EP4547209A1 - Mixtures comprising climbazole with improved foam volume and stability - Google Patents

Abstract

The present invention primarily relates to a mixture comprising or consisting of climbazole, one or more polymer(s), and one or more surfactant(s). The present invention further relates to semi-finished, cosmetic, and pharmaceutical products comprising or consisting of a mixture as described herein. Moreover, the invention relates to the use of climbazole and/or of one or more polymer(s) for improving the foam volume and/or foam stability of a mixture, semi-finished product or product as described herein, to methods for the manufacture of mixtures, semi-finished products, and products as described herein, and to a method for improving the foam volume and/or foam stability of a semi-finished product or product as described herein.

Description

Munich, 20 September 2023 Our Ref.: SM 6720-01WO SOE/PAP Applicant: Symrise AG Serial Number: New Application Symrise AG Mühlenfeldstraße 1, 37603 Holzminden, Germany Mixtures comprising climbazole with improved foam volume and stability The present invention primarily relates to a mixture comprising or consisting of climbazole, one or more polymer(s), and one or more surfactant(s). The present invention further relates to semi-finished, cosmetic, and pharmaceutical products comprising or consisting of a mixture as described herein. Moreover, the invention relates to the use of climbazole and/or of one or more polymer(s) for improving the foam volume and/or foam stability of a mixture, semi-finished product or product as described herein, to methods for the manufacture of mixtures, semi-finished products, and products as described herein, and to a method for improving the foam volume and/or foam stability of a semi-finished product or product as described herein. Further aspects of the present invention will arise from the description below, in particular from the examples, as well as from the attached patent claims. Sulfates are surfactants with a cleansing effect that are responsible for the formation of foam in many cosmetic products. The most commonly used sulfate compounds within the cosmetic industry are, for instance, sodium laureth sulfate, sodium lauryl sulfate, and ammonium laureth sulfate. These cleansing substances are e.g. added to shampoos to dissolve fat and dirt and to clean the hair particularly thoroughly. After washing, the hair is supposed to feel fresh and clean. One disadvantage is that sulfates are considered to be possible irritants that can damage the protective lipid layer of the scalp. They can make the scalp more permeable to pollutants and dry out the hair. Therefore, especially for color- treated, dry hair and dry scalp there is a preference for using mild, sulfate free formulations and globally more and more sulfate free cosmetic formulations are being brought onto the market. However, very often sulfate free formulations tend to have poor foaming properties compared to sulfate based formulations. Moreover, it is more difficult to adjust the viscosity of sulfate free formulations to the desired level, because they cannot be thickened with sodium chloride. Therefore, a larger amount of polymers is used in sulfate free formulations, especially biologically produced and degradable ones. Said polymers tend to have an additional detrimental effect on the foaming properties of cosmetic formulations, such as e.g. shampoos. Consumers, however, usually strongly prefer cosmetic formulations which easily deliver a large volume of foam and high foam stability during application. It was thus an object of the present invention to provide cosmetic formulations that solve the above mentioned problems. Sulfate free cosmetic formulations, which are able to provide a high foam volume and/or high foam stability, are particularly sought after. According to a first aspect of the present invention, the stated object is surprisingly achieved by a mixture comprising or consisting of (i) climbazole (also known as (RS)-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3- dimethylbutan-2-one with the CAS number 38083-17-9) (ii) one or more polymer(s), and (iii) one or more, preferably sulfate free, surfactant(s). In the studies underlying the present invention, it was surprisingly found that a higher foam volume and/or foam stability, which are of great importance to consumers of cosmetic formulations, can be achieved through a combination of climbazole, one or more polymer(s), and one or more surfactant(s) (cf. also the examples shown further below). This was particularly surprising, because to date both climbazole and polymers are not known to be foam boosters. Climbazole is known as an effective topical antifungal agent and is commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema. It displays a high in vitro and in vivo efficacy against Malassezia spp., which plays an important role in the pathogenesis of dandruff. According to a preferred embodiment, the, one, several, or all, preferably all, of the surfactant(s) in the mixture according to the invention (cf. component (iii)) is/are sulfate free surfactants, preferably is/are sulfate free surfactants selected from the group consisting of dimethyl lauramide/myristamide, cetyl betaine, lauramidopropyl betaine, cocamidopropyl betaine, coco-betaine, almondamidopropyl betaine, apricotamidopropyl betaine, avocadamidopropyl betaine, babassuamidopropyl betaine, behenamidopropyl betaine, behenyl betaine, capric/lauric/myristic/oleic amidopropyl betaine, capryl/capramidopropyl betaine, cocamidoethyl betaine, coco/sunfloweramidopropyl betaine, cupuassuamidopropyl betaine, hippophae rhamnoidesamidopropyl betaine, isostearamidopropyl betaine, lauryl betaine, macadamiamidopropyl betaine, meadowfoamamidopropyl betaine, myristyl betaine, oleamidopropyl betaine, oleyl betaine, palmamidopropyl betaine, palm kernelamidopropyl betaine, pineamidopropyl betaine, ricinoleamidopropyl betaine, shea butteramidopropyl betaine, soyamidopropyl betaine, undecyleneamidopropyl betaine, wheat germamidopropyl betaine, rhamnolipids, sophorolipids, glycolipids, sodium lauryl glucose carboxylate, sodium cocoamphoacetate, PEG-7 glyceryl cocoate, cocamide DEA, cocamide MEA, lauramide DEA, glycol distearate, lauryl glucoside, caprylyl/capryl glucoside, decyl glucoside, coco glucoside, glycereth-26 arachidyl glucoside, butyl glucoside, C9-11 alkyl glucoside, C20-22 alkyl glucoside, cetearyl glucoside, heptyl glucoside, hydroxystearyl glucoside, isostearyl glucoside, myristyl glucoside, sodium cocoyl glutamate, alkyl glutamates, disodium cocoyl glutamate, sodium lauroyl glutamate, ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl methyl isethionate, sodium lauroyl lactylate, cocamido MEA, PEG-55 propylene glycol oleate, PPG-5-ceteth-20, disodium cocoamphodipropionate, sodium lauroyl sarcosinate, ammonium cocoyl sarcosinate, sodium oleoyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, isopropyl lauroyl sarcosinate, MIPA- cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium palmitoyl sarcosinate, TEA- cocoyl sarcosinate, TEA-lauroyl sarcosinate, TIPA-lauroyl sarcosinate, sodium lauryl sulfoacetate, sodium caprylyl sulfonate, sodium dodecylbenzene sulfonate, sodium xylene sulfonate, sodium C12-C14 olefin sulfonate, sodium dioctyl sulfosuccinate, diethylhexyl sodium sulfosuccinate, disodium laureth sulfosuccinate, sodium methyl cocoyl taurate, sodium taurine cocoyl methyltaurate, sodium methyltaurate isopalmitamide, sodium methyl stearoyl taurate, sodium methyl palmitoyl taurate, sodium methyl oleoyl taurate, sodium methyl myristoyl taurate, sodium methyl lauroyl taurate, sodium N-isostearoyl methyltaurate, sodium cocoyl taurate, and sodium caproyl methyltaurate. As discussed above, sulfate free surfactants are particularly advantageous as they avoid irritation of the skin. Particularly preferably, the, one, several, or all, preferably all, of the surfactant(s) is/are sulfate free surfactants selected from the group consisting of cocamidopropyl betaine, lauryl glucoside, caprylyl/capryl glucoside, decyl glucoside, sodium lauroyl sarcosinate, coco-betaine, PPG-5-ceteth-20, coco glucoside, diethylhexyl sodium sulfosuccinate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, cocamide MEA, PEG-7 glyceryl cocoate, glycol distearate, sodium oleoyl sarcosinate, sodium cocoyl isethionate, sodium cocoamphoacetate, sodium cocoyl glutamate, sodium methyl cocoyl taurate, sodium C12-C14 olefin sulfonate, disodium laureth sulfosuccinate, and sodium lauryl glucose carboxylate. According to a preferred embodiment, the mixture according to the invention is (completely) sulfate free. Hence, the mixture according to the invention preferably does not comprise any sulfate based surfactants. According to another preferred embodiment, the, one, several, or all of the polymer(s) in the mixture according to invention (cf. component (ii)) is/are natural polymers. Within the context of the present text, natural polymers (also often referred to as biopolymers) are defined as a diverse group of non-petrochemically derived polymers, i.e. polymers from natural origin or natural feedstock or produced by fermentation, whereas synthetic polymers are derived from petroleum oil. Proteins, starches, gums, and polysaccharides are some examples of natural polymers (further examples will be given below). Natural polymers have attracted considerable interest in the field of cosmetic ingredients owing to their biocompatibility, nontoxicity, renewability, and mild processing conditions. These polymers are preferably degradable in vivo, either enzymatically or non- enzymatically, and preferably can be metabolised and excreted via normal physiological pathways. Preferably, in the mixture according to the invention, the, one, several, or all of the (natural) polymer(s) is/are selected from the group consisting of natural gums, polysaccharides, proteins, starches, cellulose and derivatives thereof, hyaluronic acid, pectin, collagen, gelatine, chitosan, keratin, hectorite, and mixtures thereof. Said polymers are particularly advantageous due to their natural origin and/or environmental friendliness. According to a preferred embodiment of the mixture according to the invention, the, one, several, or all of the (natural) polymer(s) is/are natural gum(s), preferably selected from the group consisting of - natural gum obtained from seaweeds, in particular agar, algin (alginic acid) or carrageenan, - natural gum obtained from non-marine botanical resources, in particular gum arabic (acacia senegal gum), gum ghatti, gum tragacanth, karaya gum, guar gum, locust bean gum, beta-glucan, dammer gum, galactomannan, glucomannan, psyllium seed husks, tara gum, or caesalpinia spinosa gum, - natural gum produced by bacterial fermentation, in particular gellan gum, xanthan gum, or sclerotium gum, and mixtures thereof. According to another preferred embodiment of the mixture according to the invention, the, one, several, or all of the (natural) polymer(s) is/are starch(es), preferably selected from the group consisting of wheat starch, rice starch, maize starch, zea mays (corn) starch, tapioca starch, potatoes starch, cassava starch, acorns starch, arrowroot starch, arracacha starch, bananas starch, barley starch, breadfruit starch, buckwheat starch, canna starch, colocasia starch, katakuri starch, kudzu starch, malanga starch, millet starch, oats starch, oca starch, polynesian arrowroot starch, sago starch, sorghum starch, sweet potatoes starch, rye starch, taro starch, chestnuts starch, water chestnuts starch, yams starch, beans starch, peas starch, physically, chemically or enzymatically modified starches, and mixtures thereof. According to another preferred embodiment of the mixture according to the invention, the, one, several, or all of the (natural) polymer(s) is/are cellulose(s) or derivatives thereof, preferably selected from the group consisting of microcrystalline cellulose, cellulose gum, hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, and mixtures thereof. According to a particularly preferred embodiment of the mixture according to the invention, the, one, several, or all of the polymer(s) is/are natural polymer(s) selected from the group consisting of agar, algin (alginic acid), carrageenan, gum arabic (acacia senegal gum), guar gum, xanthan gum, caesalpinia spinosa gum, sclerotium gum, microcrystalline cellulose, cellulose gum, zea mays (corn) starch, tapioca starch, pectin, hectorite, and mixtures thereof. According to another preferred embodiment, the mixture according to the invention further comprises (iv) 1,2-decanediol. Another aspect of the present invention relates to a semi-finished product comprising or consisting of a mixture according to the invention, wherein the semi-finished product preferably is a semi-finished product for the preparation of a surfactant-based rinse-off product, more preferably of a hair care product. Another aspect of the present invention relates to a cosmetic or pharmaceutical product comprising or consisting of a mixture according to the invention or a semi-finished product according to the invention, preferably comprising or consisting of (i) 0.01 to 2 wt.%, preferably 0.05 to 1.5 wt.%, more preferably 0.1 to 1 wt.%, of climbazole, (ii) 0.01 to 2.0 wt.%, preferably 0.05 to 1.5 wt.%, more preferably 0.1 to 1 wt.%, of one or more (natural) polymer(s), preferably of one or more polymer(s) as defined herein, and (iii) 1 to 30 wt.%, preferably 3 to 25 wt.%, more preferably 4 to 20 wt.%, of one or more surfactant(s), preferably of one or more sulfate free surfactant(s), more preferably of one or more (sulfate free) surfactant(s) as defined herein, based on the total weight of the product. According to a preferred embodiment, the cosmetic or pharmaceutical product according to the invention is sulfate free. Hence, the cosmetic or pharmaceutical product according to the invention preferably does not comprise any sulfate based surfactants. According to a preferred embodiment of the cosmetic or pharmaceutical product according to the invention, the product is a surfactant-based rinse-off product, preferably a hair care product, more preferably is a hair care product selected from the group consisting of shampoos, preferably anti-dandruff shampoos, hair conditioners, hair cures, hair colourings, hair rinses, hair styling products, preferably gels, mousses, foams, waxes, and sprays, hair oils, scalp creams, hair masks, hair tonics, and hair serums, and/or preferably the cosmetic or pharmaceutical product additionally comprises 1,2- decanediol. The presence of 1,2-decanediol (decylene glycol) in the products according to the invention is particularly advantageous as it supports the anti-dandruff efficacy of said products. Furthermore, it can balance the sebum content on/in skin. Therefore, it was found to be beneficial to combine 1,2-decanediol with anti-dandruff actives. Moreover, within the studies underlying the present invention, a synergistic effect with regard to a further increased foam volume and/or foam stability was surprisingly observed when 1,2- decanediol was included into the cosmetic or pharmaceutical products according to the invention (compared to cosmetic or pharmaceutical products according to the invention, which do not comprise any 1,2-decanediol). A further aspect of the present invention relates to the use of climbazole and/or of one or more (natural) polymer(s), preferably as defined herein, for improving (increasing) the foam volume and/or foam stability of a mixture, semi-finished product, or product as defined herein, preferably of a surfactant-based rinse-off product. According to a preferred embodiment of the use according to the invention, the one or more polymer(s) used is/are natural polymers selected from the group consisting of agar, algin (alginic acid), carrageenan, gum arabic (acacia senegal gum), guar gum, xanthan gum, caesalpinia spinosa gum, sclerotium gum, microcrystalline cellulose, cellulose gum, zea mays (corn) starch, tapioca starch, pectin, hectorite, and mixtures of two or more of the aforesaid natural polymers. Another aspect of the present invention relates to a method for the manufacture of a mixture according to the invention (as defined herein) comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more (natural) polymer(s), preferably as defined herein, and (iii) one or more surfactant(s), preferably one or more sulfate free surfactant(s), more preferably one or more (sulfate free) surfactant(s) as defined herein, (b) mixing the components provided in step (a). Another aspect of the present invention relates to a method for the manufacture of a semi- finished product according to the invention, or for the manufacture of a product according to the invention, comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more (natural) polymer(s), preferably as defined herein, and (iii) one or more surfactant(s), preferably one or more sulfate free surfactant(s), more preferably one or more (sulfate free) surfactant(s) as defined herein, or a mixture thereof, (b) providing the remaining ingredients of the semi-finished product according to the invention or of the product according to the invention, (c) mixing the components provided in steps (a) and (b). Another aspect of the present invention relates to a method for improving (increasing) the foam volume and/or foam stability of a semi-finished product according to the invention, or of a product according to the invention, comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more (natural) polymer(s), preferably as defined herein, and (iii) one or more surfactant(s), preferably one or more sulfate free surfactant(s), more preferably one or more (sulfate free) surfactant(s) as defined herein, or a mixture thereof, (b) providing the remaining ingredients of the semi-finished product according to the invention or of the product according to the invention, (c) mixing the components provided in steps (a) and (b). Another aspect of the present invention relates to a method for improving (increasing) the foam volume and/or foam stability of a mixture according to the invention, comprising or consisting of the following steps: (a) Providing a solution, preferably an aqueous solution, of one or more surfactant(s), preferably of one or more sulfate free surfactant(s), more preferably of one or more (sulfate free) surfactant(s) as defined herein, (b) adding climbazole and one or more (natural) polymer(s), preferably as defined herein, to the solution provided in step (a). (Preferred) embodiments of the mixtures according to the invention correspond to or can be derived from the (preferred) embodiments of the products according to the invention, which are explained above, or vice versa. (Preferred) embodiments of the mixtures according to the invention correspond to or can be derived from the (preferred) embodiments of the use according to the invention, which are explained above, or vice versa. (Preferred) embodiments of the mixtures according to the invention correspond to or can be derived from the (preferred) embodiments of the methods according to the invention, which are explained above, or vice versa. Moreover, the embodiments described herein can be arbitrarily combined with each other as long as it makes technical sense. FIGURES Figure 1: Photograph of the used Ernst Haage foam testing device Figure 2: Evaluation of foam volume after 5 minutes for surfactant mixture 1 (vertical lines: formulation B1; horizontal lines: formulation B2; checkered: formulation B3; black: formulation B6) Figure 3: Evaluation of foam volume after 5 minutes for mixtures with disodium laureth sulfosuccinate (vertical lines: formulation C1; horizontal lines: formulation C2; checkered: formulation C3; black: formulation C6) Figure 4: Evaluation of foam volume after 5 minutes for mixtures with coco glucoside (vertical lines: formulation E1; horizontal lines: formulation E2; checkered: formulation E3; black: formulation E6) Figure 5: Evaluation of foam volume after 5 minutes for mixtures with sodium cocoamphoacetate (vertical lines: formulation G1; horizontal lines: formulation G2; checkered: formulation G4; black: formulation G7) Figure 6: Evaluation of foam volume after 5 minutes for mixtures with sodium C12-14 olefin sulfonate (vertical lines: formulation H1; horizontal lines: formulation H2; checkered: formulation H3; black: formulation H6) Figure 7: Evaluation of foam volume after 5 minutes for mixtures with sodium C12-14 olefin sulfonate (vertical lines: formulation H1; horizontal lines: formulation H2; checkered: formulation H4; black: formulation H7) Figure 8: Evaluation of foam volume after 5 minutes for mixtures with sodium lauroyl sarcosinate (vertical lines: formulation K1; horizontal lines: formulation K2; checkered: formulation K4; black: formulation K7) Figure 9: Evaluation of foam volume after 5 minutes for mixtures with sodium lauroyl sarcosinate (vertical lines: formulation K1; horizontal lines: formulation K2; checkered: formulation K5; dotted: formulation K9; black: formulation K8; diagonal stripes: K12) The invention will now be described in more detail hereinafter with references to selected examples. EXAMPLES 1. Composition of solutions The following mixtures were prepared by stirring and heating up to 70°C: a) Mixtures with surfactant mixture 1 w/w% INCI B1 B2 B3 B6 Sodium cocoamphoacetate, glycerin, lauryl glucoside, sodium cocoyl glutamate, sodium lauryl glucose 33.3 33.3 33.3 33.3 carboxylate (30% active matter) = surfactant mixture 1 Water Ad 100 Climbazole - 0.3 - 0.3 Carrageenan - - 0.5 0.5 Table 1: Composition of mixtures with surfactant mixture 1 b) Mixtures with disodium laureth sulfosuccinate w/w% INCI C1 C2 C3 C6 Disodium laureth sulfosuccinate (30% active matter) 33.3 33.3 33.3 33.3 Water Ad 100 Climbazole - 0.3 - 0.3 Carrageenan - - 0.5 0.5 Table 2: Composition of mixtures with disodium laureth sulfosuccinate c) Mixtures with coco glucoside w/w% INCI E1 E2 E3 E6 Coco glucoside (52% Active matter) 19.2 19.2 19.2 19.2 Water Ad 100 Climbazole - 0.3 - 0.3 Carrageenan - - 0.5 0.5 Table 3: Composition of mixtures with coco glucoside d) Mixtures with sodium cocoamphoacetate w/w% INCI G1 G2 G4 G7 Sodium cocoamphoacetate (50% active matter) 20.0 20.0 20.0 20.0 Water Ad 100 Climbazole - 0.3 - 0.3 Caesalpinia spinosa gum - - 0.5 0.5 Table 4: Composition of mixtures with sodium cocoamphoacetate e) Mixtures with sodium C14-16 olefin sulfonate w/w% INCI H1 H2 H3 H6 H4 H7 Sodium C14-16 olefin sulfonate (40% active 25.0 25.0 25.0 25.0 25.0 25.0 matter) Water Ad 100 Climbazole - 0.3 - 0.3 - 0.3 Carrageenan - - 0.5 0.5 - - Caesalpinia spinosa gum - - - - 0.5 0.5 Table 5: Composition of mixtures with sodium C14-16 olefin sulfonate f) Mixtures with sodium lauroyl sarcosinate w/w% INCI K1 K2 K4 K7 Sodium lauroyl sarcosinate (30% active matter) 33.3 33.3 33.3 33.3 Water Ad 100 Climbazole - 0.3 - 0.3 Caesalpinia spinosa gum - - 0.5 0.5 Table 6: Composition of mixtures with sodium lauroyl sarcosinate w/w% INCI K1 K2 K5 K9 K8 K12 Sodium lauroyl sarcosinate (30% active 33.3 33.3 33.3 33.3 33.3 33.3 matter) Water Ad 100 Climbazole - 0.3 - 0.3 0.3 0.3 Xanthan gum - - 0.5 - 0.5 0.5 Decylene glycol - - - 0.1 - 0.1 Table 6’: Composition of mixtures with sodium lauroyl sarcosinate 2. Determination of foam volume of surfactant solution Evaluation of foam volume (w/w%) For foam volume evaluation, each solution is diluted to 1% by using demineralized water. 200 ml of the obtained diluted solution are transferred into an Ernst Haage foam testing device (cf. Figure 1). The stamp is pulled up and down 80 times. After each 10 swings, the foam volume is recorded. The foam stability is recorded 1, 3, and 5 minutes by foam volume [ml]. Results Scale Description 0 No effect + Positive effect ++ Strongly positive effect - Slightly negative effect Table 7 a) Mixtures with surfactant mixture 1 Mixture B1 B2 B3 B6 Description Surfactant + 0.3% + 0.5% + 0.3% Climbazole mixture 1 Climbazole Carrageenan + 0.5% Carrageenan Foam volume 0 ++ - ++ Foam stability 0 0 0 ++ Foam volume 925 1000 825 1025 after 80 swings Foam volume 725 800 650 900 after 5 minutes Table 8: Test results for mixtures with surfactant mixture 1 (cf. Figure 2) b) Mixtures with disodium laureth sulfosuccinate Mixture C1 C2 C3 C6 Description Disodium + 0.3% + 0.5% + 0.3% Climbazole laureth Climbazole Carrageenan + 0.5% sulfosuccinate Carrageenan Foam volume 0 + + ++ Foam stability 0 - + ++ Foam volume after 80 325 475 425 625 swings Foam volume after 5 225 325 325 525 minutes Table 9: Test results for mixtures with disodium laureth sulfosuccinate (cf. Figure 3) c) Mixtures with coco glucoside Mixture E1 E2 E3 E6 Description Coco + 0.3% + 0.5% + 0.3% Climbazole glucoside Climbazole Carrageenan + 0.5% Carrageenan Foam volume 0 + + ++ Foam volume 1300 1450 1625 1725 after 80 swings Foam volume 1250 1375 1500 1550 after 5 minutes Table 10: Test results for mixtures with coco glucoside (cf. Figure 4) d) Mixtures with sodium cocoamphoacetate Mixture G1 G2 G4 G7 Description Sodium + 0.3% + 0.5% + 0.3% cocoamphoacetate Climbazole Caesalpinia Climbazole spinosa gum + 0.5% Caesalpinia spinosa gum Foam volume 0 + + ++ Foam 0 - + + stability Foam volume after 80 1200 1325 1275 1450 swings Foam volume after 5 1125 1225 1225 1375 minutes Table 11: Test results for mixtures with sodium cocoamphoacetate (cf. Figure 5) e) Mixtures with sodium C12-14 olefin sulfonate Mixture H1 H2 H3 H6 H4 H7 Description Sodium + 0.3% +0.5% + 0.3% +0.5% +0.3% C12-14 Climbazole Carrageenan Climbazole Caesalpinia Climbazole olefin + 0.5% spinosa + 0.5% sulfonate Carrageenan gum Caesalpinia spinosa gum Foam volume 0 + + ++ 0 ++ Foam stability 0 + 0 ++ + + Foam volume 1775 1850 1950 1975 1650 1975 after 80 swings Foam volume 1525 1700 1775 1975 1525 1825 after 5 minutes Table 12: Test results for mixtures with sodium C12-14 olefin sulfonate (cf. Figure 6 and Figure 7) f) Mixtures with sodium lauroyl sarcosinate Mixture K1 K2 K4 K7 Description Sodium + 0.3% + 0.5% + 0.3% Climbazole lauroyl Climbazole Caesalpinia + 0.5% Caesalpinia sarcosinate spinosa gum spinosa gum Foam volume 0 + + ++ Foam stability 0 + + ++ Foam volume 1200 1300 1275 1350 after 80 swings Foam volume 1100 1200 1225 1325 after 5 minutes Table 13: Test results for mixtures with sodium lauroyl sarcosinate (cf. Figure 8) Mixture K1 K2 K5 K9 K8 K12 Description Sodium + 0.3% +0.5% + 0.3% + 0.3% +0.3% lauroyl Climbazole Xanthan Climbazole Climbazole Climbazole sarcosinate gum + 0.1% + 0.5% + 0.5% Decylene Xanthan Xanthan glycol gum gum + 0.1% Decylene glycol Foam 0 + + + + ++ volume Foam 0 + + + + + stability Foam 1200 1300 1225 1300 1325 1400 volume after 80 swings Foam 1100 1200 1175 1250 1275 1350 volume after 5 minutes Table 13’: Test results for mixtures with sodium lauroyl sarcosinate (cf. Figure 9) Arithmetic mean foam volume in ml (n=2) Time (min) 0 1 3 5 B1 900 850 775 725 B2 1000 950 850 800 B3 825 750 675 650 B6 1000 950 900 900 C1 325 275 225 225 C2 475 400 325 325 C3 425 350 325 325 C6 625 575 525 525 E1 1300 1275 1275 1250 E2 1450 1425 1375 1375 E3 1625 1550 1400 1500 E6 1725 1650 1575 1550 G1 1200 1150 1125 1125 Volume (ml) G2 1325 1300 1225 1225 G4 1275 1250 1250 1225 G7 1450 1450 1375 1375 H1 1675 1650 1550 1525 H2 1850 1800 1725 1700 H3 1950 1875 1825 1775 H6 1975 1975 1975 1975 H4 1600 1575 1525 1525 H7 1975 1900 1825 1825 K1 1200 1175 1150 1100 K2 1300 1225 1225 1200 K4 1275 1250 1225 1225 K7 1350 1325 1325 1325 K5 1225 1175 1175 1175 K9 1300 1275 1250 1250 K8 1325 1275 1275 1275 K12 1400 1350 1350 1350 Table 14: Test results for foam volume measurements at specific time points (as indicated)

Claims

Claims 1. Mixture comprising or consisting of (i) climbazole (ii) one or more polymer(s), and (iii) one or more surfactant(s). 2. Mixture according to claim 1, wherein the, one, several, or all of the surfactant(s) is/are sulfate free surfactants, preferably is/are sulfate free surfactants selected from the group consisting of dimethyl lauramide/myristamide, cetyl betaine, lauramidopropyl betaine, cocamidopropyl betaine, coco-betaine, almondamidopropyl betaine, apricotamidopropyl betaine, avocadamidopropyl betaine, babassuamidopropyl betaine, behenamidopropyl betaine, behenyl betaine, capric/lauric/myristic/oleic amidopropyl betaine, capryl/capramidopropyl betaine, cocamidoethyl betaine, coco/sunfloweramidopropyl betaine, cupuassuamidopropyl betaine, hippophae rhamnoidesamidopropyl betaine, isostearamidopropyl betaine, lauryl betaine, macadamiamidopropyl betaine, meadowfoamamidopropyl betaine, myristyl betaine, oleamidopropyl betaine, oleyl betaine, palmamidopropyl betaine, palm kernelamidopropyl betaine, pineamidopropyl betaine, ricinoleamidopropyl betaine, shea butteramidopropyl betaine, soyamidopropyl betaine, undecyleneamidopropyl betaine, wheat germamidopropyl betaine, rhamnolipids, sophorolipids, glycolipids, sodium lauryl glucose carboxylate, sodium cocoamphoacetate, PEG-7 glyceryl cocoate, cocamide DEA, cocamide MEA, lauramide DEA, glycol distearate, lauryl glucoside, caprylyl/capryl glucoside, decyl glucoside, coco glucoside, glycereth-26 arachidyl glucoside, butyl glucoside, C9-11 alkyl glucoside, C20-22 alkyl glucoside, cetearyl glucoside, heptyl glucoside, hydroxystearyl glucoside, isostearyl glucoside, myristyl glucoside, sodium cocoyl glutamate, alkyl glutamates, disodium cocoyl glutamate, sodium lauroyl glutamate, ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl methyl isethionate, sodium lauroyl lactylate, cocamido MEA, PEG-55 propylene glycol oleate, PPG-5-ceteth-20, disodium cocoamphodipropionate, sodium lauroyl sarcosinate, ammonium cocoyl sarcosinate, sodium oleoyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, isopropyl lauroyl sarcosinate, MIPA-cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TIPA-lauroyl sarcosinate, sodium lauryl sulfoacetate, sodium caprylyl sulfonate, sodium dodecylbenzene sulfonate, sodium xylene sulfonate, sodium C12-C14 olefin sulfonate, sodium dioctyl sulfosuccinate, diethylhexyl sodium sulfosuccinate, disodium laureth sulfosuccinate, sodium methyl cocoyl taurate, sodium taurine cocoyl methyltaurate, sodium methyltaurate isopalmitamide, sodium methyl stearoyl taurate, sodium methyl palmitoyl taurate, sodium methyl oleoyl taurate, sodium methyl myristoyl taurate, sodium methyl lauroyl taurate, sodium N-isostearoyl methyltaurate, sodium cocoyl taurate, and sodium caproyl methyltaurate. 3. Mixture according to claim 1 or 2, wherein the, one, several, or all of the surfactant(s) is/are sulfate free surfactants selected from the group consisting of cocamidopropyl betaine, lauryl glucoside, caprylyl/capryl glucoside, decyl glucoside, sodium lauroyl sarcosinate, coco-betaine, PPG-5-ceteth-20, coco glucoside, diethylhexyl sodium sulfosuccinate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, cocamide MEA, PEG-7 glyceryl cocoate, glycol distearate, sodium oleoyl sarcosinate, sodium cocoyl isethionate, sodium cocoamphoacetate, sodium cocoyl glutamate, sodium methyl cocoyl taurate, sodium C12-C14 olefin sulfonate, disodium laureth sulfosuccinate, and sodium lauryl glucose carboxylate. 4. Mixture according to any of the preceding claims, wherein the, one, several, or all of the polymer(s) is/are natural polymers. 5. Mixture according to any of the preceding claims, wherein the, one, several, or all of the polymer(s) is/are selected from the group consisting of natural gums, polysaccharides, proteins, starches, cellulose and derivatives thereof, hyaluronic acid, pectin, collagen, gelatine, chitosan, keratin, hectorite, and mixtures thereof. 6. Mixture according any of the preceding claims, wherein the, one, several, or all of the polymer(s) is/are natural gum(s), preferably selected from the group consisting of - natural gum obtained from seaweeds, in particular agar, algin (alginic acid) or carrageenan, - natural gum obtained from non-marine botanical resources, in particular gum arabic (acacia senegal gum), gum ghatti, gum tragacanth, karaya gum, guar gum, locust bean gum, beta-glucan, dammer gum, galactomannan, glucomannan, psyllium seed husks, tara gum, or caesalpinia spinosa gum, - natural gum produced by bacterial fermentation, in particular gellan gum, xanthan gum, or sclerotium gum, and mixtures thereof. 7. Mixture according any of the preceding claims, wherein the, one, several, or all of the polymer(s) is/are starch(es), preferably selected from the group consisting of wheat starch, rice starch, maize starch, zea mays (corn) starch, tapioca starch, potatoes starch, cassava starch, acorns starch, arrowroot starch, arracacha starch, bananas starch, barley starch, breadfruit starch, buckwheat starch, canna starch, colocasia starch, katakuri starch, kudzu starch, malanga starch, millet starch, oats starch, oca starch, polynesian arrowroot starch, sago starch, sorghum starch, sweet potatoes starch, rye starch, taro starch, chestnuts starch, water chestnuts starch, yams starch, beans starch, peas starch, physically, chemically or enzymatically modified starches, and mixtures thereof. 8. Mixture according any of the preceding claims, wherein the, one, several, or all of the polymer(s) is/are cellulose(s) or derivatives thereof, preferably selected from the group consisting of microcrystalline cellulose, cellulose gum, hydroxyethylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, and mixtures thereof. 9. Semi-finished product comprising or consisting of a mixture according any of the preceding claims, wherein the semi-finished product preferably is a semi-finished product for the preparation of a surfactant-based rinse-off product, more preferably of a hair care product. 10. Cosmetic or pharmaceutical product comprising or consisting of a mixture according any of the claims 1 to 8 or a semi-finished product according to claim 9, preferably comprising or consisting of (i) 0.01 to 2 wt.%, preferably 0.05 to 1.5 wt.%, more preferably 0.1 to 1 wt.%, of climbazole, (ii) 0.01 to 2.0 wt.%, preferably 0.05 to 1.5 wt.%, more preferably 0.1 to 1 wt.%, of one or more polymer(s), preferably as defined in any of the claims 4 to 8, and (iii) 1 to 30 wt.%, preferably 3 to 25 wt.%, more preferably 4 to 20 wt.%, of one or more surfactant(s), preferably as defined in claim 2 or 3, based on the total weight of the product. 11. Cosmetic or pharmaceutical product according to claim 10, wherein the product is a surfactant-based rinse-off product, preferably a hair care product, more preferably is a hair care product selected from the group consisting of shampoos, preferably anti- dandruff shampoos, hair conditioners, hair cures, hair colourings, hair rinses, hair styling products, preferably gels, mousses, foams, waxes, and sprays, hair oils, scalp creams, hair masks, hair tonics, and hair serums, and/or wherein the cosmetic or pharmaceutical product additionally comprises 1,2- decanediol. 12. Use of climbazole and/or of one or more polymer(s), preferably as defined in any of the claims 4 to 8, for improving the foam volume and/or foam stability of a mixture, semi-finished product, or product as defined in any of claims 1 to 11, preferably of a surfactant-based rinse-off product. 13. Method for the manufacture of a mixture according to any of the claims 1 to 8 comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more polymer(s), preferably as defined in any of the claims 4 to 8, and (iii) one or more surfactant(s), preferably as defined in claim 2 or 3, (b) mixing the components provided in step (a). 14. Method for the manufacture of a semi-finished product according to claim 9, or for the manufacture of a product according to claim 10 or 11, comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more polymer(s), preferably as defined in any of the claims 4 to 8, and (iii) one or more surfactant(s), preferably as defined in claim 2 or 3, or a mixture thereof, (b) providing the remaining ingredients of the semi-finished product according to claim 9 or of the product according to claim 10 or 11, (c) mixing the components provided in steps (a) and (b). 15. Method for improving the foam volume and/or foam stability of a semi-finished product according to claim 9, or of a product according to claim 10 or 11, comprising or consisting of the following steps: (a) Providing (i) climbazole, (ii) one or more polymer(s), preferably as defined in any of the claims 4 to 8, and (iii) one or more surfactant(s), preferably as defined in claim 2 or 3, or a mixture thereof, (b) providing the remaining ingredients of the semi-finished product according to claim 9 or of the product according to claim 10 or 11, (c) mixing the components provided in steps (a) and (b).