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WO1992021654A3 - Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives - Google Patents

Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives Download PDF

Info

Publication number
WO1992021654A3
WO1992021654A3 PCT/US1992/001652 US9201652W WO9221654A3 WO 1992021654 A3 WO1992021654 A3 WO 1992021654A3 US 9201652 W US9201652 W US 9201652W WO 9221654 A3 WO9221654 A3 WO 9221654A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxamido
carbocyclic
aminotetralin derivatives
aminotetralin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1992/001652
Other languages
French (fr)
Other versions
WO1992021654A2 (en
Inventor
Chiu-Hong Lin
Montford E Piercey
Susanne R Haadsma-Svensson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to JP5500378A priority Critical patent/JPH06507906A/en
Publication of WO1992021654A2 publication Critical patent/WO1992021654A2/en
Publication of WO1992021654A3 publication Critical patent/WO1992021654A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of formula (I), wherein R is C1-C8 alkyl and n is 1 or 2.
PCT/US1992/001652 1991-05-20 1992-03-11 Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives Ceased WO1992021654A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5500378A JPH06507906A (en) 1991-05-20 1992-03-11 Carboxamide-(3,2N)-carbocyclic-2-aminotetralin derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70281391A 1991-05-20 1991-05-20
US702,813 1991-05-20

Publications (2)

Publication Number Publication Date
WO1992021654A2 WO1992021654A2 (en) 1992-12-10
WO1992021654A3 true WO1992021654A3 (en) 1993-01-07

Family

ID=24822712

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/001652 Ceased WO1992021654A2 (en) 1991-05-20 1992-03-11 Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives

Country Status (6)

Country Link
EP (1) EP0586553A1 (en)
JP (1) JPH06507906A (en)
AU (1) AU2153592A (en)
MX (1) MX9202291A (en)
TW (1) TW200460B (en)
WO (1) WO1992021654A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds
DE19834714A1 (en) * 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma New 2,3,3a, 4,9,9a-hexahydro-8-hydroxy-1H-ben [f] indoles, process for their preparation and their use as pharmaceuticals

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402601A1 (en) * 1983-02-01 1984-08-02 Sandoz-Patent-GmbH, 7850 Lörrach NEW PHARMACEUTICAL ACTIVE 1,2,3,4,4A, 5,10,10A-OCTAHYDROBENZO (G) CHINOLINE DERIVATIVES, THEIR PRODUCTION AND USE
EP0272534A2 (en) * 1986-12-22 1988-06-29 Bayer Ag 8-substituted 2-aminotetralins
WO1991000856A2 (en) * 1989-07-13 1991-01-24 The Upjohn Company (1,2n) and (3,2n)-carbocyclic-2-amino tetralin derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402601A1 (en) * 1983-02-01 1984-08-02 Sandoz-Patent-GmbH, 7850 Lörrach NEW PHARMACEUTICAL ACTIVE 1,2,3,4,4A, 5,10,10A-OCTAHYDROBENZO (G) CHINOLINE DERIVATIVES, THEIR PRODUCTION AND USE
EP0272534A2 (en) * 1986-12-22 1988-06-29 Bayer Ag 8-substituted 2-aminotetralins
WO1991000856A2 (en) * 1989-07-13 1991-01-24 The Upjohn Company (1,2n) and (3,2n)-carbocyclic-2-amino tetralin derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 106, no. 3, 19 January 1987, Columbus, Ohio, US; abstract no. 18332B, 'p-dimethoxy-substituted trans-octahydrobenzo(f)- and -(g)quinolines: synthesis and assessment of dopaminergic agonist effects' page 584 ; *
MOLECULAR PHARMACOLOGY vol. 35, no. 5, 1989, pages 643 - 651; 'characterization of dopamine receptor subtypes by comparative structure-activity relationships' *
PHARMAC. BIOCHEM. BEHAV. vol. 17, no. SUP1, 1982, pages 11 - 19; 'presynaptic Dopamine Receptor Agonists' *

Also Published As

Publication number Publication date
AU2153592A (en) 1993-01-08
WO1992021654A2 (en) 1992-12-10
JPH06507906A (en) 1994-09-08
MX9202291A (en) 1992-11-01
TW200460B (en) 1993-02-21
EP0586553A1 (en) 1994-03-16

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