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WO1983000623A1 - Composition pour une utilisation par voie orale - Google Patents

Composition pour une utilisation par voie orale Download PDF

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Publication number
WO1983000623A1
WO1983000623A1 PCT/JP1981/000194 JP8100194W WO8300623A1 WO 1983000623 A1 WO1983000623 A1 WO 1983000623A1 JP 8100194 W JP8100194 W JP 8100194W WO 8300623 A1 WO8300623 A1 WO 8300623A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral composition
dextranase
composition according
carbon
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1981/000194
Other languages
English (en)
Japanese (ja)
Inventor
Corporation Lion
Isao Iioka
Keiiti Yamagishi
Hiroshi Sato
Nobuo Suganuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to PCT/JP1981/000194 priority Critical patent/WO1983000623A1/fr
Publication of WO1983000623A1 publication Critical patent/WO1983000623A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a dextranase-containing oral composition having an excellent feeling in use.
  • Japanese Patent Publication No. 50-33778 states that in order to stabilize dextranase, there is a certain flavor component, namely C17-C17 lunar aliphatic alcohol or its alcohol. It is disclosed that ester, terpenic hydrocarbon, phenol ether, and -lactone are used in combination with dextranase o
  • oral compositions are used in the oral cavity Since it is a product, it should be excellent in usability, but it is not enough to blend the above-mentioned perfume components in terms of usability. For this reason, according to the type of consumer's taste, etc., in order to improve usability, carbon, oike, knoll, methyl, methyl salicylate, cigarette It is necessary to mix fragrance components such as natural aldehyde. However, as described in Japanese Patent Publication No. 50-33778, these fragrance components such as carbon have a bad influence on the stability of dextranase. Therefore, there was a problem in stabilizing the dextranase without impairing the use of the oral composition.
  • An object of the present invention is to provide an oral composition having excellent stability of dextranase and excellent use feeling.
  • dextranase is stably blended and used.
  • a good oral composition can be obtained.
  • a flavor such as soda, knoll, methyl salicylate, and cinnamaldehyde
  • dextran It may impair the stability of Ize. Therefore, the conventionally known index
  • flavors such as carbohydrate, nitrogen, eugenol, methyl salicylate, and cinnamic aldehyde in addition to the tranase stabilized fragrance. This can broaden the range of choices of flavor components that can be added to the oral composition.
  • liquid mouth fresheners such as toothpaste, powdered toothpaste, liquid toothpaste, and mouthwash
  • solid mouth fresheners such as troches, and chewing gum.
  • carbon and -menthol are contained in a weight ratio.
  • calcium and -menthol are defined as having a total content of oral cavity from the viewpoint of improving the stability of dextranase and improving the feeling of use of the oral composition.
  • the composition for use It is preferably used in a total of 0.1 to 5 (weight, the same applies hereinafter), etc.), or preferably 0.3 to 3 as desired. 0.1% yo jp A small amount of the mixture will not give a sufficient body and refreshing sensation, while a higher amount of 5 will have a too strong and too rich taste, and will have a good balance between carbon and menthol. Even if it is added to 'excess', the stability of dextranase will not be further improved.
  • carbon and -menthol may be blended in the oral composition as a single substance or as a synthetic product.
  • Essential oils containing menthol such as spearmint oil (which contains caron), ⁇ ha. It may be compounded in the form of a mint oil (containing -menthol).
  • the present invention thus uses a combination of carnone and -menthol, but additionally contains other usual fragrance ingredients, such as carbon number? To 17 alcohols or their esters, terpenic hydrocarbons, phenol ethers, and lactones. it can .
  • fragrances which are conventionally considered to inhibit dextranase, such as eugenol, methyl salicylate,
  • 0.001 to 0.5 of the whole oral composition may be mixed with natural aldehyde. This means that the choice of perfume components is increased, and it is possible to easily produce an oral composition having an excellent feeling in use. It is also advisable to add 0.01 to 0.5 of an ether to the oral composition in order to improve the quality of the sweetness and further improve the composition.
  • the amount of dextranase to be added is not particularly limited, but is usually 1 ⁇ per oral composition. ? 100-: 100,000 units (uZ9 oral composition :), particularly preferably 1,000-50,000 u / 9-oral composition.
  • 1 unit means the amount of the enzyme that produces free reducing sugars equivalent to 1 g of glucose 1 ⁇ when the reaction is performed using dextran as a substrate.
  • composition for the oral cavity of the present invention in addition to dextranase, enzymes such as amylase, protease, mutanase, lysozyme, lithogenzyme, etc.
  • Metal metal fluorophosphates for example, disposable monolithic phosphates, dipotteric monolithic phosphates, etc.
  • G Fluoride, such as metal fluorides (eg, sodium fluoride, 1st metal fluoride), etc. 1 Tin compounds, chlorhexidine salts, ip Silicone power probe Tranexam, aluminum chlorohydroxide Alantoin ⁇ Hydrocholester
  • one or more active ingredients such as sodium chloride, glycerin salts, glycerol phosphite, sodium chloride, and water-soluble inorganic phosphoric acid compounds.
  • active ingredients such as sodium chloride, glycerin salts, glycerol phosphite, sodium chloride, and water-soluble inorganic phosphoric acid compounds.
  • an aluminum metal monophosphate such as a sodium monofluorophosphate
  • the dextran is reduced. Desirable because it stabilizes lanase and can maintain a high residual ratio of dextranase in the dentifrice composition after long-term storage.
  • water-soluble inorganic phosphoric acid compounds include potassium phosphate, pyrrolic acid, and boron phosphate, and sodium phosphate. I like it.
  • the abrasive when the oral composition of the present invention is a dentifrice composition, the abrasive is usually used in a total amount of 20 to 90, especially 20 to 60 in the case of toothpaste. Can be.
  • the abrasive include aluminum oxide compounds, calcium phosphate dibasic dihydrate and anhydrous silica, aluminum silicate, and carbonate. Le Shium, Pi Calcium phosphate, aluminum silicate, insoluble sodium metaphosphate, tertiary linoleic acid, magnesium, magnesium carbonate One or more of um, calcium sulphate, synthetic resin and the like are selected.
  • the preferred main engraving agent is an aluminum oxide compound.
  • the aluminum and the hydrated aluminum ⁇ , ⁇ , 8, ⁇ ,%, ⁇ , and ⁇ types are known from their crystal systems and physical properties. However, among these, stable 0: alumina and hydrated alumina are desirable. Also, in the A Le Mi Na hydrate, Jipusa wells, pie catcher La wells (both represented by ⁇ 2 0 5 ⁇ 3H 2 0 ) and Bae Mai DOO, die Aboa (ii deviation also A 2 O s ⁇ H 20 ) can be used. Of these aluminum oxide compounds, aluminum hydrate is preferred from the viewpoints of abrasiveness and abrasion of teeth, and in particular, aluminum hydrate is particularly preferred.
  • the aluminum trihydrate represented by And is excellent.
  • this aluminum trihydrate it is preferable to use -cupsite because of its industrial availability.
  • the above-mentioned aluminum oxide compound may be used alone or in combination of two or more.
  • the particle size of the aluminum oxide-aluminum compound (value determined by the sedimentation method) may be 1 to 50 H, particularly 3 to 25, from the viewpoint of the cleaning effect and the abrasion of the teeth. I like it.
  • -In addition, when producing dentifrice compositions as a binder, Ragengan, Canoleboxyl methylcellulose, sodium sodium, etc.
  • Sodium phosphate 3 ⁇ 4 Which alkaline metal alginate, Vegam, Xanthan gam: 3 ⁇ 4 Which gamms, polyvinyl alcohol, Which synthetic binders, silica gel, Aluminum silica gel
  • alkaline metal monofluorophosphate when blended as an active ingredient, when the dentifrice composition has stability and feeling of use, it can be used in combination with lagenan and algin. It is preferable to use a combination with an acid metal salt.
  • the dentist composition is more effective in preventing skin roughness of the dentifrice composition than the usual copper-Ziota one-component stimulant ragnan.
  • the stability of the sword it is a must. -Preference is given to using caragunnan.
  • sorbit As a thickener, sorbit, glycerin, ethylene, silicone, propylenelink, silicone, 1,3-butylene, One or two or more types of coconut, coconut, coconut, coconut, lacquer, etc. are blended at a blending amount of usually 10 to 70. Get. In this case, it is desirable to use 1 to 5% of propylene alcohol as the binder dispersion, but if it is used in a large amount, the residual ratio of dextranase due to storage can be reduced. Therefore, it is desirable to mix sorbit as a main thickener and to use sorbit in combination with lipoline and alcohol.
  • water solubility of higher alkyl sulfates having 8 to 18 carbon atoms in the alkyl group such as sodium raurylsulfate and sodium myristyl sulfate, Salts, soybean plastic monoko, lycetone snore honey, coconut coconut moss honey, lysolide sulhonate etc.
  • sucrose fatty acid ester lactose fatty acid ester, lactotol fatty acid ester, maltitol per month fatty acid Ethanol, ethylene glycol, and solvitanomonostearate condensate to which about 60 mol has been added, ethylene oxide and propylene Nonionic activators such as polymers of oxosides and derivatives such as polyoxyethylene propylene glycol monoesters; One or more kinds of amphoteric surfactants such as betaine type and amino acid type. Surfactants can be blended in a blending amount of usually 0.5 to 7.
  • Saccharin Triumum, Steviaside, Neo-Hesperidyl Dihydrocarbon, Taumatine, Glycilitin, ⁇ Reraltin, p-methoxycinnamic aldehyde, sweetener, p-hydroxyshethyl penzoic acid, P-hydroxybutyrate Benzozide can contain any preservatives, gelatin, peptone, and other ingredients.
  • the desired component is prepared by combining the desired component with an appropriate amount of water or another solvent.
  • the dentifrice compositions of the present invention generally have a density of 4.5 to 10, preferably! ⁇ 6 to 8.5.
  • the dentifrice composition thus obtained is a laminate obtained by laminating both sides of an aluminum foil or aluminum foil with a plastic or the like. Used in tubes, plastic tubes, bottles, aerosol containers, etc.
  • composition for baking it can be manufactured according to a usual method using a commonly used base material.
  • Toothpaste compositions (the dentifrices of the present invention and comparative dentifrices A and B) having the formulations shown in Table 1 were prepared, and the dextran content in the composition immediately after preparation and after storage at 40 ° C for one month was measured. The amount of dextranase was measured to determine the residual ratio of dextranase.
  • the total amount of carbon and -menthol was set to 1.0 ⁇ , and the weight ratio of carbon and -menthol was changed.
  • the same experiment was conducted on the dentifrice as to the residual ratio of dextranase and the feeling of use.
  • the evaluation criteria are the same as in Table 1.
  • Table 2 shows that Karun and -menthol should be used together at a ratio of 13 ⁇ 4 to 8 ⁇ 2, especially 2 ⁇ 8 to 7 ⁇ 3.]? Stabilize the dextranase and improve the usability. It is shown to be good.
  • methyl salicylate and 0.2% of cinnamic aldehyde were further added to the dentifrice formulation of the present invention, and the dextranase residual ratio was similarly examined. At that time, the results were all “ ⁇ ” in the same evaluation criteria as above.
  • Alumina hydrate (pylumite, average particle size I Qu) 40 ⁇ Silicon force 3 Solvite 15 Glycerin 15 Sodium sulphate sodium sulfate 1.0 Diethanolamide laurate 1.5 Al Sodium formate 1.0 sodium monofluorophospho-phosphate 0.76 gelatin 0.3 saccharin sodium 0.1 • 6-menthol 0.5 carbo 0.3 Anet 0.2 Dextranase 5000 u / 9 Toothpaste Water

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Composition contenant de la dextranase et destinée à une utilisation orale, contenant de la carvone et du -menthol avec un rapport de poids de 1:9 à 8:2 et, de préférence, dont la quantité totale dans la composition varie entre 0,1 et 5 % en poids. Cette composition est stable, possède un goût agréable et peut être utilisée en tant que dentifrice.
PCT/JP1981/000194 1981-08-27 1981-08-27 Composition pour une utilisation par voie orale Ceased WO1983000623A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP1981/000194 WO1983000623A1 (fr) 1981-08-27 1981-08-27 Composition pour une utilisation par voie orale

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1981/000194 WO1983000623A1 (fr) 1981-08-27 1981-08-27 Composition pour une utilisation par voie orale

Publications (1)

Publication Number Publication Date
WO1983000623A1 true WO1983000623A1 (fr) 1983-03-03

Family

ID=13734280

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1981/000194 Ceased WO1983000623A1 (fr) 1981-08-27 1981-08-27 Composition pour une utilisation par voie orale

Country Status (1)

Country Link
WO (1) WO1983000623A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1013261A1 (fr) * 1998-12-18 2000-06-28 Mitsui & Co., Ltd. Composition pulvérisable pour bain de bouche
CN1069517C (zh) * 1994-06-29 2001-08-15 狮子株式会社 口腔组合物
WO2008040681A1 (fr) 2006-10-02 2008-04-10 Birgit Riesinger Article de traitement de blessures en vue de l'extraction et du contrôle de fluides de blessures

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981989A (en) * 1973-11-26 1976-09-21 The Lion Dentifrice Co., Ltd. Oral preparation
US3991177A (en) * 1973-11-27 1976-11-09 Colgate-Palmolive Company Oral compositions containing dextranase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981989A (en) * 1973-11-26 1976-09-21 The Lion Dentifrice Co., Ltd. Oral preparation
US3991177A (en) * 1973-11-27 1976-11-09 Colgate-Palmolive Company Oral compositions containing dextranase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cosmetic SCIENCE AND TECHNOLOGY, Second Edition Volume 1 1972, by john Wiley & Sons, Inc., P. 457, P. 470, P. 482-483, P. 494-496, P. 507 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069517C (zh) * 1994-06-29 2001-08-15 狮子株式会社 口腔组合物
EP1013261A1 (fr) * 1998-12-18 2000-06-28 Mitsui & Co., Ltd. Composition pulvérisable pour bain de bouche
WO2008040681A1 (fr) 2006-10-02 2008-04-10 Birgit Riesinger Article de traitement de blessures en vue de l'extraction et du contrôle de fluides de blessures

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