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WO1992015274A1 - Syteme de sacs de sang - Google Patents

Syteme de sacs de sang Download PDF

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Publication number
WO1992015274A1
WO1992015274A1 PCT/DE1992/000031 DE9200031W WO9215274A1 WO 1992015274 A1 WO1992015274 A1 WO 1992015274A1 DE 9200031 W DE9200031 W DE 9200031W WO 9215274 A1 WO9215274 A1 WO 9215274A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
blood bag
bag
bags
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1992/000031
Other languages
German (de)
English (en)
Inventor
Harald Mohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Original Assignee
Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FI933891A priority Critical patent/FI933891A0/fi
Priority to EP92903227A priority patent/EP0574410B1/fr
Priority to RU93057955A priority patent/RU2127107C1/ru
Priority to JP4503452A priority patent/JPH06504925A/ja
Priority to AU11675/92A priority patent/AU663069C/en
Priority to DE59206383T priority patent/DE59206383D1/de
Application filed by Blutspendedienst der Landsverbande des Deutschen Roten Kreuses filed Critical Blutspendedienst der Landsverbande des Deutschen Roten Kreuses
Priority to US08/108,741 priority patent/US5405343A/en
Publication of WO1992015274A1 publication Critical patent/WO1992015274A1/fr
Priority to NO93933154A priority patent/NO933154L/no
Anticipated expiration legal-status Critical
Priority to GR960401762T priority patent/GR3020831T3/el
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0213—Multiple bag systems for separating or storing blood components with isolated sections of the tube used as additive reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/221—Frangible or pierceable closures within tubing
    • A61M2039/222—Frangible or pierceable closures within tubing frangible within tubing or bags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/24—Medical-surgical bags

Definitions

  • the invention relates to a blood bag arrangement for blood products, with a bag and a hose connected to it and to a blood bag arrangement for donor blood and blood products with bags and tubes, the arrangements consisting of at least partially translucent plastic material.
  • Known blood bag arrangements consist of a withdrawal and / or one or more other connected bags which are connected to one another by tubes.
  • the bags are made of flexible plastic film; the hoses are also made of flexible plastic.
  • the plastics of bags and tubes are at least partially translucent.
  • the bags serve on the one hand to absorb blood or blood fractions into which the donor blood is separated by centrifugation, e.g. B. plasma, platelets and erythrocytes, and on the other hand the inclusion of special washing or additive solutions.
  • the object is achieved in a blood bag arrangement with a blood or plasma bag and at least one hose connected to it according to the invention in that in the ready-to-use arrangement, which is to be handled individually as an independent unit, one or more substances are provided in the sterile state.
  • the object is also achieved in a blood bag arrangement with a plurality of bags which are connected to one another by hoses and / or connected to the other hoses in that, in the ready-to-use arrangement, which is to be handled individually as an independent unit, one in the sterile state or several substances are provided.
  • one or more substances in particular one or more photoactive substances, are arranged in these during the manufacture of the blood bag arrangements, and if these substances are sterilized in the blood bag arrangement, then after use in the blood bag arrangements, these additives can be used for treatment, in particular virus inactivation of the donor blood or blood plasma can be made by the blood bag assemblies after mixing the
  • the photoactive substances have the property of being stimulated by the light and releasing energy, which leads to the fact that any viruses present in the preparation are inactivated.
  • a blood bag arrangement for blood products with at least one bag and at least one connected hose via which the bag can be connected, in particular with other bags, in that an independently and individually handled blood bag arrangement, consisting of a single bag and a Tube, with another blood bag arrangement which is also independent and can be handled individually and which consists of a single bag and a tube or of several bags with tubes connecting the bags, kombi ierbaj. is by connecting these blood bag assemblies to one another, only one of the two combined bag assemblies being provided with enclosed substances.
  • One of the two blood bag arrangements can be free of photoactive substances while maintaining the mechanism of action. Despite fully effective virus inactivation, one of the combined arrangements can thus be made available more economically.
  • the combining can be carried out in such a way that a tube of one blood bag arrangement is coupled to a tube of the other blood bag arrangement with the aid of a welding apparatus under sterile conditions.
  • the bags are a removal bag and other bags connected to it. This means that the donor blood can be treated in a self-contained system from the outset.
  • the substances are provided in closed areas of the hoses.
  • the substances can be enclosed in the hoses by means of break valves.
  • the bags are free of substances until they are used.
  • the substances are enclosed in the individual bags of the arrangement.
  • Enclosing in certain areas ensures that the substances are ready everywhere to come into contact with the blood or blood fractions.
  • the enclosed substances can be specifically brought into connection with the blood or the elute fractions.
  • the photoactive substances are provided in the liquid or dissolved state.
  • the liquid state of aggregation allows a particularly rapid mixing of the photoactive substances with the blood or the blood fractions.
  • phenothiazine dyes are used as photoactive substances, preferably methylene blue or tolunidine blue.
  • FIG. 1 shows the second blood bag arrangement for donor blood, in which the individual bags are connected to one another via break valves and tubes and photoactive substances are enclosed in tube areas,
  • FIG. 1a shows an enlarged section A of a tube section filled with a photoactive substance
  • FIG. 2 shows a variant of the second blood bag arrangement for donor blood, in which photoactive substances are enclosed in the individual bags,
  • FIG. 3 shows the first blood bag arrangement, consisting of a bag and a tube, with photoactive substances enclosed in the tube.
  • This blood bag arrangement can be handled individually as an independent unit and can be welded to a second blood bag arrangement according to FIG. 1 or 2, likewise to be handled as an independent unit, with or without photoactive substances.
  • FIG. 3 shows a variant of the first blood bag arrangement according to FIG. 3, consisting of a bag and a tube, with photoactive substances enclosed in the bag.
  • This Blood bag arrangement can be handled individually as an independent unit and can be welded to a second blood bag arrangement according to FIG. 1 or 2, likewise to be handled individually as an independent unit, with or without photoactive substances.
  • Fig. 1 shows a second embodiment of a
  • Removal bag 7 and a bag 9 for an additive solution Removal bag 7 and a bag 9 for an additive solution.
  • the removal bag 7 and the satellite bag 5 and the removal bag 7 are connected to one another via tubes 11, 13.
  • a tube end 9, which is referred to as a pig tail and is closed at the free end 27, is arranged on the satellite bag 5.
  • a removal hose 21 connects to the removal bag 7.
  • the tubes 11 and 13 coming from the satellite bags 3 and 5 are brought together in the area of a one-way valve 23. In this way, they are connected to the extraction yield 1 7 via a common hose 15.
  • a middle piece 11a which is closed by means of break valves 25 when the blood bag arrangement is ready for operation.
  • a center piece 13a in the hose 13 which is closed on both sides by means of break valves 25 in the operational state.
  • the hose end 19 closed at its free end 27 is connected to the satellite bag 5 by means of a further break valve 25.
  • the break valves shown only schematically are from known design. These are injection-molded plastic parts with a passage channel, the passage of which is initially blocked after production by means of a co-injected membrane or the like.
  • the break valves are so-called one-way valves and are designed in such a way that the blocking of the passage is released when the kink is bent. The membrane is removed when it kinks. The passage is then open and media can be exchanged through the passage.
  • a hose 17 connects the removal bag 7 directly to the additive bag 9.
  • the connections of the hose 17 to the bags 7 and 9 take over break valves 25.
  • a removal hose 21 is connected to the removal bag via a further break valve 25.
  • FIG. 1 areas of the tubes 11, 13, 19 and 17 designated by circles A are highlighted. These areas A are shown greatly enlarged in FIG. 1a. This shows a sectional view of the hose areas. In the cutting area it can be seen that the tube areas 11a, 13a, 17, 19 contain a photoactive substance 31 between the tube walls 29. The photoactive substances 31 are enclosed in the tube regions 11a, 13a, 17, 19 between the break valves 25 in the operational state. By breaking the valves 25, the photoactive substances can flow into the respective bags 3, 5, 7, 9.
  • Fig. 2 shows a variant of the second embodiment of the invention, in which the photoactive substances immediately are enclosed in the individual bags 3, 5, 7, 9.
  • the hose lines 11, 13, 15, 17, 19, 21 are again connected to the individual bags via break valves 25.
  • the break valves are closed when ready for operation. During commissioning, the valves are opened by breaking. It can be seen in the bottom recesses 33 of the bags that the photoactive substances 31 are on the bottom of the bags 3, 5, 7 and / or 9.
  • FIG. 3 shows a first embodiment of the blood bag arrangement with a bag 70 which is provided with a tube 71.
  • the hose 71 opens into the bag 70 via a break valve 25.
  • a further break valve 25 is provided in the hose 71 at a distance from the break valve 25 on the bag 70.
  • a closed hose section 71a is thereby formed.
  • a photoactive substance is enclosed in the sealed tube section 71a. This can be seen from section A.
  • the free end 71b of the delivery hose 71 is initially free.
  • the free end 71b of the delivery tube 71 can, for example, be coupled to a tube of the blood bag arrangement according to FIG.
  • a welding device which welds the free end 71b to, for example, the hose 15 according to FIG. 1 and connects it to it.
  • Fig.4 shows another variant of the first
  • Embodiment of the blood bag arrangement with a bag 70 which is provided with a hose 71.
  • the hose 71 is connected to the bag 70 via a break valve 25.
  • a space 74 which is closed off by a membrane 73 and in which a photoactive substance 31 is enclosed is provided inside the bag 70.
  • the photoactive substances can also be in the bag.
  • the tube 71 is initially free and open up to its free end 71b.
  • the free end 71b can be connected to a hose piece, for example the hose piece 15 of the second embodiment according to FIG. 1 or 2.
  • the photoactive substances are used as liquids 31 in the context of the invention. Of course, it is also possible to use them in solid form (for example as a powder).
  • the breaking valves 25 are opened by breaking. With this procedure, the bag arrangement remains closed. There is no risk of bacterial infection. Analogously, other arrangements with more or fewer bags could of course also be equipped with photoactive substances in the same way.
  • Phenothiazine dyes are again the most suitable are methylene blue and toluidine blue.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Revetment (AREA)
  • Air Bags (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Jellies, Jams, And Syrups (AREA)

Abstract

La présente invention se rapporte à un système de sacs de sang destiné au sang d'un donneur comportant au moins un sac (70) et un tuyau flexible (71), ledit système étant constitué d'une matière plastique au moins partiellement transparente. Dans le système prêt à l'usage et pouvant être manipulé comme une unité autonome sont prévues à l'état stérile, dans des compartiments clos (71a), une ou plusieurs substances (31). Chaque système de sacs de sang de ce type peut être combiné, par liaison, avec un autre système de sacs de sang pouvant comporter un ou plusieurs sacs (3, 5, 7, 9) et être également manipulé comme une unité autonome.
PCT/DE1992/000031 1991-03-07 1992-01-20 Syteme de sacs de sang Ceased WO1992015274A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP92903227A EP0574410B1 (fr) 1991-03-07 1992-01-20 Syteme de sacs de sang
RU93057955A RU2127107C1 (ru) 1991-03-07 1992-01-20 Устройство для хранения и переработка крови и ее продуктов (варианты)
JP4503452A JPH06504925A (ja) 1991-03-07 1992-01-20 血液バッグユニット
AU11675/92A AU663069C (en) 1991-03-07 1992-01-20 plood-bag system
DE59206383T DE59206383D1 (de) 1991-03-07 1992-01-20 Blutbeutelanordnung
FI933891A FI933891A0 (fi) 1991-03-07 1992-01-20 Blodpaoseanordning
US08/108,741 US5405343A (en) 1991-03-07 1992-01-20 Blood bag system
NO93933154A NO933154L (no) 1991-03-07 1993-09-03 Blodposeanordning
GR960401762T GR3020831T3 (en) 1991-03-07 1996-08-21 Blood-bag system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEG9102709.8U 1991-03-07
DE9102709U DE9102709U1 (de) 1991-03-07 1991-03-07 Blutbeutelanordnung

Publications (1)

Publication Number Publication Date
WO1992015274A1 true WO1992015274A1 (fr) 1992-09-17

Family

ID=6864992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000031 Ceased WO1992015274A1 (fr) 1991-03-07 1992-01-20 Syteme de sacs de sang

Country Status (14)

Country Link
US (1) US5405343A (fr)
EP (1) EP0574410B1 (fr)
JP (1) JPH06504925A (fr)
AT (1) ATE138259T1 (fr)
CA (1) CA2104296A1 (fr)
DE (2) DE9102709U1 (fr)
DK (1) DK0574410T3 (fr)
ES (1) ES2089496T3 (fr)
FI (1) FI933891A0 (fr)
GR (1) GR3020831T3 (fr)
HU (1) HU214345B (fr)
NO (1) NO933154L (fr)
RU (1) RU2127107C1 (fr)
WO (1) WO1992015274A1 (fr)

Cited By (6)

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Publication number Priority date Publication date Assignee Title
WO1997018844A1 (fr) * 1995-11-21 1997-05-29 Pall Corporation Procede et systeme d'inactivation utilises dans des fluides biologiques
US5660731A (en) * 1994-11-08 1997-08-26 Pall Corporation Filter for separating photoactive agent
EP0884057A3 (fr) * 1993-07-12 1999-02-10 Baxter International Inc. Appareil et procédé d'inactivation des contaminants viraux des liquides biologiques
EP0804072A4 (fr) * 1994-07-03 1999-06-02 Crotty Daphna Procede et systeme de mise en culture de cellules notamment de macrophages
EP0933090A1 (fr) 1998-01-30 1999-08-04 Maco Pharma International GmbH Système de poches de sang pour l'inactivation de pathogènes dans le sang, les composants sanguins et le plasma
CN1126514C (zh) * 1993-12-21 2003-11-05 巴克斯特国际有限公司 血液贮存容器及其使用方法

Families Citing this family (23)

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US5527704A (en) 1994-12-06 1996-06-18 Baxter International Inc. Apparatus and method for inactivating viral contaminants in body fluids
US6190609B1 (en) * 1996-11-19 2001-02-20 Baxter International Inc. Methods and apparatus for inactivating contaminants in biological fluid
US6123859A (en) * 1998-04-22 2000-09-26 Hemasure Inc. Method for in-line filtering biological liquid
US7068361B2 (en) 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US7445756B2 (en) * 1999-06-03 2008-11-04 Fenwal, Inc. Fluid processing sets and organizers for the same
US6565802B1 (en) 1999-06-03 2003-05-20 Baxter International Inc. Apparatus, systems and methods for processing and treating a biological fluid with light
US7025877B1 (en) * 1999-06-03 2006-04-11 Baxter International Inc. Processing set for processing and treating a biological fluid
FR2817152B1 (fr) * 2000-11-29 2003-05-09 Maco Pharma Sa Systeme a poches et procede pour l'inactivation virale d'un fluide prealablement deleucocyte
US6936413B1 (en) * 2001-12-05 2005-08-30 Baxter International Inc. Methods and systems for preparing blood products
US7264608B2 (en) * 2001-12-05 2007-09-04 Fenwal, Inc. Manual processing systems and methods for providing blood components conditioned for pathogen inactivation
RU2223794C1 (ru) * 2002-06-04 2004-02-20 Сидорук Евгений Александрович Аппарат для крови и её компонентов
DE102005035528A1 (de) * 2005-07-26 2007-02-01 Heim Medizintechnik Gmbh Dampfsterilisierbare Bluttrennvorrichtung
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
EA201790265A1 (ru) 2014-07-23 2017-07-31 Сирус Корпорейшн Способы получения тромбоцит-содержащих продуктов
EP3313418B1 (fr) 2015-06-26 2024-03-13 Cerus Corporation Compositions de cryoprécipités et leurs procédés de préparation
EP3364986B1 (fr) 2015-10-23 2023-12-13 Cerus Corporation Plasma cryogénique inactivé par des agents pathogènes et procédé pour son utilisation
CN116571191A (zh) 2017-12-29 2023-08-11 塞鲁斯公司 用于处理生物流体的系统和方法
MX2021015653A (es) 2019-06-22 2022-04-11 Cerus Corp Sistemas de tratamiento de fluidos biologicos.
CA3143732A1 (fr) 2019-06-28 2020-12-30 Cerus Corporation Systeme et procedes permettant de mettre en ƒuvre un dispositif de traitement de fluide biologique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0196515A1 (fr) * 1985-03-14 1986-10-08 Baxter Travenol Laboratories, Inc. Inactivation photodynamique de virus dans des compositions thérapeutiques contenant des protéines
WO1987006119A1 (fr) * 1986-04-07 1987-10-22 Al Sioufi Habib Procede et systeme de recuperation de sang anti-pathogene
EP0382018A2 (fr) * 1989-02-10 1990-08-16 Miles Inc. Système de sacs pour le sang viricide
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EP0804072A4 (fr) * 1994-07-03 1999-06-02 Crotty Daphna Procede et systeme de mise en culture de cellules notamment de macrophages
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FI933891L (fi) 1993-09-06
AU663069B2 (en) 1995-09-28
CA2104296A1 (fr) 1992-09-08
NO933154D0 (no) 1993-09-03
ATE138259T1 (de) 1996-06-15
HU9302253D0 (en) 1993-11-29
DE9102709U1 (de) 1991-05-23
EP0574410B1 (fr) 1996-05-22
EP0574410A1 (fr) 1993-12-22
NO933154L (no) 1993-09-03
RU2127107C1 (ru) 1999-03-10
DK0574410T3 (da) 1996-06-17
FI933891A7 (fi) 1993-09-06
US5405343A (en) 1995-04-11
AU1167592A (en) 1992-10-06
HUT67120A (en) 1995-02-28
HU214345B (hu) 1998-03-30
GR3020831T3 (en) 1996-11-30
JPH06504925A (ja) 1994-06-09
DE59206383D1 (de) 1996-06-27
FI933891A0 (fi) 1993-09-06
ES2089496T3 (es) 1996-10-01

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