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WO1992002212A3 - Emploi de membranes a polymerisation interfaciale dans des dispositifs de liberation - Google Patents

Emploi de membranes a polymerisation interfaciale dans des dispositifs de liberation Download PDF

Info

Publication number
WO1992002212A3
WO1992002212A3 PCT/US1991/005337 US9105337W WO9202212A3 WO 1992002212 A3 WO1992002212 A3 WO 1992002212A3 US 9105337 W US9105337 W US 9105337W WO 9202212 A3 WO9202212 A3 WO 9202212A3
Authority
WO
WIPO (PCT)
Prior art keywords
interfacially
delivery devices
polymerized membranes
membranes
polymerized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/005337
Other languages
English (en)
Other versions
WO1992002212A2 (fr
Inventor
Scott Max Herbig
Richard Wilker Korsmeyer
Avinash Govind Thombre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Priority to JP3516602A priority Critical patent/JPH0794379B2/ja
Priority to EP91919243A priority patent/EP0542926B1/fr
Priority to US07/969,844 priority patent/US5876752A/en
Priority to DE69107461T priority patent/DE69107461T2/de
Publication of WO1992002212A2 publication Critical patent/WO1992002212A2/fr
Publication of WO1992002212A3 publication Critical patent/WO1992002212A3/fr
Priority to FI930509A priority patent/FI108610B/fi
Anticipated expiration legal-status Critical
Priority to GR950400864T priority patent/GR3015731T3/el
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Dispositifs de libération régulée de substances actives se présentant sous la forme de comprimés, de capsules et de globules, composés d'une sous-structure poreuse entourée par une ou plusieurs membranes interfaciales.
PCT/US1991/005337 1990-08-07 1991-08-01 Emploi de membranes a polymerisation interfaciale dans des dispositifs de liberation Ceased WO1992002212A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP3516602A JPH0794379B2 (ja) 1990-08-07 1991-08-01 放出製剤における界面重合膜の使用方法
EP91919243A EP0542926B1 (fr) 1990-08-07 1991-08-01 Emploi de membranes a polymerisation interfaciale dans des dispositifs de liberation
US07/969,844 US5876752A (en) 1990-08-07 1991-08-01 Use of interfacially-polymerized membranes in delivery devices
DE69107461T DE69107461T2 (de) 1990-08-07 1991-08-01 Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen.
FI930509A FI108610B (fi) 1990-08-07 1993-02-05 Rajapintapolymeroitujen membraanien käyttö annosteluvälineissä
GR950400864T GR3015731T3 (en) 1990-08-07 1995-04-10 Use of interfacially-polymerized membranes in delivery devices.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56400890A 1990-08-07 1990-08-07
US564,008 1990-08-07

Publications (2)

Publication Number Publication Date
WO1992002212A2 WO1992002212A2 (fr) 1992-02-20
WO1992002212A3 true WO1992002212A3 (fr) 1992-04-02

Family

ID=24252794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/005337 Ceased WO1992002212A2 (fr) 1990-08-07 1991-08-01 Emploi de membranes a polymerisation interfaciale dans des dispositifs de liberation

Country Status (13)

Country Link
US (1) US5876752A (fr)
EP (1) EP0542926B1 (fr)
JP (1) JPH0794379B2 (fr)
AT (1) ATE118345T1 (fr)
CA (1) CA2087435C (fr)
DE (2) DE69107461T2 (fr)
DK (1) DK0542926T3 (fr)
ES (1) ES2067957T3 (fr)
FI (1) FI108610B (fr)
GR (1) GR3015731T3 (fr)
IE (1) IE65403B1 (fr)
PT (1) PT98571B (fr)
WO (1) WO1992002212A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2281758C2 (ru) * 1999-09-29 2006-08-20 Новартис Аг Композиции с контролируемым высвобождением для перорального применения

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA933725B (en) * 1992-05-28 1993-12-15 Elan Corp Plc Tablet formulation
ATE173616T1 (de) * 1992-11-30 1998-12-15 Pfizer Verabreichungsvorrichtungen mit gestützten flüssigen membranen
ES2120354B1 (es) * 1996-02-12 1999-07-01 Univ Sevilla Dispositivo terapeutico para direccionar farmacos hacia el tramo del tracto gastrointestinal deseado en funcion de las caracteristicas fisicoquimicas del mismo.
EP0811374A1 (fr) 1996-05-29 1997-12-10 Pfizer Inc. Formulation d'une combinaison de cetirizine et pseudoephedrine
WO1999001121A1 (fr) 1997-07-01 1999-01-14 Pfizer Inc. Sels de sertraline et formes posologiques de sertraline, a liberation prolongee
US20030133974A1 (en) * 1997-07-01 2003-07-17 Curatolo William John Encapsulated solution dosage forms of sertraline
DK1035834T3 (da) * 1997-12-05 2002-07-08 Alza Corp Osmotisk doseringsform omfattende en første og anden coating
DE19814256A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Feste, schnellzerfallende Cetirizin-Formulierungen
DE69940557D1 (de) 1998-12-11 2009-04-23 Nostrum Pharmaceuticals Inc Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
US6613357B2 (en) * 2000-01-13 2003-09-02 Osmotica Corp. Osmotic device containing pseudoephedrine and an H1 antagonist
AU767812B2 (en) 2000-02-04 2003-11-27 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
US6464688B1 (en) 2000-02-15 2002-10-15 Microsolutions, Inc. Osmotic pump delivery system with flexible drug compartment
US6616652B1 (en) 2000-02-15 2003-09-09 Microsolutions, Inc. Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter
AU2002220248A1 (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
IL159287A0 (en) * 2001-06-28 2004-06-01 Ucb Farchim Sa Tablet comprising cetirizine and pseudoephedrine
MXPA04009617A (es) 2002-04-04 2005-01-11 Pfizer Prod Inc Comprimido masticable con sabor agradable.
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20040131672A1 (en) * 2003-01-07 2004-07-08 Nilobon Podhipleux Direct compression pharmaceutical composition containing a pharmaceutically active ingredient with poor flowing properties
DE60330909D1 (de) * 2003-08-08 2010-02-25 Biovail Lab Int Srl Tablette mit modifizierter freisetzung von bupropion hydrochlorid
US20060200250A1 (en) * 2005-03-04 2006-09-07 Ku David N Biocompatible implant device
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
JP5121824B2 (ja) * 2006-06-01 2013-01-16 メルク・シャープ・アンド・ドーム・コーポレーション フェニレフリンの徐放のための薬学的組成物
WO2007143158A2 (fr) * 2006-06-01 2007-12-13 Schering-Plough Healthcare Products, Inc. Formulations pharmaceutiques de phényléphrine et compositions pour absorption par le côlon
PE20080313A1 (es) * 2006-06-01 2008-04-10 Schering Corp Formulaciones de liberacion pulsada de fenilefrina y composiciones farmaceuticas
NZ573174A (en) * 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
US20080299186A1 (en) * 2007-06-01 2008-12-04 Schering-Plough Healthcare Products, Inc. Coatings for applying substances onto substrate carrier
PE20091084A1 (es) * 2007-12-07 2009-07-23 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal
US8857629B2 (en) 2010-07-15 2014-10-14 International Business Machines Corporation Composite membrane with multi-layered active layer
US9022227B2 (en) 2011-03-21 2015-05-05 International Business Machines Corporation Composite membranes and methods of preparation thereof
US9561474B2 (en) * 2012-06-07 2017-02-07 International Business Machines Corporation Composite membrane with multi-layered active layer
JP6532010B2 (ja) * 2015-03-25 2019-06-19 トッパン・フォームズ株式会社 マイクロカプセル、シート、樹脂組成物及び液状組成物
AU2021217209A1 (en) 2020-02-03 2022-09-29 Kenvue Brands Llc A single layer chewable tablet comprising cetirizine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041210A1 (fr) * 1980-05-31 1981-12-09 Hoechst Aktiengesellschaft Procédé pour la préparation de microcapsules résistant à la pression, contenant une pellicule extérieure en polyamide et une structure intérieure en polyuréthane-polyurée
EP0357369B1 (fr) * 1988-08-30 1993-05-12 Pfizer Inc. Utilisation de membranes asymétriques en dispositifs de libération

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL271831A (fr) * 1960-11-29
US3270100A (en) * 1962-08-01 1966-08-30 Delvan Mfg Company Method for making capsules by interfacial polymerization
US3577515A (en) * 1963-12-13 1971-05-04 Pennwalt Corp Encapsulation by interfacial polycondensation
US3615536A (en) * 1968-01-02 1971-10-26 Eastman Kodak Co Photographic element and process having a light-sensitive metal complex
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3875074A (en) * 1972-03-06 1975-04-01 Champion Int Corp Formation of microcapsules by interfacial cross-linking of emulsifier, and microcapsules produced thereby
US3884801A (en) * 1972-05-02 1975-05-20 Us Interior Preparation of reverse osmosis membranes by complete evaporation of the solvent system
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3952741A (en) * 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4056610A (en) * 1975-04-09 1977-11-01 Minnesota Mining And Manufacturing Company Microcapsule insecticide composition
US3977404A (en) * 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4016880A (en) * 1976-03-04 1977-04-12 Alza Corporation Osmotically driven active agent dispenser
HU174057B (hu) * 1976-09-17 1979-10-28 Richter Gedeon Vegyeszet Sostav dlja pokrytij obespechivajuhhij uregulirovannuju otdachy aktivnogo vehhestva biologicheski aktivnykh preparatov i sposob poluchenija takikh preparatov s uregulirovannoj otdachej aktivnogo vehhestva
US4203439A (en) * 1976-11-22 1980-05-20 Alza Corporation Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
CA1086226A (fr) * 1976-11-26 1980-09-23 Yegnaswami Raghunathan Preparations pharmaceutiques a liberation lente composees d'une resine echangeuse d'ions
US4160452A (en) * 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4251387A (en) * 1979-04-17 1981-02-17 Damon Corporation Process for preparing semipermeable microcapsules
IL59063A (en) * 1979-01-11 1983-12-30 Key Pharma Polymeric diffusion matrix for release of pharmaceutical dosage
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
US4423009A (en) * 1980-04-02 1983-12-27 Aluminium Pechiney Carbonate, sulphate and hydroxide or hydrogen carbonate
US4333972A (en) * 1980-06-25 1982-06-08 Puropore, Inc. Highly anisotropic membranes
ATE10582T1 (de) * 1981-01-22 1984-12-15 Capsugel A.G. Verfahren zur herstellung pharmazeutischer, darmloeslicher kapseln.
DE3264867D1 (en) * 1981-04-27 1985-08-29 Haessle Ab New pharmaceutical preparation
ZA822995B (en) * 1981-05-21 1983-12-28 Wyeth John & Brother Ltd Slow release pharmaceutical composition
FR2514261B1 (fr) * 1981-10-08 1986-08-22 Aec Chim Organ Biolog Nouvelle composition pour l'enrobage des aliments et des medicaments et granules ainsi enrobes
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4439196A (en) * 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4455143A (en) * 1982-03-22 1984-06-19 Alza Corporation Osmotic device for dispensing two different medications
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4557925A (en) * 1982-07-08 1985-12-10 Ab Ferrosan Membrane-coated sustained-release tablets and method
DK152744C (da) * 1982-08-13 1988-10-31 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4576604A (en) * 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
GB8322007D0 (en) * 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
US4563212A (en) * 1983-12-27 1986-01-07 Monsanto Company High concentration encapsulation by interfacial polycondensation
US4643764A (en) * 1984-01-09 1987-02-17 Stauffer Chemical Company Multiple types of microcapsules and their production
DE3404310A1 (de) * 1984-02-08 1985-08-08 Henkel KGaA, 4000 Düsseldorf Verwendung von salicylsaeureestern als riechstoffe und diese enthaltende riechstoffkompositionen
US4684524A (en) * 1984-03-19 1987-08-04 Alza Corporation Rate controlled dispenser for administering beneficial agent
NL8401912A (nl) * 1984-06-15 1986-01-02 Tno Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan.
DE3485618D1 (de) * 1984-08-17 1992-04-30 Wellcome Found Zusammensetzung zur kontrollierten abgabe eines wirkstoffes und ihre herstellung.
US4629619A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4629620A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
SE8404467D0 (sv) * 1984-09-06 1984-09-06 Ferrosan Ab Controlled-release medical preparations
BR8506634A (pt) * 1984-12-20 1986-09-09 Rhone Poulenc Sante Composicoes para o revestimento de aditivos alimentares destinados aos ruminantes e granulados sob forma de microcapsulas assim revestidos
FR2577227B1 (fr) * 1985-02-11 1987-05-15 Inst Nat Rech Chimique Membranes asymetriques ou composites a base de polyquinoxalines, leur application possible en permeation gazeuse et plus particulierement pour le fractionnement des melanges gazeux, et notamment la deshydratation et la desacidification des gaz, specialement les hydrocarbures gazeux
ES8801121A1 (es) * 1985-02-19 1988-01-01 Key Pharma Procedimiento de fabricacion de una unidad de dosificacion para la administracion oral de cloruro potasico.
US4609374A (en) * 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
US4693896A (en) * 1985-10-07 1987-09-15 Fmc Corporation Ethylcellulose-coated, gastric-disintegrable aspirin tablet
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
SE450087B (sv) * 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
US4892742A (en) * 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
JPS62197183A (ja) * 1986-02-24 1987-08-31 Nisshinbo Ind Inc 表面多孔性プラスチツクシ−トの製造方法
ES2019634B3 (es) * 1986-04-17 1991-07-01 Alza Corp Terapia con clorfeniramina.
US4816264A (en) * 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
US4786500A (en) * 1986-06-26 1988-11-22 Alza Corporation Programmable agent delivery system
US4803076A (en) * 1986-09-04 1989-02-07 Pfizer Inc. Controlled release device for an active substance
US4767789A (en) * 1986-10-21 1988-08-30 American Home Products Corporation (Del.) Spray dried acetaminophen
US4828705A (en) * 1986-10-31 1989-05-09 Kingston Technologies, Inc. Pressure-dependent anisotropic-transport membrane system
US4954381A (en) * 1986-12-30 1990-09-04 The Research Foundation Of The State University Of New York Preparation of porous substrates having well defined morphology
US4837111A (en) * 1988-03-21 1989-06-06 Alza Corporation Dosage form for dispensing drug for human therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041210A1 (fr) * 1980-05-31 1981-12-09 Hoechst Aktiengesellschaft Procédé pour la préparation de microcapsules résistant à la pression, contenant une pellicule extérieure en polyamide et une structure intérieure en polyuréthane-polyurée
EP0357369B1 (fr) * 1988-08-30 1993-05-12 Pfizer Inc. Utilisation de membranes asymétriques en dispositifs de libération

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 90, no. 20, May 1979, Columbus, Ohio, US; abstract no. 153125C, E.SHCHORI ET AL.: 'semipermeable composite microcapsules' page 36 ;column 1 ; see abstract *
WORLD PATENTS INDEX LATEST Week 8734, Derwent Publications Ltd., London, GB; AN 87--239745 (34) & JP,A,62 163 702 (NIPPON OIL SEAL IND) 20 July 1987 see abstract *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2281758C2 (ru) * 1999-09-29 2006-08-20 Новартис Аг Композиции с контролируемым высвобождением для перорального применения

Also Published As

Publication number Publication date
FI930509L (fi) 1993-02-05
JPH0794379B2 (ja) 1995-10-11
CA2087435A1 (fr) 1992-02-08
WO1992002212A2 (fr) 1992-02-20
US5876752A (en) 1999-03-02
EP0542926B1 (fr) 1995-02-15
IE912781A1 (en) 1992-02-12
ES2067957T3 (es) 1995-04-01
IE65403B1 (en) 1995-10-18
JPH05509107A (ja) 1993-12-16
EP0542926A1 (fr) 1993-05-26
PT98571A (pt) 1993-09-30
DE69107461T2 (de) 1995-06-22
GR3015731T3 (en) 1995-07-31
FI108610B (fi) 2002-02-28
CA2087435C (fr) 1998-05-05
DE9190107U1 (de) 1993-12-16
PT98571B (pt) 1999-03-31
DE69107461D1 (de) 1995-03-23
ATE118345T1 (de) 1995-03-15
FI930509A0 (fi) 1993-02-05
DK0542926T3 (da) 1995-05-15

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