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UY23589A1 - Nuevos derivados de n-aril-y n-heteroaril-urea como inhibidores de acil-coenzima a: colesterol acil transferasa (acat) - Google Patents

Nuevos derivados de n-aril-y n-heteroaril-urea como inhibidores de acil-coenzima a: colesterol acil transferasa (acat)

Info

Publication number
UY23589A1
UY23589A1 UY23589A UY23589A UY23589A1 UY 23589 A1 UY23589 A1 UY 23589A1 UY 23589 A UY23589 A UY 23589A UY 23589 A UY23589 A UY 23589A UY 23589 A1 UY23589 A1 UY 23589A1
Authority
UY
Uruguay
Prior art keywords
acil
acat
urea
inhibitors
aril
Prior art date
Application number
UY23589A
Other languages
English (en)
Inventor
Ernest Hamanaka
Original Assignee
Pfizer Inc Una Corporacion Organizada Bajo Las Leyes Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc Una Corporacion Organizada Bajo Las Leyes Del Estado De Delaware filed Critical Pfizer Inc Una Corporacion Organizada Bajo Las Leyes Del Estado De Delaware
Publication of UY23589A1 publication Critical patent/UY23589A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de un compuesto de fórmula I (figura 1) en donde Q es oxígeno o azufre; R17 es -(CH2)n-(CR19R20)z(CH2)r-Ar en donde - R19 y R20 y el átomo de carbono al que están unidos forman un anillo cicloalquilo de C4-C7 o un anillo cicloalquilo o heteroalquilo de C5-C7 condensado con un anillo de benceno; con la salvedad de que R19 y R20 no pueden ser los dos hidrógeno; - Ar se selecciona entre el grupo de la figura 2; R1 se selecciona entre el grupo de la figura 3. Como ejemplo no limitante: N-[2,4-bis(metiltio)-6-metilpiridin-3-il]-N'-(indan-2-il)-N'-(4-isopropilbencil)urea. El compuesto de fórmula I comprende al menos un elemento radiomarcado. Los compuestos son inhibidores de la ACAT y son útiles como agentes hipolipidémicos y antiaterosclerosis.
UY23589A 1992-05-28 1993-05-28 Nuevos derivados de n-aril-y n-heteroaril-urea como inhibidores de acil-coenzima a: colesterol acil transferasa (acat) UY23589A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89005092A 1992-05-28 1992-05-28

Publications (1)

Publication Number Publication Date
UY23589A1 true UY23589A1 (es) 1993-11-15

Family

ID=25396173

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23589A UY23589A1 (es) 1992-05-28 1993-05-28 Nuevos derivados de n-aril-y n-heteroaril-urea como inhibidores de acil-coenzima a: colesterol acil transferasa (acat)

Country Status (23)

Country Link
US (1) US6001860A (es)
EP (1) EP0642498A1 (es)
JP (1) JPH07503737A (es)
KR (1) KR950701621A (es)
CN (1) CN1080919A (es)
AU (1) AU4028393A (es)
BG (1) BG99188A (es)
BR (1) BR9306421A (es)
CA (1) CA2134359C (es)
FI (1) FI932423L (es)
HR (1) HRP930931A2 (es)
HU (1) HUT64303A (es)
IL (1) IL105756A0 (es)
IS (1) IS4023A (es)
MA (1) MA22896A1 (es)
MX (1) MX9303100A (es)
OA (1) OA10114A (es)
PL (1) PL299082A1 (es)
RU (1) RU94046149A (es)
SK (1) SK142694A3 (es)
UY (1) UY23589A1 (es)
WO (1) WO1993024458A1 (es)
YU (1) YU37193A (es)

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FI932423A7 (fi) 1993-11-29
RU94046149A (ru) 1996-11-27
HRP930931A2 (en) 1997-06-30
MX9303100A (es) 1994-06-30
EP0642498A1 (en) 1995-03-15
PL299082A1 (en) 1994-04-05
YU37193A (sh) 1997-07-31
BR9306421A (pt) 1998-09-15
SK142694A3 (en) 1995-06-07
JPH07503737A (ja) 1995-04-20
FI932423L (fi) 1993-11-29
CA2134359A1 (en) 1993-12-09
WO1993024458A1 (en) 1993-12-09
BG99188A (bg) 1995-07-28
HUT64303A (en) 1993-12-28
HU9301552D0 (en) 1993-09-28
US6001860A (en) 1999-12-14
KR950701621A (ko) 1995-04-28
CN1080919A (zh) 1994-01-19
CA2134359C (en) 1997-07-01
OA10114A (en) 1996-12-18
AU4028393A (en) 1993-12-30
FI932423A0 (fi) 1993-05-27
MA22896A1 (fr) 1993-12-31
IL105756A0 (en) 1993-09-22

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