[go: up one dir, main page]

ES2067326T3 - Variante especifica de activador de plasminogeno tisular. - Google Patents

Variante especifica de activador de plasminogeno tisular.

Info

Publication number
ES2067326T3
ES2067326T3 ES92903441T ES92903441T ES2067326T3 ES 2067326 T3 ES2067326 T3 ES 2067326T3 ES 92903441 T ES92903441 T ES 92903441T ES 92903441 T ES92903441 T ES 92903441T ES 2067326 T3 ES2067326 T3 ES 2067326T3
Authority
ES
Spain
Prior art keywords
variants
plasminogen activator
tissue plasminogen
prepared
expression vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92903441T
Other languages
English (en)
Inventor
William F Bennett Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2067326T3 publication Critical patent/ES2067326T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE PREPARAN VARIANTES ACTIVADORAS PLASMINOGENAS (T-PA) DE TEJIDO ACTIVAS BIOLOGICAMENTE CON ACTIVIDAD AMPLIAMENTE AUMENTADA DE LA LISIS DEL COAGULO CUANDO SE COMPARAN CON EL TIPO SALVAJE T-PA, EN LAS QUE EL RESIDUO DE ARGININA EN LA POSICION 299 ES SUSTITUIDO POR UN RESIDUO DE ACIDO ASPARTICO. PUEDEN SER PREPARADAS SECUENCIAS DNA QUE CODIFIQUEN LAS VARIANTES, ASI COMO VECTORES EXPRESION QUE INCORPORAN LAS SECUENCIAS DNA Y CELULAS HUESPED TRANSFORMADAS CON LOS VECTORES EXPRESION. LAS VARIANTES PUEDEN SER USADAS EN PREPARACIONES FARMACEUTICAS PARA TRATAR UNA ENFERMEDAD O CONDICION VASCULAR, O PARA PREVENIR DEPOSICION DE FIBRINA O FORMACION DE ADHESION O NUEVA FORMACION EN MAMIFEROS.
ES92903441T 1990-12-18 1991-12-16 Variante especifica de activador de plasminogeno tisular. Expired - Lifetime ES2067326T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62986390A 1990-12-18 1990-12-18

Publications (1)

Publication Number Publication Date
ES2067326T3 true ES2067326T3 (es) 1995-03-16

Family

ID=24524805

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92903441T Expired - Lifetime ES2067326T3 (es) 1990-12-18 1991-12-16 Variante especifica de activador de plasminogeno tisular.

Country Status (10)

Country Link
EP (1) EP0563280B1 (es)
JP (1) JP2532193B2 (es)
AT (1) ATE114170T1 (es)
AU (1) AU649765B2 (es)
CA (1) CA2096851C (es)
DE (1) DE69105213T2 (es)
DK (1) DK0563280T3 (es)
ES (1) ES2067326T3 (es)
GR (1) GR3015094T3 (es)
WO (1) WO1992011377A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0943332A1 (en) * 1998-03-19 1999-09-22 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Prevention and treatment of adhesions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
ATE226636T1 (de) * 1989-03-06 2002-11-15 Univ Texas Serpin-resistenter t-pa; mutanten; gene

Also Published As

Publication number Publication date
EP0563280A1 (en) 1993-10-06
DK0563280T3 (da) 1995-04-18
AU9171491A (en) 1992-07-22
CA2096851A1 (en) 1992-06-19
ATE114170T1 (de) 1994-12-15
JPH06502544A (ja) 1994-03-24
CA2096851C (en) 1999-10-12
JP2532193B2 (ja) 1996-09-11
WO1992011377A1 (en) 1992-07-09
AU649765B2 (en) 1994-06-02
EP0563280B1 (en) 1994-11-17
DE69105213D1 (de) 1994-12-22
GR3015094T3 (en) 1995-05-31
DE69105213T2 (de) 1995-05-18

Similar Documents

Publication Publication Date Title
FI911049A0 (fi) Vaevnadsplasminogenaktivator med zymogena eller fibrinspecifika egenskaper.
GEP20012448B (en) Tissue Plasminogen Activators (Improved Variants)
GB1533205A (en) Plasmin fractions and complexes thereof
EP0273774A3 (en) Plasminogen activators, dna encoding the same and their preparation and use
DK274990A (da) Vaevsplasminogenaktivator-(t-pa)-varianter, dma-sekvenser, som koder for disse, replicerbare udtrykkelsesvektorer for dna-sekvenserne, eukaryote vaertsceller transformeret med vektorerne og farmaceutiske praeparater indeholdende t-pa-varianterne
SE8702562L (sv) Nya fibrinolytiska enzymer
ES2067326T3 (es) Variante especifica de activador de plasminogeno tisular.
DK0542869T3 (da) Vævsplasminogenaktivatorvarianter med nedsat udskillelse
DK0517756T3 (da) Vævs-plasminogenaktivator med fibrinspecifikke egenskaber
US5260060A (en) Fibrinolytic enzymes
ATE145669T1 (de) T-pa substitutionsvarianten mit verbesserter fibrinspezifität
Petri et al. Novel plasminogen activators from the vampire bat Desmodus rotundus
Klimova et al. Collagenolytic protease preparations from invertebrates: biochemical aspects of medical and cosmetological applications
EP0326013A3 (en) Novel proteins derived from human alpha2-plasmin inhibitor or proteins similar thereto
EP0386240A4 (en) Novel polypeptide compounds
NZ229611A (en) A bolus formulation containing at least 12.5 mu of t-pa
Blackwell Patent Update: Fibrinolytic Agents Covered in the Patents in 1991

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 563280

Country of ref document: ES