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WO1988005081A3 - Nouveaux activateurs du plasminogene - Google Patents

Nouveaux activateurs du plasminogene Download PDF

Info

Publication number
WO1988005081A3
WO1988005081A3 PCT/US1987/003362 US8703362W WO8805081A3 WO 1988005081 A3 WO1988005081 A3 WO 1988005081A3 US 8703362 W US8703362 W US 8703362W WO 8805081 A3 WO8805081 A3 WO 8805081A3
Authority
WO
WIPO (PCT)
Prior art keywords
urokinase
domain
fibrin
novel
novel plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1987/003362
Other languages
English (en)
Other versions
WO1988005081A2 (fr
Inventor
James J Devlin
Patricia E Devlin
David F Mark
Robin Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of WO1988005081A2 publication Critical patent/WO1988005081A2/fr
Publication of WO1988005081A3 publication Critical patent/WO1988005081A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Parmi les nouveaux activateurs du plasminogène décrits, l'un est une urokinase qui est modifiée pour la rendre susceptible de former deux urokinases en chaîne et d'augmenter la spécificité de l'urokinase vis-à-vis de la fibrine. Parmis ces nouveaux activateurs du plasminogène, on trouve également des protéines fibrinolytiques constituées d'au moins un domaine capable d'une interaction avec la fibrine et le domaine de protéase de l'urokinase. Ce domaine capable d'une interaction avec la fibrine peut présenter une séquence amino-acide sensiblement identique à celles des domaines kringle-2 de t-PA, kringle-1 et/ou -4 du plasminogène et digital de t-PA. Le domaine de protéase peut présenter une séquence amino-acide sensiblement identique à celle d'une urokinase de 30 Kd. Sont également décrits et revendiqués des séquences d'ADN codant les nouveaux activateurs du plasminogène, des vecteurs d'expression ainsi que des systèmes d'expression qui leur sont destinés.
PCT/US1987/003362 1986-12-30 1987-12-17 Nouveaux activateurs du plasminogene Ceased WO1988005081A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94784686A 1986-12-30 1986-12-30
US947,846 1986-12-30
US7758687A 1987-07-24 1987-07-24
US077,586 1987-07-24

Publications (2)

Publication Number Publication Date
WO1988005081A2 WO1988005081A2 (fr) 1988-07-14
WO1988005081A3 true WO1988005081A3 (fr) 1988-10-20

Family

ID=26759435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/003362 Ceased WO1988005081A2 (fr) 1986-12-30 1987-12-17 Nouveaux activateurs du plasminogene

Country Status (3)

Country Link
EP (1) EP0273774A3 (fr)
AU (1) AU8309387A (fr)
WO (1) WO1988005081A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
EP0440709B1 (fr) * 1988-10-27 1995-05-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Agents thrombolytiques a domaines kringle modifies
EP0429663A1 (fr) * 1989-06-13 1991-06-05 Nippon Soda Co., Ltd. Polypeptides apparentes a la pro-urokinase humaine et procedes de preparation de tels polypeptides
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
GB9019120D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
DK0786257T3 (da) * 1992-06-03 2003-10-06 Genentech Inc Glycolyseringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
US5550213A (en) * 1993-12-27 1996-08-27 Rutgers, The State University Of New Jersey Inhibitors of urokinase plasminogen activator
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127839A2 (fr) * 1983-05-27 1984-12-12 THE TEXAS A&M UNIVERSITY SYSTEM Procédé pour la préparation d'un vecteur recombinant d'expression de baculovirus
EP0155387A2 (fr) * 1983-12-24 1985-09-25 Beecham Group Plc Protéine hybride à activité fibrinolytique, son procédé de préparation et composition pharmaceutique
WO1986004351A1 (fr) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Prourokinase humaine stabilisee
EP0200451A1 (fr) * 1985-04-22 1986-11-05 Genentech, Inc. Composition d'urokinase résistant aux protéinases, sa production et son utilisation
EP0201153A2 (fr) * 1985-02-09 1986-11-12 Beecham Group Plc Enzyme modifié et son procédé de préparation
EP0231883A1 (fr) * 1986-01-31 1987-08-12 Sagami Chemical Research Center Polypeptide hybride du type activeur de plasminogène
EP0236040A2 (fr) * 1986-02-26 1987-09-09 Collaborative Research Inc. Prourokinase modifiée dans des acides aminés, et méthode de préparation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127839A2 (fr) * 1983-05-27 1984-12-12 THE TEXAS A&M UNIVERSITY SYSTEM Procédé pour la préparation d'un vecteur recombinant d'expression de baculovirus
EP0155387A2 (fr) * 1983-12-24 1985-09-25 Beecham Group Plc Protéine hybride à activité fibrinolytique, son procédé de préparation et composition pharmaceutique
WO1986004351A1 (fr) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Prourokinase humaine stabilisee
EP0201153A2 (fr) * 1985-02-09 1986-11-12 Beecham Group Plc Enzyme modifié et son procédé de préparation
EP0200451A1 (fr) * 1985-04-22 1986-11-05 Genentech, Inc. Composition d'urokinase résistant aux protéinases, sa production et son utilisation
EP0231883A1 (fr) * 1986-01-31 1987-08-12 Sagami Chemical Research Center Polypeptide hybride du type activeur de plasminogène
EP0236040A2 (fr) * 1986-02-26 1987-09-09 Collaborative Research Inc. Prourokinase modifiée dans des acides aminés, et méthode de préparation

Also Published As

Publication number Publication date
WO1988005081A2 (fr) 1988-07-14
EP0273774A2 (fr) 1988-07-06
AU8309387A (en) 1988-08-11
EP0273774A3 (fr) 1988-12-14

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