CN120021411A

CN120021411A - Mixtures containing climbazole having improved foam volume and foam stability

Info

Publication number: CN120021411A
Application number: CN202380036427.4A
Authority: CN
Inventors: 扎比内·朗格; 里卡达·克雷林; 塞巴斯蒂安·布朗克; 劳拉·梅尼耶; 弗洛里安·根里希
Original assignee: Symrise AG
Current assignee: Symrise AG
Priority date: 2023-09-20
Filing date: 2023-09-20
Publication date: 2025-05-20
Also published as: EP4547209A1; WO2025061274A1; WO2025061274A8

Abstract

The present invention relates generally to a mixture comprising or consisting of climbazole, one or more polymers, and one or more surfactants. The invention also relates to semi-finished products, cosmetic products and pharmaceutical products comprising or consisting of the mixture as described herein. Furthermore, the present invention relates to the use of a climbazole and/or one or more polymers for improving the foam volume and/or foam stability of a mixture, a semi-finished product or a product as described herein, a method for manufacturing a mixture, a semi-finished product and a product as described herein, and a method for improving the foam volume and/or foam stability of a semi-finished product or a product as described herein.

Description

Mixture comprising climbazole with improved foam volume and foam stability

Technical Field

The present invention relates generally to a mixture comprising or consisting of climbazole, one or more polymers, and one or more surfactants. The invention also relates to semi-finished products, cosmetic products and pharmaceutical products comprising or consisting of the mixture as described herein. Furthermore, the present invention relates to the use of climbazole and/or one or more polymers for improving the foam volume and/or foam stability of a mixture, a semi-finished product or a product as described herein, to a method for manufacturing a mixture, a semi-finished product and a product as described herein, and to a method for improving the foam volume and/or foam stability of a semi-finished product or a product as described herein.

Further aspects of the invention will emerge from the description below, in particular from the examples and from the appended patent claims.

Background

Sulfates are cleansing surfactants responsible for foam formation in many cosmetic products. The sulfate compounds most commonly used in the cosmetic industry are, for example, sodium laureth sulfate, sodium lauryl sulfate, and ammonium laureth sulfate. These cleaning substances are added, for example, to shampoos to dissolve oils and dirt and to clean the hair thoroughly in particular. After washing, the hair should be perceived as fresh and clean. One disadvantage is that sulfate is considered a potential irritant, potentially damaging the protective lipid layer of the scalp. They may make the scalp more permeable to contaminants and dry the hair. Thus, particularly for dry hair and dry scalp after dyeing, a mild sulfate-free formulation is preferably used, and more sulfate-free cosmetic formulations are introduced into the market worldwide. However, sulfate-free formulations tend to have poor foaming properties compared to sulfate-based formulations. In addition, it is more difficult to adjust the viscosity of sulfate-free formulations to the desired level because they cannot be thickened with sodium chloride. Thus, larger amounts of polymer are used in sulfate-free formulations, especially bio-produced and biodegradable formulations. The polymers often have an additional adverse effect on the foaming properties of cosmetic formulations such as shampoos. However, consumers often have strong preference for cosmetic formulations that easily generate a large amount of foam and high foam stability in use.

It is therefore an object of the present invention to provide a cosmetic formulation which solves the above mentioned problems. In particular, a sulfate-free cosmetic formulation is sought that provides high lather volume and/or high lather stability.

Disclosure of Invention

According to a first aspect of the invention, the stated object is surprisingly achieved by a mixture comprising or consisting of:

(i) Climbazole (also known as (RS) -1- (4-chlorophenoxy) -1- (1H-imidazol-1-yl) -3, 3-dimethylbut-2-one, CAS number 38083-17-9),

(Ii) One or more polymers, and

(Iii) One or more, preferably sulfate-free surfactants.

In the basic research of the present invention, it has surprisingly been found that higher foam volumes and/or foam stability critical to the consumer of cosmetic formulations can be achieved by a combination of climbazole, one or more polymers, and one or more surfactants (also with reference to the examples further shown below). This is particularly surprising since it has not been known to date that both climbazole and polymer are foam boosters. Chlorbazole is known as an effective topical antifungal agent and is commonly used to treat fungal skin infections such as dandruff, seborrheic dermatitis, and eczema in humans. It demonstrates high in vitro and in vivo efficacy against Malassezia (Malassezia spp), which plays an important role in the pathogenesis of dandruff.

According to a preferred embodiment, one, several or all, preferably all, of the surfactants (reference component (iii)) in the mixture according to the invention are sulfate-free surfactants,

Preferably a sulphate-free surfactant selected from the group consisting of dimethyl lauramide/myristamide, cetyl betaine, lauramidopropyl betaine, cocoamidopropyl betaine, almond oleaamidopropyl betaine, wild oleaamidopropyl betaine, avocado amidopropyl betaine, babassam amidopropyl betaine, behenamidopropyl betaine, behenyl betaine, capric/lauric/myristic/oleic amidopropyl betaine (capric/lauric/myristic/oleic amidopropyl betaine), Caprylyl/capramidopropyl betaine, cocoamidoethyl betaine, coco/sunflower amidopropyl betaine, cocoa amidopropyl betaine, seabuckthorn amidopropyl betaine, isostearamidopropyl betaine, lauryl betaine, macadamia amidopropyl betaine (macadamiamidopropyl betaine), white pool amidopropyl betaine, myristyl betaine, oleamidopropyl betaine, oleyl betaine, palm amidopropyl betaine, pine amidopropyl betaine (pineamidopropyl betaine), Ricinoleic acid amidopropyl betaine, shea butter amidopropyl betaine, soybean oil amidopropyl betaine, undecylenamide amidopropyl betaine, wheat germ amidopropyl betaine, rhamnolipid, sophorolipid, glycolipid, sodium lauryl glucose carboxylate, sodium cocoyl amphoacetate, PEG-7 cocoyl glyceride, cocoamide DEA, cocoamide MEA, lauramide DEA, ethylene glycol distearate, lauryl glucoside, caprylyl/decanoyl glucoside, decyl glucoside, cocoyl glucoside, glyceryl polyether-26 arachidyl glucoside, butyl glucoside, C9-11 alkyl glucoside, C20-22 alkyl glucosides, cetostearyl glucosides, heptyl glucosides, hydroxystearyl glucosides, isostearyl glucosides, myristyl glucosides, sodium cocoyl glutamate, alkyl glutamate, disodium cocoyl glutamate, sodium lauroyl glutamate, cocoyl isethionate, sodium lauroyl lactylate, cocoamidoMEA, PEG-55 propylene glycol oleate, PPG-5-cetyl polyether-20, disodium cocoyl amphodipropionate, sodium lauroyl sarcosinate, ammonium cocoyl sarcosinate, sodium oleoyl sarcosinate, sodium cocoyl sarcosinate, Sodium myristoyl sarcosinate, isopropyl lauroyl sarcosinate, MIPA-cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TIPA-lauroyl sarcosinate, sodium laurylsulfonate, sodium octanoyl sulfonate, sodium dodecylbenzenesulfonate, sodium xylene sulfonate, sodium C12-C14 olefin sulfonate, dioctyl sodium sulfosuccinate, diethyl hexyl sulfosuccinate, disodium laureth sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, sodium isopalmitoyl methyl taurate, Sodium methyl stearoyl taurate, sodium methyl palmitoyl taurate, sodium methyl oleoyl taurate, sodium methyl myristoyl taurate, sodium methyl lauroyl taurate, sodium N-isostearoyl methyl taurate, sodium cocoyl taurate and sodium decanoyl methyl taurate.

As discussed above, sulfate-free surfactants are particularly advantageous because they avoid irritating the skin.

It is particularly preferred that one, some or all, preferably all of the surfactants are sulfate-free surfactants selected from the group consisting of cocamidopropyl betaine, lauryl glucoside, caprylyl/caproyl glucoside, decyl glucoside, sodium lauroyl sarcosinate, cocobetaine, PPG-5-cetyl polyether-20, cocoyl glucoside, sodium diethylhexyl sulfosuccinate, cocoyl isethionate, cocoyl sarcosinate, cocoyl amide MEA, PEG-7 cocoyl glyceride, ethylene glycol distearate, sodium oleoyl sarcosinate, sodium cocoyl isethionate, sodium cocoyl amphoacetate, sodium cocoyl glutamate, sodium methyl cocoyl taurate, sodium C12-C14 olefin sulfonate, disodium laureth sulfosuccinate and sodium lauryl glucose carboxylate.

According to a preferred embodiment, the mixture according to the invention is (completely) sulfate-free. The mixture according to the invention therefore preferably does not comprise any sulphate-based surfactant.

According to another preferred embodiment, one, several or all of the polymers (reference component (ii)) in the mixture according to the invention are natural polymers.

Within the context of this document, natural polymers (also commonly referred to as biopolymers) are defined as a diverse group of non-petrochemical derived polymers, i.e. polymers derived from natural sources or produced by fermentation, whereas synthetic polymers are derived from petroleum. Proteins, starches, gums, and polysaccharides are some examples of natural polymers (other examples will be given below). Natural polymers are of great interest in the field of cosmetic ingredients because of their biocompatibility, non-toxicity, reproducibility and mild processing conditions. These polymers are preferably degradable in vivo by enzymatic or non-enzymatic means and preferably can be metabolized and excreted via normal physiological pathways.

Preferably, in the mixture according to the invention, one, several or all (natural) polymers are selected from the group consisting of natural gums, polysaccharides, proteins, starches, celluloses and derivatives thereof, hyaluronic acid, pectins, collagens, gelatins, chitosan, keratins, hectorites and mixtures thereof.

The polymers are particularly advantageous because they are of natural origin and/or are environmentally friendly.

According to a preferred embodiment of the mixture according to the invention, one, several or all of said (natural) polymers are natural gums, preferably selected from the group consisting of:

Natural gums obtained from seaweed, in particular agar, algin (alginic acid) or carrageenan;

-natural gums obtained from non-marine plant sources, in particular acacia gum, gum ghatti, tragacanth, karaya gum, guar gum, locust bean gum, β -glucan, dammar gum, galactomannan, glucomannan, psyllium husk, tara gum or tara gum (CAESALPINIA SPINOSA GUM);

Natural gums produced by bacterial fermentation, in particular gellan gum, xanthan gum or micronucleus gum;

And mixtures thereof.

According to another preferred embodiment of the mixture according to the invention, one, several or all of the (natural) polymers are starches selected from the group consisting of wheat starch, rice starch, maize (mail) starch, maize (zea mays/corn) starch, tapioca (tapioca) starch, potato starch, tapioca root (cassava) starch, acorn starch, arrowroot starch, peru carrot starch, banana starch, barley starch, bread fruit starch, buckwheat starch, canna starch, taro starch, guava (katakuri) starch, kudzu starch, sweet potato starch, oat starch, oca (oca) starch, bolinia sago (polynesian arrowroot) starch, sago starch, sorghum starch, sweet potato starch, rye starch, taro starch, potato starch, water chestnut starch, yam (yam) starch, legumes, peas, physically modified starch, chemically modified starch of chestnut, enzymatically modified starch, and mixtures thereof.

According to another preferred embodiment of the mixture according to the invention, one, several or all of the (natural) polymers are cellulose or derivatives thereof, preferably selected from the group consisting of microcrystalline cellulose, cellulose gum, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose and mixtures thereof.

According to a particularly preferred embodiment of the mixture according to the invention, one, several or all of the polymers are natural polymers selected from the group consisting of agar, algin (alginic acid), carrageenan, gum arabic (acacia gum), guar gum, xanthan gum, tara gum, small-core fungus gum, microcrystalline cellulose, cellulose gum, corn starch, tapioca starch, pectin, hectorite and mixtures thereof.

According to another preferred embodiment, the mixture according to the invention further comprises (iv) 1, 2-decanediol.

Another aspect of the invention relates to a semi-finished product comprising or consisting of the mixture according to the invention, wherein the semi-finished product is preferably a semi-finished product for preparing a surfactant-based rinse-off product, more preferably a semi-finished product for preparing a hair care product.

Another aspect of the invention relates to a cosmetic or pharmaceutical product comprising or consisting of the mixture according to the invention or the semi-finished product according to the invention, preferably comprising or consisting of:

(i) 0.01 to 2wt.%, preferably 0.05 to 1.5wt.%, more preferably 0.1 to 1wt.% of climbazole;

(ii) 0.01 to 2.0wt.%, preferably 0.05 to 1.5wt.%, more preferably 0.1 to 1wt.% of one or more (natural) polymers, preferably one or more polymers as defined herein, and

(Iii) 1 to 30wt.%, preferably 3 to 25wt.%, more preferably 4 to 20wt.% of one or more surfactants, preferably one or more sulfate-free surfactants, more preferably one or more (sulfate-free) surfactants as defined herein,

The above are based on the total weight of the product.

According to a preferred embodiment, the cosmetic or pharmaceutical product according to the invention is sulfate-free. Therefore, the cosmetic or pharmaceutical product according to the invention preferably does not comprise any sulphate-based surfactant.

According to a preferred embodiment of the cosmetic or pharmaceutical product according to the invention, the product is a surfactant-based rinse-off product, preferably a hair care product, more preferably a hair care product selected from the group consisting of shampoos, preferably anti-dandruff shampoos, hair conditioners, hair dyes, hair conditioners (HAIR RINSE), hair styling products, preferably gels, mousses, foams, waxes and sprays, hair oils, scalp creams, hair films, hair growth lotions, and hair care essences,

And/or preferably, the cosmetic or pharmaceutical product additionally comprises 1, 2-decanediol.

The presence of 1, 2-decanediol (decylene glycol)) in the product according to the invention is particularly advantageous, since it supports the anti-dandruff efficacy of said product. In addition, it is capable of balancing sebum content on/in the skin. Thus, it was found to be beneficial to combine 1, 2-decanediol with an anti-dandruff active. Furthermore, in the basic research of the present invention, when 1, 2-decanediol is included in the cosmetic or pharmaceutical product according to the present invention, a synergistic effect with respect to further increased foam volume and/or foam stability (compared to the cosmetic or pharmaceutical product according to the present invention which does not comprise any 1, 2-decanediol) was surprisingly observed.

Another aspect of the invention relates to the use of a climbazole and/or one or more (natural) polymers, preferably (natural) polymers as defined herein, for improving (increasing) the foam volume and/or foam stability of a mixture, semi-finished product or product as defined herein, preferably a surfactant-based rinse-off product.

According to a preferred embodiment of the use according to the invention the one or more polymers used are natural polymers selected from the group consisting of agar, algin (alginic acid), carrageenan, gum arabic (acacia gum), guar gum, xanthan gum, tara gum, micronucleus pulposus gum, microcrystalline cellulose, cellulose gum, corn starch, tapioca starch, pectin, hectorite and mixtures of two or more of the foregoing natural polymers.

Another aspect of the invention relates to a process for manufacturing a mixture according to the invention (as defined herein) comprising or consisting of the following steps:

(a) Providing

(I) Chlorimipram,

(Ii) One or more polymers, preferably a (natural) polymer as defined herein, and

(Iii) One or more surfactants, preferably one or more sulfate-free surfactants, more preferably one or more (sulfate-free) surfactants as defined herein;

(b) Mixing the components provided in step (a).

Another aspect of the invention relates to a method for manufacturing a semi-finished product according to the invention or for manufacturing a product according to the invention, comprising or consisting of the following steps:

(a) Providing

(I) Chlorimipram,

(Ii) One or more (natural) polymers, preferably (natural) polymers as defined herein, and

(Iii) One or more surfactants, preferably one or more sulphate-free surfactants, more preferably one or more (sulphate-free) surfactants as defined herein,

Or mixtures thereof;

(b) Providing the remaining components of the semifinished product according to the invention or of the product according to the invention;

(c) Mixing the components provided in step (a) and step (b).

Another aspect of the invention relates to a method for improving (increasing) the foam volume and/or foam stability of a semifinished product according to the invention or of a product according to the invention, comprising or consisting of the following steps:

(a) Providing

(I) Chlorimipram,

Or mixtures thereof;

(c) Mixing the components provided in step (a) and step (b).

Another aspect of the invention relates to a method for improving (increasing) the foam volume and/or foam stability of a mixture according to the invention, comprising or consisting of the steps of:

(a) Providing a solution of one or more surfactants, preferably one or more sulphate-free surfactants, more preferably a solution of one or more (sulphate-free) surfactants as defined herein, preferably an aqueous solution;

(b) Adding climbazole and one or more (natural) polymers, preferably (natural) polymers as defined herein, to the solution provided in step (a).

The (preferred) embodiments of the mixture according to the invention correspond to or can be derived from the (preferred) embodiments of the product according to the invention set forth above, or vice versa. The (preferred) embodiments of the mixture according to the invention correspond to or can be derived from the (preferred) embodiments of the use according to the invention set forth above or vice versa. The (preferred) embodiments of the mixture according to the invention correspond to or can be derived from the (preferred) embodiments of the method according to the invention set forth above or vice versa. Furthermore, the embodiments described herein may be arbitrarily combined with each other as long as it has technical meaning.

Drawings

FIG. 1 photograph of ERNST HAAGE foam testing apparatus used

FIG. 2 evaluation of foam volume after 5 minutes of surfactant mixture 1 (vertical bars: formulation B1; horizontal bars: formulation B2; square bars: formulation B3; black: formulation B6)

FIG. 3 evaluation of foam volume after 5 minutes of mixture containing disodium laureth sulfosuccinate (vertical bars: formulation C1; horizontal bars: formulation C2; square bars: formulation C3; black: formulation C6)

FIG. 4 results of foam volume evaluation after 5 minutes for mixtures containing cocoyl glucoside (vertical bars: formulation E1; horizontal bars: formulation E2; square bars: formulation E3; black: formulation E6)

FIG. 5 evaluation of foam volume after 5 minutes of mixture containing sodium cocoyl amphoacetate (vertical bars: preparation G1; horizontal bars: preparation G2; square bars: preparation G4; black: preparation G7)

FIG. 6 evaluation of foam volume after 5 minutes of mixture containing sodium C12-14 olefin sulfonate (vertical bars: preparation H1; horizontal bars: preparation H2; square bars: preparation H3; black: preparation H6)

FIG. 7 evaluation of foam volume after 5 minutes of mixture containing sodium C12-14 olefin sulfonate (vertical stripes: preparation H1; horizontal stripes: preparation H2; square stripes: preparation H4; black: preparation H7)

FIG. 8 evaluation of foam volume after 5 minutes of mixture containing sodium lauroyl sarcosinate (vertical bars: preparation K1; horizontal bars: preparation K2; square bars: preparation K4; black: preparation K7)

FIG. 9 evaluation of foam volume after 5 minutes of the mixture containing sodium lauroyl sarcosinate (vertical bars: preparation K1; horizontal bars: preparation K2; square bars: preparation K5; circular bars: preparation K9; black: preparation K8; diagonal bars: K12)

Detailed Description

The invention will now be described in more detail below with reference to selected embodiments.

Examples

Composition of the solution

The following mixture was prepared by stirring and heating to 70 ℃):

a) Mixture containing surfactant mixture 1

TABLE 1 composition of mixture containing surfactant mixture 1 b) mixture containing disodium laureth sulfosuccinate

TABLE 2 composition of mixture containing disodium laureth sulfosuccinate c) mixture containing coco glucoside

TABLE 3 composition of mixture containing cocoyl glucoside d) mixture containing sodium cocoyl amphoacetate

TABLE 4 composition of mixtures containing sodium cocoyl amphoacetate e) mixtures containing sodium C14-16 olefin sulfonates

TABLE 5 composition of mixture containing sodium C14-16 olefin sulfonate f) mixture containing sodium lauroyl sarcosinate

TABLE 6 composition of mixture containing sodium lauroyl sarcosinate

Determination of foam volume of surfactant solution

Evaluation of foam volume (w/w%)

For foam volume evaluation, each solution was diluted to 1% using demineralized water. 200ml of the diluted solution obtained was transferred to ERNST HAAGE foam testing apparatus (see figure 1). The hammer (stamp) was pulled up and down 80 times. After every 10 swings, the foam volume was recorded. Foam stability was recorded as foam volume [ ml ] at time points of 1 minute, 3 minutes and 5 minutes.

Results

Scale with a scale bar	Description of the invention
		0	No effect
+	Positive effect
		++	Strong positive effect
-	Slight negative effects

TABLE 7 a) mixture containing surfactant mixture 1

TABLE 8 results of testing mixtures containing surfactant mixture 1 (see FIG. 2) b) mixtures containing disodium laureth sulfosuccinate

TABLE 9 test results of mixtures containing disodium laureth sulfosuccinate (see FIG. 3) c) mixtures containing coco glucoside

TABLE 10 results of test of mixtures containing cocoyl glucoside (see FIG. 4) d) mixtures containing sodium cocoyl amphoacetate

TABLE 11 results of test of mixtures containing sodium cocoyl amphoacetate (see FIG. 5) e) mixtures containing sodium C12-14 olefin sulfonate

TABLE 12 test results for mixtures containing sodium C12-14 olefin sulfonate (see FIGS. 6 and 7) f) mixtures containing sodium lauroyl sarcosinate

TABLE 13 test results for mixtures containing sodium lauroyl sarcosinate (see FIG. 8)

TABLE 13 arithmetically averaged foam volume in ml (n=2) for the test results of the mixture containing sodium lauroyl sarcosinate (cf. FIG. 9)

TABLE 14 test results of foam volume measurement at specific time points (as indicated)

Claims

1. A mixture comprising or consisting of:

(i) Climbazole,

(ii) one or more polymers, and

(iii) one or more surfactants.

2. A mixture according to claim 1, wherein one, several or all of the surfactants are sulfate-free surfactants,

Preferred are sulfate-free surfactants selected from the group consisting of dimethyl lauramide/myristic amide, cetyl betaine, lauramidopropyl betaine, cocamidopropyl betaine, cocoyl betaine, almond oleamidopropyl betaine, apricot oleamidopropyl betaine, avocado oleamidopropyl betaine, babassu oleamidopropyl betaine, behenamidopropyl betaine, behenyl betaine, capric/lauric/myristic/oleic amidepropyl betaine, capryl/capric amidepropyl betaine, cocamidoethyl betaine, coconut/sunflower seed amidepropyl betaine, theobroma cacao amidepropyl betaine, sea buckthorn amidepropyl betaine, isostearamidopropyl betaine, lauryl betaine, macadamia nut amidepropyl betaine, white meadowfoam seed amidepropyl betaine Aminopropyl Betaine, Myristyl Betaine, Oleamidopropyl Betaine, Oleyl Betaine, Palm Amidopropyl Betaine, Palm Kernel Amidopropyl Betaine, Pinoleamidopropyl Betaine, Ricinole Amidopropyl Betaine, Shea Butter Amidopropyl Betaine, Soybean Amidopropyl Betaine, Undecylenamidopropyl Betaine, Wheat Germ Amidopropyl Betaine, Rhamnolipids, Sophorolipids, Glycolipids, Sodium Lauryl Glucose Carboxylate, Sodium Cocoamphoacetate, PEG-7 Cocoyl Glyceryl Cocoate, Cocamide DEA, Cocamide MEA, Lauramide DEA, Glycol Distearate, Lauryl Glucoside, Caprylyl/Capryl Glucoside, Decyl Glucoside, Cocoyl Glucoside, Glycereth-26 Arachidyl Glucoside, Butyl Glucoside , C9-11 Alkyl Glucoside, C20-22 Alkyl Glucoside, Cetearyl Glucoside, Heptyl Glucoside, Hydroxystearyl Glucoside, Isostearyl Glucoside, Myristyl Glucoside, Sodium Cocoyl Glutamate, Alkyl Glutamate, Disodium Cocoyl Glutamate, Sodium Lauroyl Glutamate, Cocoyl Isethionate Ammonium, Sodium Cocoyl Isethionate, Sodium Lauroyl Hydroxymethyl Ethyl Sulfonate, Sodium Lauroyl Lactylate, Cocamide MEA, PEG-55 Propylene Glycol Oleate, PPG-5-Ceteth-20, Disodium Cocoamphodipropionate, Sodium Lauroyl Sarcosinate, Ammonium Cocoyl Sarcosinate, Sodium Oleoyl Sarcosinate, Sodium Cocoyl Sarcosinate, Sodium Myristoyl Sarcosinate, Isopropyl Lauroyl Sarcosinate, MIPA-Cocoyl Sarcosinate, Lauroyl Potassium acyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TIPA-lauroyl sarcosinate, sodium lauryl sulfoacetate, sodium caprylyl sulfonate, sodium dodecylbenzene sulfonate, sodium xylene sulfonate, sodium C12-C14 olefin sulfonate, dioctyl sodium sulfosuccinate, diethylhexyl sodium sulfosuccinate, disodium lauryl polyoxyethylene ether sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, sodium isopalmitoyl methyl taurate, sodium methyl stearoyl taurate, sodium methyl palmitoyl taurate, sodium methyl oleoyl taurate, sodium methyl myristoyl taurate, sodium methyl lauroyl taurate, sodium N-isostearoyl methyl taurate, sodium cocoyl taurate and sodium caproyl methyl taurate.

3. A mixture according to claim 1 or 2, wherein one, several or all of the surfactants are sulfate-free surfactants selected from the group consisting of: cocamidopropyl betaine, lauryl glucoside, capryl/capryl glucoside, decyl glucoside, sodium lauroyl sarcosinate, coco betaine, PPG-5-ceteth-20, coco glucoside, sodium diethylhexyl sulfosuccinate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, cocamide MEA, PEG-7 glyceryl cocoate, glycol distearate, sodium oleoyl sarcosinate, sodium cocoyl isethionate, sodium cocoamphoacetate, sodium cocoyl glutamate, sodium methyl cocoyl taurate, sodium C12-C14 olefin sulfonate, disodium laureth sulfosuccinate and sodium lauryl glucose carboxylate.

4. A mixture according to any one of the preceding claims, wherein one, several or all of the polymers are natural polymers.

5. A mixture according to any one of the preceding claims, wherein one, several or all of the polymers are selected from the group consisting of natural gums, polysaccharides, proteins, starches, cellulose and its derivatives, hyaluronic acid, pectin, collagen, gelatin, chitosan, keratin, hectorite and mixtures thereof.

6. A mixture according to any one of the preceding claims, wherein one, several or all of the polymers are natural gums, preferably selected from the group consisting of:

- natural gums obtained from seaweed, in particular agar, algin (alginic acid) or carrageenan;

- natural gums obtained from non-marine plant sources, in particular gum arabic (gum arabic), gum ghatti, gum tragacanth, gum karaya, guar gum, locust bean gum, beta-glucan, gum dammar, galactomannans, glucomannan, psyllium husk, tara gum or tara gum;

- natural gums produced by bacterial fermentation, in particular gellan gum, xanthan gum or sclerotium gum;

and mixtures thereof.

7. A mixture according to any of the preceding claims, wherein one, several or all of the polymers are starches, preferably selected from the group consisting of wheat starch, rice starch, maize starch, corn starch, tapioca starch, potato starch, cassava root starch, acorn starch, arrowroot starch, Peruvian carrot starch, banana starch, barley starch, breadfruit starch, buckwheat starch, canna starch, taro starch, yam starch, chufa starch, kudzu starch, dark green yam starch, millet starch, oat starch, oxalis starch, Polynesian arrowroot starch, sago starch, sorghum starch, sweet potato starch, rye starch, taro starch, chestnut starch, water chestnut starch, yam starch, bean starch, pea starch, physically modified starch, chemically modified starch or enzymatically modified starch and mixtures thereof.

8. A mixture according to any of the preceding claims, wherein one, several or all of the polymers are cellulose or a derivative thereof, preferably selected from the group consisting of microcrystalline cellulose, cellulose gum, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose and mixtures thereof.

9. A semi-finished product comprising or consisting of a mixture according to any of the preceding claims, wherein the semi-finished product is preferably a semi-finished product for the preparation of a rinse-off product based on surfactants, more preferably a semi-finished product for the preparation of a hair care product.

10. A cosmetic or pharmaceutical product comprising or consisting of a mixture according to any one of claims 1 to 8 or a semi-finished product according to claim 9, preferably comprising or consisting of:

(i) 0.01 wt.% to 2 wt.%, preferably 0.05 wt.% to 1.5 wt.%, more preferably 0.1 wt.% to 1 wt.% of climbazole;

(ii) 0.01 wt.% to 2.0 wt.%, preferably 0.05 wt.% to 1.5 wt.%, more preferably 0.1 wt.% to 1 wt.% of one or more polymers, preferably a polymer according to any one of claims 4 to 8; and

(iii) 1 wt.% to 30 wt.%, preferably 3 wt.% to 25 wt.%, more preferably 4 wt.% to 20 wt.% of one or more surfactants, preferably a surfactant according to claim 2 or 3,

The above is based on the total weight of the product.

11. The cosmetic or pharmaceutical product according to claim 10, wherein the product is a rinse-off product based on a surfactant, preferably a hair care product, more preferably a hair care product selected from the group consisting of: shampoo, preferably an anti-dandruff shampoo; hair conditioner; hair conditioning agent; hair dye; hair conditioner; hair styling products, preferably gels, mousses, foams, waxes and sprays; hair oils; scalp creams; hair masks; hair tonics; and hair essences,

And/or wherein the cosmetic or pharmaceutical product additionally comprises 1,2-decanediol.

12. Use of climbazole and/or one or more polymers, preferably a polymer according to any one of claims 4 to 8, for improving the foam volume and/or foam stability of a mixture, semi-finished product or product according to any one of claims 1 to 11, the product preferably being a rinse-off product based on a surfactant.

13. A method for producing a mixture according to any one of claims 1 to 8, comprising or consisting of the following steps:

(a) Provide

(i) Climbazole,

(ii) one or more polymers, preferably a polymer according to any one of claims 4 to 8, and

(iii) one or more surfactants, preferably a surfactant according to claim 2 or 3;

(b) mixing the components provided in step (a).

14. A method for producing a semi-finished product according to claim 9 or a product according to claim 10 or 11, comprising or consisting of the following steps:

(a) Provide

(i) Climbazole,

(iii) one or more surfactants, preferably a surfactant according to claim 2 or 3, or a mixture thereof;

(b) providing the remaining ingredients of a semi-finished product according to claim 9 or a product according to claim 10 or 11;

(c) mixing the components provided in step (a) and step (b).

15. A method for improving the foam volume and/or foam stability of a semi-finished product according to claim 9 or a product according to claim 10 or 11, comprising or consisting of the following steps:

(a) Provide

(i) Climbazole,

(c) mixing the components provided in step (a) and step (b).