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WO1990014069A3 - Keratinocyte autocrine factor - Google Patents

Keratinocyte autocrine factor Download PDF

Info

Publication number
WO1990014069A3
WO1990014069A3 PCT/US1990/002884 US9002884W WO9014069A3 WO 1990014069 A3 WO1990014069 A3 WO 1990014069A3 US 9002884 W US9002884 W US 9002884W WO 9014069 A3 WO9014069 A3 WO 9014069A3
Authority
WO
WIPO (PCT)
Prior art keywords
kaf
methods
autocrine factor
keratinocyte autocrine
keratinocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1990/002884
Other languages
French (fr)
Other versions
WO1990014069A2 (en
Inventor
Gary D Shipley
Mark R Pittelkow
Paul W Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon State
Original Assignee
Oregon State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon State filed Critical Oregon State
Publication of WO1990014069A2 publication Critical patent/WO1990014069A2/en
Publication of WO1990014069A3 publication Critical patent/WO1990014069A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Keratinocyte autocrine factor (KAF) can be isolated from human keratinocytes and is an effective and selective mitogen for keratinocytes in comparison to fibroblasts. Methods of purifying KAF using sulfated glycosaminoglycans, methods to inhibit the effect of KAF using sulfated glycosaminoglycans, and methods to assay for stimulators and inhibitors of KAF activity and production are described.
PCT/US1990/002884 1989-05-12 1990-05-14 Keratinocyte autocrine factor Ceased WO1990014069A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35169589A 1989-05-12 1989-05-12
US351,695 1989-05-12

Publications (2)

Publication Number Publication Date
WO1990014069A2 WO1990014069A2 (en) 1990-11-29
WO1990014069A3 true WO1990014069A3 (en) 1991-01-10

Family

ID=23381973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/002884 Ceased WO1990014069A2 (en) 1989-05-12 1990-05-14 Keratinocyte autocrine factor

Country Status (2)

Country Link
AU (1) AU5816990A (en)
WO (1) WO1990014069A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068931A2 (en) 2003-02-07 2004-08-19 Protein Design Labs Inc. Amphiregulin antibodies and their use to treat cancer and psoriasis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874746A (en) * 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874746A (en) * 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C.R. LOWE and P.D.G. DEAN, "Affinity Chromatography", 1974, JOHN WILEY & SONS, New York, page 10. *
THE JOURNAL OF CELLULAR BIOCHEMISTRY, Supplement 13B, 21 January - 11 February 1989, New York, RHEINWALD et al.: "Introduction of a "Transforming" Gene (EJras or SV40-LT) into Normal, Diploid Human Mesothelial Cells, Fibroblasts, and Epidermal Keratinocytes Induced EGF-Independence and a Preneoplastic State Associated with Production of an Autocrine, Heparin-Binding Growth Factor", page 158. *

Also Published As

Publication number Publication date
WO1990014069A2 (en) 1990-11-29
AU5816990A (en) 1990-12-18

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