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WO1996031206A3 - Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose - Google Patents

Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose Download PDF

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Publication number
WO1996031206A3
WO1996031206A3 PCT/US1996/004028 US9604028W WO9631206A3 WO 1996031206 A3 WO1996031206 A3 WO 1996031206A3 US 9604028 W US9604028 W US 9604028W WO 9631206 A3 WO9631206 A3 WO 9631206A3
Authority
WO
WIPO (PCT)
Prior art keywords
coumarins
flavones
atherosclerosis
treatment
agents
Prior art date
Application number
PCT/US1996/004028
Other languages
English (en)
Other versions
WO1996031206A2 (fr
Inventor
Uday Saxena
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Priority to AU52592/96A priority Critical patent/AU5259296A/en
Publication of WO1996031206A2 publication Critical patent/WO1996031206A2/fr
Publication of WO1996031206A3 publication Critical patent/WO1996031206A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les flavones et les coumarines ou leurs sels pharmaceutiquement acceptables sont des inhibiteurs de VCAM-1 et ICAM-1 et sont donc utiles dans le traitement de l'athérosclérose, de la resténose et de troubles immunitaires tels que l'arthrite et le rejet des transplantations.
PCT/US1996/004028 1995-04-07 1996-03-25 Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose WO1996031206A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52592/96A AU5259296A (en) 1995-04-07 1996-03-25 Flavones and coumarins as agents for the treatment of athero sclerosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41870995A 1995-04-07 1995-04-07
US08/418,709 1995-04-07

Publications (2)

Publication Number Publication Date
WO1996031206A2 WO1996031206A2 (fr) 1996-10-10
WO1996031206A3 true WO1996031206A3 (fr) 1996-12-12

Family

ID=23659261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/004028 WO1996031206A2 (fr) 1995-04-07 1996-03-25 Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose

Country Status (2)

Country Link
AU (1) AU5259296A (fr)
WO (1) WO1996031206A2 (fr)

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US8889698B2 (en) 2007-02-01 2014-11-18 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US9987379B2 (en) 2008-09-30 2018-06-05 Case Western Reserve University Molecular probes for imaging of myelin

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DE19845372A1 (de) * 1998-10-02 2000-04-20 Gruenenthal Gmbh Verwendung von Katecholderivaten als Proteinaseninhibitoren
WO2000035435A1 (fr) * 1998-12-15 2000-06-22 Warner-Lambert Company Technique de prevention du rejet de greffe par utilisation d'un inhibiteur du mek
US6291456B1 (en) 1998-12-30 2001-09-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6331562B1 (en) 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
WO2000050030A1 (fr) * 1999-02-25 2000-08-31 Ted Ebendal Nouvelle utilisation
AU2001278980A1 (en) * 2000-07-21 2002-02-05 Chugai Seiyaku Kabushiki Kaisha Coumarin derivatives useful as tnfalpha inhibitors
WO2002074307A1 (fr) * 2001-03-16 2002-09-26 Novogen Research Pty Ltd Traitement de la restenose
KR20020096368A (ko) * 2001-06-19 2002-12-31 주식회사 티지 바이오텍 연골세포의 분화촉진, 연골세포의 탈분화 억제 또는탈분화된 연골세포의 재분화 촉진제, 그것의 스크리닝방법 및 그것을 이용한 연골세포의 제조방법
KR20020096367A (ko) * 2001-06-19 2002-12-31 주식회사 티지 바이오텍 관절염 예방 또는 치료제 및 그것의 스크리닝 방법
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
JP4587652B2 (ja) * 2002-09-09 2010-11-24 株式会社フラバミン 新規フラボノイド化合物及びその利用
EP1546162B1 (fr) 2002-09-20 2011-06-22 Promega Corporation Procedes fondes sur la luminescence et sondes permettant de mesurer l'activite du cytochrome p450
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GB1175808A (en) * 1967-11-24 1969-12-23 Laroche Navarron Lab Improvements in or relating to new Therapeutic Composition, new Coumarin Derivatives and their process of preparation
FR2244493A1 (en) * 1973-08-09 1975-04-18 Pluripharm Flavonoid amino-acid salts - for treatment of haemorrhage, circulatory disorders and atherosclerosis
DE3601417A1 (de) * 1986-01-20 1987-07-23 Nattermann A & Cie 2'-alkyl-(alkenyl-) substituierte quercetine
EP0347864A2 (fr) * 1988-06-24 1989-12-27 Andries Johannes Cornelus Strydom Agents antiathérogéniques
US5242397A (en) * 1989-06-20 1993-09-07 Cedars-Sinai Medical Center Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889698B2 (en) 2007-02-01 2014-11-18 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US9987379B2 (en) 2008-09-30 2018-06-05 Case Western Reserve University Molecular probes for imaging of myelin
US11382991B2 (en) 2008-09-30 2022-07-12 Case Western Reserve University Molecular probes for imaging of myelin

Also Published As

Publication number Publication date
AU5259296A (en) 1996-10-23
WO1996031206A2 (fr) 1996-10-10

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