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WO1991004260A3 - Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine - Google Patents

Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine Download PDF

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Publication number
WO1991004260A3
WO1991004260A3 PCT/US1990/005172 US9005172W WO9104260A3 WO 1991004260 A3 WO1991004260 A3 WO 1991004260A3 US 9005172 W US9005172 W US 9005172W WO 9104260 A3 WO9104260 A3 WO 9104260A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
methylenedioxy
camptothecin
ch2ch2ch2n
ch2ch2n
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/005172
Other languages
English (en)
Other versions
WO1991004260A2 (fr
Inventor
Monroe E Wall
Mansukh C Wani
Allan W Nicholas
Govindarajan Manikumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RTI International Inc
Original Assignee
RTI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RTI International Inc filed Critical RTI International Inc
Priority to KR1019920700585A priority Critical patent/KR0180245B1/ko
Priority to CA002066780A priority patent/CA2066780C/fr
Publication of WO1991004260A2 publication Critical patent/WO1991004260A2/fr
Publication of WO1991004260A3 publication Critical patent/WO1991004260A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Analogues de camptothécine ayant la structure illustrée par les formules (I) ou (II), dans lesquelles Z représente H ou alkyle contenant 1 à 8 atomes de carbone, et R représente NO2NH2N3 hydrogène, halogène, COOH, OH, alkyle O-C1-3, SH, alkyle S-C1-3, CN, CH2NH2, alkyle NH-C1-3, alkyle CH2-NH-C1-3, N(alkyle C1-3)2, CH2N(alkyle C1-3)2, O-, NH- ou S-CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2CH2N(CH2CH2OH)2, O-, NH- ou S-CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2N(alkyle C1-3)2, O-, NH- ou S-CH2CH2CH2N(alkyle C1-3)2, CHO, alkyle contenant 1 à 3 atomes de carbone ou NHCOCHR?1NR2R3, où R1¿ représente la chaîne latérale d'un acide aminé α et R2 et R3 représentent indépendamment hydrogène ou un groupe alkyle inférieur, où R3 représente une unité pepditique contenant 1 à 3 unités d'acides aminés liées à l'azote par une liaison peptidique; NHCO-C¿2-8?-alkylène-X, ou NHCO-C1-8-alcénylène-X où X représente COOH; CONR?2-(CH¿2)n-NR2R3, où n = 1-10, et R2 ainsi que R3 sont définis comme précédemment; NHCO-B-(CH¿2?)n-NR?2R3¿, où B = oxygène ou NH, ou la formule (III) dans laquelle m + y = 3-6, ainsi que leurs sels.
PCT/US1990/005172 1989-09-15 1990-09-17 Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine Ceased WO1991004260A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019920700585A KR0180245B1 (ko) 1989-09-15 1990-09-17 10,11-메틸렌디옥시-20(rs)-캠프토테신 및 10,11-메틸렌디옥시-20(s)-캠프토테신 동족체
CA002066780A CA2066780C (fr) 1989-09-15 1990-09-17 Analogues de la 10,11-methylenedioxy-20(rs)-camptothecine et de la 10,11-methylenedioxy-20(s)-camptothecine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40777989A 1989-09-15 1989-09-15
US407,779 1989-09-15
USNOTFURNISHED 1991-10-31

Publications (2)

Publication Number Publication Date
WO1991004260A2 WO1991004260A2 (fr) 1991-04-04
WO1991004260A3 true WO1991004260A3 (fr) 1991-05-02

Family

ID=23613497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/005172 Ceased WO1991004260A2 (fr) 1989-09-15 1990-09-17 Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine

Country Status (1)

Country Link
WO (1) WO1991004260A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254480A (en) * 1992-02-20 1993-10-19 Minnesota Mining And Manufacturing Company Process for producing a large area solid state radiation detector
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
JPH0873461A (ja) * 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
JP4094710B2 (ja) 1997-11-06 2008-06-04 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
WO2015148415A2 (fr) * 2014-03-26 2015-10-01 Canget Biotekpharma, Llc Utilisation de la plate-forme structurale chimique centrale de fl118 pour produire des dérivés de fl118 pour le traitement d'une maladie humaine
CA3168882A1 (fr) * 2020-02-25 2021-09-02 Mediboston, Inc. Derives de camptothecine et leurs utilisations
CN116712562A (zh) * 2022-12-29 2023-09-08 杭州爱科瑞思生物医药有限公司 N-叠氮烷基取代的喜树碱衍生物的抗体偶联药物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4914205A (en) * 1987-06-25 1990-04-03 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4914205A (en) * 1987-06-25 1990-04-03 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 88, No. 16, 20 Augustus 1966, WALL et al. *

Also Published As

Publication number Publication date
WO1991004260A2 (fr) 1991-04-04

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