WO1996032419B1 - Polymeres de polyacetals biodegradables, formation et utilisation - Google Patents
Polymeres de polyacetals biodegradables, formation et utilisationInfo
- Publication number
- WO1996032419B1 WO1996032419B1 PCT/US1996/004476 US9604476W WO9632419B1 WO 1996032419 B1 WO1996032419 B1 WO 1996032419B1 US 9604476 W US9604476 W US 9604476W WO 9632419 B1 WO9632419 B1 WO 9632419B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polyacetal
- biodegradable biocompatible
- biodegradable
- biocompatible polyacetal
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
La présente invention a pour objet des polyacétals biocompatibles et biodégradables, leurs procédés de fabrication et des méthodes de traitement des mammifères par l'administration desdits polyacétals. Une des méthodes de formation des polyacétals biocompatibles et biodégradables consiste à combiner un agent d'oxydation spécifique du glycol avec un polysaccharide afin de former une aldéhyde intermédiaire que l'on combine avec un agent de réduction pour former le polyacétal biocompatible et biodégradable. Les polyacétals biocompatibles et biodégradables qui en résultent peuvent être modifiés chimiquement afin d'inclure des parties hydrophiles supplémentaires. Une des méthodes de traitement des mammifères consiste à administrer le polyacétal biocompatible et biodégradable dans lequel on peut disposer des composés biologiquement actifs ou des marqueurs de diagnostic.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK96912522T DK0820473T4 (da) | 1995-04-14 | 1996-04-01 | Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse |
| AU55312/96A AU5531296A (en) | 1995-04-14 | 1996-04-01 | Biodegradable polyacetal polymers and formation and use |
| JP53104096A JP4187265B2 (ja) | 1995-04-14 | 1996-04-01 | 生体分解性ポリアセタールポリマーおよび生成および使用 |
| DE69613569T DE69613569T3 (de) | 1995-04-14 | 1996-04-01 | Biologisch abbaubare polyacetalpolymere und bildung und verwendung |
| AT96912522T ATE202573T1 (de) | 1995-04-14 | 1996-04-01 | Biologisch abbaubare polyacetal-polymere, herstellung und anwendung |
| EP96912522A EP0820473B2 (fr) | 1995-04-14 | 1996-04-01 | Polymeres de polyacetals biodegradables, formation et utilisation |
| CA002215997A CA2215997C (fr) | 1995-04-14 | 1996-04-01 | Polymeres de polyacetals biodegradables, formation et utilisation |
| GR20010401553T GR3036696T3 (en) | 1995-04-14 | 2001-09-24 | Biodegradable polyacetal polymers and formation and use |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/421,766 US5811510A (en) | 1995-04-14 | 1995-04-14 | Biodegradable polyacetal polymers and methods for their formation and use |
| US08/421,766 | 1995-04-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996032419A1 WO1996032419A1 (fr) | 1996-10-17 |
| WO1996032419B1 true WO1996032419B1 (fr) | 1996-12-12 |
Family
ID=23671966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/004476 Ceased WO1996032419A1 (fr) | 1995-04-14 | 1996-04-01 | Polymeres de polyacetals biodegradables, formation et utilisation |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5811510A (fr) |
| EP (1) | EP0820473B2 (fr) |
| JP (1) | JP4187265B2 (fr) |
| AT (1) | ATE202573T1 (fr) |
| AU (1) | AU5531296A (fr) |
| CA (1) | CA2215997C (fr) |
| DE (1) | DE69613569T3 (fr) |
| DK (1) | DK0820473T4 (fr) |
| GR (1) | GR3036696T3 (fr) |
| WO (1) | WO1996032419A1 (fr) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| WO1998058258A1 (fr) * | 1997-06-18 | 1998-12-23 | Elvira Schecklies | Formulation pour systemes reactionnels immunologiques |
| BR9813465A (pt) * | 1997-12-09 | 2002-01-22 | Biomed Frontiers Inc | Polissacarìdeos modificados que exibem reconhecimento biológico alterado |
| US6958148B1 (en) | 1998-01-20 | 2005-10-25 | Pericor Science, Inc. | Linkage of agents to body tissue using microparticles and transglutaminase |
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| WO2001010468A2 (fr) * | 1999-08-09 | 2001-02-15 | The General Hospital Corporation | Complexes vecteurs de medicament et technique d'utilisation de ceux-ci |
| ES2294026T3 (es) * | 2000-09-06 | 2008-04-01 | Ap Pharma, Inc. | Polimeros degradables de poliacetal. |
| US6648883B2 (en) | 2001-04-26 | 2003-11-18 | Medtronic, Inc. | Ablation system and method of use |
| US7250048B2 (en) | 2001-04-26 | 2007-07-31 | Medtronic, Inc. | Ablation system and method of use |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| US7838619B2 (en) * | 2002-01-14 | 2010-11-23 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| ATE441706T1 (de) * | 2002-02-20 | 2009-09-15 | Gen Hospital Corp | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| WO2004004794A1 (fr) * | 2002-07-05 | 2004-01-15 | Asahi Kasei Kabushiki Kaisha | Resine compatible avec le liquide organique et le tissu vivant |
| CA2492803C (fr) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Conjugats d'oximes, procedes de synthese de ces produits et leurs usages |
| AU2003256613A1 (en) * | 2002-07-19 | 2004-02-09 | Amgen Inc. | Protein conjugates with a water-soluble biocompatible, biogradable polymer |
| US7045589B2 (en) | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| US6878374B2 (en) * | 2003-02-25 | 2005-04-12 | Nitto Denko Corporation | Biodegradable polyacetals |
| US7048925B2 (en) * | 2003-08-28 | 2006-05-23 | Nitto Denko Corporation | Acid-sensitive polyacetals and methods |
| JP5537763B2 (ja) * | 2003-09-05 | 2014-07-02 | ザ ジェネラル ホスピタル コーポレイション | 放出システムとしてのポリアセタール薬物抱合体 |
| US20050181018A1 (en) * | 2003-09-19 | 2005-08-18 | Peyman Gholam A. | Ocular drug delivery |
| WO2005032597A1 (fr) * | 2003-09-29 | 2005-04-14 | Nitto Denko Corporation | Polyacetals biodegradables pour administration de polynucleotides in vivo |
| DE102004023117A1 (de) * | 2004-05-11 | 2005-12-08 | A. u. K. Müller GmbH & Co KG | Elektromagnetventil für flüssige Medien, insbesondere Heißwasser |
| US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| ATE493444T1 (de) * | 2004-10-18 | 2011-01-15 | Nitto Denko Corp | Intrazelluläre peptidabgabe |
| US20060275230A1 (en) | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
| KR20070095921A (ko) | 2004-12-10 | 2007-10-01 | 탈리마 테라퓨틱스 인코포레이티드 | 조갑 단위의 상태를 치료하기 위한 조성물 및 방법 |
| US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
| JP5137814B2 (ja) * | 2005-04-06 | 2013-02-06 | ジェンザイム・コーポレーション | 治療ターゲティングのための酸不安定リンカーを介するpegおよびポリシアルリソソーム酵素のコンジュゲート |
| US7722581B2 (en) * | 2005-04-11 | 2010-05-25 | Gholam A. Peyman | Crystalline lens drug delivery |
| US20060229585A1 (en) * | 2005-04-11 | 2006-10-12 | Minu, L.L.C. | Drug delivery to the crystalline lens and other ocular structures |
| US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
| WO2007098041A1 (fr) * | 2006-02-17 | 2007-08-30 | Medtronic, Inc. | Polymeres de polycetal et leurs procedes de fabrication et d'utilisation |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| US7458953B2 (en) * | 2006-06-20 | 2008-12-02 | Gholam A. Peyman | Ocular drainage device |
| US20090061515A1 (en) * | 2007-08-29 | 2009-03-05 | Michael Eric Benz | Methods of inhibiting or suppressing cellular proliferation |
| EA020251B1 (ru) * | 2007-11-28 | 2014-09-30 | Мерсана Терапьютикс, Инк. | Биосовместимые и биоразлагаемые конъюгаты аналогов фумагиллина |
| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| CN102307473A (zh) * | 2008-12-10 | 2012-01-04 | 摩萨纳医疗有限公司 | 可生物降解的生物相容性喜树碱-聚合物共轭物的药物制剂 |
| LT2889043T (lt) | 2008-12-16 | 2019-07-10 | Genzyme Corporation | Sintetiniai tarpiniai junginiai oligosacharido-baltymo konjugatų gamybai |
| EP2435053B1 (fr) | 2009-05-28 | 2018-11-14 | Mersana Therapeutics, Inc. | Conjugués de médicament/polyal comprenant des liants à taux de libération variable |
| JP2013528665A (ja) | 2010-03-26 | 2013-07-11 | メルサナ セラピューティックス, インコーポレイテッド | ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法 |
| WO2012129070A2 (fr) | 2011-03-24 | 2012-09-27 | Unversity Of Florida Research Foundation, Inc. | Polymérisation par métathèse d'acétal |
| CA2837840C (fr) | 2011-06-10 | 2020-08-04 | Mersana Therapeutics, Inc. | Conjugues de medicament-proteine-polymere |
| US20140017265A1 (en) * | 2012-07-05 | 2014-01-16 | Mersana Therapeutics, Inc. | Terminally Modified Polymers and Conjugates Thereof |
| EP2928503B1 (fr) | 2012-12-10 | 2019-02-20 | Mersana Therapeutics, Inc. | Conjugués de composés auristatine |
| JP6334553B2 (ja) | 2012-12-10 | 2018-05-30 | メルサナ セラピューティクス,インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
| CN105377355A (zh) | 2013-03-14 | 2016-03-02 | 拇趾公司 | 治疗甲单元的感染、疾病或病症的方法 |
| KR102087850B1 (ko) | 2013-10-11 | 2020-03-12 | 메르사나 테라퓨틱스, 인코포레이티드 | 단백질-고분자-약물 접합체 |
| PL3054992T3 (pl) | 2013-10-11 | 2020-01-31 | Asana Biosciences, Llc | Koniugaty białko-polimer-lek |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
| US11324827B2 (en) | 2014-10-01 | 2022-05-10 | Xiamen Sinopeg Biotech Co., Ltd. | Multifunctionalized polyethylene glycol derivative and preparation method therefor |
| CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
| EP4183806A3 (fr) | 2014-11-12 | 2023-08-02 | Seagen Inc. | Composés interagissant avec le glycane et procédés d'utilisation |
| AU2016353153B2 (en) | 2015-11-12 | 2023-11-23 | Seagen Inc. | Glycan-interacting compounds and methods of use |
| AU2017234163B2 (en) | 2016-03-15 | 2023-01-19 | Mersana Therapeutics, Inc. | NaPi2b-targeted antibody-drug conjugates and methods of use thereof |
| EP3541847A4 (fr) | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | Composés interagissant avec le glycane et méthodes d'utilisation |
| TW201834697A (zh) | 2017-02-28 | 2018-10-01 | 美商梅爾莎納醫療公司 | Her2標靶抗體-藥物結合物之組合療法 |
| MX2019010202A (es) | 2017-03-03 | 2019-10-02 | Seattle Genetics Inc | Compuestos que interactuan con glicano y metodos de uso. |
| JP7320458B2 (ja) | 2017-06-22 | 2023-08-03 | メルサナ セラピューティクス インコーポレイテッド | 薬物担持ポリマースキャフォールドおよびタンパク質-ポリマー-薬物コンジュゲートを製造する方法 |
| EP4380973A2 (fr) | 2021-08-02 | 2024-06-12 | Yeda Research and Development Co. Ltd. | Anticorps pour le traitement du cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024073A (en) * | 1972-01-08 | 1977-05-17 | Toray Industries, Inc. | Hydrogel and production thereof |
| US4303767A (en) * | 1976-12-02 | 1981-12-01 | Basf Wyandotte Corporation | Flame retardant antistatic additives and antistatic fibers |
| US4304767A (en) * | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| DE51707T1 (de) * | 1980-11-12 | 1983-04-14 | Izu West Hill Ontario Hattori | Dextranpolycarboxylierte saeuren, ihre komplexe mit ferrihydroxyd, sie enthaltende arzneimittel und verfahren zu deren herstellung. |
| JPS59124901A (ja) * | 1982-12-29 | 1984-07-19 | Dai Ichi Seiyaku Co Ltd | 多糖誘導体 |
| US4549010A (en) * | 1984-06-27 | 1985-10-22 | Merck & Co., Inc. | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal |
| US4863964A (en) * | 1985-07-02 | 1989-09-05 | Biomedical Frontiers, Inc. | Method for the stabilization of deferoxamine to chelate free ions in physiological fluid |
| US4713441A (en) * | 1986-08-01 | 1987-12-15 | Sandoz Pharmaceuticals Corp. | Polyacetal hydrogels formed from divinyl ethers and polyols |
| US4793986A (en) * | 1987-02-25 | 1988-12-27 | Johnson Matthey, Inc. | Macromolecular platinum antitumor compounds |
| JPH01190636A (ja) * | 1988-01-22 | 1989-07-31 | Green Cross Corp:The | 制癌作用物質複合体 |
| US4975519A (en) * | 1989-05-12 | 1990-12-04 | Hoechst Celanese Corporation | Novel polyacetal terpolymers of trioxane and alpha, alpha- and alpha, beta-isomers of glycerol formal and functional derivatives thereof |
| US5202434A (en) * | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
| EP0581752B1 (fr) * | 1992-07-15 | 1998-12-09 | The Procter & Gamble Company | Compositions pour éviter le transfert de colorant contenant des adjuvants |
| US5393737A (en) * | 1992-08-20 | 1995-02-28 | Health Research, Inc. | Cytotoxic drug conjugates for treatment of neoplastic diseases |
| US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
-
1995
- 1995-04-14 US US08/421,766 patent/US5811510A/en not_active Expired - Lifetime
-
1996
- 1996-04-01 JP JP53104096A patent/JP4187265B2/ja not_active Expired - Lifetime
- 1996-04-01 DK DK96912522T patent/DK0820473T4/da active
- 1996-04-01 DE DE69613569T patent/DE69613569T3/de not_active Expired - Lifetime
- 1996-04-01 WO PCT/US1996/004476 patent/WO1996032419A1/fr not_active Ceased
- 1996-04-01 CA CA002215997A patent/CA2215997C/fr not_active Expired - Lifetime
- 1996-04-01 AT AT96912522T patent/ATE202573T1/de active
- 1996-04-01 AU AU55312/96A patent/AU5531296A/en not_active Abandoned
- 1996-04-01 EP EP96912522A patent/EP0820473B2/fr not_active Expired - Lifetime
-
1997
- 1997-06-09 US US08/871,528 patent/US5863990A/en not_active Expired - Lifetime
-
1998
- 1998-12-07 US US09/207,102 patent/US5958398A/en not_active Expired - Lifetime
-
2001
- 2001-09-24 GR GR20010401553T patent/GR3036696T3/el unknown
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