UY27645A1 - Mctodo para preparar dispersiones snlidas amorfas de farmacos secadas por pulverizacinn utilizando inyectores a presinn - Google Patents
Mctodo para preparar dispersiones snlidas amorfas de farmacos secadas por pulverizacinn utilizando inyectores a presinnInfo
- Publication number
- UY27645A1 UY27645A1 UY27645A UY27645A UY27645A1 UY 27645 A1 UY27645 A1 UY 27645A1 UY 27645 A UY27645 A UY 27645A UY 27645 A UY27645 A UY 27645A UY 27645 A1 UY27645 A1 UY 27645A1
- Authority
- UY
- Uruguay
- Prior art keywords
- dispersions
- snlid
- presinn
- mctod
- amorphes
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000006185 dispersion Substances 0.000 title abstract 2
- 238000005507 spraying Methods 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Glanulating (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Disintegrating Or Milling (AREA)
Abstract
Dispersiones sólidas amorfas homogéneas de fármacos en polímeros mejoradores de la concentración se preparan en tamanos de partícula más grande adecuadas con minimo contenido de finos, utilizando un atomizador y condiciones de procedimiento capaces de producir gotas que tienen un diámetro medio de al menos 50 micrones y un D10 de al menos 10 micrones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35398602P | 2002-02-01 | 2002-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY27645A1 true UY27645A1 (es) | 2003-09-30 |
Family
ID=27663274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY27645A UY27645A1 (es) | 2002-02-01 | 2003-01-31 | Mctodo para preparar dispersiones snlidas amorfas de farmacos secadas por pulverizacinn utilizando inyectores a presinn |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7780988B2 (es) |
| EP (1) | EP1469830A2 (es) |
| JP (1) | JP2005523260A (es) |
| KR (1) | KR100758045B1 (es) |
| CN (1) | CN1787808A (es) |
| AR (1) | AR038369A1 (es) |
| AU (1) | AU2003239463B2 (es) |
| BR (1) | BR0307515A (es) |
| CA (1) | CA2474958A1 (es) |
| GT (1) | GT200300024A (es) |
| MX (1) | MXPA04007435A (es) |
| PA (1) | PA8565401A1 (es) |
| PE (1) | PE20030804A1 (es) |
| PL (1) | PL371593A1 (es) |
| RS (1) | RS67304A (es) |
| RU (1) | RU2288703C2 (es) |
| TW (1) | TW200404576A (es) |
| UY (1) | UY27645A1 (es) |
| WO (1) | WO2003063821A2 (es) |
| ZA (1) | ZA200405971B (es) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| EP1469830A2 (en) | 2002-02-01 | 2004-10-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
| PL372247A1 (en) | 2002-02-01 | 2005-07-11 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| ES2339682T3 (es) | 2004-06-01 | 2010-05-24 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la preparacion de la forma amorfa de un farmaco. |
| PL2489659T3 (pl) | 2004-06-24 | 2018-06-29 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą atp |
| JP2007519758A (ja) | 2004-12-01 | 2007-07-19 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 結晶マクロライドの生成方法 |
| US9265731B2 (en) | 2005-01-28 | 2016-02-23 | Bend Research, Inc. | Drying of drug-containing particles |
| JP2009502969A (ja) | 2005-07-28 | 2009-01-29 | アイエスピー インヴェストメンツ インコーポレイテッド | 非晶質エファビレンツ及びその製造 |
| CN101304970A (zh) * | 2005-12-21 | 2008-11-12 | 卫材R&D管理有限公司 | 1,2-二氢吡啶化合物的无定形物 |
| JP5409010B2 (ja) | 2005-12-28 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | N−[2,4−ビス(1,1−ジメチルエチル)−5−ヒドロキシフェニル]−1,4−ジヒドロ−4−オキソキノリン−3−カルボキサミドの固体形態 |
| NZ569700A (en) | 2006-02-09 | 2011-09-30 | Merck Sharp & Dohme | Polymer formulations of CETP inhibitors |
| DK2029110T3 (da) | 2006-06-06 | 2011-12-19 | Tibotec Pharm Ltd | Fremgangsmåde til fremstilling af sprøjtetørrede formuleringer med TMC125 |
| EP2043610B1 (en) | 2006-07-21 | 2015-07-01 | Bend Research, Inc. | Drying of drug-containing particles |
| US8613946B2 (en) | 2006-12-21 | 2013-12-24 | Isp Investment Inc. | Carotenoids of enhanced bioavailability |
| EP2125938A2 (en) | 2007-01-26 | 2009-12-02 | Isp Investments Inc. | Formulation process method to produce spray dried products |
| EP2046777A2 (en) | 2007-05-01 | 2009-04-15 | Plus Chemicals B.V. | Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide |
| US20100048912A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| ES2552087T3 (es) | 2009-02-05 | 2015-11-25 | Tokai Pharmaceuticals, Inc. | Nuevos profármacos de inhibidores de CYP17 esteroidales/antiandrógenos |
| US8476442B2 (en) | 2009-03-20 | 2013-07-02 | Vertex Pharmaceutical Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US9724664B2 (en) * | 2009-03-27 | 2017-08-08 | Bend Research, Inc. | Spray-drying process |
| CN104997634A (zh) | 2010-04-09 | 2015-10-28 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
| SG2014013502A (en) | 2010-06-09 | 2014-05-29 | Abbvie Inc | Solid dispersions containing kinase inhibitors |
| WO2011163090A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| WO2012031129A2 (en) | 2010-09-03 | 2012-03-08 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| US9084944B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| WO2012040502A1 (en) * | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| TW201309346A (zh) | 2011-01-05 | 2013-03-01 | Hospira Inc | 噴霧乾燥萬古黴素 |
| TWI590821B (zh) * | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
| PT106063B (pt) * | 2011-12-19 | 2017-05-30 | Inst Superior Tecnico | Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono |
| CA2865519C (en) | 2012-02-27 | 2018-01-02 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis |
| CN104321059A (zh) | 2012-05-31 | 2015-01-28 | 默沙东公司 | 食欲素受体拮抗剂的固体剂量制剂 |
| IN2015DN02875A (es) * | 2012-09-11 | 2015-09-11 | Medivation Prostate Therapeutics Inc | |
| CN104144682A (zh) | 2013-01-31 | 2014-11-12 | 吉利德法莫赛特有限责任公司 | 两个抗病毒化合物的联用制剂 |
| CN105163735B (zh) | 2013-02-01 | 2018-12-11 | 格力尔罗格克斯股份有限公司 | 用于治疗神经退行性疾病和其他疾病的组合物和方法 |
| BR112015023098A2 (pt) | 2013-03-14 | 2017-07-18 | Univ Jefferson | agentes de infrarregulação do receptor de andrógeno e usos dos mesmos |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| KR102239196B1 (ko) | 2013-08-27 | 2021-04-12 | 길리애드 파마셋 엘엘씨 | 2종의 항바이러스 화합물의 조합 제제 |
| CN103694903B (zh) * | 2013-12-02 | 2015-07-01 | 南通瑞普埃尔生物工程有限公司 | 一种瞬干胶粘剂及其制备方法 |
| CA2928772A1 (en) * | 2013-12-05 | 2015-06-11 | Alrise Biosystems Gmbh | Process for the production of drug formulations for oral administration |
| US10406127B2 (en) | 2014-07-25 | 2019-09-10 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
| ES3009527T3 (en) * | 2014-07-25 | 2025-03-27 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
| KR20170063954A (ko) | 2014-10-07 | 2017-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정 |
| CA2962719A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
| RS66323B1 (sr) | 2014-12-05 | 2025-01-31 | Aragon Pharmaceuticals Inc | Sastavi protiv raka |
| EA201791251A1 (ru) | 2014-12-05 | 2017-11-30 | Арагон Фармасьютикалз, Инк. | Противораковые композиции |
| RU2585023C1 (ru) * | 2014-12-18 | 2016-05-27 | Общество с ограниченной ответственностью "Нанолек" | Способ гранулирования |
| WO2016198983A1 (en) | 2015-06-09 | 2016-12-15 | Bend Research Inc. | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
| SG10202011827YA (en) | 2016-04-15 | 2021-01-28 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| TW201818933A (zh) | 2016-10-21 | 2018-06-01 | 美商吉利亞洛吉克斯公司 | 用於神經退化性及其他疾病的治療之組成物和方法 |
| EP3765011A1 (en) | 2018-03-14 | 2021-01-20 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| CN112770750A (zh) | 2018-07-30 | 2021-05-07 | 中外制药株式会社 | 乙内酰脲衍生物的固体分散体 |
| US20200147032A1 (en) | 2018-11-14 | 2020-05-14 | Robert K. Prud'homme | Dihydromyricetin hot melt extrusion formulations and methods for forming them |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| US20220370444A1 (en) * | 2019-11-06 | 2022-11-24 | Mannkind Corporation | Compositions of Clofazimine, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them |
| WO2021138483A1 (en) | 2019-12-30 | 2021-07-08 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| LT4084779T (lt) | 2019-12-30 | 2024-11-11 | Deciphera Pharmaceuticals, Llc | 1-(4-brom-5-(1-etil-7-(metilamino)-2-okso-1,2-dihidro-1,6-naftiridin-3-il) -2- fluorfenil)-3-fenilkarbamido kompozicijos |
| IL293866A (en) | 2019-12-30 | 2022-08-01 | Deciphera Pharmaceuticals Llc | Compositions of amorphous kinase inhibitors and methods of using them |
| WO2022068876A1 (en) | 2020-09-29 | 2022-04-07 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical compositions |
| EP4499064A1 (en) * | 2022-03-25 | 2025-02-05 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical compositions of protac compounds and uses thereof |
| CN120418354A (zh) | 2022-12-28 | 2025-08-01 | 中外制药株式会社 | 含有待分散的物质的固体分散体、含有其的药物组合物及其生产方法 |
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|---|---|---|---|---|
| GB1131242A (en) | 1965-02-18 | 1968-10-23 | Gen Foods Ltd | Improvements in or relating to spray-drying apparatus |
| GB1329791A (en) | 1971-01-19 | 1973-09-12 | Niro Atomizer As | Spray drying devices for the production of powder eg milk powder |
| IT1025765B (it) | 1974-11-18 | 1978-08-30 | Gastaldi Francesco | Essiccatore perfezionato a spruzzo |
| DE2741196A1 (de) * | 1977-09-13 | 1979-03-15 | Bayer Ag | Verfahren zur herstellung von perlpolymeren |
| US4187617A (en) * | 1978-12-18 | 1980-02-12 | Becker James J Jr | Spray dryer |
| US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
| PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| SI9520049A (en) * | 1994-05-06 | 1997-12-31 | Pfizer | Controlled-release dosage forms of azithromycin |
| US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| DE19613691A1 (de) * | 1996-04-05 | 1997-10-09 | Boehringer Ingelheim Int | Arzneimittel für die Behandlung von Tumorerkrankungen |
| US5858409A (en) * | 1996-04-17 | 1999-01-12 | Fmc Corporation | Hydrolyzed cellulose granulations for pharmaceuticals |
| PT901786E (pt) | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
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| GT200100039A (es) * | 2000-03-16 | 2001-12-31 | Pfizer | Inhibidor de la glucogeno fosforilasa. |
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| PL372247A1 (en) * | 2002-02-01 | 2005-07-11 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
| EP1469830A2 (en) | 2002-02-01 | 2004-10-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
-
2003
- 2003-01-20 EP EP20030700071 patent/EP1469830A2/en not_active Withdrawn
- 2003-01-20 KR KR1020047011807A patent/KR100758045B1/ko not_active Expired - Fee Related
- 2003-01-20 WO PCT/IB2003/000120 patent/WO2003063821A2/en not_active Ceased
- 2003-01-20 CN CNA038047640A patent/CN1787808A/zh active Pending
- 2003-01-20 MX MXPA04007435A patent/MXPA04007435A/es active IP Right Grant
- 2003-01-20 BR BR0307515-0A patent/BR0307515A/pt not_active IP Right Cessation
- 2003-01-20 CA CA002474958A patent/CA2474958A1/en not_active Abandoned
- 2003-01-20 AU AU2003239463A patent/AU2003239463B2/en not_active Ceased
- 2003-01-20 PL PL03371593A patent/PL371593A1/xx not_active Application Discontinuation
- 2003-01-20 RS YU67304A patent/RS67304A/sr unknown
- 2003-01-20 RU RU2004123639/04A patent/RU2288703C2/ru not_active IP Right Cessation
- 2003-01-20 JP JP2003563515A patent/JP2005523260A/ja active Pending
- 2003-01-24 US US10/351,568 patent/US7780988B2/en active Active
- 2003-01-28 TW TW092101817A patent/TW200404576A/zh unknown
- 2003-01-29 PE PE2003000096A patent/PE20030804A1/es not_active Application Discontinuation
- 2003-01-30 AR ARP030100268A patent/AR038369A1/es unknown
- 2003-01-30 GT GT200300024A patent/GT200300024A/es unknown
- 2003-01-31 UY UY27645A patent/UY27645A1/es not_active Application Discontinuation
- 2003-02-03 PA PA20038565401A patent/PA8565401A1/es unknown
-
2004
- 2004-07-27 ZA ZA200405971A patent/ZA200405971B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100758045B1 (ko) | 2007-09-11 |
| JP2005523260A (ja) | 2005-08-04 |
| US20030185893A1 (en) | 2003-10-02 |
| RS67304A (sr) | 2006-10-27 |
| RU2288703C2 (ru) | 2006-12-10 |
| CA2474958A1 (en) | 2003-08-07 |
| KR20040083491A (ko) | 2004-10-02 |
| ZA200405971B (en) | 2006-05-31 |
| CN1787808A (zh) | 2006-06-14 |
| TW200404576A (en) | 2004-04-01 |
| PE20030804A1 (es) | 2003-09-19 |
| WO2003063821A3 (en) | 2003-11-13 |
| WO2003063821A2 (en) | 2003-08-07 |
| BR0307515A (pt) | 2004-12-07 |
| GT200300024A (es) | 2003-09-22 |
| US7780988B2 (en) | 2010-08-24 |
| PA8565401A1 (es) | 2003-12-10 |
| PL371593A1 (en) | 2005-06-27 |
| RU2004123639A (ru) | 2005-04-20 |
| AR038369A1 (es) | 2005-01-12 |
| AU2003239463B2 (en) | 2007-10-18 |
| MXPA04007435A (es) | 2004-10-11 |
| EP1469830A2 (en) | 2004-10-27 |
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| Date | Code | Title | Description |
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| 109 | Application deemed to be withdrawn |
Effective date: 20150126 |