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UY33276A - Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y métodos de uso - Google Patents

Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y métodos de uso

Info

Publication number
UY33276A
UY33276A UY33276A UY33276A UY33276A UY 33276 A UY33276 A UY 33276A UY 33276 A UY33276 A UY 33276A UY 33276 A UY33276 A UY 33276A UY 33276 A UY33276 A UY 33276A
Authority
UY
Uruguay
Prior art keywords
amino
beta
compounds
oxazines
dihydrotiazine
Prior art date
Application number
UY33276A
Other languages
English (en)
Inventor
Jian J Chen
Cheng Yuan
White Ryan
Dineen Thomas
Epstein Oleg
Judd Ted
Lopez Patricia
Marx Isaac
Nick A Paras
Weiss Matthew
Zhong Wenge
Yang Bryant
Qian Wenyuan
Powers Timothy
Low Jonathan
Ana Elena Minatti
Potashman Michele
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of UY33276A publication Critical patent/UY33276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de amino oxazinas y de amino dihidrotiazinas útiles para la modulación de actividad de enzima Beta-secretasa y para el tratamiento de enfermedades mediadas por Beta-secretasa, incluyendo enfermedad de Alzheimer (AD) y afecciones relacionadas .
UY33276A 2010-03-15 2011-03-15 Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y métodos de uso UY33276A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31402410P 2010-03-15 2010-03-15

Publications (1)

Publication Number Publication Date
UY33276A true UY33276A (es) 2011-09-30

Family

ID=43982433

Family Applications (1)

Application Number Title Priority Date Filing Date
UY33276A UY33276A (es) 2010-03-15 2011-03-15 Compuestos de amino-oxazinas y amino-dihidrotiazina como moduladores de beta-secretasa y métodos de uso

Country Status (11)

Country Link
US (2) US8497264B2 (es)
EP (1) EP2547686B1 (es)
JP (1) JP5584352B2 (es)
AR (1) AR081154A1 (es)
AU (1) AU2011227501B9 (es)
CA (1) CA2791389C (es)
ES (1) ES2450568T3 (es)
MX (1) MX2012010657A (es)
TW (1) TW201144323A (es)
UY (1) UY33276A (es)
WO (1) WO2011115928A1 (es)

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US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
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Also Published As

Publication number Publication date
AR081154A1 (es) 2012-07-04
EP2547686B1 (en) 2014-01-22
US20110251186A1 (en) 2011-10-13
EP2547686A1 (en) 2013-01-23
CA2791389C (en) 2014-04-29
CA2791389A1 (en) 2011-09-22
US20140045828A1 (en) 2014-02-13
US8497264B2 (en) 2013-07-30
AU2011227501A1 (en) 2012-09-20
AU2011227501B2 (en) 2013-08-15
ES2450568T3 (es) 2014-03-25
TW201144323A (en) 2011-12-16
MX2012010657A (es) 2013-02-07
JP5584352B2 (ja) 2014-09-03
JP2013522304A (ja) 2013-06-13
WO2011115928A1 (en) 2011-09-22
US9012446B2 (en) 2015-04-21
AU2011227501B9 (en) 2013-08-22

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