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MX2012010657A - Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico. - Google Patents

Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico.

Info

Publication number
MX2012010657A
MX2012010657A MX2012010657A MX2012010657A MX2012010657A MX 2012010657 A MX2012010657 A MX 2012010657A MX 2012010657 A MX2012010657 A MX 2012010657A MX 2012010657 A MX2012010657 A MX 2012010657A MX 2012010657 A MX2012010657 A MX 2012010657A
Authority
MX
Mexico
Prior art keywords
sup
beta
amino
compounds
formula
Prior art date
Application number
MX2012010657A
Other languages
English (en)
Inventor
Michele Potashman
Wenyuan Qian
Yuan Cheng
Matthew Weiss
Patricia Lopez
Ryan White
Nick A Paras
Timothy Powers
Wenge Zhong
Ted Judd
Bryant Yang
Thomas Dineen
Jian J Chen
Oleg Epstein
Isaac Marx
Ana Elena Minatti
Jonathan Low
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2012010657A publication Critical patent/MX2012010657A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención comprende una nueva clase de compuestos útiles para la modulación de la actividad de la enzima Beta-secretasa y para el tratamiento de enfermedades mediadas por Beta-secretasa, que incluyen enfermedad de Alzheimer (AD) y afecciones relacionadas. En una modalidad, los compuestos tienen una Fórmula general (I): en donde A1, A2, A3, A4, A5, A6, R2, R7, X, Y y Z de la Fórmula (I) se definen en la presente. La invención también incluye el uso de estos compuestos en composiciones farmacéuticas para el tratamiento, profiláctico o terapéutico, de trastornos y afecciones relacionados con la actividad de la proteína beta-secretasa. Tales trastornos incluyen, por ejemplo, enfermedad de Alzheimer, deficiencias cognitivas, deterioro cognitivo, esquizofrenia y otras afecciones del sistema nervioso central relacionadas con y/o provocadas por la formación y/o deposición de placa en el cerebro. La invención también comprende modalidades adicionales de la Fórmula (I), intermediarios y procesos útiles para la preparación de compuestos de la Fórmula (I).
MX2012010657A 2010-03-15 2011-03-14 Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico. MX2012010657A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31402410P 2010-03-15 2010-03-15
PCT/US2011/028401 WO2011115928A1 (en) 2010-03-15 2011-03-14 Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as beta - secretase modulators and their medical use

Publications (1)

Publication Number Publication Date
MX2012010657A true MX2012010657A (es) 2013-02-07

Family

ID=43982433

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012010657A MX2012010657A (es) 2010-03-15 2011-03-14 Compuestos de espiro amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso medico.

Country Status (11)

Country Link
US (2) US8497264B2 (es)
EP (1) EP2547686B1 (es)
JP (1) JP5584352B2 (es)
AR (1) AR081154A1 (es)
AU (1) AU2011227501B9 (es)
CA (1) CA2791389C (es)
ES (1) ES2450568T3 (es)
MX (1) MX2012010657A (es)
TW (1) TW201144323A (es)
UY (1) UY33276A (es)
WO (1) WO2011115928A1 (es)

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Also Published As

Publication number Publication date
JP2013522304A (ja) 2013-06-13
CA2791389A1 (en) 2011-09-22
EP2547686A1 (en) 2013-01-23
JP5584352B2 (ja) 2014-09-03
ES2450568T3 (es) 2014-03-25
US20140045828A1 (en) 2014-02-13
AU2011227501A1 (en) 2012-09-20
TW201144323A (en) 2011-12-16
US9012446B2 (en) 2015-04-21
EP2547686B1 (en) 2014-01-22
UY33276A (es) 2011-09-30
US8497264B2 (en) 2013-07-30
AU2011227501B9 (en) 2013-08-22
AR081154A1 (es) 2012-07-04
US20110251186A1 (en) 2011-10-13
WO2011115928A1 (en) 2011-09-22
AU2011227501B2 (en) 2013-08-15
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