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WO1991013606A2 - Utilisation de 3,7-dimethyloctan-1-ol et dans des compositions cosmetiques et dermatologiques - Google Patents

Utilisation de 3,7-dimethyloctan-1-ol et dans des compositions cosmetiques et dermatologiques Download PDF

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Publication number
WO1991013606A2
WO1991013606A2 PCT/EP1991/000468 EP9100468W WO9113606A2 WO 1991013606 A2 WO1991013606 A2 WO 1991013606A2 EP 9100468 W EP9100468 W EP 9100468W WO 9113606 A2 WO9113606 A2 WO 9113606A2
Authority
WO
WIPO (PCT)
Prior art keywords
dimethyloctan
cosmetic
preparations according
effective
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1991/000468
Other languages
German (de)
English (en)
Other versions
WO1991013606A3 (fr
Inventor
Jürgen JACOB
Udo Hoppe
Ulrich Eigener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1991013606A2 publication Critical patent/WO1991013606A2/fr
Publication of WO1991013606A3 publication Critical patent/WO1991013606A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/04—Nail coating removers

Definitions

  • the present invention relates to antimicrobial agents.
  • the invention relates to antimycetic and antibacterial compositions, preferably cosmetic or dermatological formulations.
  • Human skin is of a variety
  • Microorganisms colonized. Some of them are inconspicuous, others, especially coryneform bacteria, are able to enzymatically break down the odorless fresh sweat. The result is unpleasant body odor.
  • Staphylococcus aureus Attempts to selectively destroy or at least decimate the gram-positive bacteria and at the same time protect the physiological skin flora are so far without any noteworthy success.
  • Dermatomycoses are diseases in which certain types of fungi, especially dermatophytes, penetrate the skin and hair follicles. The symptoms of dermatomycoses are
  • Clothing, jewelry or footwear can accumulate moisture and heat.
  • the athlete's foot is one of the best known and most widespread dermatomycoses. Fungal diseases of the finger and toenail areas are still particularly unpleasant.
  • Dermatomycoses are treated with medication or with other methods, for example with light radiation.
  • the previously known antimycetic agents have the disadvantage that they smell unpleasant and / or additionally irritate the affected area of the skin. In severe cases of dermatomycosis, the drug can even cause severe pain.
  • the object of the present invention was therefore to provide an antimicrobial agent which does not have the disadvantages of the prior art
  • Bacteria such as staphylococci should be destroyed or at least greatly decimated, but the physiological microflora of the skin should be protected.
  • the agents should not irritate the skin.
  • compositions with an effective content of 3,7-dimethyloctan-1-ol according to the present invention
  • compositions according to the invention are not only suitable for the purposes described, but moreover are more effective and
  • 3,7-Dimethyloctan-1-ol is very effective against dermatophytes and staphylococci and leaves the physiological microflora of the human skin largely unaffected.
  • the 3S configuration, the 3R configuration and any mixtures of 3S and 3R configuration are well suited for the use according to the invention. It is particularly advantageous to use the racemate.
  • compositions containing 0.01-10.0% by weight of 3,7-dimethyloctane 1-ol, based on the total weight of the composition are preferred.
  • compositions advantageously contain 0.02-1.00% by weight of 3,7-dimethyloctan-1-ol, particularly advantageously 0.03-0.75% by weight, based on the total weight of the
  • 3,7-Dimethyloctan-1-ol can be easily incorporated into common cosmetic or dermatological formulations, advantageously in pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, nail care products (e.g. nail polishes, nail polish remover, nail balms) and the like.
  • nail care products e.g. nail polishes, nail polish remover, nail balms
  • a pH range of 2.5 - 7.5 is advantageous. It is particularly favorable to choose the pH in a range from 3.5 to 4.8.
  • additives and / or additives may also be advantageous to incorporate additives and / or additives into the formulations, e.g.
  • compositions for example preservatives, antioxidants, photostabilizers, etc.
  • a base coat is made from the following components:
  • the information in the examples relates to
  • compositions according to the invention correspond to the compositions according to the invention
  • Examples 1 to 7 are excellent fungistatic and
  • Gram-positive bacteria and fungi are effective. This could be checked using the following organisms:
  • Trichophyton mentagrophytes very effective
  • Microsporum gypseum very effective
  • Staphylococcus aureus well effective
  • Staphylococcus epidermidis effective
  • Propionibacteria acnes effective
  • 3,7-Dimethyloctan-1-ol can be used particularly advantageously to prevent the further spread of new infections with athlete's foot, for example in public swimming pools and other public communal facilities.
  • water-thinnable concentrates according to Example 7 can be used, which are diluted with water to a concentration of about 0.3 to 1% 3,7-dimethyloctan-1-ol for foot disinfection.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

On utilise du 3,7-diméthyloctan-1-ol à l'état pur, comme substance à effet antimicrobien, ou comme substance active dans des compositions cosmétiques ou dermatologiques à effet antimicrobien.
PCT/EP1991/000468 1990-03-15 1991-03-13 Utilisation de 3,7-dimethyloctan-1-ol et dans des compositions cosmetiques et dermatologiques Ceased WO1991013606A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904008307 DE4008307A1 (de) 1990-03-15 1990-03-15 Verwendung von 3,7-dimethyloctan-1-ol als antimikrobieller wirkstoff sowie als wirksames prinzip in antimikrobiell wirksamen kosmetischen und dermatologischen zubereitungen
DEP4008307.1 1990-03-15

Publications (2)

Publication Number Publication Date
WO1991013606A2 true WO1991013606A2 (fr) 1991-09-19
WO1991013606A3 WO1991013606A3 (fr) 1991-11-28

Family

ID=6402285

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000468 Ceased WO1991013606A2 (fr) 1990-03-15 1991-03-13 Utilisation de 3,7-dimethyloctan-1-ol et dans des compositions cosmetiques et dermatologiques

Country Status (2)

Country Link
DE (1) DE4008307A1 (fr)
WO (1) WO1991013606A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2353579A1 (fr) * 2010-02-09 2011-08-10 Unilever N.V. Composition déodorante

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025244A1 (fr) * 2007-07-27 2009-02-18 Basf Se Nourriture pour animaux comportant du tétrahydrogéraniol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1961152A1 (de) * 1968-12-09 1970-06-25 Kolmar Laboratories Fungizid und bakterizid wirkendes Mittel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2353579A1 (fr) * 2010-02-09 2011-08-10 Unilever N.V. Composition déodorante
WO2011099849A3 (fr) * 2010-02-09 2012-04-05 Unilever N.V. Composition désodorisante

Also Published As

Publication number Publication date
WO1991013606A3 (fr) 1991-11-28
DE4008307A1 (de) 1991-09-19

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