PT95324A - Processo de preparacao de 20(s) ou 20(rs)-camptotecinas, dos seus sais e intermediarios e de composicoes farmaceuticas que os contem - Google Patents
Processo de preparacao de 20(s) ou 20(rs)-camptotecinas, dos seus sais e intermediarios e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT95324A PT95324A PT9532490A PT9532490A PT95324A PT 95324 A PT95324 A PT 95324A PT 9532490 A PT9532490 A PT 9532490A PT 9532490 A PT9532490 A PT 9532490A PT 95324 A PT95324 A PT 95324A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- camptothecin
- amino
- group
- methylenedioxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000003915 DNA Topoisomerases Human genes 0.000 title 1
- 108090000323 DNA Topoisomerases Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 229940127093 camptothecin Drugs 0.000 abstract 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 3
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical compound [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001414 amino alcohols Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
- -1 cyclic diamine Chemical class 0.000 abstract 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40777989A | 1989-09-15 | 1989-09-15 | |
| US07/581,916 US5180722A (en) | 1987-04-14 | 1990-09-13 | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT95324A true PT95324A (pt) | 1991-05-22 |
| PT95324B PT95324B (pt) | 1997-06-30 |
Family
ID=27020007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT9532490A PT95324B (pt) | 1989-09-15 | 1990-09-14 | Processo de preparacao de 20(s) ou 20(rs)-camptotecinas, dos seus sais e intermediarios e de composicoes farmaceuticas que os contem |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU640950B2 (pt) |
| IE (1) | IE903347A1 (pt) |
| PT (1) | PT95324B (pt) |
-
1990
- 1990-09-14 IE IE334790A patent/IE903347A1/en not_active IP Right Cessation
- 1990-09-14 PT PT9532490A patent/PT95324B/pt not_active IP Right Cessation
- 1990-09-17 AU AU63404/90A patent/AU640950B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IE903347A1 (en) | 1991-04-10 |
| AU6340490A (en) | 1991-04-18 |
| AU640950B2 (en) | 1993-09-09 |
| PT95324B (pt) | 1997-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910115 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19970320 |
|
| MM4A | Annulment/lapse due to non-payment of fees;searched & examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20090921 |