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WO1991001796A1 - Systeme de filtrage a mouvement orbital/oscillatoire sans joint d'etancheite rotatif - Google Patents

Systeme de filtrage a mouvement orbital/oscillatoire sans joint d'etancheite rotatif Download PDF

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Publication number
WO1991001796A1
WO1991001796A1 PCT/US1990/004206 US9004206W WO9101796A1 WO 1991001796 A1 WO1991001796 A1 WO 1991001796A1 US 9004206 W US9004206 W US 9004206W WO 9101796 A1 WO9101796 A1 WO 9101796A1
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WO
WIPO (PCT)
Prior art keywords
filter
container
fluid
filtration system
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/004206
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English (en)
Inventor
Yao-Tzu Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YT Li Engineering Inc
Original Assignee
YT Li Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YT Li Engineering Inc filed Critical YT Li Engineering Inc
Publication of WO1991001796A1 publication Critical patent/WO1991001796A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16—Rotary, reciprocated or vibrated modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2033—By influencing the flow dynamically
    • B01D2321/2041—Mixers; Agitators

Definitions

  • This invention relates in general to filtration systems and in particular to a filtration system useful in the down-stream processing of biologically manufactured products.
  • a product such as a protein or enzyme is produced by cells in a bio-reactor.
  • the cells are immersed in a processing fluid and the product is released into the fluid.
  • difficulties in separating the product from the process fluid and undesired material carried by the fluid "downstream", of the bio-reactor has been a significant limitation on the utilization of this approach manufacturing, as compared to artificial, . chemical production of the product.
  • One desirable feature of a filter is to minimize the piling up of he particles in front of the filter, a phenomenon known as polarization, which seriously diminish the flux rate of the filtration process.
  • One conventional method to alleviate the polarization is to use a cross flow arrangement as is commonly used in spiral wound or hollow fiber types.
  • a more direct scheme is to use a propeller-shaped stirrer placed in the vicinity of the filter surface to produce a turbulence to clear up the polarized filter surface.
  • Another scheme involves a cylindrical-shaped filter rotating inside a fixed mating cylinder where a set of ring-shaped vortices, known as Taylor vortices, will be induced in the gap between the filter and the stationary cylinder to provide the mechanism of generating the stirring motion of the fluid to clear up the polarization.
  • Taylor vortices a set of ring-shaped vortices
  • Direct drive rotary filters utilizing Taylor vortices for anti-polarization effect
  • the Membrex system involves the use-of an inward flowing rotary filter cartridge driven to rotate by a magnetic drive coupling to avoid one rotary seal.
  • the flow passage of the filtrant from the inside volume of container still must be contained by a rotary seal to have a total sealed system.
  • a rotary filter can sustain much higher flow rate per unit area then the cross flow types.
  • a rotary motion is involved with the need of some form of rotary seal which is objectional for biotech applications.
  • Another principal object is to provide a filtration system with the foregoing advantages that produces a low level of shear and mechanical action on cells and other particles carried in the fluid.
  • a further principal object is to provide a filtration system with the foregoing advantages that uses no rotary seals in the container.
  • Still another object is to provide a system with the foregoing advantages which may be scaled up in size without sacrificing a favorable surface/volume ratio.
  • Another object is to provide a filtration system with all of the foregoing advantages which is reliable, has a comparatively simple construction, and has a favorable cost of manufacture.
  • a system for filtering suspended particles from a fluid particularly a system for downstream processing of the process fluid of a bio-reactor in the production of biological products, has a filter mounted within a closed container having a fluid inlet and fluid outlets for the retentate and the filtrate, including the product.
  • the inlet and outlet(s) are secured to the container in a non-rotating manner.
  • the filter is typically a cylindrical membrane or mesh.
  • a key aspect of this invention is an arrangement to depolarize the inlet side of the filter without having a drive shaft that penetrates the container and requires a rotary seal, which is highly effective, and which does not damage cells and/or the product due to mechanical action or fluid shear forces.
  • One class of embodiments of the present invention uses dynamically coupled filters driven by an orbital/oscillatory motion applied to its container so that flexible tubings may be used to conduct* the processing fluids in and out of the system without the need of any rotary seal.
  • the motion of an orbital drive swings a blade, whip rod, the filter itself, or an eccentrically weighted cylinder mounted within the filter to produce a turbulence at the inlet side of the filter or to produce Taylor vortices.
  • These revolving elements are mounted within the container at their top and bottom for a free pivotal rotation in response to the orbital motion.
  • the container may have multiple filters and associated depolarizing members, such as surrounding tubes, blades, whip rods, etc., mounted within one container.
  • the filter or the container is suspended by an elastic conduit which exerts a spring force in a torsional mode.
  • a drive rotates the filter or the container in an oscillatory manner with the oscillation resisted by the torsional spring force of the coupling.
  • the mutual oscillatory motion produces Taylor vortices in the fluid disposed between the filter and the container.
  • the filtered fluid outlet from the filter is in part the elastic conduit and a magnetic drive oscillates the filter.
  • the conduit supports the container and a direct mechanical drive is coupled to the elastic " conduit at a point over the container.
  • Figure 1 is a simplified view in perspective, with portions broken away, of an orbital drive filter according to the present invention with revolving blade;
  • Figure 2 is a view in horizontal section of the rotating blade filter shown in Fig. 1;
  • Figure 3 is a view in horizontal section of an orbital drive rotating cylinder filter according to the present ' invention.
  • Figure 4 is a simplified perspective view of the filter system of the general type shown in Fig. 3 showing the formation of Taylor vortices;
  • Figure 5 is a graph of the flux for various types of filters as function of time
  • Figure 6 is a simplified view in horizontal section of an oscillating type filter according to the present invention.
  • Figure 7 is a graph showing the acceleration, velocity and centrifugal force of the oscillating type filter shown in Fig. 6 as a function * of time;
  • Figure 8 is a simplified view in vertical section along the line 8-8 in Fig. 9 of a multi-tube orbital drive filter according to the present invention.
  • Figure 9 is a simplified view in horizontal section along the line 9-9 in Fig. 8;
  • Figure 10 is a simplified view inside elevation of an orbital drive platform according to the present invention.
  • Figure 11 is a simplified view in vertical section of a multi-tube oscillatory filter
  • Figure 12 is a simplified view in vertical section of a filter system according to the present invention utilizing an orbital whip rod;
  • Figure 13 is a simplified view in vertical section of a filter system according to the present inyention with an orbiting filter cartridge
  • Figure 14 is a view in vertical section of a direct drive oscillatory filter with magnetic coupling according to the present invention.
  • Figure 15 is a view in vertical section of a. direct drive oscillatory filter with flexible seal.
  • FIG. 1 illustrates a simple orbital drive filter system according to the present invention with a revolving blade 4 inside a cylindrical filter 3 to perform the anti-polarization effect on the inlet (interior as shown) side of the filter 3.
  • the filter is preferably formed of a membrane material such as the uniform pore size material sold by Millipore Corp. of Bedford, Massachusetts.
  • a conventional laboratory orbital shaker 1 provides the orbital drive.
  • a filter container 2 is mounted with stand-offs 10.
  • the filter 3, which is cylindrical, is mounted inside the container 2.
  • Chamber 5 defines the space inside the filter and an annular chamber 6 defines the space outside the filter.
  • Fluid to be filtered is fed through inlet port 7 into chamber 5 and exits through outlet port 8 as the retentate (or "filtrant").
  • a pressure gradiant e.g. 10 psi
  • the flow stream of the retentate that passes from the inlet 7 and out through outlet 8 can help to sweep away some of the particles that piled behind the filter. This is known as the cross flow anti-polarization effect and is used in each embodiment of the invention in conjunction with other depolarizing techniques.
  • the rotary blade 4 is hinged to revolve freely about the axis 11-11' .
  • the blade 4 is made of material heavier than the density of the fluid so that under the influence of the orbital motion it will push the fluid inside the chamber 5 to revolve as shown by arrow 12 at the orbiting speed 13 of the shaker 1.
  • the blade 4 is preferably formed of a rigid structural material that is compatible with the fluids being processed. Stainless steel is suitable.
  • a narrow gap is maintained between the outer edge of blade 4 and the inside surface of the filter to avoid direct rubbing, but the turbulence created at the gap is quite effective to sweep away the particles piling up due to filtration.
  • Fig. 2 is a cross section view of Fig. 1 showing the relationship of the container 2, the filter 3 and the wiper blade 4.
  • Fig. 3 shows an orbital drive rotating cylinder filter system .of the present invention. Like parts in the various figures are denoted with the same reference number.
  • the only change is the replacing of the wiper blade 4 by a rotating cylinder 14 which is also pivotally mounted to rotate freely about the center axis 11-11'.
  • the mass center 15 of cylinder 14 is displaced away from axis 11-11' by a radius r so that in response to the orbital motion 13 the cylinder will revolve as indicated by arrow 12.
  • Sector 16 represents a heavy bar that may be used to shift the mass center 15 away from the axis 11-11'.
  • Fig. 4 illustrates the effect of a revolving cylinder 17 inside a stationary cylinder 18 upon the fluid that fills the gap between the two cylinders.
  • the gap is generally uniform.
  • Arrow 20 represents the tangential velocity of the fluid near the surface of cylinder 17 which revolves with a speed indicated by the arrow 19.
  • a centrifugal force " 21 which tends to move the fluid outwardly as shown by the interface between vortices 23 and 24.
  • the fluid thus moves outwardly to reach the stationary cylinder 18, its tangential velocity will slow down with the consequence of a lowering of the centrifugal force as represented by arrow 22.
  • the outwardly moving fluid will have a higher centrifugal force than the inwardly moving fluid and thereby creates a condition for sustaining a sequence of ring-shaped vortices, known as Taylor vortices. These vortices are more effective for the depolarization of filters than the cross flow scheme.
  • Taylor vortices can be generated only when the inside cylinder is rotating to create the centrifugal force gradiant.
  • function of either the inside cylinder 17 or the outside cylinder 18 may be performed by the filter 3.
  • the filter 3 as shown corresponds to the stationary cylinder 18 of Fig. 4, while cylinder 14 has a non-porous wall and corresponds to the rotating cylinder 17.
  • the container 2 collects the retentate.
  • cylinder 14 of Fig. 3 may be the filter with the position of the filter 3 taken up by a non-porous cylinder and with the elimination of cylinder 2.
  • the arrangement of Fig. 3 corresponds directly to Figs.
  • Fig. 5 illustrates typical performances of three kinds of filters.
  • Curve 26 shows that the flux (flow rate per unit area per unit pressure gradiant) of a simple filter drops from the initial value of Uo down to the zero base line very quickly.
  • Curve 27 represents the situation with cross flow while curve 28 represents that of a rotary filter of the present invention.
  • Fig. 6 illustrates an oscillatory cylindrical filter system where the cylinder 17 oscillates about pivot 11 with a double amplitude of angle ⁇ inside a stationary cylinder 18.
  • a centrifugal force vector 31 On the surface of cylinder 17 every point would experience a tangential velocity vector 30, a centrifugal force vector 31 and a tangential acceleration vector 32.
  • Fig. 7 illustrates the time function of the magnitude of these three vectors. Since the centrifugal force is proportional to the square of the tangential velocity, it remains positive at all times. For this reason there exists the necessary condition of generating vortices as shown in Fig. 4.
  • the tangential acceleration is an effective means of shaking loose those particles polarizing the filter surface.
  • Fig. 8 illustrates a multi-tube orbital drive filter with its horizontal cross-sectional view shown in Fig. 9.
  • Filter tubes 3 are outward flowing type with their outside wall reinforced with grid structure 38 inside the container 35.
  • the grid structure can be an open lattice of extruded plastic cemented to the filter where the materials chosen are compatible with the fluid being processed.
  • the two ends of the filter tubes are connected to chambers 36 and 37 to. receive process fluid from an inlet port 40 and to discharge the retentate through an outlet 41.
  • the filtrate collected from the outside surfaces of tubes 3 passes through the grid 38 and is discharged through port 42.
  • each tube 3 there is a cylinder 14 with an Qff-axis mass center so that it will be driven by an orbital-type drive to rotate with respect to axis 11-11' and to generate Taylor vortices in the annular gap between cylinder 14 and filter cylinder 3 to achieve the desired anti-polarization effect.
  • a full-sized system of the type shown in Fig. 8 can weigh thousands of pounds and with a life, load varying according to the amount of fluid it carries. It* is important to dynamically balance a system of this kind that is in orbital motion. Even for a small laboratory-sized filter system, the setup shown in Fig. 1 by mounting the filter on top of a laboratory orbital shake table, operational stability cannot be • assured with the system running at the effective speed. Therefore, the proven orbital drive system of the type described and illustrated in applicant's U.S. Patent 4,762, 592, is preferred. The disclosure of this patent is incorporated herein by reference. A system of this type is, however, also shown in Fig. 10.
  • the filter container 35 of Figure 8 is shown in Fig. 10 as being supported by a number of struts 52 through elastic couplers 53 and 54 upon the base plate 50.
  • the elastic support keeps the system standing upright with a certain degree of freedom for lateral movement, ' such as to maintain a lateral mode of natural frequency around one Hertz.
  • the supports allow a wobbling orbital motion of the container 35, but resist a revolving of the system.
  • this mass center 55 of the counterweight system is illustrated by the use of two counterweights 55',55' one above and one below the filter system 35.
  • the counterweight 55 As the counterweight 55 is driven to revolve with respect to mass center 101, they will automatically seek a common axis 100-100' to balance each other. This axis 100-100' may go through a spiral pattern as the system gets started.
  • system 35 also carries many other revolving bodies such as the filter cylinders 14 of Fig. 8 and each cylinder revolves under the influence of the orbital motion of system 35 against certain viscous drag. All of these dynamic loadings will affect the relative location and phase angles between the mass centers of the counterweight and the main system 35.
  • the orbital filter of Figs. 8 and 10 may be driven to move in an orbital/oscillatory mode by driving the counterweights 55 in an oscillatory swing.
  • the orbital filter system 35 may be driven to move in an oscillatory arc with respect to a fixed frame work. Detail dynamic tuning of this type of system to operate at or near a natural frequency is preferred. Those skilled in the art will readily calculate or empirically determine the desired values for variables such as the length of the struts, the stiffness of the supports and the mass of the container.
  • Fig. 11 shows another orbital/oscillatory filter system according to the present invention with the filtrate passing inward through the surface of each filter tube and then upwardly to flow through a flexible hose 61 into chamber 60.
  • each filter tube may be secured by a pivot or by a torsional spring 62 to achieve some tuning effect. Note that the container of Fig. 11 must be driven to oscillate through an angle ⁇ , and that this is the appropriate manner to use the inward flowing filter 17 without a rotary seal,
  • Fig. 11 The system shown in Fig. 11 involves oscillating filter 17 inside non-porous tubes 18 which may be packed closely inside the shell 35. This is different from the construction of Fig. 8 where a grid structure is used to separate the filter tubes.
  • Fig. 12 shows another form of orbital filter system according to the present invention where a whip rod 65 is driven to revolve and is guided by two cables 66 and 67 so that rod 65 revolves, but does not rotate in contrast to the blade 4 of Figs. 1 and 2.
  • the lengths of the cables 66 and 67 allows the whip rod to move around the inside surface of the filter tube 3 in a closely spaced relationship to avoid wear and excessive shear forces on the material being processed.
  • Fig. 13 shows ' yet another orbital filter system with a filter cartridge 3' coupled to a flexible tube 70.
  • the cartridge is loaded by a dead .weight 72 to provide the needed offset of the mass center in a submerged system in order to respond to the orbital drive.
  • Guide, rings 71 made of a low friction material such as that sold under the trade designation Teflon are mounted at the exterior of the filter cartridge 3' at its upper and lower ends to maintain the desired gap between the filter cartridge and the surrounding tube.
  • Fig. 14 shows a direct drive oscillatory filter system where a flexible tube 92 supports the filter 3" and forms parts of the outlet conduit 9 for the filtrate.
  • the filter 3" has a cylindrical membrane, mesh or other porous material forming its side walls, but is enclosed by non-porous end walls 3a and 3b.
  • a magnetic coupling 93 and 94 drives the filter 3 in an angular oscillatory mode 76 to produce oscillatory Taylor Vortices in the chamber 5 to depolarize the inward flow filter.
  • Chamber 79 secured to bottom end wall 3a is shown as a void space ' to minimize the volume of the chamber of the filter.
  • the tube 92 is preferable a length of rubber hose with a sufficient torsional spring constant to develope a natural resonant oscillation of the filter at the desired speed and amplitude to produce a good depolarization.
  • the tube is suspended from a cap 90 mounted on a rigid sleeve 91 extending from the upper wall of the container 2.
  • the cap 90 has a central opening that provides an outlet 9 for the filtrate.
  • the retentate exits outlet 8 at the bottom wall of the container.
  • the lower end of the tube 92 is open to an outlet opening in the upper end wall 3b.
  • Fig. 15 is a further improvement of Fig. 14 to drive the filter 3 in oscillatory mode 76 directly by a crank shaft 75 through hollow shaft 78 inside a flexible hose 77, also preferably of rubber.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

L'invention se rapporte à un système de filtrage pour un fluide contenant des particules suspendues, sur lequel est monté un filtre (3) à l'intérieur d'un récipient fermé (2) présentant une entrée (7) pour le fluide et des sorties (8, 9) pour le fluide filtré et le fluide retenu. L'entrée et les sorties communiquent avec l'intérieur du récipient sans effectuer de mouvement de rotation par rapport à lui. Un organe d'entraînement (1) orbital et/ou oscillatoire imprime au récipient soit un mouvement de nutation continu soit un mouvement oscillatoire. Dans une forme de réalisation, un élément mécanique (4) pivote autour du côté d'entrée du filtre. Dans une autre forme de réalisation, un cylindre rotatif (17) avec un centre de gravité excentrique effectue un mouvement de révolution ou un mouvement oscillatoire par rapport à un cylindre non poreux circonvoisin (18), afin de créer des tourbillons de Taylor dans le fluide. Dans un autre mode de réalisation à entraînement direct, un conduit (92) débouchant à l'intérieur d'un élément de filtre fermé (3) ou un manchon (77) enveloppant soutenant le récipient (2) est constitué en un matériau élastiquement flexible.
PCT/US1990/004206 1989-08-01 1990-07-26 Systeme de filtrage a mouvement orbital/oscillatoire sans joint d'etancheite rotatif Ceased WO1991001796A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38824889A 1989-08-01 1989-08-01
US388,248 1989-08-01

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WO1991001796A1 true WO1991001796A1 (fr) 1991-02-21

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313708A1 (de) * 1993-04-27 1994-11-03 Robert Dr Med Tecl Querstromfilter
US5954674A (en) * 1997-10-13 1999-09-21 Kinex Iha Corporation Apparatus for gathering biomechanical parameters
US5991701A (en) * 1997-10-13 1999-11-23 Kinex Iha Corp. Method for improved instantaneous helical axis determination
RU2142330C1 (ru) * 1998-07-20 1999-12-10 Воронежская государственная технологическая академия Реверсивный мембранный аппарат
RU2148427C1 (ru) * 1998-10-20 2000-05-10 Воронежская государственная технологическая академия Мембранный аппарат с погружным фильтрующим элементом
DE202010000751U1 (de) * 2010-01-08 2011-05-12 Big Dutchman International Gmbh Antriebsvorrichtung für eine Membranfiltrationseinrichtung
WO2011103496A3 (fr) * 2010-02-18 2012-01-05 NAB & Associates, Inc. Filtration à membrane en spirale améliorée
RU2506990C1 (ru) * 2012-07-03 2014-02-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВПО "ВГУИТ") Мембранный аппарат с неустановившейся гидродинамикой
RU2560417C1 (ru) * 2014-04-22 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Воронежский государственный университет инженерных технологий (ФГБОУ ВПО ВГУИТ) Мембранный аппарат
WO2016200806A1 (fr) * 2015-06-08 2016-12-15 Becton, Dickinson And Company Extracteur à plasma
US10709370B2 (en) 2016-06-09 2020-07-14 Becton, Dickinson And Company Biological fluid separation device
WO2020226490A1 (fr) * 2019-05-03 2020-11-12 Jemp Holding Bv Matériau de lit rempli de chromatographie de nettoyage à l'aide d'un récipient de traitement, et ledit récipient
US11344851B2 (en) 2016-03-02 2022-05-31 Becton, Dickinson And Company Biological fluid separation device
US11344849B2 (en) 2015-06-08 2022-05-31 Becton, Dickinson And Company Filtration cell and method for filtering a biological sample
EP4292694A1 (fr) * 2022-06-16 2023-12-20 Levitronix GmbH Système de filtre rotatif, dispositif de filtre rotatif et système de séparation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618399A (en) * 1978-11-16 1986-10-21 Li Yao T Wobble tube evaporator with whip rod fluid distributor
US4713176A (en) * 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
US4762592A (en) * 1980-10-27 1988-08-09 Li Yao T Orbital drive evaporator
US4808307A (en) * 1985-12-23 1989-02-28 Haemonetics Corporation Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
US4871462A (en) * 1985-12-23 1989-10-03 Haemonetics Corporation Enhanced separation of blood components
US4876013A (en) * 1983-12-20 1989-10-24 Membrex Incorporated Small volume rotary filter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618399A (en) * 1978-11-16 1986-10-21 Li Yao T Wobble tube evaporator with whip rod fluid distributor
US4762592A (en) * 1980-10-27 1988-08-09 Li Yao T Orbital drive evaporator
US4876013A (en) * 1983-12-20 1989-10-24 Membrex Incorporated Small volume rotary filter
US4713176A (en) * 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
US4808307A (en) * 1985-12-23 1989-02-28 Haemonetics Corporation Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
US4871462A (en) * 1985-12-23 1989-10-03 Haemonetics Corporation Enhanced separation of blood components

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313708A1 (de) * 1993-04-27 1994-11-03 Robert Dr Med Tecl Querstromfilter
US5954674A (en) * 1997-10-13 1999-09-21 Kinex Iha Corporation Apparatus for gathering biomechanical parameters
US5991701A (en) * 1997-10-13 1999-11-23 Kinex Iha Corp. Method for improved instantaneous helical axis determination
RU2142330C1 (ru) * 1998-07-20 1999-12-10 Воронежская государственная технологическая академия Реверсивный мембранный аппарат
RU2148427C1 (ru) * 1998-10-20 2000-05-10 Воронежская государственная технологическая академия Мембранный аппарат с погружным фильтрующим элементом
DE202010000751U1 (de) * 2010-01-08 2011-05-12 Big Dutchman International Gmbh Antriebsvorrichtung für eine Membranfiltrationseinrichtung
US9101884B2 (en) 2010-02-18 2015-08-11 NAB & Associates, Inc. Enhanced spiral-wound membrane filtration
WO2011103496A3 (fr) * 2010-02-18 2012-01-05 NAB & Associates, Inc. Filtration à membrane en spirale améliorée
RU2506990C1 (ru) * 2012-07-03 2014-02-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВПО "ВГУИТ") Мембранный аппарат с неустановившейся гидродинамикой
RU2560417C1 (ru) * 2014-04-22 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Воронежский государственный университет инженерных технологий (ФГБОУ ВПО ВГУИТ) Мембранный аппарат
WO2016200806A1 (fr) * 2015-06-08 2016-12-15 Becton, Dickinson And Company Extracteur à plasma
US10549242B2 (en) 2015-06-08 2020-02-04 Becton Dickinson And Company Plasma extractor
US11344849B2 (en) 2015-06-08 2022-05-31 Becton, Dickinson And Company Filtration cell and method for filtering a biological sample
US11344851B2 (en) 2016-03-02 2022-05-31 Becton, Dickinson And Company Biological fluid separation device
US10709370B2 (en) 2016-06-09 2020-07-14 Becton, Dickinson And Company Biological fluid separation device
WO2020226490A1 (fr) * 2019-05-03 2020-11-12 Jemp Holding Bv Matériau de lit rempli de chromatographie de nettoyage à l'aide d'un récipient de traitement, et ledit récipient
EP4292694A1 (fr) * 2022-06-16 2023-12-20 Levitronix GmbH Système de filtre rotatif, dispositif de filtre rotatif et système de séparation

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