WO1993000892A1 - Pharmaceutical preparation - Google Patents

Abstract

A pharmaceutical preparation for treatment of infectious and inflammatory diseases containing an effective quantity of an active component consisting of myristamidopropyldimethylbenzylammonium chloride of formula (I) in a pharmaceutical solvent, and its use for prophylaxis and treatment of specific and nonspecific diseases of urogenital system, as spermatocide, antiherpetic and anti-HIV agent, as well as antiseptic and disinfectant agent.

Description

 ЛΕΚΑΡ'7ΤΒΕΗШЫ ПΡШΑΡΑΤ

Good news

Ηasτοyaschee izοbρeτenie οτnοsiτsya κ οblasτi medicine and τοchnee κasaeτsya πρeπaρaτa προφilaκτiκn for treating and 5 sπetsiφichesκiχ π nesπetsiφichesκiχ zabοlevanii ινϊοcheποlοvοn sisτemy and τaκzhe isποlzevaniya egο in κachesτve sρedsτva vοzdeysτviya on viρusy geρπesa and immuyοdeφitsiτa chelοveκa, anτiseπτichesκοgο, and dezinφitsiρuyuschegο sπeρmaτοtsidnοgο sρedsτva.

10 Practical level of technology

Surfactants-active substances have found a name for medicine in the basic form of antiseptics and disinfecting substances - pharmaceuticals, detergents, and medicines. (Μ.D. Kashkovsky, Medicare is better than medication,

15 Μ. "Medicine, 1987). The impaired use of medicine in medicine is associated with therapies, many of which, in addition to the anti-inflammatory effect, have an irritating effect on the metabolism of the substance and substances that are harmful to the body. and κ ο ρ ани зм ’

20 bοτany προsτye and inshορmaτivnye meτοdy, ποzvοlyayuschie bys- τρο and τοchnο χaρaκτeρizοvaτ bezvρednοsτ deϋsτviya, neτ information ο muτagennyχ svοδsτvaχ, sπορnym οsτaeτsya vοπ- ροs οb iχ κantseροgennοsτi (YS Κρivοshein with sοavτ., Αnτibiοτiκi, 1984, .. 7, . 519-526; Skuratautich Α .Α. S

25 comp. Access to Dermat. and Vienna ρ. , 1983,] * II p. 29-32). Sorbents for specific diseases (venereal) are well known - potassium permanganate, furucillin, cerebric oxide, and cerebate salt.

30 Vienna, 1978,. * 6, p. 49; Skurataut Α .Α. Topical Issues of Dermatology and Venereology, Finnish, 1980, p. 172-175).

None of the listed substances are effective for specific exciters and - 2 - nonspecific diseases of the urinary system, most of them in bactericidal concentrations cause irritating and / or nonsignificant health

For the treatment of specific and nonspecific diseases of the urinary system, they use a wide range of antibiotics, acid, zinc sulfide, copper sulfate, and sulfate. 10 • The listed products are often ineffective. With it, it is produced by the microorganism that is resistant, they ι, can cause harmful effects.

Experimental work is known) on the basis of inconsequential deceases of incapacitated activities.

LIQUID EI AND SYSTEMS (Cегегтаηηηύ 0 0.

1986, V. 20,:. 164, ϋ. 7-9; Ροϊзку Β., Βагсп Ρ.Α., СЗЗ3 Ι Α еτ аϊ. Ιη ϊ г η ас ^"""" ------------20 20 20 20 20 20 20 20 20 20 20 е е е 20 § § § § η η η 20 се 9 9 9.

1988, I,. 3600, ρ. 1456). However, until now no reliable remedy has been found for the above purposes.

Winning down an election

25 Purpose izοορeτenyl - ρazρabοτκa leκaρsτvennοgο πρeπa- ρaτa, οbladayuschegο sποsοbnοsτyu gubiτelnο vοzdeysτvοvaτ on vοzbudiτeley iπϊeκtsiοnnyχ and vοsπaliτel.shχ zabοleΕa- Nij (baκτeρii, viρusϊ, προsτeyshie) without causing phenomena ποbοchnyχ πρi egο πρimenenii.

80 The task is addressed by the fact that it is proposed to treat drugs on the basis of a material with an amide with a chemical formula with a chemical formula.

^[C 13 ^N 27- £ - - ^SΗ 2- ^SΗ 2- ^SΗ 2- ^Ν - ^SΗ 2- ^C 6 ^{Η 5] C1} ϋIρaΜISΤIΗ ν)

35 - 3 - as a medicament for the treatment of infections and inflammatory diseases, including for the prevention and treatment of specific and nonspecific diseases,

5 οsτρye uρeτροπροsτaτiτy and dρ.) And τaκzhe sρedsτva for προ- φilaκτiκi geρπes and Μ- inφeκtsii πρi ΠΟLΟBΟΜ πuτi πeρeda- chi sπeρmaτοtsidnοgο, and anτiseπτichesκοgο dezinφitsiρuyuschegο sρedsτva, sοdeρzhaschego eφφeκτivnοe κοlichesτvο aκτivnοgο κοmποnenτa, πρedsτavlyayuschegο sοbοy miρisτamidοπροπildime-

10 tylenzylamide acid formula: sn ₃

SS ₁₃ Η ₂₇ -С-ΝΗ-СΗ ₂ -СΗ -СΗ ₂ + Ν-СΗ -с ₆ н ₅ ] сι ^~

(miramistin) in the $ pharmaceutical diluent. 15 Chiramistin receives a well-known general reaction of the condensation of myristamide with propyl dimethyl amine with clean benzyl with the resulting calculated value.

The resulting material provides a white petty- 20 crystalline product without protection, which can be consumed in the water, low-molecular weight, aceletome.

For the purposes of treatment and treatment, it is proposed to use 0.01 - 2.0% of the aqueous solution of miramistin, and it is also used as an ointment, suppository or powder; 25 ^' live or synthetic WSSA at the following ratio of components (in%): solid, live or synthetic basis - 98 - 99.9 miramistin - 2.0 - 0.01

30 Such medicinal forms ensure the protection against bacterial, viral and direct infections, which is also safe.

BEST MODE FOR CARRYING OUT THE INVENTION

35 The proposed preparation is issued in the form of 0.01 - 00138

- 4 -

2.0% of water for distilled water in special flasks made of polietilen, as well as in the form of ointment, suppositories and in aerosol containers.

Pre-test trials

5 Antimicrobial Properties

With the help of the methodology recommended by the General Health Organization (UZ), we examined the antimicrobial effect of the miramistin in the 608 standard

10 museum and wild states of microorganisms (413 households, 185 municipal bacteria, 52 cities, 8 viruses).

The data obtained showed that the miramistin is most active in relation to the gamma-positive bacteria,

15 vegetative forms of bacilli and pests, pathogens of dermatomycosis (0.0001 - 0.002%). The range of the antimicrobial effect of miramistin on the hostile bacteria was necessary for the majority of the test culture in general

0.0025 - 0.02%. ΡΡΤΤΤΟΟΟρΚΤρ ΟΒΟΒ ± ± ± ± изθ, 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20:::::::::::::::::::::::::::::::::::::::::::: :ег: егББББББББЛЯЛЯЛЯЛЯБЛЯЛЯЛЯБЛЯББ П П П П П П П П П П 0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5 - - - - - - - - - - - - - - - - - - - 0,5 - is 0.5 - 2.0% (see

- 5 - Table I

Antimicrobial action of miramistin

/Kg / ml Multiple beneficial organisms: steady-state, severe.

Βas. аητ: ϊ.гасοχάез, Βас. wow Βas. τηusοχάе s

Grib:

Saάάάάάa ΙΙηз, Са,, Саάάάά------------,,,,,,,-------,,,,,,,, ,ΜгггзρρρρηΙΙΙитититΙΙΙΙϊ,,,,,,,,,,,, ,егегегегегегегегизизизизизизизизизизизизизизизизизизиз

Усы and усы: ρ ес ес ес ви ви,, г ρ--Ι Β

fifty

Gρamοτρitsaτelnye miκροορganizmy: Gοnοκοκκi (diκie and museum shτammy) Esheρiχii (πaτοgennye and neπaτοgennye seροτiπy) Shigella (. Zοnne, Φleκsneρa and dρ) Salmοnelly (όρyushnοgο τiπa, πaρaτiφa Α and Β, vοzbudiτeli πischevyχ τοκsiκοinφeκtsy) vibρiοny (χοleρny, ΗΑG-, πaρaχοleρny, πaρagemοliτichesκy and dρ.)

United States (Τgeροηeta ρаϊϊχάит)

Инορinbacteriopathy

PRESENT: ΤΤχсЪЪοοοο νχЪсЪον111111

Ρгο-_еиз νиϊдагχз, Ρзейάοтοηаз аеги§χηοза

500 Homestay

- 6 -

Chiramistin showed high virucidal properties in relation to complex viruses (herpesviruses, ΒI4-Ι, group and others).

The intrinsic properties of the miramistin last for 5 long periods under conditions of a room temperature and a cooler (observation period for up to 3 years). Bactericidal activity of miramistina is dependent on the medicinal stability of the microorganism Ε. Chiramistin suppresses the conjugated transfer of plasmids, the determinant pathogenic properties of 10 bacteria (nu, Εη-s, Κ, etc.).

Μeχanizm anτimiκροbnοgο and viρulitsidnοgο deysτviya miρamisτina, studied with ποmοschyο eleκτροnnοy miκροsκοπii, φiziκο-χimichesκiχ and οiοχimichesκiχ meτοdοv ποκazal, chτο οn οbuslοvlen tsezinτegρatsiey ποveρχnοsτnyχ gliκοπροτei- 15 dοv κleτοchnοy sτenκn and τaκzhe naρusheniem in κleτκe φeρ- menτnyχ sisτem. These processes go in parallel and depend on the dose of the drug.

Imm.vnomod.vliruyuschie property. Using the common methods of evaluating the humanitarian and clerical immunity, 20η 20 νχ-ϊιгο and χη νχνο were found to be at their own expense. Ен Responsible for the solution of the concentration of the drug is an immune stimulant, causing a strengthening of the human and cell-mediated immunity.

25 History

The direct toxicity was divided ^into white mice and pearls and the single and external administration of the device. 30 Pοluchennye data ποκazali, chτο ^ D ^ η ^t $ of ^tαgΣΑ - on πρi vnuτρizheludοchnοm administered to mice sοsτavlyaeτ 1000 mκg / κg and white κρysam - 1200 mg / κg.

Efficient drug injections caused live fat loss with a smaller dose and a drug of _{50 were} left for - 7 - mice 628 mg / κg κρys and 670 mg / κg Dgη ^{π minutes} vnuτρivennοm vvetsenii πρeπaρaτa Misham sοsτavlyala 38.5 mg / κg and κρy- itself - 42.5 mg / κg. The household rate was studied on a regular basis, on 5 days, for 45 days, a daily rate of 3 times per day was applied to the excluded sections of the skin 0.01% - 0.1% - 2.0% - 0.1% 2.0% for the mucous membrane of the eye for 10 days. So far I’ve taken a dose of 5. 10 ^• Οtsenκu sοsτοyaniya ορganizma κροliκοv in οπyτaχ προvυ- dili πο ποκazaτelyam follows: mass τela, leiκοtsiτaρyaal φορmuly, aκτivnοsτ leyκοtsiτaρnοy πeροκsidazy with ποmοschyu ρeaκtsii Gρeχeιla, αοtseρzhanie gliκοgena πο meτοdu ΗΟ-SSΚΙΚB and Schabadasha, iagοtsiτaρnaya aκτivnοsτ leyκοtsiτοv and 15 zaveρshennοsτ φagοtsiτοza πο Beρmenu and Slavsκοi , temperate-reactive differential aspect of the surgical function of the serum aluminum.

Ηa οsnοanii ποluchennyχ dannyχ made vyvοd ο τοm, chτο ρasτvορy miρamisτina in κοntsenτρatsiyaχ dυ 4.9 πρi 20 dliτelnοm ποοτuπleπii in ορganizm cheρez κοzhu slizisτye and not on vliyayuτ gemοτοlοgichesκie ποκazaτeli, and ψeρmenτaτinuyu φunκtsiοnalnuyu aκτivnοsτ leyκοtsiτοv, nυ vyzyvayuτ κοn- φορmatsiοnnyχ changes alόumina syvοροτκi κροvi, that indicates the absence of the drug 25 in the indicated doses on the organism.

An abnormal discharge>, the effect of myrhaliztin on the skin and mucous eyes was studied in young mumps and urinary tracts, and mucous urinary tract and urinary tracts were studied. Of course, in our country there were used 20, 20 30 pigs and 6 pigs.

Hepatic preparations at a concentration of 0.01 - 2.0 _/ 1 were applied to the excluded areas of the skin and to the mucous membrane of the eye, LIFE daily daily for 1 - 40 days. Conventional miramistin products at a concentration of ..- Χ 0.01 - 35 2.0% (with only 2 livelihoods per dose) were sprayed in the dog house with the aid of a 4-stroke installer. (after 2-3 hours) in the course of time> 10 days. - 8 -

Β προ process; Experiences watched the .. .. live. Οtsenκu ρazdρa & ayuschegο deysτviya on slizisτye eye προvο- dili πο aκale Dρaize (in ballaχ οτ 0 dο 120 and meτοdu Οguρa (οtsenκi Α, ή, 0, A). Changes sο sτοροny κοzhi 5 ρegisτρiροvall vizualnο and τaκzhe πρi gisτοlοgichesκiχ issledοvaniyaχ κοzhi, slizisτοy uρeτρy , urinary bladder and other arthritis.

The data obtained showed that the application of miramistin to each of the small and medium-sized pigs at a concentration of 10 0, ϊ - 2.0 for 40 days did not cause any visual or slight changes.

An increase in the percentage of the drug up to 1.0% was achieved on the 50th day of applications for the mild skin condition, a slight epidemic was shared 15. Higher concentrations of miramistin (3–5%), starting from 10–15 days, caused more significant changes in the skin.

Injection of the drug into the eyes of the pigs and the pigs for 10 days at a concentration of 0.1 - 2.0% 20 Irritating to mucous membranes did not cause a negative effect on the skin.

Bοlee vysοκie κοntsenτρatsii miρamisτshϊa phenomenon caused ρazdρazheniya slizisτοy (πο shκale Dρayze 8 - 25 October ballοv, πο κlasοiφiκatsii Οgu ^'ρa - gρuππa b).

After the instillation of 0.01 - 2.0% of the water of miramistin in the males was only 20 ml and for 10 days 4 times, there were no significant changes in the consumption of fish 50 descriptions. Analysis of urine collected on days 5 and 10. I didn’t say a mistake to the physical user.

Hysterologic studies of mucosal and urinary tracts, results of 6 dogs did not reveal any significant changes after instillations of 55 cases. In these animals, there is no need for a pedologic and anatomical and histological changes in the testis, - 9 - to the visible gland, hypothesis, adrenal glands, in the kidneys, liver, lungs and heart.

The measurement of the annoying and allergic effects of miramistin was carried out in conjunction with 5 approved by v_03 and mediating

We tried 40 home-grown pork-male males weighing 300 - 400 g. From the front of the group of 20

10 people studied the effect of 0.01 # foreign water miramistin, and at the second (20 live) - 0.1%.

The results of the research showed that both the primary contact and the secondary contact are excluded from the visual observation.

15 labeled reactions of irritation. About 10 animals from each group after the end of the observation period (41 days) were killed. In the case of a hysterical collapse of the skin, processed by a miramistin, in no other case is there any noticeable of any distant microcirculatory system.

20 In general, toxicological studies suggest that the miramistin is not affected by substances (small class). 3 Working concentration of 0.01% - 2.0% does not have a detrimental effect on the skin, slimy eyes, urethra, and urine

25 puzzles and allergic properties. Easy-to-use side effects are only apparent when using miramisine in a product that enhances performance.

The study of the metabolic and embryonic effects of miramistin

30 Studying the mutagenic properties of miramistin by using the recommendations of the United States with the use of microstatic systems that are dependent on histids

ΜУΤЭΗΤΗЫΧ ШΤаΜινЮΒ ϊϊοηϊϊ уϊϊΜΜΜΜЛιЛΚΟЛЛЛκ

Β.Α synthesis. The presence of a mutagenic effect of the drugs was controlled by 35, taking into account the reciprocal mutations in the presence of histidine as a result of histidine. ΡСΤ / ΙШ92 / 00138

- 10 -

Isποlzοvany meτοdy ucheτa gennyχ muτatsy without meτabοlichesκοy aκτivatsii ϊη ν ± το, with meτaοοlichesκοy aκ- τivatsieO ϊη νϊ-sgο - τesτ Αtev - miκροsοmy and meτabοlichesκοy aκτivatsiey ϊη νϊνο with isποlzοvaniem 5 mleκοπiτayuschiχ and κacheατve προmezhuτοchnοgο χοzyaina.

On the basis of the obtained data, it is possible to conclude that the miramistin does not have a direct mutagenic effect on the indicative strains h. -su Utgϊt • For the metabolic activation of η νι-sog with the use of 10 full and incomplete active mixtures, as well as. ^η νϊνο miramistin does not use compounds with mutagenic compounds.

Researches on the embryo activity of the world and its influence on the industrial function of the producer-15 have been carried out in a total of 303 methods. In the first place, at the very end of the sixth day of the eighteenth day of pregnancy, we entered into an internal gastric disruption. The total of each animal received up to 1000 mg / kg of the drug. The second group of miramistins was introduced from the beginning of the 20th day to the end of the pregnancy only one at a time. The groups - males for 60 days, females - 30 days, and then pairing.

Ηa οsnοvanii πρυvedennyχ issledοvany g.ιοzhnο ber laτ zaκlyuchenie ο το_l, chτο miρamisτin not οοladaeτ τeρa- 25 τοgennym, embρiοτοκsichesκim eφφeκτοm not sniκaeτ ρeπρο- duκτivnuyu φunκtsiyu not naρushaeτ ρazviτiya ποτοmsτva in ποsτnaτalnοm πeρiοde life.

Exploring the cancer of the miramistin

30 Οπyτy προvοdshy on melκiχ labορaτορnyχ zhivοτnyχ (myshaχ, κρysaχ, mορsκiχ svinκaχ) and sοbaκaχ, πρibliziv sποsοb administration πρeπaρaτa κ τοm, κοτορy budeτ πρime- nyaτsya in πρaκτiκe (naκοzhny in uρeτρu and mοchevοy πuzyρ). We used the technique referred to as the latest recommendations.

35,303 for the cancer and cancer properties of the hygienic - II - distinctions in an experimental economy by introducing them into the urinary bladder, lively in a mixture with a fast-solidified, non-compliant, non-compliant 5 The addition of a study of the drug did not affect the process of the rationalization of nanakila-65. The resulting test mass containing miramistin was introduced into the cattle livestock: female: 0.06 ml to mice (15 pieces), 0.15 ml to breeds (15 pieces), two males to 2 males.

10 ^{'Pρedvaρiτelnοe} study ϊη νϊgο ποκazalο, chτο ποsle zaτveρdevaniya nοnaκρila in uκazannyχ οοemaχ οbρa- zuyuτsya οvalnye κusοchιsh πlasτmaesy vesοm sοοτveτsτven- nο 25,70 and 1000 mg, 0.5 mg sοdeρzhaschie miρashyuτina to I ml. The control was 15 mice and 15 rats, κοτο-

On the 15th, in the urinary bladder, it was injected without adding to it a negative preparation. Experienced and competitive mice and puffs were separated under standard conditions for natural death, dogs were killed after 2.5 years.

Cancer Research 0.01% - 2.0

20 vοdnοgο ρasτvορa miρamisτina on κοzhu προvοdili 25 besποροdnyχ belyχ myshaχ and 25 belyχ κρysaχ, κοτορym on vysτρezhenny uchasτοκ κοzhi mezhlοπaτοchnοy οblasτi whether nanοsi- 3 - 5 ρaz weekly τechenie οdnοgο gοda πο 3 κaπli ρasτvορa miρamisτina in ρabοchey κοntsenτρatsii (20 zhivοτ-

25 today) and a lot of water (5 animals), then rubbing them with a spatula. Over the course of the experiment, about 160 applications were made to each animal.

After the natural death of mice and rusks, and the dog was killed, a pediatric-anatomical and histology

30 major studies.

Generally, the best data you can conclude that the miramistin does not cause the development of patients or is related to the change of the urine is lower. he is not

35 has a carcinogenic effect. - 12 -

Studying of the operational activity of the methodology, the methodology of the Republic of Kazakhstan. For this purpose, people who were better off after scaling up were mixed with different concentrations of 5 and a small volume of the mediator. A total of 27 men were studied between 18 and 23 years old. The results of experiments showed that miramistin at a concentration of 0.01% - 2.0%. It eliminates the movement of vehicles in 1-3 minutes, 10 minutes and travels to and from Sweden after 30 seconds. Contact, and after 1-1, minutes will occur in small cases and their lysis.

Dezinφitsiρuyushie svοysτva miρamisτina uchalπ nυ meτοdiκe ΒΟZ La mοtselnyχ οbeκτaχ of sτeκ ^ a meτalla 15 deρeΕa, ηlasτmass, οblitsοvοchnοi πliτκi on κοτορye πρedvaρiτelnο nanοsπli τesτ-shτammy gρamποlοzhiτelnyχ, gρamοτρitsaτelnyχ mshsροορganizmοv and gρibο ^. The processing of infected infections resulted in differences in the concentration of one of the miramistin discharges, which increased from 20 pulses. The new product was dispensed with 0.2} 1 sultanas in 10 _/ th young man. Some of the findings showed that the miramistin is in the range of 0.01 - 2.0> “ ^' calls 100',;. Disinfecting. within 15 to 20 minutes.

25 Prevention and treatment and treatment

Investigation of the practical activity of the drug was carried out on the basis of the experimental practice of the disease. The experiments were delivered to 156 residents of the country, and the tire was delivered to the country.; And (2.5 - 3.0 kg). The infection of 30 days ago was accompanied by a fresh suspension of fumes (the strains of Yykols and TsI-8) were left unattended. Then after 30, 60, 120, 180, 240 minutes after infection, we processed * / the infected part _^ -, 01% - 2, due to the fact that the patient was in peace:, - 13 - We tried to handle distilled water.

All the clinics were at the clinic-serological center of 6-12 months. The following were used for the response: the response of Casserman (ΡΒ), IIBΤ and ΡИФ, which were 5 and 1.5 months after infection, every 2-3 months. Τaκzhe were isποlzοvany meτοdy πassiροvaniya limφaτichesκiχ narrow lοv and ποvτορnοgο zaρazheniya in κοzhu mοshοnκi _^ zvesyu τρe- ποnem analοgichnοgο shτamma.

The results of the experiments showed that the treatment of 10 of the 0.01% - 2.0% of the cases resulted in an increase of 60 minutes of infection, which leads to a loss of health.

The therapeutic effect of miramistin was studied in models of virulent ryan and obesity in experimental animals 15 (males, males, and males), all over the world. The effects of miramistin and rheumatoid infection and exerted by virulent immunodeficiency in patients with virility and biliary disease

The data obtained showed a high therapeutic activity of the rams, used in the form of a single extract, ointment and aerosol, and an increase in inflammation Chiramistin 25 turned out to be more effective in comparison with the widespread use of an antibiotic chemiglyceride (table 2).

- 14 -

гнοиныχ ρан у эκсπеρименτальныχ живοτныχ (κρысы, мορсκие свинκи, κροлακи) πρи лечении миρамисτинοм в сρавнении . χлορ- геκсидинοм биглюκοнаτοм (в дняχ)Table 2

gynoins are experienced in experimental animals (rusks, pedigree pigs, dogs) in the treatment of miramistinom in comparison. лlορ- hexidine biglucone (in days)

Group of companies, first of all, Full registration for;

Onset (without treatment 7.2 ^ 1.1 20, ϋ 3.5

Treatment 0.02 with a cold sidine biglucone 4.5 + 0.7 14.7 1.3

Treatment 0.01% miramistinom 2, 7 + 0.3 10.13 _ 0.9

Pre-trial research

The clinical study of miramistin as a part of an individual. προφilaκτiκi veneρichesκπl zabοlevani and gnοynο-vοsπaliτzlnyχ προtsessοv were προvetseny in July 5 κρuπnyχ κοzhnο-veneροlοgichesκiχ uchρezhtseniyaχ π 12 κlini- κaχ χiρuρgichesκοgο aκusheρsκο π-gineκοlοgych ^ sκοgο πρθάy- la.

The analysis of the reports showed that the relationship does not affect the personal operation of the lucentus; 10 outdoor and urban areas and introduction into the territory and vagina. The use of C, 0Ι% - 2.0% of the total world economy, has shown that it protects 100; In the case of people who are infected with venereal diseases, if they were ill, if they had been sick before 2, 5 15 hours after that. All in all, more than 1,000 patients who are in possession of a group have been observed. The use of miramistin in the treatment of obstructive and chronic retardation has been impaired due to its high efficiency - 15 - by judgment, and by the decrease of ροκο in treating.

Βο Εseχ κliniκaχ χiρuρgichesκοgο and aκush _{'zρsκο-gineκο-} lοgichesκοgο προφilya, πρimenyavshim πρeπaρaτ mlρamisτin πρi ρazlichnyχ gnοinο-vοsπaliτelnyχ zabοlevaniyaχ. Οτme- chenο, chτο miρamisτin πρevοsχοdiτ πο eφωeκτi _-_ nοsτi shiροκο πρimenyaemy anτiseπτshs χlορgeκsidin biglyuκοιϊaτ and ρeκο- mendueτsya for πρimeneliya s shiροκοy κlinichesκοy πρaκτiκe treatment gnοynο-vοsπalyaτelyshχ zabοlevany.

Improved applicability

The proposed medicinal product is intended to be used in the best :: :: obstetric-gynecological, non-inflammatory, medical treatment.

Claims

^~ 16 ^" ΦΟΡΜ / lΑ IZBΟSHIA I. Leκaρsτvennshι πρeπaρaτ to treat ιshφeκtsiοnny and vοsπaliτelnyχ zabοlevany, sοdeρzhaschy aκϊϊιny κοmπο- nenτ and φaρmatsevτichesκy ρazόaviτel, οτlichaιLdyysya τem, delta chτο οn eοdeρzhiτ eφiϊeκτivnοe κοlichesτvο aκτshznοgο κοmπο- nenτa, πρedsτa_lyaωschegο sοθοy mnρisτamidοπηοshιldimeτil- benzilammοny χlορid φορmuly: СΗ- [ ^С 13 ^Η 27 - ^{с "Νн" н} ₂ ~ ^{СΗ "СΗ} 2 * ^{Ν ~ |} '?

- ^{1 01} 10 ο sn ₃ in a pharmaceutical manufacturer, 2. Medicinal products πο π. I, distinguished by the fact that, as a pharmaceutical company, you are provided with 15 water. 3. Healing of the good news. I, which differs in that, in the form of a pharmaceutical diluent, it contains any plant,>, sewing or synthetic base. 4. Lexicar π е π π π 1, 2 in a liquid of 20 ppm, it is known that it contains C, υΙ - 2.0 γό of the aqueous solution of mythystamide and erythrocytes. 5. Healing drugs πp π.π. 1,;, in the form of mazp or candles, which is different from the fact that it is part of the world> 2δ is effective, healthy or lively, live or synthetic, and the following is a natural, 99-hour, natural: 30 myrististamide-propyl dimethyl benzylamide ^χ loride - 2.0 -.- - 0.01 6. The use of a medicinal product πo π.π. Ι-ό for the prevention and treatment of specific and nonspecific diseases of the urinary system. - 17 - 7. The name of the medicine π π.π. HAZARDOUS ANNOUNCEMENT. 8. Applied medicine π π.π. V-b Ε κachesτve προgivοgeρπeτichesκοgο sρedsτva υ anτi - ιZICh sρedsτva. 9. Applied medicine π π.π. Ι-аче as an antiseptic and disinfectant.