WO1997008312B1 - Human jtv1 gene overlaps pms2 gene - Google Patents
Human jtv1 gene overlaps pms2 geneInfo
- Publication number
- WO1997008312B1 WO1997008312B1 PCT/US1996/013598 US9613598W WO9708312B1 WO 1997008312 B1 WO1997008312 B1 WO 1997008312B1 US 9613598 W US9613598 W US 9613598W WO 9708312 B1 WO9708312 B1 WO 9708312B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hpms2
- gene
- jtv1
- sequence
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
The hPMS2 gene encodes a protein which is involved in DNA mismatch repair and is mutated in a subset of patients with hereditary nonpolyposis colon cancer (HNPCC). The previously published hPMS2 cDNA sequence lacks an upstream in-frame stop codon preceding the presumptive initiating methionine. To further evaluate the 5' terminus of the hPMS2 coding region, we isolated additional cDNA clones, RT-PCR products, and the corresponding 5' genomic segment of the hPMS2 locus. The hPMS2 gene transcripts were found to have heterogeneous but collinear 5' termini, one of which contained an in-frame termination codon preceding the initiating methionine. In addition, a gene encoding a 34.5 kDa polypeptide was found to transcriptionally initiate within hPMS2 from the opposite strand.
Claims
1. A segment of cDNA consisting of the nucleotide sequence shown in Figure 2.
2. A vector comprising the segment of DNA of claim 1.
3. A host cell which comprises the vector of claim 2.
4. A composition consisting essentially of a protein consisting of the amino add sequence shown in Figure 2.
5. A composition of protein JTV1 as shown in Figure 2, wherein said composition is free of other human proteins.
6. A segment of cDNA which encodes the amino acid sequence of JTV1 protein shown in Figure 2 .
7. A cDNA probe wherein said cDNA consists of between 15 and 1176 contiguous nucleotides of the sequence shown in SEQ ID NO:3.
STATEMENT UNDER ARTICLE 19
Claim 5 has been amended to refer to the proper figure (figure 2) which shows the sequence of JTV1 protein. Claim 7 has been amended to refer to the proper sequence identifier for the gene JTV1 Reference to Sequence ID NO:1 has been replaced with reference to Sequence ID NO:3.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69630458T DE69630458D1 (en) | 1995-08-24 | 1996-08-26 | THE HUMANE JTVI GEN OVERLAPPED WITH THE PMS2 GEN |
| EP96930577A EP0852620B1 (en) | 1995-08-24 | 1996-08-26 | Human jtv1 gene overlaps pms2 gene |
| AT96930577T ATE252638T1 (en) | 1995-08-24 | 1996-08-26 | THE HUMAN JTVI GENE OVERLAPS WITH THE PMS2 GENE |
| JP9510440A JPH11511323A (en) | 1995-08-24 | 1996-08-26 | Human JTV1 gene partially overlaps PMS2 gene |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/518,862 US5843757A (en) | 1995-08-24 | 1995-08-24 | Human JTV1 gene overlaps PMS2 gene |
| US08/518,862 | 1995-08-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997008312A1 WO1997008312A1 (en) | 1997-03-06 |
| WO1997008312B1 true WO1997008312B1 (en) | 1997-04-10 |
| WO1997008312A9 WO1997008312A9 (en) | 1997-05-29 |
Family
ID=24065808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/013598 Ceased WO1997008312A1 (en) | 1995-08-24 | 1996-08-26 | Human jtv1 gene overlaps pms2 gene |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5843757A (en) |
| EP (1) | EP0852620B1 (en) |
| JP (1) | JPH11511323A (en) |
| AT (1) | ATE252638T1 (en) |
| CA (1) | CA2229789A1 (en) |
| DE (1) | DE69630458D1 (en) |
| WO (1) | WO1997008312A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6146894A (en) | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
| CA2398094C (en) | 2000-02-11 | 2013-01-08 | The Johns Hopkins University | Methods for generating hypermutable microbes |
| ATE399871T1 (en) | 2000-02-18 | 2008-07-15 | Morphotek Inc | METHOD FOR PRODUCING HYPERMUTIABLE PLANTS |
| DK1259628T5 (en) | 2000-02-23 | 2018-06-14 | Univ Johns Hopkins | Process for the formation of hypermutable yeast |
| WO2001088192A2 (en) | 2000-05-12 | 2001-11-22 | The Johns Hopkins University | A method for generating hypermutable organisms |
| WO2002010375A1 (en) * | 2000-07-17 | 2002-02-07 | Jiahui Xia | Human source gene leading sequence, gene vector and gene expression strategy |
| US20020058265A1 (en) * | 2000-09-15 | 2002-05-16 | Promega Corporation | Detection of microsatellite instability and its use in diagnosis of tumors |
| US6844152B1 (en) * | 2000-09-15 | 2005-01-18 | Promega Corporation | Detection of microsatellite instability and its use in diagnosis of tumors |
| DE60030172T2 (en) * | 2000-11-14 | 2007-07-05 | Morphotek Inc. | METHOD OF GENERICALLY MODIFIED ANTIGENIC GENERATION |
| US6737268B1 (en) | 2000-11-14 | 2004-05-18 | Morphotek, Inc. | Method for generating genetically altered antigens |
| US7070940B2 (en) * | 2002-07-18 | 2006-07-04 | Aventis Pharma S.A. | Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein |
| KR100575251B1 (en) * | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | Pharmaceutical composition for treatment of cancer containing p38/JTV-1 as an effective component and screening method for pharmaceutical composition for treatment of cancer |
| WO2008103474A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
| AU2011248101B2 (en) * | 2010-05-04 | 2016-10-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
-
1995
- 1995-08-24 US US08/518,862 patent/US5843757A/en not_active Expired - Lifetime
-
1996
- 1996-08-26 AT AT96930577T patent/ATE252638T1/en not_active IP Right Cessation
- 1996-08-26 EP EP96930577A patent/EP0852620B1/en not_active Expired - Lifetime
- 1996-08-26 WO PCT/US1996/013598 patent/WO1997008312A1/en not_active Ceased
- 1996-08-26 DE DE69630458T patent/DE69630458D1/en not_active Expired - Lifetime
- 1996-08-26 CA CA002229789A patent/CA2229789A1/en not_active Abandoned
- 1996-08-26 JP JP9510440A patent/JPH11511323A/en active Pending
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