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WO1996037214A3 - Compositions of interleukin and pyrimidine nucleosides - Google Patents

Compositions of interleukin and pyrimidine nucleosides Download PDF

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Publication number
WO1996037214A3
WO1996037214A3 PCT/EP1996/002088 EP9602088W WO9637214A3 WO 1996037214 A3 WO1996037214 A3 WO 1996037214A3 EP 9602088 W EP9602088 W EP 9602088W WO 9637214 A3 WO9637214 A3 WO 9637214A3
Authority
WO
WIPO (PCT)
Prior art keywords
interleukin
compositions
pyrimidine nucleosides
derivative
fluorouracil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1996/002088
Other languages
French (fr)
Other versions
WO1996037214A2 (en
Inventor
Kazushige Mori
Yutaka Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to EP96917379A priority Critical patent/EP0828508A2/en
Priority to AU59982/96A priority patent/AU5998296A/en
Priority to JP8535342A priority patent/JPH10506641A/en
Priority to BR9608779A priority patent/BR9608779A/en
Publication of WO1996037214A2 publication Critical patent/WO1996037214A2/en
Publication of WO1996037214A3 publication Critical patent/WO1996037214A3/en
Priority to MXPA/A/1997/008915A priority patent/MXPA97008915A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

A synergistic antitumor pharmaceutical composition comprising an effective amount of interleukin-12 and a pyrimidine nucleoside derivative as well as a hydrate or solvate thereof that is converted into fluorouracil or its derivative, and a pharmaceutically acceptable carrier.
PCT/EP1996/002088 1995-05-26 1996-05-15 Compositions of interleukin and pyrimidine nucleosides Ceased WO1996037214A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP96917379A EP0828508A2 (en) 1995-05-26 1996-05-15 Compositions of interleukin and pyrimidine nucleosides
AU59982/96A AU5998296A (en) 1995-05-26 1996-05-15 Compositions of interleukin and pyrimidine nucleosides
JP8535342A JPH10506641A (en) 1995-05-26 1996-05-15 Composition of interleukin 12 and pyrimidine nucleoside
BR9608779A BR9608779A (en) 1995-05-26 1996-05-15 Compositions of nucleoside interleukin and pyrimidine
MXPA/A/1997/008915A MXPA97008915A (en) 1995-05-26 1997-11-19 Compositions of interleucine and nucleosides of pirimid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95108063 1995-05-26
EP95108063.9 1995-05-26

Publications (2)

Publication Number Publication Date
WO1996037214A2 WO1996037214A2 (en) 1996-11-28
WO1996037214A3 true WO1996037214A3 (en) 1997-01-09

Family

ID=8219298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/002088 Ceased WO1996037214A2 (en) 1995-05-26 1996-05-15 Compositions of interleukin and pyrimidine nucleosides

Country Status (9)

Country Link
EP (1) EP0828508A2 (en)
JP (1) JPH10506641A (en)
CN (1) CN1184430A (en)
AR (1) AR005417A1 (en)
AU (1) AU5998296A (en)
BR (1) BR9608779A (en)
CA (1) CA2220837A1 (en)
TR (1) TR199701435T1 (en)
WO (1) WO1996037214A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMI Y ET AL: "Interleukin-12 (IL-12) enhances antitumor activity of chemotherapy and radiotherapy in murine models", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, 36 (0). 01-03-1995. 480., XP000605926 *
JACOBSEN S.E.W.: "Il12, a direct stimulator and indirect inhibitor of haematopoiesis", RESEARCH IN IMMUNOLOGY, 01-01-1995, 146/7-8 (506-514), FRANCE, XP000607088 *

Also Published As

Publication number Publication date
BR9608779A (en) 1999-07-06
AR005417A1 (en) 1999-06-23
MX9708915A (en) 1998-03-31
JPH10506641A (en) 1998-06-30
AU5998296A (en) 1996-12-11
WO1996037214A2 (en) 1996-11-28
CA2220837A1 (en) 1996-11-28
TR199701435T1 (en) 1998-03-21
CN1184430A (en) 1998-06-10
EP0828508A2 (en) 1998-03-18

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