UY29078A1 - Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon) - Google Patents
Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon)Info
- Publication number
- UY29078A1 UY29078A1 UY29078A UY29078A UY29078A1 UY 29078 A1 UY29078 A1 UY 29078A1 UY 29078 A UY29078 A UY 29078A UY 29078 A UY29078 A UY 29078A UY 29078 A1 UY29078 A1 UY 29078A1
- Authority
- UY
- Uruguay
- Prior art keywords
- epsilon
- formula
- inhibitors
- amyalalkyl
- cinasa
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000005018 casein Substances 0.000 title 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title 1
- 235000021240 caseins Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000005403 Casein Kinases Human genes 0.000 abstract 1
- 108010031425 Casein Kinases Proteins 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención describe y reivindica compuestos de fórmula (I) y fórmula (II) como inhibidores de la caseína cinasa IE(epsilon) humana, y métodos de uso de dichos compuestos de fórmula (I) y fórmula (II) para el tratamiento de enfermedades y trastornos del sistema nervioso central incluyendo trastornos del estado de ánimo y trastornos del sueno. También se describen y reivindican composiciones farmacéuticas que comprenden compuestos de fórmula (I) o fórmula (II).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60338004P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY29078A1 true UY29078A1 (es) | 2006-03-31 |
Family
ID=35311279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY29078A UY29078A1 (es) | 2004-08-19 | 2005-08-19 | Amidas del ácido 5 y 6-aminoalquil indol-2-carboxílico 3-sustituidas y análogos relacionados como inhibidores de la caseína cinasa ie(epsilon) |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7629376B2 (es) |
| EP (1) | EP1794122B1 (es) |
| JP (1) | JP4843608B2 (es) |
| KR (2) | KR20070043012A (es) |
| CN (1) | CN101006055B (es) |
| AR (1) | AR050919A1 (es) |
| AT (1) | ATE508112T1 (es) |
| AU (1) | AU2005277523B2 (es) |
| BR (1) | BRPI0514380A (es) |
| CA (1) | CA2577667C (es) |
| DE (1) | DE602005027858D1 (es) |
| GT (1) | GT200500214A (es) |
| IL (1) | IL181156A (es) |
| JO (1) | JO2724B1 (es) |
| MA (1) | MA28863B1 (es) |
| MX (1) | MX2007001382A (es) |
| NO (1) | NO20071466L (es) |
| NZ (1) | NZ552800A (es) |
| PA (1) | PA8642901A1 (es) |
| PE (1) | PE20060498A1 (es) |
| RU (1) | RU2369599C2 (es) |
| SV (1) | SV2006002192A (es) |
| TW (1) | TWI357897B (es) |
| UY (1) | UY29078A1 (es) |
| WO (1) | WO2006023467A1 (es) |
| ZA (1) | ZA200700651B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9018238B2 (en) | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
| KR20120044281A (ko) * | 2009-04-17 | 2012-05-07 | 사일린 파마슈티칼스, 인크 | 단백질 키나제 ｃｋ2 활성과 관련된 장애의 치료 방법 |
| CN104540831B (zh) | 2012-06-27 | 2017-11-07 | 4Sc探索有限责任公司 | 用于治疗癌症、自身免疫性炎症和cns紊乱的二氟二氧戊环‑氨基‑苯并咪唑激酶抑制剂 |
| CN111757879A (zh) | 2018-01-29 | 2020-10-09 | 卡地拉健康护理有限公司 | 用作抗菌剂的杂环化合物 |
| WO2022006377A2 (en) * | 2020-07-02 | 2022-01-06 | Mbq Pharma | Heterocyclic inhibitors of rho gtpases for the treatment of disease |
| US12209078B2 (en) | 2021-10-06 | 2025-01-28 | Mbq Pharma | Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| US6555328B1 (en) * | 1999-06-08 | 2003-04-29 | Aventis Pharmaceuticals Inc. | Screening methods for altering circadian rhythms and for human casein kinase I δ and/or ε phosphorylation of human clock proteins, period 1, -2 and -3 |
| BR0110420A (pt) * | 2000-04-28 | 2003-07-01 | Acadia Pharm Inc | Agonistas muscarìnicos |
| JP4332112B2 (ja) * | 2002-08-09 | 2009-09-16 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害薬 |
| RS50823B (sr) * | 2003-12-11 | 2010-08-31 | Aventis Pharmaceuticals Inc. | Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon |
-
2005
- 2005-07-24 JO JO2005108A patent/JO2724B1/en active
- 2005-08-09 GT GT200500214A patent/GT200500214A/es unknown
- 2005-08-10 SV SV2005002192A patent/SV2006002192A/es active IP Right Grant
- 2005-08-16 BR BRPI0514380-2A patent/BRPI0514380A/pt not_active IP Right Cessation
- 2005-08-16 WO PCT/US2005/029053 patent/WO2006023467A1/en not_active Ceased
- 2005-08-16 RU RU2007109783/04A patent/RU2369599C2/ru not_active IP Right Cessation
- 2005-08-16 DE DE602005027858T patent/DE602005027858D1/de not_active Expired - Lifetime
- 2005-08-16 NZ NZ552800A patent/NZ552800A/en not_active IP Right Cessation
- 2005-08-16 KR KR1020077003922A patent/KR20070043012A/ko not_active Abandoned
- 2005-08-16 EP EP05786210A patent/EP1794122B1/en not_active Expired - Lifetime
- 2005-08-16 CN CN2005800284407A patent/CN101006055B/zh not_active Expired - Fee Related
- 2005-08-16 KR KR1020137005469A patent/KR20130038409A/ko not_active Withdrawn
- 2005-08-16 AR ARP050103442A patent/AR050919A1/es not_active Application Discontinuation
- 2005-08-16 AU AU2005277523A patent/AU2005277523B2/en not_active Ceased
- 2005-08-16 MX MX2007001382A patent/MX2007001382A/es active IP Right Grant
- 2005-08-16 AT AT05786210T patent/ATE508112T1/de not_active IP Right Cessation
- 2005-08-16 CA CA2577667A patent/CA2577667C/en not_active Expired - Fee Related
- 2005-08-16 JP JP2007527928A patent/JP4843608B2/ja not_active Expired - Fee Related
- 2005-08-17 PE PE2005000955A patent/PE20060498A1/es not_active Application Discontinuation
- 2005-08-19 UY UY29078A patent/UY29078A1/es unknown
- 2005-08-19 TW TW094128283A patent/TWI357897B/zh not_active IP Right Cessation
- 2005-08-19 PA PA20058642901A patent/PA8642901A1/es unknown
-
2007
- 2007-01-22 ZA ZA200700651A patent/ZA200700651B/xx unknown
- 2007-02-04 IL IL181156A patent/IL181156A/en not_active IP Right Cessation
- 2007-02-13 US US11/674,385 patent/US7629376B2/en active Active
- 2007-03-14 MA MA29757A patent/MA28863B1/fr unknown
- 2007-03-19 NO NO20071466A patent/NO20071466L/no not_active Application Discontinuation
-
2008
- 2008-11-12 US US12/269,216 patent/US7923466B2/en active Active
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