MX9708915A - Compositions of interleukin and pyrimidine nucleosides. - Google Patents
Compositions of interleukin and pyrimidine nucleosides.Info
- Publication number
- MX9708915A MX9708915A MX9708915A MX9708915A MX9708915A MX 9708915 A MX9708915 A MX 9708915A MX 9708915 A MX9708915 A MX 9708915A MX 9708915 A MX9708915 A MX 9708915A MX 9708915 A MX9708915 A MX 9708915A
- Authority
- MX
- Mexico
- Prior art keywords
- interleukin
- compositions
- pyrimidine nucleosides
- derivative
- fluorouracil
- Prior art date
Links
- 239000002718 pyrimidine nucleoside Substances 0.000 title abstract 2
- 102000015696 Interleukins Human genes 0.000 title 1
- 108010063738 Interleukins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 102000013462 Interleukin-12 Human genes 0.000 abstract 1
- 108010065805 Interleukin-12 Proteins 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
A synergistic antitumor pharmaceutical composition comprising an effective amount of interleukin-12 and a pyrimidine nucleoside derivative as well as a hydrate or solvate thereof that is converted into fluorouracil or its derivative, and a pharmaceutically acceptable carrier.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95108063.9 | 1995-05-26 | ||
| EP95108063 | 1995-05-26 | ||
| PCT/EP1996/002088 WO1996037214A2 (en) | 1995-05-26 | 1996-05-15 | Compositions of interleukin and pyrimidine nucleosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9708915A true MX9708915A (en) | 1998-03-31 |
| MXPA97008915A MXPA97008915A (en) | 1998-10-15 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU5998296A (en) | 1996-12-11 |
| EP0828508A2 (en) | 1998-03-18 |
| JPH10506641A (en) | 1998-06-30 |
| TR199701435T1 (en) | 1998-03-21 |
| BR9608779A (en) | 1999-07-06 |
| CN1184430A (en) | 1998-06-10 |
| AR005417A1 (en) | 1999-06-23 |
| WO1996037214A3 (en) | 1997-01-09 |
| WO1996037214A2 (en) | 1996-11-28 |
| CA2220837A1 (en) | 1996-11-28 |
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