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UY37818A - Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico - Google Patents

Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Info

Publication number
UY37818A
UY37818A UY0001037818A UY37818A UY37818A UY 37818 A UY37818 A UY 37818A UY 0001037818 A UY0001037818 A UY 0001037818A UY 37818 A UY37818 A UY 37818A UY 37818 A UY37818 A UY 37818A
Authority
UY
Uruguay
Prior art keywords
oxifenil
fluoropropil
diclorophenil
anulen
pirrolidin
Prior art date
Application number
UY0001037818A
Other languages
English (en)
Inventor
Monsif Bouaboula
Maysoun Shomali
Fangxian Sun
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY37818A publication Critical patent/UY37818A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan en la presente memoria una combinación de palbociclib y del ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7Hbenzo[7]anuleno-2-carboxílico o una de sus sales farmacéuticamente aceptables, una composición farmacéutica que contiene dicha combinación, y sus usos terapéuticos, en particular para el tratamiento del cáncer, incluyendo el cáncer de mama.
UY0001037818A 2017-07-24 2018-07-24 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico UY37818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762536121P 2017-07-24 2017-07-24
EP17305998.1A EP3434272A1 (en) 2017-07-25 2017-07-25 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid

Publications (1)

Publication Number Publication Date
UY37818A true UY37818A (es) 2020-08-31

Family

ID=59569252

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037818A UY37818A (es) 2017-07-24 2018-07-24 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Country Status (30)

Country Link
US (2) US11260057B2 (es)
EP (2) EP3434272A1 (es)
JP (1) JP6741897B1 (es)
KR (1) KR20200031622A (es)
CN (1) CN111107851B (es)
AR (1) AR112284A1 (es)
AU (1) AU2018308871A1 (es)
BR (1) BR112020001398A2 (es)
CA (1) CA3070754A1 (es)
CO (1) CO2020000240A2 (es)
DK (1) DK3658147T3 (es)
ES (1) ES2906279T3 (es)
HR (1) HRP20212030T1 (es)
HU (1) HUE057271T2 (es)
IL (1) IL272166B2 (es)
LT (1) LT3658147T (es)
MA (1) MA49673B1 (es)
MX (1) MX393852B (es)
MY (1) MY195271A (es)
PH (1) PH12020500091A1 (es)
PL (1) PL3658147T3 (es)
PT (1) PT3658147T (es)
RS (1) RS62837B1 (es)
RU (1) RU2764116C2 (es)
SG (1) SG11202000367RA (es)
SI (1) SI3658147T1 (es)
TW (1) TWI768087B (es)
UY (1) UY37818A (es)
WO (1) WO2019020559A1 (es)
ZA (1) ZA202000145B (es)

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EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
CN112638869B (zh) 2018-09-07 2025-04-25 赛诺菲 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法
KR20220006553A (ko) * 2019-05-09 2022-01-17 사노피 전이성 또는 진행성 유방암 환자에서 사용하기 위한 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디하이드로-7h-벤조[7]아눌렌-2-카르복실산
JP2023504912A (ja) * 2019-12-09 2023-02-07 サノフイ ７ｈ－ベンゾ［７］アヌレン－２－カルボン酸誘導体の結晶形態
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
CN116782895A (zh) * 2020-11-23 2023-09-19 赛诺菲 包含阿贝西利和6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸的组合
TW202302084A (zh) * 2021-03-02 2023-01-16 法商賽諾菲公司 以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) * 2021-04-12 2023-02-01 法商賽諾菲公司 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
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Also Published As

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AU2018308871A1 (en) 2020-02-06
ES2906279T3 (es) 2022-04-18
MY195271A (en) 2023-01-11
HUE057271T2 (hu) 2022-04-28
LT3658147T (lt) 2022-01-10
JP2020526572A (ja) 2020-08-31
BR112020001398A2 (pt) 2020-07-28
EP3658147B1 (en) 2021-11-10
IL272166B (en) 2022-12-01
TWI768087B (zh) 2022-06-21
EP3658147A1 (en) 2020-06-03
SG11202000367RA (en) 2020-02-27
AR112284A1 (es) 2019-10-09
RU2020107416A3 (es) 2021-08-25
MX393852B (es) 2025-03-24
EP3434272A1 (en) 2019-01-30
DK3658147T3 (da) 2022-01-31
IL272166B2 (en) 2023-04-01
CN111107851A (zh) 2020-05-05
CA3070754A1 (en) 2019-01-31
PT3658147T (pt) 2022-02-02
MA49673A (fr) 2021-03-24
US11260057B2 (en) 2022-03-01
KR20200031622A (ko) 2020-03-24
JP6741897B1 (ja) 2020-08-19
TW201919612A (zh) 2019-06-01
WO2019020559A1 (en) 2019-01-31
RU2020107416A (ru) 2021-08-25
HRP20212030T1 (hr) 2022-04-01
PL3658147T3 (pl) 2022-03-07
RU2764116C2 (ru) 2022-01-13
US20200171033A1 (en) 2020-06-04
CN111107851B (zh) 2023-05-12
PH12020500091A1 (en) 2020-09-14
CO2020000240A2 (es) 2020-04-24
RS62837B1 (sr) 2022-02-28
MA49673B1 (fr) 2022-02-28
IL272166A (en) 2020-03-31
SI3658147T1 (sl) 2022-02-28
ZA202000145B (en) 2021-07-28
US20220362248A1 (en) 2022-11-17

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