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UY28109A1 - Derivado hemisulfato de azido citosina cristalino anhidro - Google Patents

Derivado hemisulfato de azido citosina cristalino anhidro

Info

Publication number
UY28109A1
UY28109A1 UY28109A UY28109A UY28109A1 UY 28109 A1 UY28109 A1 UY 28109A1 UY 28109 A UY28109 A UY 28109A UY 28109 A UY28109 A UY 28109A UY 28109 A1 UY28109 A1 UY 28109A1
Authority
UY
Uruguay
Prior art keywords
citosine
azid
anhydr
hemisulphate
crystalline
Prior art date
Application number
UY28109A
Other languages
English (en)
Inventor
Keshab Sarma
Anthony Prince
Joseph Armstrong Martin
Terrence Joseph Connolly
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY28109A1 publication Critical patent/UY28109A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a la sal hemisulfato de 1-(4(S)- azido-2(S), 3(R)_dihidrosi-4-(hidroximetil)-1(R)-ci-clopentil)citosina (Ia) con una mayor estabilidad y mejores propiedades físicas, las cuales facilitan la obtención, manipulación y formulación de I y formas cristalinas polimórficas del mismo.
UY28109A 2002-12-09 2003-12-08 Derivado hemisulfato de azido citosina cristalino anhidro UY28109A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09

Publications (1)

Publication Number Publication Date
UY28109A1 true UY28109A1 (es) 2004-06-30

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28109A UY28109A1 (es) 2002-12-09 2003-12-08 Derivado hemisulfato de azido citosina cristalino anhidro

Country Status (32)

Country Link
US (1) US6864244B2 (es)
EP (1) EP1572711B1 (es)
JP (1) JP4563818B2 (es)
KR (1) KR100675544B1 (es)
CN (1) CN1314697C (es)
AR (1) AR042312A1 (es)
AT (1) ATE430755T1 (es)
AU (1) AU2003292212B2 (es)
BR (1) BR0317146A (es)
CA (1) CA2506532C (es)
CY (1) CY1109296T1 (es)
DE (1) DE60327554D1 (es)
DK (1) DK1572711T3 (es)
ES (1) ES2324654T3 (es)
GT (1) GT200300276A (es)
HR (1) HRP20050503A2 (es)
IL (1) IL168685A (es)
JO (1) JO2542B1 (es)
MX (1) MXPA05006044A (es)
MY (1) MY130927A (es)
NO (1) NO330454B1 (es)
NZ (1) NZ540297A (es)
PA (1) PA8590701A1 (es)
PE (1) PE20040767A1 (es)
PL (1) PL213734B1 (es)
PT (1) PT1572711E (es)
RU (1) RU2334756C2 (es)
SI (1) SI1572711T1 (es)
TW (1) TWI294882B (es)
UY (1) UY28109A1 (es)
WO (1) WO2004052906A1 (es)
ZA (1) ZA200504472B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576198B1 (en) * 1999-09-02 2009-08-18 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) * 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
ES2327252T3 (es) * 2004-08-23 2009-10-27 F. Hoffmann-La Roche Ag 4'-azido nucleosidos antivirales.
EP2084175B1 (en) * 2006-10-10 2010-12-29 Medivir AB Hcv nucleoside inhibitor
AU2007342367B2 (en) 2007-01-05 2012-12-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
MY190867A (en) 2015-03-06 2022-05-13 Atea Pharmaceuticals Inc ? -d-2'-deoxy-2'-?-fluoro-2'- ? -c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
PL3512863T3 (pl) 2016-09-07 2022-04-04 Atea Pharmaceuticals, Inc. 2'-Podstawione-N6-podstawione nukleotydy purynowe do leczenia zakażeń wirusem RNA
IL295609B2 (en) 2017-02-01 2023-11-01 Atea Pharmaceuticals Inc Nucleotide hemisulfate salt for the treatment of hepatitis C virus
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
BR112023026356A2 (pt) 2021-06-17 2024-03-05 Atea Pharmaceuticals Inc Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
ZA898834B (en) * 1988-11-21 1990-08-29 Syntex Inc Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
JP2002503212A (ja) * 1996-10-16 2002-01-29 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 単環式ヌクレオシド、その類似体および使用
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
HUP0400726A3 (en) * 2001-01-22 2007-05-29 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
NZ540297A (en) 2007-05-31
BR0317146A (pt) 2005-10-25
HK1085483A1 (en) 2006-08-25
CN1723215A (zh) 2006-01-18
GT200300276A (es) 2004-09-02
US20040162265A1 (en) 2004-08-19
EP1572711B1 (en) 2009-05-06
PL377472A1 (pl) 2006-02-06
DK1572711T3 (da) 2009-07-13
ZA200504472B (en) 2006-02-22
ATE430755T1 (de) 2009-05-15
WO2004052906A1 (en) 2004-06-24
JP4563818B2 (ja) 2010-10-13
KR20050084217A (ko) 2005-08-26
CA2506532C (en) 2011-09-20
RU2005121927A (ru) 2006-01-27
CA2506532A1 (en) 2004-06-24
HRP20050503A2 (en) 2006-12-31
EP1572711A1 (en) 2005-09-14
TWI294882B (en) 2008-03-21
AU2003292212A1 (en) 2004-06-30
IL168685A (en) 2010-11-30
AU2003292212B2 (en) 2009-10-01
PA8590701A1 (es) 2004-11-26
TW200502243A (en) 2005-01-16
NO20052732L (no) 2005-09-06
MXPA05006044A (es) 2005-08-18
DE60327554D1 (de) 2009-06-18
MY130927A (en) 2007-07-31
CY1109296T1 (el) 2014-07-02
JP2006510649A (ja) 2006-03-30
RU2334756C2 (ru) 2008-09-27
ES2324654T3 (es) 2009-08-12
PE20040767A1 (es) 2004-11-06
US6864244B2 (en) 2005-03-08
KR100675544B1 (ko) 2007-01-30
JO2542B1 (en) 2010-09-05
CN1314697C (zh) 2007-05-09
PT1572711E (pt) 2009-06-25
AR042312A1 (es) 2005-06-15
NO20052732D0 (no) 2005-06-07
SI1572711T1 (sl) 2009-08-31
NO330454B1 (no) 2011-04-18
PL213734B1 (pl) 2013-04-30

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Legal Events

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Effective date: 20150520