WO1996029983B1 - Skin care products containing anti-itching/anti-irritant agents - Google Patents
Skin care products containing anti-itching/anti-irritant agentsInfo
- Publication number
- WO1996029983B1 WO1996029983B1 PCT/US1996/003821 US9603821W WO9629983B1 WO 1996029983 B1 WO1996029983 B1 WO 1996029983B1 US 9603821 W US9603821 W US 9603821W WO 9629983 B1 WO9629983 B1 WO 9629983B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- composition
- level
- present
- climbazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
Mild aqueous detergent, e.g., shampoo, compositions are disclosed based on a mixture comprising anionic surfactant and amphoteric surfactant, such as betaines, present in the composition at a level of from about 0.75 to 1.25 parts by weight per part by weight of anionic surfactant. The compositions also contain one or a mixture of climbazole and one or more co-therapeutics such as salicylic acid. The combination of mild surfactant system and therapeutic agent serve to prevent or treat mild skin disorders such as scalp itch and scalp irritation when applied to the scalp as a shampoo. Shampoo compositions also preferably contain one or more conditioning agents and suitable suspending agents. The invention also provides a method for treating dry skin comprising applying certain of the therapeutic agents to dry skin to promote the natural secretion of sebum.
Claims
1. A mild, aqueous detergent composition having a therapeutic effect on skin and scalp disord ers comprising:
(a) from about 4 to about 12% by weight of an anionic surfactant selected from the group consisting of the sodium or ammonium C10 to C18 alkyl sulfates or suifonates, C14 to C18 alpha olefin sulfonates, C8 to C12 alkyl polyethoxy sulfates and mixtures thereof, and mixtures of the foregoing with a sodium salt of cumene, xylene or benzene sulfonate;
(b) a betaine or sulfobetaine amphoteric surfactant present in said composition at a level of about 0.75 to 1.25 parts per weight of amphoteric surfactant per part by weight of anionic surfactant;
(c) about 0.3 to 7% by weight of a long chain alcohol or ethoxylated alcohol averaging about 26 to 40 carbon atoms as a suspending and conditioning agent;
(d) an effective amount of a therapeutic agent selected from the group consisting of
1-imidazolyl-1-(4-chlorcphenoxy)- 3,3-dimethylbutan-2-one (climbazole); acetylsalicylic acid; salicyclic acid; 2,4,4' trichloro-2'-hydroxy diphenyl ether (triclosan);
1-acetyl-4-(4-(2 ,4-dichlorophenyl)-2-(1H-imi dazolyl-1-methyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-piperazine (Ketoconazole);
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt (piroctone olamine); selenium sulfide; zinc pyrithione; coal tar; sulfur; 2-(4'-isobutylphenyl) propionic acid (ibuprofen) and mixtures thereof; and
(e) about 50 to 85% by weight of water.
2. The composition of claim 1 containing from about 0.9 to 1.1 parts by weight of said amphoteric surfactant per part by weight of anionic surfactant.
3. The composition of claim 1 wherein said detergent composition is a shampoo.
4. The composition of claim 3 wherein said therapeutic agent is climbazole present at a level of from about 0.1 to about 4% by weight.
5. The composition of claim 4 wherein said climbazole is present at a level of from about 0.25 to about 2.5% by weight.
6. The composition of claim 4 wherein said therapeutic agent comprises a mixture of climbazole and salicylic acid wherein said salicylic acid is present at a level of from about 0.1 to about 10% by weight.
7. The composition of claim 6 wherein said salicylic acid is present at a level of from about 0.25 to about 2.5% by weight.
8. The composition of claim 3 wherein said betaine is cocoamidoethyl betaine or cocoamidopropyl betaine.
9. The composition of claim 1 wherein said anionic surfactant is present at a level of from about
6 to 10% by weight.
10. The composition of claim 3 further containing a hair conditioning agent selected from the group consisting of organosilicone compounds, aminosilicones, water insoluble hydrocarbons, water insoluble fatty acid esters, quaternary ammonium salts and mixtures thereof, present at a level of from about 0.2 to 5% by weight.
11. The composition of claim 10 wherein said hair conditioner comprises a quaternary ammonium salt.
12. The composition of claim 11 wherein said therapeutic agent comprises a mixture of climbazole and salicylic acid.
13. The composition of claim 12 wherein said anionic surfactant is said C14 - C18 alpha olefin sulfonate.
14. The composition of claim 11 wherein said quaternary ammonium salt is selected from the group consisting of tricetyl methyl ammonium chloride, dicetyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, tristearyl methyl ammonium chloride and mixtures thereof.
15. The composition of claim 10 wherein said conditioner is a polysiloxane or aminopolysiloxane.
16. The composition of claim 10 wherein said quaternary ammonium salt is the salt of a polymer of dimethyl ammonium chloride or copolymers thereof with acrylamide.
17. A method of treating or preventing scalp disorders such as irritation, inflammation, dryness, redness and itching comprising applying to the hair and scalp an aqueous composition comprising: (a) from about 4 to about 12% by weight of an anionic surfactant selected from the group consisting of the sodium or ammonium C10 to C18 alkyl sulfates or sulfonates, C14 to C18 alpha olefin sulfonates, C8 to C12 alkyl polyethoxy sulfates and mixtures thereof, and mixtures of the foregoing with a sodium salt of cumene, xylene or benzene sulfonate;
(b) a betaine or sulfobetaine amphoteric surfactant present in said composition at a level of about 0.75 to 1.25 parts per weight of amphoterio surfactant per part by weight of anionic surfactant;
(c) about 0.5 to 7% by weight of a long chain aicchol or ethoxylated alcohol averaging about 26 to 40 carbon atoms as a suspending and conditioning agent;
(d) an effective amount of a therapeutic agent selected from the group consisting of 1-imidazolyl-1- (4-chlorophenoxy)-3,3-dimethylbutan-2-one (climbazole); acetylsalicylic acid; salicyclic acid; 2,4,4' trichlcro-2'-hydroxy diphenyl ether (triclosan); 1- acetyl-4-(4-(2,4-dichlorophenyl)-2-(1H-imidazolyl- methyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-piperazine (Ketoconazole);
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolaraine salt (piroctone olami ne); selenium sulfide; zinc pyrithione; coal tar; sulfur; 2-(4,iso- butylphenyl) propionic acid (ibuprofen) and mixtures thereof; and
(e) about 50 to 85% by weight of water.
18. The method according to claim 17 wherein the composition contains from about 0.9 to 1.1 parts by weight of said amphoteric surfactant per part by weight of anionic surfactant.
19. The method according to claim 17 wherein said therapeutic agent is climbazole present at a level of from about 0.1 to about 4% by weight.
20. The method according to claim 19 wherein said climbazole is present at a level of from about 0.25 to about 2.5% by weight.
21. The method according to claim 19 wherein said therapeutic agent comprises a mixture of climbazole and salicylic acid wherein said salicylic acid is present at a level of from about 0.1 to about 10% by weight.
22. The method according to claim 21 wherein said salicylic acid is present at a level of from about 0.25 to 2.5% by weight.
23. The method according to clam. 17 wherein said betaine is cocoamidoethyl betaine or cocoamidopropyl betaine.
24. The method according to claim 17 wherein said anionic surfactant is present at a level of from about 6 to 10% by weight.
25. The method according to claim 17 wherein the composition further contains a hair conditioning agent selected from the group consisting of organosilicone compounds, aminosilicones, water insoluble hydrocarbons, water insoluble fatty acid esters, quaternary ammonium salts and mixtures thereof, present at a level of from 0.2 to 5% by weight.
26. The method according to claim 25 wherein said hair conditioner comprises a quaternary ammonium salt.
27. The method according to claim 25 wherein said therapeutic agent comprises a mixture of climbazole and salicylic acid.
28. The method according to claim 27 wherein said anionic surfactant is said C14 - C18 alpha olefin sulfonate.
29. The method according to claim 26 wherein said quaternary ammonium salt is selected from the group consisting of tricetyl methyl ammonium chloride, dicetyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, tristearyl methyl ammonium chloride and mixtures thereof.
30. The method according to claim 25 wherein said conditioner is a polysiloxane or aminopolysiloxane.
31. The method according to claim 26 wherein said quaternary ammonium salt is the salt of a polymer of dimethyl ammonium chloride or copolymers thereof with acrylamide.
32. A method for treating dry skin conditions in skin areas other than the scalp by moisturizing the skin comprising the step of rubbing the affected dry skin area with a skin care composition comprising an effective amount of an agent that stimulates the sebaceous glands to promote the secretion of oily sebum in the skin, said agent being selected from the group consisting of 1-imidazolyl-1-( 4-ch lorophenoxy) -3 , 3 - dimethylbutan-2-one; 2,4,4'-trichloro-2'-hydroxy diphenyl ether; 1-acetyl-4-(4-(2-(2,4-dichlorophenyl) -2-(1H-imidazolyl-1-methyl)-1,3-dioxolan-4-yl)methoxy) phenyl)-piperazine; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; selenium sulfide and zinc pyrithione and said agent being dispersed in a compatible carrier.
33. The method according to claim 32 wherein said skin care composition contains from about 0.1 to about
5% by weight of said agent.
34. The method according to claim 33 wherein said agent is zinc pyrithione or 1-imidazol-1-(4-chlorophen- oxy)-3,3-dimethylbutan-2-one.
35. The method according to claim 34 wherein said agent is present in an amount of about 0.25 to 2.5% by weight.
36. The method according to claim 32 wherein said skin care composition is in the form of a cleannnsing lotion, gel, bar soap, liquid soap, foam, cleansing liquid or cream.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU53185/96A AU5318596A (en) | 1995-03-31 | 1996-03-21 | Skin care products containing anti-itching/anti-irritant age nts |
| BR9607952A BR9607952A (en) | 1995-03-31 | 1996-03-21 | Soft aqueous detergent composition and processes to treat or prevent scalp disorders and dry skin conditions |
| MXPA/A/1997/007482A MXPA97007482A (en) | 1995-03-31 | 1997-09-30 | Skin care products containing anti-irritating agents / against the come |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41188395A | 1995-03-31 | 1995-03-31 | |
| US08/411,883 | 1995-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996029983A1 WO1996029983A1 (en) | 1996-10-03 |
| WO1996029983B1 true WO1996029983B1 (en) | 1996-11-21 |
Family
ID=23630688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/003821 Ceased WO1996029983A1 (en) | 1995-03-31 | 1996-03-21 | Skin care products containing anti-itching/anti-irritant agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5834409A (en) |
| AU (1) | AU5318596A (en) |
| BR (1) | BR9607952A (en) |
| TW (1) | TW449485B (en) |
| WO (1) | WO1996029983A1 (en) |
| ZA (1) | ZA962501B (en) |
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| US5100658A (en) * | 1989-08-07 | 1992-03-31 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
| CA2077398A1 (en) * | 1991-09-06 | 1993-03-07 | William J. Cook | Acidic disinfectant all-purpose liquid cleaning composition |
| FR2694494B1 (en) * | 1992-08-05 | 1994-09-30 | Rhone Poulenc Chimie | Cosmetic composition containing non-water-soluble particles in suspension. |
| AU5096393A (en) * | 1992-09-08 | 1994-03-29 | Procter & Gamble Company, The | Mild, substantially colorless shampoo composition |
| GB9223034D0 (en) * | 1992-11-03 | 1992-12-16 | Surtech Int Ltd | Method and composition for prevention and/or treatment of dandruff and seborrhoeic dermatitis |
| GB9310241D0 (en) * | 1993-05-18 | 1993-06-30 | Unilever Plc | Cosmetic treatment of substrates |
| US5505949A (en) * | 1994-10-13 | 1996-04-09 | Benitez; Juan E. | Topical treatment for acne |
| US5582832A (en) * | 1995-06-06 | 1996-12-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Compositions for topical application to skin |
-
1995
- 1995-06-21 TW TW084106353A patent/TW449485B/en not_active IP Right Cessation
-
1996
- 1996-02-08 US US08/598,411 patent/US5834409A/en not_active Expired - Fee Related
- 1996-03-21 WO PCT/US1996/003821 patent/WO1996029983A1/en not_active Ceased
- 1996-03-21 AU AU53185/96A patent/AU5318596A/en not_active Abandoned
- 1996-03-21 BR BR9607952A patent/BR9607952A/en not_active Application Discontinuation
- 1996-03-28 ZA ZA9602501A patent/ZA962501B/en unknown
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