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WO1996012738A3 - Pepstatin-derivatives for the treatment and detection of fungal infections - Google Patents

Pepstatin-derivatives for the treatment and detection of fungal infections Download PDF

Info

Publication number
WO1996012738A3
WO1996012738A3 PCT/US1995/014501 US9514501W WO9612738A3 WO 1996012738 A3 WO1996012738 A3 WO 1996012738A3 US 9514501 W US9514501 W US 9514501W WO 9612738 A3 WO9612738 A3 WO 9612738A3
Authority
WO
WIPO (PCT)
Prior art keywords
sta
val
ala
asp
absent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/014501
Other languages
French (fr)
Other versions
WO1996012738A2 (en
Inventor
Joel Bolonick
Steven A Delk
Ida K Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NZYM Inc
Original Assignee
NZYM Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NZYM Inc filed Critical NZYM Inc
Priority to AU41049/96A priority Critical patent/AU4104996A/en
Publication of WO1996012738A2 publication Critical patent/WO1996012738A2/en
Publication of WO1996012738A3 publication Critical patent/WO1996012738A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The subject invention provides novel proteinase inhibitors that find use in both the isolation of preoteins and the treatment and prevention of animal and plant diseases, particularly diseases stemming from fungal infections. Novel proteinase inhibitors of the subject invention are the polypeptides according to the formula (I): A-B-G-C-Sta-Ala-Sta-E-F, wherein A is absent or an amino acid blocking group; B is either absent or peptide consisting of 1-3 amino acids; C is an amino acid, E is either absent or selected from the group consisting of glycine and β-alanine; F is either absent or a 1-5 amino acid peptide composed of amino acids that are either positively charged, negatively charged, or have hydroxyl groups on side chains; and G is an amino acid. Preferred embodiments of the compounds of fomula (I) are: (II) Iva-Val-Val-Sta-Ala-Sta-Bal-D-Asp-D-Asp, (III) Iva-Val-Val-Sta-Ala-Sta-D-Ser-D-Ser, (IV) D-Asp-Bal-Val-Val-Val-Sta-Ala-Sta-Bal-D-Asp, and (V) Iva-Dab-Val-Sta-Ala-Sta. Also described are methods for assaying for the presence of fungal proteinases. The invention also provides kits for performing assays for fungal proteinases.
PCT/US1995/014501 1994-10-20 1995-10-20 Pepstatin-derivatives for the treatment and detection of fungal infections Ceased WO1996012738A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41049/96A AU4104996A (en) 1994-10-20 1995-10-20 Pepstatin-derivatives for the treatment and detection of fungal infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32650594A 1994-10-20 1994-10-20
US326,505 1994-10-20

Publications (2)

Publication Number Publication Date
WO1996012738A2 WO1996012738A2 (en) 1996-05-02
WO1996012738A3 true WO1996012738A3 (en) 1996-08-08

Family

ID=23272495

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/014501 Ceased WO1996012738A2 (en) 1994-10-20 1995-10-20 Pepstatin-derivatives for the treatment and detection of fungal infections

Country Status (2)

Country Link
AU (1) AU4104996A (en)
WO (1) WO1996012738A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2113510A1 (en) 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin A derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104964A1 (en) * 1982-08-17 1984-04-04 Sanofi S.A. Peptide derivatives as inhibitors of acid proteases
EP0165151A1 (en) * 1984-05-25 1985-12-18 Sanofi Peptide derivatives as renin inhibitors, process for their preparation and their therapeutical application
WO1994024150A2 (en) * 1993-04-21 1994-10-27 Nzym Inc. Pepstatin derivatives for treatment, prevention and detection of infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104964A1 (en) * 1982-08-17 1984-04-04 Sanofi S.A. Peptide derivatives as inhibitors of acid proteases
EP0165151A1 (en) * 1984-05-25 1985-12-18 Sanofi Peptide derivatives as renin inhibitors, process for their preparation and their therapeutical application
WO1994024150A2 (en) * 1993-04-21 1994-10-27 Nzym Inc. Pepstatin derivatives for treatment, prevention and detection of infections

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GUŸAN, R. ET AL.: "Pepstatin analogues as novel renin inhibitors", J.MED.CHEM., vol. 29, pages 1152 - 1159 *
LEI, P.-C. ET AL.: "Effects of proteinase inhibitors on the cutaneaous lesion of Sporothrix schenckii inoculated hairless mice", MYCOPATHOLOGIA, vol. 123, pages 81 - 85 *
PETÄISTÖ, R.-L. ET AL: "Analysis of the protein pattern of Gremmeniella abietina with special reference to protease activity", MYCOLOGIA, vol. 86, no. 2, pages 242 - 249 *

Also Published As

Publication number Publication date
WO1996012738A2 (en) 1996-05-02
AU4104996A (en) 1996-05-15

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