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WO1988008843A3 - New imidazols - Google Patents

New imidazols Download PDF

Info

Publication number
WO1988008843A3
WO1988008843A3 PCT/EP1988/000368 EP8800368W WO8808843A3 WO 1988008843 A3 WO1988008843 A3 WO 1988008843A3 EP 8800368 W EP8800368 W EP 8800368W WO 8808843 A3 WO8808843 A3 WO 8808843A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
alkoxycarbonyl
alkoxy
halogen
butenylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1988/000368
Other languages
German (de)
French (fr)
Other versions
WO1988008843A2 (en
Inventor
Joerg Senn-Bilfinger
Gerhard Grundler
Hartmann Shaefer
Kurt Klemm
Georg Rainer
Richard Riedel
Christian Schudt
Wolfgang Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of WO1988008843A2 publication Critical patent/WO1988008843A2/en
Publication of WO1988008843A3 publication Critical patent/WO1988008843A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I), in which R1 is H, halogen, alkyl, alkoxy, alkoxycarbonyl or cyanogen; R2 is H, alkyl, hydroxyalkyl, haloalkyl, cyanoalkyl or alkoxycarbonyl; R3 is H, alkyl, formyl, hydroxyalkyl, haloalkyl, cyanoalkyl, aminoalkyl, mono- or dialkylaminoalkyl, nitroso, nitro, amino, mono- or dialkylamino or alkoxycarbonyl; R4 is H, alkyl, alkoxy, halogen or trifluoromethyl; R5 is H, alkyl, alkoxy, halogen or trifluoromethyl; R6 is H or alkyl; n is 1 or 2; G1 is CH or N; G2 is O, NH, N-alkyl, S, (=CH-) or alkylene; G3 is ethylene, trimethylene, tetramethylene, pentamethylene, propenylene, 1-butenylene or 2-butenylene; G4 is S, O or (-CH=CH-). These compounds have interesting pharmacological properties. They have in particular a protective effect on the stomach and intestines of warm-blooded animals.
PCT/EP1988/000368 1987-05-08 1988-05-04 New imidazols Ceased WO1988008843A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH177187 1987-05-08
CH1771/87-0 1987-05-08

Publications (2)

Publication Number Publication Date
WO1988008843A2 WO1988008843A2 (en) 1988-11-17
WO1988008843A3 true WO1988008843A3 (en) 1988-12-01

Family

ID=4218204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1988/000368 Ceased WO1988008843A2 (en) 1987-05-08 1988-05-04 New imidazols

Country Status (6)

Country Link
EP (1) EP0290003A3 (en)
AU (1) AU1686088A (en)
IL (1) IL86269A0 (en)
PT (1) PT87426B (en)
WO (1) WO1988008843A2 (en)
ZA (1) ZA883169B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005136A1 (en) * 1988-11-07 1990-05-17 Byk Gulden Lomberg Chemische Fabrik Gmbh New imidazopyridines
KR910011852A (en) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 Imidazo [1,2-a] pyridinylalkyl compounds for the treatment of neurotoxin disorders
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
AU8712191A (en) * 1990-10-15 1992-05-20 Byk Gulden Lomberg Chemische Fabrik Gmbh New diazines
DE10145457A1 (en) 2001-09-14 2003-04-03 Basf Ag Substituted imidazo [1,2-a] -5,6,7,8-tetrahydropyridin-8-ones, process for their preparation and their use in the preparation of imidazo [1,2, -a] pyridines
EA008304B1 (en) * 2002-11-19 2007-04-27 Алтана Фарма Аг 8-substituted imidazopyridines
WO2007026218A2 (en) * 2005-09-01 2007-03-08 Pfizer Japan Inc. Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068378A1 (en) * 1981-06-26 1983-01-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0033094B1 (en) * 1980-01-23 1984-10-10 Schering Corporation Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
EP0204285B1 (en) * 1985-06-04 1992-01-15 Fujisawa Pharmaceutical Co., Ltd. Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0033094B1 (en) * 1980-01-23 1984-10-10 Schering Corporation Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
EP0068378A1 (en) * 1981-06-26 1983-01-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0204285B1 (en) * 1985-06-04 1992-01-15 Fujisawa Pharmaceutical Co., Ltd. Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
PT87426B (en) 1992-09-30
ZA883169B (en) 1988-11-08
WO1988008843A2 (en) 1988-11-17
EP0290003A3 (en) 1988-12-28
IL86269A0 (en) 1988-11-15
AU1686088A (en) 1988-12-06
EP0290003A2 (en) 1988-11-09
PT87426A (en) 1989-05-31

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