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UY38926A - INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA - Google Patents

INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA

Info

Publication number
UY38926A
UY38926A UY0001038926A UY38926A UY38926A UY 38926 A UY38926 A UY 38926A UY 0001038926 A UY0001038926 A UY 0001038926A UY 38926 A UY38926 A UY 38926A UY 38926 A UY38926 A UY 38926A
Authority
UY
Uruguay
Prior art keywords
alfa4beta7
inhibition
human integrin
integrin
human
Prior art date
Application number
UY0001038926A
Other languages
English (en)
Inventor
Matthew G Bursavich
Dan Cui
James E Dowling
Kristopher N Hahn
Bryce A Harrison
fu-yang Lin
Blaise S Lippa
Dawn M Troast
Cheng Zhong
Kyle D Konze
Aleksey I Gerasyuto
Byungchan Kim
Salma Rafi
Tyler Day
Eugene Hickey
Evelyne Houang
Robert Zahler
Bruce N Rogers
Original Assignee
Morphic Therapeutic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphic Therapeutic Inc filed Critical Morphic Therapeutic Inc
Publication of UY38926A publication Critical patent/UY38926A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Moléculas pequeñas antagonistas de la integrina humana alfa4beta7, y métodos para usarlas en el tratamiento de varias enfermedades y afecciones.
UY0001038926A 2019-10-16 2020-10-16 INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA UY38926A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16

Publications (1)

Publication Number Publication Date
UY38926A true UY38926A (es) 2021-05-31

Family

ID=73198501

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038926A UY38926A (es) 2019-10-16 2020-10-16 INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA

Country Status (36)

Country Link
US (3) US11104661B1 (es)
EP (3) EP4559525A3 (es)
JP (7) JP7437490B2 (es)
KR (2) KR20220102669A (es)
CN (3) CN115087444B (es)
AR (1) AR120244A1 (es)
AU (2) AU2020366435A1 (es)
BR (1) BR112022007284A2 (es)
CA (1) CA3154269A1 (es)
CL (1) CL2022000959A1 (es)
CO (1) CO2022005759A2 (es)
CR (1) CR20220205A (es)
CU (1) CU20220027A7 (es)
DK (1) DK4045039T3 (es)
DO (2) DOP2022000081A (es)
EC (1) ECSP22038978A (es)
ES (1) ES3035561T3 (es)
FI (1) FI4045039T3 (es)
HR (1) HRP20250749T1 (es)
HU (1) HUE071814T2 (es)
IL (2) IL319053A (es)
LT (1) LT4045039T (es)
MA (1) MA57399B1 (es)
MD (1) MD4045039T2 (es)
MX (1) MX2022004406A (es)
PE (1) PE20221829A1 (es)
PH (1) PH12022550886A1 (es)
PL (1) PL4045039T3 (es)
PT (1) PT4045039T (es)
RS (1) RS66976B1 (es)
SI (1) SI4045039T1 (es)
TW (6) TWI775182B (es)
UA (1) UA130059C2 (es)
UY (1) UY38926A (es)
WO (3) WO2021076902A1 (es)
ZA (2) ZA202203872B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202528300A (zh) 2018-04-12 2025-07-16 美商莫菲克醫療股份有限公司 人類整合素α4β7拮抗劑
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin
CN114585359B (zh) 2019-10-16 2025-08-12 凯莫森特里克斯股份有限公司 用于治疗pd-l1疾病的杂芳基联苯酰胺
MX2022004450A (es) 2019-10-16 2022-05-03 Chemocentryx Inc Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1.
MA57399B1 (fr) * 2019-10-16 2025-06-30 Morphic Therapeutic, Inc. Inhibition de l'intégrine humaine alpha4beta7
WO2023125182A1 (zh) * 2021-12-27 2023-07-06 海思科医药集团股份有限公司 一种丙酸衍生物及其在医药上的应用
CN119836415A (zh) 2022-09-09 2025-04-15 西藏海思科制药有限公司 一种丙酸衍生物及其在医药上的应用
EP4638438A1 (en) 2022-12-22 2025-10-29 Xinthera, Inc. Alpha4 beta7 integrin antagonists and uses thereof
KR20250152075A (ko) * 2023-02-21 2025-10-22 씨4엑스 디스커버리 리미티드 거대환식 알파4베타7 인테그린 억제제
AU2024279767A1 (en) 2023-05-26 2025-12-04 Adarx Pharmaceuticals, Inc. Sod1-modulating compositions and methods of use thereof
WO2025026955A1 (en) * 2023-07-28 2025-02-06 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2025176107A1 (zh) * 2024-02-20 2025-08-28 西藏海思科制药有限公司 一种吡啶酮衍生物及其在医药上的应用
CN118702712B (zh) * 2024-07-04 2025-11-11 安徽普利药业有限公司 一种n-(3-苯10硼酸)-l-天冬氨酸中间体制备方法
CN119504796A (zh) * 2024-11-20 2025-02-25 南通大学附属医院 一种具有抗肿瘤活性的化合物及其应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE195117T1 (de) 1993-03-31 2000-08-15 Searle & Co 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
DE4427979A1 (de) 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US5849736A (en) 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
DE19622489A1 (de) 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
CA2268270A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Heterocyclic derivatives as factor xa inhibitors
CA2268381A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
EP1034164B1 (en) 1997-11-24 2004-05-19 Merck & Co., Inc. Substituted beta-alanine derivatives as cell adhesion inhibitors
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2000000481A1 (en) 1998-06-29 2000-01-06 Du Pont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as iib/iiia antagonists
WO2000006169A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
GB9826174D0 (en) * 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
AU4826900A (en) 1999-05-07 2000-11-21 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
DE60035204T2 (de) 1999-09-24 2008-02-21 Genentech, Inc., South San Francisco Tyrosinderivate
DE10041423A1 (de) 2000-08-23 2002-03-07 Merck Patent Gmbh Biphenylderivate
BR0113671A (pt) * 2000-08-30 2004-01-06 Pharmacia Corp Antagonistas de integrina alfa v beta 3 gem-substituìda
DE10111876A1 (de) 2001-03-10 2002-09-19 Aventis Pharma Gmbh Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe
DE10154280A1 (de) 2001-11-05 2003-05-15 Wilex Ag Antagonisten für alpha¶4¶-Integrine
KR20040105740A (ko) 2002-02-25 2004-12-16 엘란 파마슈티칼스, 인크. 염증 치료제의 투여 방법
EP1784426B1 (en) 2004-09-03 2011-11-23 Genentech, Inc. Humanized anti-beta7 antagonists and uses therefor
US7972775B2 (en) 2005-03-03 2011-07-05 Seedlings Life Science Ventures, Llc Method of risk management for patients undergoing Natalizumab treatment
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. 6,7-不飽和-7-カルバモイル置換モルヒナン誘導体
NZ563739A (en) 2005-06-09 2009-12-24 Ucb Pharma Sa 2,6 Quinolinyl derivatives, processes for preparing them and their use as medicament
LT2676967T (lt) 2006-02-28 2019-09-10 Biogen Ma Inc. Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu
WO2010091411A1 (en) 2009-02-09 2010-08-12 Glaxosmithkline Llc Piperidinyl cyclic amido antiviral agents
SG193565A1 (en) 2011-03-31 2013-11-29 Genentech Inc Methods of administering beta7 integrin antagonists
RU2015112024A (ru) 2012-10-05 2016-11-27 Дженентек, Инк. Способы диагностики и лечения воспалительного заболевания кишечника
JP7054990B2 (ja) 2014-03-27 2022-04-15 ジェネンテック, インコーポレイテッド 炎症性腸疾患の診断及び治療のための方法
WO2016011940A1 (zh) 2014-07-25 2016-01-28 江苏恒瑞医药股份有限公司 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用
WO2016086147A1 (en) * 2014-11-26 2016-06-02 Millennium Pharmaceuticals, Inc. Vedolizumab for the treatment of fistulizing crohn's disease
AR103782A1 (es) 2015-02-26 2017-05-31 Genentech Inc ANTAGONISTAS DE INTEGRINA b7 Y MÉTODOS DE TRATAMIENTO DE LA ENFERMEDAD DE CROHN
BR112019017929A2 (pt) * 2017-02-28 2020-05-19 Morphic Therapeutic Inc inibidores de integrina (alfa-v)(beta-6)
US10246451B2 (en) 2017-04-26 2019-04-02 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof
US10875875B2 (en) * 2017-04-26 2020-12-29 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof
TW202528300A (zh) 2018-04-12 2025-07-16 美商莫菲克醫療股份有限公司 人類整合素α4β7拮抗劑
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CN112996786B (zh) * 2018-10-30 2024-08-20 吉利德科学公司 用于抑制α4β7整合素的化合物
MA57399B1 (fr) * 2019-10-16 2025-06-30 Morphic Therapeutic, Inc. Inhibition de l'intégrine humaine alpha4beta7

Also Published As

Publication number Publication date
CN119192137A (zh) 2024-12-27
IL292296B2 (en) 2025-07-01
RS66976B1 (sr) 2025-07-31
WO2021076890A1 (en) 2021-04-22
DOP2025000034A (es) 2025-04-08
US11104661B1 (en) 2021-08-31
TW202315868A (zh) 2023-04-16
ZA202203872B (en) 2024-01-31
TW202332675A (zh) 2023-08-16
JP7437495B2 (ja) 2024-02-22
ZA202303992B (en) 2024-06-26
TW202500559A (zh) 2025-01-01
HUE071814T2 (hu) 2025-09-28
CN116783161A (zh) 2023-09-19
CL2022000959A1 (es) 2023-04-28
PE20221829A1 (es) 2022-11-29
BR112022007284A2 (pt) 2022-07-05
KR20220102669A (ko) 2022-07-20
EP4228634A4 (en) 2024-12-18
UA130059C2 (uk) 2025-10-29
JP2024116230A (ja) 2024-08-27
IL292296B1 (en) 2025-03-01
DK4045039T3 (da) 2025-06-30
EP4045039A4 (en) 2023-12-13
JP7702004B2 (ja) 2025-07-02
JP7717202B2 (ja) 2025-08-01
MD4045039T2 (ro) 2025-11-30
TW202244040A (zh) 2022-11-16
JP7209116B2 (ja) 2023-01-19
CN115087444B (zh) 2024-09-17
JP2023500437A (ja) 2023-01-06
CU20220027A7 (es) 2022-12-12
MA57399B1 (fr) 2025-06-30
TW202500558A (zh) 2025-01-01
AR120244A1 (es) 2022-02-09
JP7500785B2 (ja) 2024-06-17
AU2020366435A1 (en) 2022-04-21
WO2021076902A1 (en) 2021-04-22
EP4559525A3 (en) 2025-08-20
JP2023036958A (ja) 2023-03-14
PL4045039T3 (pl) 2025-09-15
JP7437490B2 (ja) 2024-02-22
JP2024054296A (ja) 2024-04-16
TWI791304B (zh) 2023-02-01
CR20220205A (es) 2022-07-22
TW202126624A (zh) 2021-07-16
TWI888065B (zh) 2025-06-21
PH12022550886A1 (en) 2023-05-03
CO2022005759A2 (es) 2022-05-20
TWI840047B (zh) 2024-04-21
KR20230088376A (ko) 2023-06-19
JP2022542184A (ja) 2022-09-29
US20240174632A1 (en) 2024-05-30
ES3035561T3 (en) 2025-09-04
TWI802477B (zh) 2023-05-11
SI4045039T1 (sl) 2025-07-31
ECSP22038978A (es) 2022-06-30
AU2021361031A1 (en) 2023-06-08
EP4045039B1 (en) 2025-04-23
WO2021076890A4 (en) 2021-06-10
IL319053A (en) 2025-04-01
US11370773B1 (en) 2022-06-28
HRP20250749T1 (hr) 2025-08-15
CA3154269A1 (en) 2021-04-22
WO2022081983A1 (en) 2022-04-21
CN115087444A (zh) 2022-09-20
EP4559525A2 (en) 2025-05-28
EP4045039A1 (en) 2022-08-24
MX2022004406A (es) 2022-08-25
PT4045039T (pt) 2025-07-02
FI4045039T3 (fi) 2025-06-20
JP2024054293A (ja) 2024-04-16
EP4228634A1 (en) 2023-08-23
TWI775182B (zh) 2022-08-21
IL292296A (en) 2022-06-01
LT4045039T (lt) 2025-08-11
DOP2022000081A (es) 2022-07-31
JP2022548809A (ja) 2022-11-22
TW202222793A (zh) 2022-06-16
TWI857592B (zh) 2024-10-01

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