WO 1997008312B1 US 9613598 W US9613598 W US 9613598W WO 9708312 B1 WO9708312 B1 WO 9708312B1
Authority
WO
WIPO (PCT)
Prior art keywords
hpms2
gene
jtv1
sequence
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/013598
Other languages
English (en)
Other versions
WO1997008312A9 (fr
WO1997008312A1 (fr
Filing date
Publication date
Priority claimed from US08/518,862 external-priority patent/US5843757A/en
Application filed filed Critical
Priority to AT96930577T priority Critical patent/ATE252638T1/de
Priority to JP9510440A priority patent/JPH11511323A/ja
Priority to DE69630458T priority patent/DE69630458D1/de
Priority to EP96930577A priority patent/EP0852620B1/fr
Publication of WO1997008312A1 publication Critical patent/WO1997008312A1/fr
Publication of WO1997008312B1 publication Critical patent/WO1997008312B1/fr
Publication of WO1997008312A9 publication Critical patent/WO1997008312A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Le gène hPMS2 code une protéine qui intervient dans la réparation des mésappariements de l'ADN et subit une mutation chez des patients d'un sous-ensemble, atteints de cancer colique héréditaire sans polypose (HNPCC). A la séquence d'ADNc du gène hPMS2 précédemment publiée, il manque un codon de terminaison amont, interne au cadre, et précédant la présumée méthionine d'initiation. Afin d'étudier plus avant l'extrémité 5' de la région codante du gène hPMS2, nous avons isolé des clones d'ADNc supplémentaires, des produits de réaction RT-PCR, ainsi que le segment génomique 5' correspondant du locus du gène hPMS2. On a trouvé que les produits de transcription du gène hPMS2 avaient des extrémités 5' hétérogènes mais colinéaires, l'une d'entre elles étant contenue dans un codon de terminaison, interne au cadre, et précédant la méthionine d'initiation. En outre, on a trouvé qu'un gène codant un polypeptide de 34,5 kDa pouvait effectuer une initiation par transcription à l'intérieur du gène hPMS2 à partir du brin opposé.
PCT/US1996/013598 1995-08-24 1996-08-26 Chevauchement du gene pms2 par le gene $i(jtv1) d'origine humaine Ceased WO1997008312A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT96930577T ATE252638T1 (de) 1995-08-24 1996-08-26 Das humane jtvi-gen überlappt mit dem pms2-gen
JP9510440A JPH11511323A (ja) 1995-08-24 1996-08-26 ヒトｊｔｖ１遺伝子はｐｍｓ２遺伝子と部分的に重なる
DE69630458T DE69630458D1 (de) 1995-08-24 1996-08-26 Das humane jtvi-gen überlappt mit dem pms2-gen
EP96930577A EP0852620B1 (fr) 1995-08-24 1996-08-26 Chevauchement du gene humain pms2 par le gene jtv1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/518,862 US5843757A (en) 1995-08-24 1995-08-24 Human JTV1 gene overlaps PMS2 gene
US08/518,862 1995-08-24

Publications (3)

Publication Number Publication Date
WO1997008312A1 WO1997008312A1 (fr) 1997-03-06
WO1997008312B1 true WO1997008312B1 (fr) 1997-04-10
WO1997008312A9 WO1997008312A9 (fr) 1997-05-29

Family

ID=24065808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/013598 Ceased WO1997008312A1 (fr) 1995-08-24 1996-08-26 Chevauchement du gene pms2 par le gene $i(jtv1) d'origine humaine

Country Status (7)

Country Link
US (1) US5843757A (fr)
EP (1) EP0852620B1 (fr)
JP (1) JPH11511323A (fr)
AT (1) ATE252638T1 (fr)
CA (1) CA2229789A1 (fr)
DE (1) DE69630458D1 (fr)
WO (1) WO1997008312A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146894A (en) 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
AU2001234992A1 (en) 2000-02-11 2001-08-20 The Johns-Hopkins University Methods for generating hypermutable bacteria
ATE399871T1 (de) 2000-02-18 2008-07-15 Morphotek Inc Methode zur herstellung hypermutabler pflanzen
AU2001238558A1 (en) 2000-02-23 2001-09-03 Luigi Grasso Methods for generating hypermutable yeast
US6825038B2 (en) 2000-05-12 2004-11-30 The Johns Hopkins University Method for generating hypermutable organisms
AU2000258017A1 (en) * 2000-07-17 2002-02-13 Jiahui Xia Human source gene leading sequence, gene vector and gene expression strategy
US20020058265A1 (en) * 2000-09-15 2002-05-16 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6844152B1 (en) * 2000-09-15 2005-01-18 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6737268B1 (en) 2000-11-14 2004-05-18 Morphotek, Inc. Method for generating genetically altered antigens
ATE336505T1 (de) * 2000-11-14 2006-09-15 Morphotek Inc Verfahren zur erzeugung von genetisch veränderten antigenen
US7070940B2 (en) * 2002-07-18 2006-07-04 Aventis Pharma S.A. Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein
KR100575251B1 (ko) * 2003-03-03 2006-05-02 재단법인서울대학교산학협력재단 ｐ38／ＪＴＶ－1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법
US20090075378A1 (en) 2007-02-20 2009-03-19 Anaptysbio, Inc. Somatic hypermutation systems
EP2566499B1 (fr) * 2010-05-04 2017-01-25 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées à des fragments protéiques de complexe multi-arnt synthétase p38

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