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WO1988008711A1 - Pharmaceutical substance - Google Patents

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Publication number
WO1988008711A1
WO1988008711A1 PCT/DE1988/000283 DE8800283W WO8808711A1 WO 1988008711 A1 WO1988008711 A1 WO 1988008711A1 DE 8800283 W DE8800283 W DE 8800283W WO 8808711 A1 WO8808711 A1 WO 8808711A1
Authority
WO
WIPO (PCT)
Prior art keywords
family
radix
pharmaceutical
pharmaceutical according
components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1988/000283
Other languages
German (de)
French (fr)
Inventor
Vladimir Badmajew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of WO1988008711A1 publication Critical patent/WO1988008711A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)

Definitions

  • the invention relates to a pharmaceutical which is predominantly and preferably composed exclusively of comminuted plant components and minerals.
  • the invention is based on the object of specifying a pharmaceutical of the type mentioned at the outset which has improved therapeutic properties. is tolerated better and is particularly suitable for the therapy of abdominal inflammation, especially of women, for example premenstrual syndrome, ureter inflammation, kidney inflammation and other weaknesses of the immune system (antiseptic system) in the lower abdomen.
  • Trichosante radix in the form of an infusion or tea has antiseptic, anti-inflammatory and analgesic properties.
  • Trichosantes is used in the pharmaceutical preparation for the treatment of pelvic inflammation.
  • Pelvic inflammation is mainly caused by venereal diseases, such as infection with gonorrhea and chlamydia.
  • Pelvic inflammation is also one of the most common causes of infertility in women.
  • the active components of Trichosantes are known as Cucurbitacine, they are common to the family to which Trichosantes belongs, namely the Cucurbitaceae.
  • Tribulus radix has been used in pharmaceutical preparation to improve and support the antiseptic and anti-inflammatory properties of Trichosantes.
  • This ingredient also has diuretic properties.
  • the combination of diuretic and antiseptic properties makes this ingredient suitable in the pharmaceutical preparation for the treatment of urinary tract infections, which are a common complication in venereal diseases of women.
  • Polygonum herba has its application in the pharmaceutical according to the invention due to the diuretic (diuretic) coupled with anti-inflammatory, antipyretic and analgesic properties.
  • Taraxacum radix has similar therapeutic properties to Polygonum and is used in pharmaceuticals to support the biological effects of Polygonum.
  • the decisive effect and the therapeutic effect of the pharmaceutical are achieved by the special combination of its four components.
  • the pharmaceutical is recommended for the treatment of premenstrual syndromes, whereby this condition is characterized by three groups of symptoms:
  • the pharmaceutical according to the invention has proven particularly successful in combating and alleviating symptom groups 1 and 2.
  • An even more important application of the pharmaceutical according to the invention lies in the prevention of complications which can arise from venereal diseases, in particular infertility.
  • the current, modern therapy for venereal diseases uses antibiotics which, although they fight the infection, are not effective in treating inflammation which can influence and destroy the normal anatomical conditions in the reproductive apparatus of women.
  • the pharmaceutical according to the invention should be used in combination with antibiotic treatment for anti-inflammatory and antiseptic therapy.
  • the pharmaceutical is taken orally.
  • the active ingredients are available in high oophatic dosage.
  • the four constituents mentioned, Trichosantes palmata, Polygonum aviculare, Tribulus terrestris and Tara ⁇ xacum officinale (dandelion) are present in a weight ratio of 30: 30: 30: 10.
  • the completely dry plant constituents are crushed into powder and either compressed to tablets at a sufficiently high pressure or filled into a waterproof infusion bag, which e.g. is made from a filter paper.
  • the tablets do not have a coating or any other protective cover, they have sufficient mechanical stability due to their compression and, if necessary, the addition of a binder (such as gum arabic or PVP). They are therefore suitable, for example, for blister packs in which the tablet has to be pressed through an aluminum foil in order to access it.
  • a binder such as gum arabic or PVP
  • the tablet Since the tablet has no coating, one can experience the typical taste of the four plant components when ingested. As a result, the therapeutic effect begins in the mouth, the patient is consciously adjusted to the therapeutic effect by the taste of the pharmaceutical.
  • an herbal tea is brewed from the plant-based ingredients, which is consumed hot (or at least warm) (drunk).
  • one gram of the dry, powder-fine (grain size 0.025 to 0.035 mm) mixture is poured into a small infusion bag and sealed.
  • the contents of the bag are brewed (leached out) in boiling water, the cooking time (with gentle cooking) is determined either by means of a clock or by letting the amount of water used evaporate to 1/3.
  • a suitable vessel for example made of heat-resistant glass
  • two fill lines is advantageous, an upper fill line indicating the volume of 3 cups and the lower fill line indicating the volume of a cup.
  • Such a herbal tea can also be made from a tablet, leaving only a residue of brewed herbs in the container. This sentence is separated or filtered. The brew (herbal tea) is drunk warm or hot.
  • a Einrar ⁇ mtablette which is to be taken orally, or a corresponding infusion bag filling for the preparation of a tea has the following composition:

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A pharmaceutical substance composed exclusively of vegetable components is suitable for the treatment of abdominal pain in particular in women, for example of the premenstrual syndrome. This pharmaceutical substance is composed of the following dehydrated and compressed substances in powder form: Trichosantes palmata (radix), of the family Cucurbitaceae; Polygonum aviculare (herba), of the family Polygonaceae; Tribulus terrestris (radix), of the family Zygophylae, Taraxacum officinale (radix), of the family Compositae.

Description

Pharmazeutikum Pharmaceutical

Die Erfindung bezieht sich auf ein Pharmazeutikum, das vorwiegend und vorzugsweise ausschließlich aus zerkleinerten, pflanzlichen Bestand¬ teilen und Mineralien zusammengesetzt ist.The invention relates to a pharmaceutical which is predominantly and preferably composed exclusively of comminuted plant components and minerals.

Der Erfindung liegt die Aufgabe zugrunde, ein Pharmazeutikum der ein¬ gangs genannten Art anzugeben, das verbesserte therapeutische Eigen¬ schaften hat. besser toleriert wird und speziell für die Therapie von Unterleibsentzündungen insbesondere von Frauen, beispielsweise des Prä¬ menstruationssyndroms, Harnleiterentzündungen, Nierenentzündungen und anderen Schwächen des Immunapparates (antiseptischen Systems) im Unter¬ leib geeignet ist.The invention is based on the object of specifying a pharmaceutical of the type mentioned at the outset which has improved therapeutic properties. is tolerated better and is particularly suitable for the therapy of abdominal inflammation, especially of women, for example premenstrual syndrome, ureter inflammation, kidney inflammation and other weaknesses of the immune system (antiseptic system) in the lower abdomen.

Diese Aufgabe wird gelöst durch ein Pharmazeutikum mit den Merkmalen de Anspruchs 1. Zu den Bestandteilen:This object is achieved by a pharmaceutical with the features of claim 1. Regarding the components:

Trichosantes radix hat in der Form eines Aufgusses bzw. Tees antisepti¬ sche, entzündungshemmende und analgetische Eigenschaften. In der pharma zeutischen Zubereitung wird Trichosantes eingesetzt für die Behandlung von Beckenentzündungen. Beckenentzündungen werden im wesentlichen durch Geschlechtskrankheiten hervorgerufen, wie beispielsweise Infektion mit Gonorrhoe und Chlamydia. Beckenentzündungen sind auch eine der häufig¬ sten Ursachen für Unfruchtbarkeit bei Frauen. Die aktiven Wirkbestand¬ teile von Trichosantes sind als Cucurbitacine bekannt, sie sind der Familie, zu der Trichosantes gehört, nämlich der Cucurbitaceae, gemein.Trichosante radix in the form of an infusion or tea has antiseptic, anti-inflammatory and analgesic properties. Trichosantes is used in the pharmaceutical preparation for the treatment of pelvic inflammation. Pelvic inflammation is mainly caused by venereal diseases, such as infection with gonorrhea and chlamydia. Pelvic inflammation is also one of the most common causes of infertility in women. The active components of Trichosantes are known as Cucurbitacine, they are common to the family to which Trichosantes belongs, namely the Cucurbitaceae.

Tribulus radix wurde in der pharmazeutischen Zubereitung benutzt um die antiseptischen und entzündungshemmenden Eigenschaften von Trichosantes zu verbessern und zu stützen. Dieser Bestandteil hat auch harntreibende Eigenschaften. Die Kombination von harntreibenden und antiseptischen Eigenschaften macht diesen Bestandteil geeignet in der pharmazeutischen Zubereitung für die Behandlung von Harnweginfektionen, die eine häufige Komplikation bei Geschlechtskrankheiten von Frauen bilden. Polygonum herba hat in dem erfindungsgemäßen Pharmazeutikum seine An¬ wendung aufgrund der diuretischen (harntreibenden) gekoppelt mit entzün¬ dungshemmenden, antipyretischen und analgetischen Eigenschaften.Tribulus radix has been used in pharmaceutical preparation to improve and support the antiseptic and anti-inflammatory properties of Trichosantes. This ingredient also has diuretic properties. The combination of diuretic and antiseptic properties makes this ingredient suitable in the pharmaceutical preparation for the treatment of urinary tract infections, which are a common complication in venereal diseases of women. Polygonum herba has its application in the pharmaceutical according to the invention due to the diuretic (diuretic) coupled with anti-inflammatory, antipyretic and analgesic properties.

Taraxacum radix hat ähnliche therapeutische Eigenschaften wie Polygonum und wird im Pharmazeutikum eingesetzt, um die biologische Wirkung von Polygonum zu unterstützen.Taraxacum radix has similar therapeutic properties to Polygonum and is used in pharmaceuticals to support the biological effects of Polygonum.

Die entscheidende Wirkung sowie der therapeutische Effekt des Pharmazeu¬ tikums werden durch die spezielle Kombination seiner vier Bestandteile erreicht. Das Pharmazeutikum wird für die Behandlung von prämenstrualen Syndro en empfohlen, wobei dieser Krankheitszustand durch drei Gruppen von Symptomen gekennzeichnet ist:The decisive effect and the therapeutic effect of the pharmaceutical are achieved by the special combination of its four components. The pharmaceutical is recommended for the treatment of premenstrual syndromes, whereby this condition is characterized by three groups of symptoms:

1. Schmerzen durch Muskelsteifigkeit, Kopfschmerzen, Krämpfe, Rücken¬ schmerzen, Erschöpfung und generell anhaltende und kurzfristigere Schmerzen.1. Pain caused by muscle stiffness, headache, cramps, back pain, exhaustion and generally persistent and short-term pain.

2. Wasseranspeichern, wodurch eine Gewichtszunahme, Hautunregelmäßig- keiten, Brustschmerzen und Schwellungen entstehen und2. Water retention, which causes weight gain, skin irregularities, chest pain and swelling and

3. negative Affekte wie Schreien, Einsamkeitsgefühle, Angstgefühle, Unruhigkeiten, Erregbarkeiten, Stimmungswechsel, Depressionen und Span¬ nungen.3. negative affects such as screaming, feelings of loneliness, feelings of anxiety, restlessness, excitability, mood changes, depression and tension.

Das erfindungsgemäße Pharmazeutikum hat sich insbesondere erfolgreich in der Bekämpfung und Linderung der Symptomgruppen 1 und 2 gezeigt. Eine noch wichtigere Anwendung des erfindungsgemäßen Pharmazeutikums liegt in der Vorbeugung von Komplikationen, die aus Geschlechtskrankheiten her¬ rühren können, insbesondere Unfruchtbarkeit. Die derzeitige, moderne Therapie von Geschlechtskrankheiten setzt Antibiotika ein, die zwar die Infektion bekämpfen, aber nicht effektiv sind in der Behandlung von Entzündungen, die die normalen anatomischen Verhältnisse im Reproduk¬ tionsapparat der Frau beeinflussen und zerstören können. Das erfindungs gemäße Pharmazeutikum sollte in Kombination mit einer Behandlung durch Antibiotika zur entzündungshemmenden und antiseptischen Therapie einge¬ setzt werden. Das Pharmazeutikum wird oral eingenommen. Die Wirkbestandteile liegen in ho öophatischer Dosierung vor.The pharmaceutical according to the invention has proven particularly successful in combating and alleviating symptom groups 1 and 2. An even more important application of the pharmaceutical according to the invention lies in the prevention of complications which can arise from venereal diseases, in particular infertility. The current, modern therapy for venereal diseases uses antibiotics which, although they fight the infection, are not effective in treating inflammation which can influence and destroy the normal anatomical conditions in the reproductive apparatus of women. The pharmaceutical according to the invention should be used in combination with antibiotic treatment for anti-inflammatory and antiseptic therapy. The pharmaceutical is taken orally. The active ingredients are available in high oophatic dosage.

In einer bevorzugten Ausführung liegen die genannten vier Bestandteile Trichosantes palmata, Polygonum aviculare, Tribulus terrestris und Tara¬ xacum officinale (Löwenzahn) im Gewichtsverhältnis 30:30:30:10 vor. Die völlig trockenen pflanzlichen Bestandteile werden zu Pulver zerkleinert und ent-weder bei ausreichend hohem Druck zu Tabletten verpreßt oder in einen wasserfesten Aufgußbeutel gefüllt, der z.B. aus einem Filterpapier gefertigt ist. Die Tabletten erhalten keinen Überzug oder eine sonstige Schutzhülle, sie haben aufgrund ihrer Pressung und gegebenenfalls durch Zufügung eines Bindemittels (wie z. B. Gummiarabikum oder PVP) eine ausreichende mechanische Stabilität. Sie eignen sich dadurch beispiels¬ weise für Blisterverpackungen, bei denen die Tablette durch eine Alumi¬ niumfolie hindurchgedrückt werden muß, um an sie zu gelangen.In a preferred embodiment, the four constituents mentioned, Trichosantes palmata, Polygonum aviculare, Tribulus terrestris and Tara¬ xacum officinale (dandelion) are present in a weight ratio of 30: 30: 30: 10. The completely dry plant constituents are crushed into powder and either compressed to tablets at a sufficiently high pressure or filled into a waterproof infusion bag, which e.g. is made from a filter paper. The tablets do not have a coating or any other protective cover, they have sufficient mechanical stability due to their compression and, if necessary, the addition of a binder (such as gum arabic or PVP). They are therefore suitable, for example, for blister packs in which the tablet has to be pressed through an aluminum foil in order to access it.

Da die Tablette keinen Überzug aufweist, erfährt man schon beim Einneh¬ men den typischen Geschmack der vier pflanzlichen Bestandteile. Hierdurch beginnt die therapeutische Wirkung bereits im Mundraum, der Patient wird bewußt durch den Geschmack des Pharmazeutikums auf die therapeutische Wirkung eingestellt.Since the tablet has no coating, one can experience the typical taste of the four plant components when ingested. As a result, the therapeutic effect begins in the mouth, the patient is consciously adjusted to the therapeutic effect by the taste of the pharmaceutical.

In bevorzugter Darreichung wird aus den pflanzLiehen Bestandteilen ein Kräutertee gebraut, der heiß, zumindest aber warm, eingenommen (getrun¬ ken) wird. Hierzu wird ein Gramm des trockenen, pulverfeinen (Körnung 0,025 bis 0,035 mm) Gemischs in einen kleinen Aufgußbeutel abgefüllt und dieser verschlossen. Der Beutelinhalt wird in kochendem Wasser aufge¬ brüht (ausgelaugt) , die Kochzeit (bei sanftem Kochen) wird entweder mittels einer Uhr oder aber dadurch bestimmt, daß man die eingesetzte Wassermenge auf 1/3 eindampfen läßt. Man setzt zunächst 3 Tassen Wasser zu (300 ml) und kocht (gelinde) so lange, bis sich die Wassermenge auf das Volumen einer Tasse (100 ml) verringert hat. Hierzu ist ein geeig¬ netes, mit zwei Füllstrichen versehenes Gefäß (z.B. aus hitzefestem Glas) vorteilhaft, wobei ein oberer Füllstrich das Volumen von 3 Tassen und der untere Füllstrich das Volumen einer Tasse anzeigt. Auch aus einer Tablette kann ein derartiger Kräutertee hergestellt werden, dabei ergibt sich nur ein Rest an ausgebrühten Kräutern im Behälter. Dieser Satz wird abgetrennt bzw. abgefiltert. Der Sud (Kräu¬ tertee) wird warm oder heiß getrunken.In a preferred presentation, an herbal tea is brewed from the plant-based ingredients, which is consumed hot (or at least warm) (drunk). For this purpose, one gram of the dry, powder-fine (grain size 0.025 to 0.035 mm) mixture is poured into a small infusion bag and sealed. The contents of the bag are brewed (leached out) in boiling water, the cooking time (with gentle cooking) is determined either by means of a clock or by letting the amount of water used evaporate to 1/3. First add 3 cups of water (300 ml) and boil (gently) until the amount of water has reduced to the volume of one cup (100 ml). For this purpose, a suitable vessel (for example made of heat-resistant glass) provided with two fill lines is advantageous, an upper fill line indicating the volume of 3 cups and the lower fill line indicating the volume of a cup. Such a herbal tea can also be made from a tablet, leaving only a residue of brewed herbs in the container. This sentence is separated or filtered. The brew (herbal tea) is drunk warm or hot.

In einem typischen Ausführungsbeispiel hat eine Eingrarπmtablette, die oral einzunehmen ist, bzw. eine entsprechende Aufgußbeutelfullung zur Herstellung eines Tees die folgende Zusammensetzung:In a typical embodiment, a Einrarπmtablette, which is to be taken orally, or a corresponding infusion bag filling for the preparation of a tea has the following composition:

Botanischer Name Teil der Pflanze Dosis pro TabletteBotanical name part of the plant dose per tablet

1. Trichosantes palmata radix 0,300g1. Trichosantes palmata radix 0.300g

2. Polygonum aviculare herba 0,300g2. Polygonum aviculare herba 0.300g

3. Tribulus terrestris radix 0,300g3. Tribulus terrestris radix 0.300g

4. Taraxacum officinale radix 0,100g4. Taraxacum officinale radix 0.100g

1,000g 1,000g

Claims

A n s p r ü c h e Expectations 1. Pharmazeutikum, das vorwiegend, vorzugsweise ausschließlich, aus zerkleinerten, pflanzlichen Bestandteilen und Mineralien zusammen¬ gesetzt ist, dadurch gekennzeichnet, daß es folgende Bestandteile in Kombination aufweist:1. Pharmaceutical, which is predominantly, preferably exclusively, composed of comminuted plant components and minerals, characterized in that it has the following components in combination: Trichosantes palmata (radix) , aus der Familie der Cucurbitaceae; Polygonum aviculare (herba) , aus der Familie der Polygonaceae; Tribulus terrestris (radix) , aus der Familie der Zygophyllaceae und Taraxacum officinale (radix) , aus der Familie der Compositae.Trichosantes palmata (radix), from the Cucurbitaceae family; Polygonum aviculare (herba), from the family of the Polygonaceae; Tribulus terrestris (radix), from the Zygophyllaceae family and Taraxacum officinale (radix), from the Compositae family. 2. Pharmazeutikum nach Anspruch 1, dadurch gekennzeichnet, daß es die Bestandteile Trichosantes palmata, Polygonum aviculare, Tribulus terrestris und Taraxacum officinale im Gewichtsverhältnis 30:30:30:10 enthält.2. Pharmaceutical according to claim 1, characterized in that it contains the components Trichosantes palmata, Polygonum aviculare, Tribulus terrestris and Taraxacum officinale in a weight ratio of 30: 30: 30: 10. 3. Pharmazeutikum nach Anspruch 1, dadurch gekennzeichnet, das aus¬ schließlich aus den vier genannten Bestandteilen zusammengesetzt ist.3. Pharmaceutical according to claim 1, characterized in that it is composed exclusively of the four components mentioned. 4. Pharmazeutikum nach einem der Ansprüche 1 bis 3, dadurch gekennzeich¬ net, daß die pfLanzliehen Bestandteile in pulverisierter Form vorlie¬ gen und trocken zu Tabletten verpreßt werden.4. Pharmaceutical according to one of claims 1 to 3, characterized gekennzeich¬ net that the vegetable components are present in powdered form and are pressed dry into tablets. 5. Pharmazeutikum nach einem der Ansprüche 1 bis 4, dadurch gekenn¬ zeichnet, daß es keinen Überzug aufweist.5. Pharmaceutical according to one of claims 1 to 4, characterized gekenn¬ characterized in that it has no coating. 6. Pharmazeutikum nach einem der Ansprüche 1 bis 3, dadurch gekenn¬ zeichnet, daß die trockenen, pulverfδrmigen Bestandteile in einen Aufgußbeute1 gefüllt werden.6. Pharmaceutical according to one of claims 1 to 3, characterized gekenn¬ characterized in that the dry, pulverulent constituents are filled in an infusion 1. 7. Verwendung eines Pharmazeutikums nach einem der Ansprüche 1 bis 6 zur Therapie von Unterleibsschmerzen, des Prämenstruationssyndroms und Schwächen im Immunapparat im Unterleibsbereich. 7. Use of a pharmaceutical according to one of claims 1 to 6 for the therapy of abdominal pain, premenstrual syndrome and weaknesses in the immune system in the abdominal area.
PCT/DE1988/000283 1987-05-14 1988-05-13 Pharmaceutical substance Ceased WO1988008711A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3716207.1 1987-05-14
DE3716207 1987-05-14

Publications (1)

Publication Number Publication Date
WO1988008711A1 true WO1988008711A1 (en) 1988-11-17

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ID=6327577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1988/000283 Ceased WO1988008711A1 (en) 1987-05-14 1988-05-13 Pharmaceutical substance

Country Status (1)

Country Link
WO (1) WO1988008711A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021078349A1 (en) 2019-10-23 2021-04-29 Portillo Rosado Rosa Maria Pharmaceutical composition based on plant extracts for the treatment of fibromyalgia, rheumatoid arthritis, lupus and other autoimmune diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Band 97, Nr. 1, 5. Juli 1982, (Columbus, Ohio, US), M. Zhou et al.: "Pharmacological study of the effect of Radix Trichosanthis on terminating early pregnancy", siehe Seite 101 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021078349A1 (en) 2019-10-23 2021-04-29 Portillo Rosado Rosa Maria Pharmaceutical composition based on plant extracts for the treatment of fibromyalgia, rheumatoid arthritis, lupus and other autoimmune diseases

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