WO1991013606A2 - Use of 3,7-dimethyloctan-1-ol in cosmetic and dermatological preparations - Google Patents
Use of 3,7-dimethyloctan-1-ol in cosmetic and dermatological preparations Download PDFInfo
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- WO1991013606A2 WO1991013606A2 PCT/EP1991/000468 EP9100468W WO9113606A2 WO 1991013606 A2 WO1991013606 A2 WO 1991013606A2 EP 9100468 W EP9100468 W EP 9100468W WO 9113606 A2 WO9113606 A2 WO 9113606A2
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- dimethyloctan
- cosmetic
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- contain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A61Q3/02—Nail coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A61Q3/04—Nail coating removers
Definitions
- the present invention relates to antimicrobial agents.
- the invention relates to antimycetic and antibacterial compositions, preferably cosmetic or dermatological formulations.
- Human skin is of a variety
- Microorganisms colonized. Some of them are inconspicuous, others, especially coryneform bacteria, are able to enzymatically break down the odorless fresh sweat. The result is unpleasant body odor.
- Staphylococcus aureus Attempts to selectively destroy or at least decimate the gram-positive bacteria and at the same time protect the physiological skin flora are so far without any noteworthy success.
- Dermatomycoses are diseases in which certain types of fungi, especially dermatophytes, penetrate the skin and hair follicles. The symptoms of dermatomycoses are
- Clothing, jewelry or footwear can accumulate moisture and heat.
- the athlete's foot is one of the best known and most widespread dermatomycoses. Fungal diseases of the finger and toenail areas are still particularly unpleasant.
- Dermatomycoses are treated with medication or with other methods, for example with light radiation.
- the previously known antimycetic agents have the disadvantage that they smell unpleasant and / or additionally irritate the affected area of the skin. In severe cases of dermatomycosis, the drug can even cause severe pain.
- the object of the present invention was therefore to provide an antimicrobial agent which does not have the disadvantages of the prior art
- Bacteria such as staphylococci should be destroyed or at least greatly decimated, but the physiological microflora of the skin should be protected.
- the agents should not irritate the skin.
- compositions with an effective content of 3,7-dimethyloctan-1-ol according to the present invention
- compositions according to the invention are not only suitable for the purposes described, but moreover are more effective and
- 3,7-Dimethyloctan-1-ol is very effective against dermatophytes and staphylococci and leaves the physiological microflora of the human skin largely unaffected.
- the 3S configuration, the 3R configuration and any mixtures of 3S and 3R configuration are well suited for the use according to the invention. It is particularly advantageous to use the racemate.
- compositions containing 0.01-10.0% by weight of 3,7-dimethyloctane 1-ol, based on the total weight of the composition are preferred.
- compositions advantageously contain 0.02-1.00% by weight of 3,7-dimethyloctan-1-ol, particularly advantageously 0.03-0.75% by weight, based on the total weight of the
- 3,7-Dimethyloctan-1-ol can be easily incorporated into common cosmetic or dermatological formulations, advantageously in pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, nail care products (e.g. nail polishes, nail polish remover, nail balms) and the like.
- nail care products e.g. nail polishes, nail polish remover, nail balms
- a pH range of 2.5 - 7.5 is advantageous. It is particularly favorable to choose the pH in a range from 3.5 to 4.8.
- additives and / or additives may also be advantageous to incorporate additives and / or additives into the formulations, e.g.
- compositions for example preservatives, antioxidants, photostabilizers, etc.
- a base coat is made from the following components:
- the information in the examples relates to
- compositions according to the invention correspond to the compositions according to the invention
- Examples 1 to 7 are excellent fungistatic and
- Gram-positive bacteria and fungi are effective. This could be checked using the following organisms:
- Trichophyton mentagrophytes very effective
- Microsporum gypseum very effective
- Staphylococcus aureus well effective
- Staphylococcus epidermidis effective
- Propionibacteria acnes effective
- 3,7-Dimethyloctan-1-ol can be used particularly advantageously to prevent the further spread of new infections with athlete's foot, for example in public swimming pools and other public communal facilities.
- water-thinnable concentrates according to Example 7 can be used, which are diluted with water to a concentration of about 0.3 to 1% 3,7-dimethyloctan-1-ol for foot disinfection.
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- Birds (AREA)
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- Insects & Arthropods (AREA)
- Pest Control & Pesticides (AREA)
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- Wood Science & Technology (AREA)
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Abstract
Description
Beschreibung description
Vervendung von 3,7-Dimethyloctan-1-ol als antimikrobielier Wirkstoff sowie als wirksames Prinzip in antimikrobiell wirksamen kosmetischen und dermatologischen Zubereitungen Use of 3,7-dimethyloctan-1-ol as an antimicrobial active ingredient and as an effective principle in antimicrobial cosmetic and dermatological preparations
Die vorliegende Erfindung betrifft antimikrobiell wirksame Mittel. Insbesondere betrifft die Erfindung antimycetisch und antibakteriell wirksame Zusammensetzungen, bevorzugt von kosmetischen oder dermatologischen Formulierungen. The present invention relates to antimicrobial agents. In particular, the invention relates to antimycetic and antibacterial compositions, preferably cosmetic or dermatological formulations.
Die menschliche Haut ist von einer Vielzahl an Human skin is of a variety
Mikroorganismen besiedelt. Manche davon sind unauffällig, andere, namentlich coryneforme Bakterien, sind imstande, den an sich geruchlosen frischen Schweiß enzymatisch zu zersetzen. Die Folge ist unangenehmer Körpergeruch. Microorganisms colonized. Some of them are inconspicuous, others, especially coryneform bacteria, are able to enzymatically break down the odorless fresh sweat. The result is unpleasant body odor.
Weiterhin sind gerade unter den grampositiven Kokken einige Vertreter, die ausgesprochen pathogen sind, z.B. Furthermore, there are some representatives among the gram-positive cocci that are extremely pathogenic, e.g.
Staphylococcus aureus. Versuche, selektiv die grampositiven Bakterien zu vernichten oder wenigstens zu dezimieren, und gleichzeitig die physiologische Hautflora zu schonen, sind bisher ohne nennenswerten Erfolg geblieben. Staphylococcus aureus. Attempts to selectively destroy or at least decimate the gram-positive bacteria and at the same time protect the physiological skin flora are so far without any noteworthy success.
Dermatomykosen sind Krankheiten, bei der gewisse Pilzarten, insbesondere Dermatophyten, in die Haut und Haarfollikel eindringen. Die Symptome von Dermatomykosen sind Dermatomycoses are diseases in which certain types of fungi, especially dermatophytes, penetrate the skin and hair follicles. The symptoms of dermatomycoses are
beispielsweise Bläschen, Exfoliation, Rhagaden und Erosion, verbunden mit Juckreiz oder allergischem Ekzem. for example blisters, exfoliation, rhagades and erosion, associated with itching or allergic eczema.
Alle Bereiche der menschlichen Haut können von All areas of human skin can be affected by
Dermatomykosen befallen werden. Besonders häufig jedoch sind die Körperbereiche betroffen, auf welchen sich durch Dermatomycoses. However, the areas of the body that are affected are particularly often affected
Kleidung, Schmuck oder Schuhwerk Feuchtigkeit und Wärme stauen können. So gehört der Fußpilz zu den bekanntesten und am weitesten verbreiteten Dermatomykosen. Besonders unangenehm sind weiterhin Pilzerkrankungen der Finger- und Fußnägelbereiche. Clothing, jewelry or footwear can accumulate moisture and heat. The athlete's foot is one of the best known and most widespread dermatomycoses. Fungal diseases of the finger and toenail areas are still particularly unpleasant.
Behandelt werden Dermatomykosen medikamentös oder mit anderen Methoden, beispielsweise mit Lichtbestrahlung. Dermatomycoses are treated with medication or with other methods, for example with light radiation.
Gängige Medikamente sind Salicylsäure, Kresol, 1-Menthol und andere, die alle äußerlich angewandt werden und regelmäßig gute Heilerfolge zeitigen. Common medications are salicylic acid, cresol, 1-menthol and others, all of which are used externally and regularly produce good healing results.
Dennoch haben die bisher bekannten antimycetisch wirksamen Mittel den Nachteil daß sie unangenehm riechen und/oder die beeinträchtigte Hautpartie zusätzlich reizen. In schweren Fällen von Dermatomykosen kann durch das Medikament sogar schwerer Schmerz ausgelöst werden. Die Aufgabe der vorliegenden Erfindung war also, ein antimikrobiell wirksames Mittel zur Verfügung zu stellen, welches die Nachteile des Standes der Technik nicht Nevertheless, the previously known antimycetic agents have the disadvantage that they smell unpleasant and / or additionally irritate the affected area of the skin. In severe cases of dermatomycosis, the drug can even cause severe pain. The object of the present invention was therefore to provide an antimicrobial agent which does not have the disadvantages of the prior art
aufweist. Insbesondere sollten Mittel zugängig gemacht werden, die folgende Bedingungen erfüllen: having. In particular, funds should be made available that meet the following conditions:
1) Die biologischen Vorgänge der Haut dürfen nicht 1) The biological processes of the skin must not
beeinträchtigt werden. be affected.
2) Die Mittel sollen keinen ausgeprägten Eigengeruch 2) The agents should not have a distinct smell
besitzen. have.
3) Sie sollen bei Überdosierung oder sonstiger nicht 3) You should not overdose or otherwise
bestimmungsgemäßer Anwendung unschädlich sein. intended use are harmless.
4) Sie sollen sich nach wiederholter Anwendung nicht auf der Haut anreichern. 4) They should not accumulate on the skin after repeated use.
5) Dermatophyten und bestimmte pathogene grampositive 5) Dermatophytes and certain pathogenic gram-positive
Bakterien wie Staphylokokken sollen vernichtet oder wenigstens stark dezimiert werden, die physiologische Mikroflora der Haut aber geschont werden. Bacteria such as staphylococci should be destroyed or at least greatly decimated, but the physiological microflora of the skin should be protected.
6) Die wirksamen Prinzipien sollen sich gut in 6) The effective principles should work well in
handelsübliche kosmetische oder dermatoiogische commercially available cosmetic or dermatological
Formulierungen einarbeiten lassen. Have the wording incorporated.
7) Die Mittel sollen die Haut nicht reizen. 7) The agents should not irritate the skin.
Es wurde gefunden, und darin liegt die Lösung der Aufgabe, daß 3,7-Dimethyloctan-1-ol und kosmetische oder It has been found and this is the solution to the problem that 3,7-dimethyloctan-1-ol and cosmetic or
deraatologische Zubereitungen mit einem wirksamen Gehalt an 3,7-Dimethyloctan-1-ol, den Nachteilen des Standes der Technik abhelfen. 3,7-Dimethyloctan-1-ol ist durch die Strukturformel dermatological preparations with an effective content of 3,7-dimethyloctan-1-ol remedy the disadvantages of the prior art. 3,7-Dimethyloctan-1-ol has the structural formula
Es war erstaunlich und für den Fachmann nicht vorhersehbar, daß It was astonishing and unforeseeable for the expert that
- 3,7-Dimethyloctan-1-ol gegen Pilze und grampositive - 3,7-Dimethyloctan-1-ol against fungi and gram-positive
Bakterien wie Staphylokokken wirksam sein würde. Bacteria like staphylococci would be effective.
Weiterhin war erstaunlich, daß kosmetische und It was also astonishing that cosmetic and
dermatologische Zusammensetzungen mit einem wirksamen Gehalt an 3,7-Dimethyloctan-1-ol gemäß der vorliegenden Erfindung dermatological compositions with an effective content of 3,7-dimethyloctan-1-ol according to the present invention
- bei der Lagerung stabil sein würden - would be stable during storage
- eine genügend hohe Halbwertszeit auf der Haut besitzen würden - would have a sufficiently high half-life on the skin
- zur Anwendung als kosmetisches oder dermatologisches - For use as a cosmetic or dermatological
Mittel geeignet sein würden Funds would be suitable
Insbesondere war erstaunlich, daß die erfindungsgemäßen Zusammensetzungen nicht nur für die beschriebenen Zwecke geeignet sind, sondern überdies besser wirksam und In particular, it was surprising that the compositions according to the invention are not only suitable for the purposes described, but moreover are more effective and
schonender sind als die Zusammensetzungen des Standes der Technik. 3,7-Dimethyloctan-1-ol ist gut wirksam gegen Dermatophyten und Staphylokokken und läßt die physiologische Mikroflora der menschlichen Haut weitgehend unbehelligt. are gentler than the compositions of the prior art. 3,7-Dimethyloctan-1-ol is very effective against dermatophytes and staphylococci and leaves the physiological microflora of the human skin largely unaffected.
Die 3S-Konfiguration, die 3R-Konfiguration sowie beliebige Mischungen aus 3S- und 3R-Konfiguration sind für die erfindungsgemäße Verwendung gut geeignet. Besonders vorteilhaft ist es, das Racemat einzusetzen. The 3S configuration, the 3R configuration and any mixtures of 3S and 3R configuration are well suited for the use according to the invention. It is particularly advantageous to use the racemate.
Es ist erfindungsgemäß an sich möglich und vorteilhaft, 3,7-Dimethyloctan-1-ol als reinen Stoff einzusetzen, dennoch hat sich herausgestellt, daß Zusammensetzungen, enthaltend 0,01 - 10,0 Gew.-% an 3,7-Dimethyloctan-1-ol, bezogen auf das Gesamtgewicht der Zusammensetzung bevorzugt sind. According to the invention it is possible and advantageous per se to use 3,7-dimethyloctan-1-ol as the pure substance, but it has been found that compositions containing 0.01-10.0% by weight of 3,7-dimethyloctane 1-ol, based on the total weight of the composition, are preferred.
Vorteilhaft enthalten die Zusammensetzungen 0,02 - 1,00 Gew.-% 3,7-Dimethyloctan-1-ol, besonders vorteilhaft 0,03 - 0,75 Gew.-%, bezogen auf das Gesamtgewicht der The compositions advantageously contain 0.02-1.00% by weight of 3,7-dimethyloctan-1-ol, particularly advantageously 0.03-0.75% by weight, based on the total weight of the
Zusammensetzung. Composition.
3,7-Dimethyloctan-1-ol läßt sich ohne Schwierigkeiten in gängige kosmetische oder dermatologische Formulierungen einarbeiten, vorteilhaft in Pumpsprays, Aerosolsprays, Cremes, Salben, Tinkturen, Lotionen, Nagelpflegeproάukte (z.B. Nagellacke, Nagellackentferner, Nagelbalsame) und dergleichen. 3,7-Dimethyloctan-1-ol can be easily incorporated into common cosmetic or dermatological formulations, advantageously in pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, nail care products (e.g. nail polishes, nail polish remover, nail balms) and the like.
Es ist auch möglich und gegebenenfalls vorteilhaft, It is also possible and advantageous if
3,7-Dimethyloctan-1-ol mit anderen Wirkstoffen zu 3,7-Dimethyloctan-1-ol with other active ingredients
kombinieren, beispielsweise mit anderen antimikrobiell wirksamen Stoffen. combine, for example with other antimicrobial effective substances.
Es ist vorteilhaft, die erfindungsgemäßen Zusammensetzungen abzupuffern. Vorteilhaft ist ein pH-Bereich von 2,5 - 7,5. Besonders günstig ist es, den pH-Wert in einem Bereich von 3,5 - 4,8 zu wählen. It is advantageous to buffer the compositions according to the invention. A pH range of 2.5 - 7.5 is advantageous. It is particularly favorable to choose the pH in a range from 3.5 to 4.8.
Es kann ferner von Vorteil sein, den Formulierungen Hiifs- und/oder Zusatzstoffe einzuverleiben, z.B. It may also be advantageous to incorporate additives and / or additives into the formulations, e.g.
- solche, die die Stabilität der Zusammensetzungen erhöhen, beispielsweise Konservierungsstoffe, Antioxidantien, Photostabilisatoren usw., - those which increase the stability of the compositions, for example preservatives, antioxidants, photostabilizers, etc.,
- übliche Kosmetikrohstoffe, z.B. Fette, öle, Wachse, - usual cosmetic raw materials, e.g. Fats, oils, waxes,
Emuigatoren, Parfüm, Farbstoffe Emuigators, perfume, dyes
- übliche Rohstoffe der Galenik - Common raw materials in galenics
Ansonsten sind die üblichen Maßregeln für das Otherwise, the usual measures for that
Zusammenstellen von kosmetischen oder dermatologischen Formulierungen zu beachten, die dem Fachmann geläufig sind. Compilation of cosmetic or dermatological formulations to be observed, which are familiar to the expert.
Die folgenden Beispiele dienen dazu, die Erfindung zu beschreiben, ohne daß beabsichtigt ist, die Erfindung auf diese Beispiele zu beschränken. Beispiel 1 The following examples serve to describe the invention, without intending to limit the invention to these examples. example 1
Pumpspray Pump spray
Ethanol pharm. (96 %) 615,0Ethanol pharm. (96%) 615.0
Ethoxyliertes Glycerinmonococoat (7E0) 15,0 3,7-Dimethyloctan-1-ol 5,0Ethoxylated glycerol monococoate (7E0) 15.0 3,7-dimethyloctan-1-ol 5.0
Parfüm, Farbstoff nach BeliebenPerfume, dye at will
Wasser auf 1 000,0 Water to 1,000.0
Beispiel 2 Example 2
Aerosolspray Aerosol spray
Ethanol pharm. (96 %) 213,5Ethanol pharm. (96%) 213.5
1,2-Propylenglycol 30,01,2-propylene glycol 30.0
Octyldodecanol 1,0Octyldodecanol 1.0
3,7-Dimethyloctan-1-ol 4,03,7-dimethyloctan-1-ol 4.0
Isopropylmyristat 0,1Isopropyl myristate 0.1
Parfüm, Farbstoff nach BeliebenPerfume, dye at will
Treibgas auf 1 000,0 Beispiel 3 Propellant to 1,000.0 Example 3
Ölige Zubereitung Oily preparation
Ethoxyliertes Glycerinmonococoat (7EO) 100,0Ethoxylated glycerol monococoate (7EO) 100.0
Ethanol pharm. (96 %) 100,0Ethanol pharm. (96%) 100.0
3,7-Dimethyloctan-1-ol 40,03,7-dimethyloctan-1-ol 40.0
PPG-3-Myristylether 608,0PPG-3 myristyl ether 608.0
C 12-C 15-Alkohoibenzoat 152,0 C 12 -C 15 alcohol benzoate 152.0
1000,0 1000.0
Beispiel 4 Example 4
Dickflüssige Lotion Thick lotion
Ethoxylierter Fettalkohol (25 EO) 20,0Ethoxylated fatty alcohol (25 EO) 20.0
Cetylstearylalkohol 30,0Cetylstearyl alcohol 30.0
Paraffinöl 44,5Paraffin oil 44.5
3,7-Dimethyloctan-1-ol 5,53,7-dimethyloctan-1-ol 5.5
Propylenglycol 30,0Propylene glycol 30.0
Polyvinylpyrrolidon 5,0Polyvinyl pyrrolidone 5.0
Parfüm, Farbstoff, nach BeliebenPerfume, dye, as you like
Konservierungsmittel nach BeliebenPreservatives at will
Wasser auf 1 000,0 Beispiel 5 Water to 1,000.0 Example 5
Dünnflüssige Lotion Thin liquid lotion
Ethoxylierter Fettalkohol (25 EO) 10,0Ethoxylated fatty alcohol (25 EO) 10.0
Ethoxylierter Fettalkohol ( 6 EO) 10,0Ethoxylated fatty alcohol (6 EO) 10.0
Glycerinmonodistearat 20,0Glycerol monodistearate 20.0
Cetylalkohol 10,0Cetyl alcohol 10.0
Isopropylayristat 14,5Isopropylayristat 14.5
3 ,7-Dimethyloctan-1-ol 5,53,7-dimethyloctan-1-ol 5.5
Glycerin 10,0Glycerin 10.0
Polyvinylpyrrolidon 5,0Polyvinyl pyrrolidone 5.0
Parfüm nach BeliebenPerfume at will
Konservierungsmittel nach BeliebenPreservatives at will
Wasser auf 1 000,0 Water to 1,000.0
Beispiel 6 Example 6
Wäßrige Zubereitung Aqueous preparation
Polyfettsäureester 150,0Poly fatty acid ester 150.0
3,7-Dimethyloctan-1-ol 10,03,7-dimethyloctan-1-ol 10.0
PPG-3-Myristylether 10,0PPG-3 myristyl ether 10.0
1,2-Propylenglycol 30,01,2-propylene glycol 30.0
Glycerin 400,0Glycerin 400.0
Parfüm nach BeliebenPerfume at will
Wasser auf 1 000,0 Beispiel 7 Water to 1,000.0 Example 7
Konzentrat (wasserverdünnbar) Concentrate (water-dilutable)
Ethoxyliertes Glycerinmonococoat (7EO) 750,0Ethoxylated glycerol monococoate (7EO) 750.0
3,7-Dimethyloctan-1-ol 50,03,7-dimethyloctan-1-ol 50.0
PPG-3-Myristylether 50,0PPG-3 myristyl ether 50.0
1,2-Propylenglycol 150,0 1,2-propylene glycol 150.0
Beispiel 8 Example 8
Nagellack nail polish
Es wird ein Grundlack aus folgenden Bestandteilen angefertigt: A base coat is made from the following components:
Nitrocellulose E 510 feucht 250,0Nitrocellulose E 510 moist 250.0
Acronal 700 L 170,0Acronal 700 L 170.0
Uresin B 40,0Uresin B 40.0
Dibutylphthalat 30,0Dibutyl phthalate 30.0
Ethylacetat 200,0Ethyl acetate 200.0
Butylacetat 250,0Butyl acetate 250.0
Ethylglycol 40,0Ethyl glycol 40.0
Methoxybutanol 20,0 Methoxybutanol 20.0
1 000,0 1,000.0
In den vorstehend charakterisierten Grundlack werden 8a) 2,0 Gew.-% 3 ,7-Dimethyloctan-1-ol In the base coat characterized above 8a) 2.0% by weight of 3, 7-dimethyloctan-1-ol
8b) 2,5 Gew.-% 3 ,7-Dimethyloctan-1-ol 8b) 2.5% by weight of 3, 7-dimethyloctan-1-ol
8c) 3,0 Gew-.% 3,7-Dimethyloctan-1-ol 8c) 3.0% by weight of 3,7-dimethyloctan-1-ol
8d) 3,5 Gew.-% 3,7-Dimethyloctan-1-ol 8d) 3.5% by weight of 3,7-dimethyloctan-1-ol
8e) 4,0 Gew.-% 3,7-Dimethyloctan-1-ol eingearbeitet. 8e) 4.0% by weight of 3,7-dimethyloctan-1-ol incorporated.
Beispiel 9 Example 9
Nagellackentferner nail polish remover
PPG-20-Methylglucoseether (Glucan P20) 80,0PPG-20 methyl glucose ether (Glucan P20) 80.0
Ethylacetat 350,0Ethyl acetate 350.0
Aceton 350,0Acetone 350.0
Isopropylalkohol 200,0Isopropyl alcohol 200.0
3,7-Dimethyioctan-1-ol 20,0 3,7-dimethyioctan-1-ol 20.0
1 000,0 1,000.0
Beispiel 10 Example 10
Nagelbalsam Nail balm
Mischester aus Pentaerythrit-Fettalkohol, Fettsäure, Citronensäure Mixed ester of pentaerythritol fatty alcohol, fatty acid, citric acid
(Dehymuls E) 100,0 (Dehymuls E) 100.0
Decyloleat 120,0 Decyl oleate 120.0
Bienenwachs 30,0 Beeswax 30.0
Vaseline 150,0 Vaseline 150.0
2-Ethylhexylpalmitat 50,0 2-ethylhexyl palmitate 50.0
Coco-Caprylat/Caproat 30,0 Coco-Caprylate / Caproat 30.0
3,7-Dimethyloctan-1-ol 20,0 3,7-dimethyloctan-1-ol 20.0
Wasser ad 1000,0 Water ad 1000.0
Die Angaben in den Beispielen beziehen sich jeweils auf The information in the examples relates to
Gewichtsteile. Parts by weight.
Die erfindungsgemäßen Zusammensetzungen entsprechend den The compositions according to the invention correspond to the
Beispielen 1 bis 7 sind hervorragend fungistatisch und Examples 1 to 7 are excellent fungistatic and
bakteriostatisch wirksam. Insbesondere hat sich bacteriostatically effective. In particular has
herausgestellt, daß die Zusammensetzungen gut gegen found that the compositions were good against
grampositive Bakterien und Pilze wirksam sind. Dies konnte anhand folgender Organismen überprüft werden: Gram-positive bacteria and fungi are effective. This could be checked using the following organisms:
Trichophyton rubrum : sehr gut wirksam Trichophyton rubrum: very effective
Trichophyton mentagrophytes : sehr gut wirksam Microsporum gypseum : sehr gut wirksam Trichophyton mentagrophytes: very effective Microsporum gypseum: very effective
Candida albicans : gut wirksam Candida albicans: very effective
Aspergillus niger : gut wirksam Aspergillus niger: well effective
Staphylococcus aureus : gut wirksam Staphylococcus aureus: well effective
Staphylococcus epidermidis : wirksam Staphylococcus epidermidis: effective
Propionibakterien acnes : wirksam Propionibacteria acnes: effective
Besonders günstig läßt sich 3,7-Dimethyloctan-1-ol zur Verhinderung der Weiterverbreitung von Neuinfektionen mit Fußpilzen beispielswiese in öffentlichen Schwimmbädern und anderen öffentlichen Gemeinschaftsanlagen einsetzen. Dazu können beispielsweise wasserverdunnbare Konzentrate entsprechend Beispiel 7 benutzt werden, die für die Fußdesinfektion mit Wasser auf eine Konzentration von etwa 0,3 bis 1% 3,7-Dimethyloctan-1-ol verdünnt werden. 3,7-Dimethyloctan-1-ol can be used particularly advantageously to prevent the further spread of new infections with athlete's foot, for example in public swimming pools and other public communal facilities. For this purpose, for example, water-thinnable concentrates according to Example 7 can be used, which are diluted with water to a concentration of about 0.3 to 1% 3,7-dimethyloctan-1-ol for foot disinfection.
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19904008307 DE4008307A1 (en) | 1990-03-15 | 1990-03-15 | USE OF 3,7-DIMETHYLOCTAN-1-OL AS AN ANTIMICROBIAL ACTIVE AGGREGATE AND AS EFFECTIVE PRINCIPLE IN ANTIMICROBIAL EFFECTIVE COSMETIC AND DERMATOLOGICAL PREPARATIONS |
| DEP4008307.1 | 1990-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1991013606A2 true WO1991013606A2 (en) | 1991-09-19 |
| WO1991013606A3 WO1991013606A3 (en) | 1991-11-28 |
Family
ID=6402285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1991/000468 Ceased WO1991013606A2 (en) | 1990-03-15 | 1991-03-13 | Use of 3,7-dimethyloctan-1-ol in cosmetic and dermatological preparations |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE4008307A1 (en) |
| WO (1) | WO1991013606A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2353579A1 (en) * | 2010-02-09 | 2011-08-10 | Unilever N.V. | Deodorant composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025244A1 (en) * | 2007-07-27 | 2009-02-18 | Basf Se | Feed containing tetrahydrogeraniol |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1961152A1 (en) * | 1968-12-09 | 1970-06-25 | Kolmar Laboratories | Bactericidal and fungicidal skin preparation - with middle chain alcohols |
-
1990
- 1990-03-15 DE DE19904008307 patent/DE4008307A1/en not_active Withdrawn
-
1991
- 1991-03-13 WO PCT/EP1991/000468 patent/WO1991013606A2/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2353579A1 (en) * | 2010-02-09 | 2011-08-10 | Unilever N.V. | Deodorant composition |
| WO2011099849A3 (en) * | 2010-02-09 | 2012-04-05 | Unilever N.V. | Deodorant composition |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991013606A3 (en) | 1991-11-28 |
| DE4008307A1 (en) | 1991-09-19 |
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