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US9757750B2 - Medicinal device with container - Google Patents

Medicinal device with container Download PDF

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Publication number
US9757750B2
US9757750B2 US13/434,950 US201213434950A US9757750B2 US 9757750 B2 US9757750 B2 US 9757750B2 US 201213434950 A US201213434950 A US 201213434950A US 9757750 B2 US9757750 B2 US 9757750B2
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US
United States
Prior art keywords
seal
container
holder
rigid tube
insertion funnel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US13/434,950
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English (en)
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US20120325204A1 (en
Inventor
Holger Holakovsky
Lars LANGE
Maurice STEINZEN
Felix WEILAND
Klaus List
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEILAND, Felix, LANGE, LARS, STEINZEN, Maurice, LIST, KLAUS, HOLAKOVSKY, HOLGER
Publication of US20120325204A1 publication Critical patent/US20120325204A1/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0008—Sealing or attachment arrangements between sprayer and container
    • B05B11/0013—Attachment arrangements comprising means cooperating with the inner surface of the container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B05B11/0043—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • B05B11/3091—

Definitions

  • the present invention relates to devices for administering liquid medicinal formulations, the fluidic connection of these devices to, for example, propellant-free containers which contain the liquid in question, and the outward sealing of the containers and the fluidic connection between the container and the device.
  • the invention relates to smaller portable devices such as, for example, hand-operated nebulisers or injectors of the kind used for the inhalation or injection of liquid medicament formulations.
  • a large number of medical devices and nebulisers that are operated with a liquid are known from the prior art.
  • the liquid is placed in storage vessels or containers which contain several units of the liquid which is to be administered using the device.
  • a fluidic connection is provided between the device and the container, that is either permanent or capable of being interrupted, depending on the particular application.
  • the fluid connection is created either by means of removal lines such as cannulas or tubes inserted in the container, or by the exposing of openings in the container and the connection thereof to associated channels within the device.
  • This latter group also includes systems such as, for example, the metered dose inhalers (MDIs) containing propellant gas, in which a preliminary chamber or metering chamber is integrated in the container and the preliminary chamber is connected either to the liquid store or to the device by means of a switching mechanism, e.g. in the form of a movable pusher with corresponding guides.
  • MDIs metered dose inhalers
  • Some medicament formulations contain highly volatile substances such as, for example, ethanol which is often used as a solvent.
  • ethanol which is often used as a solvent.
  • concentration of the formulation may change.
  • concentration of an active substance in the solution may be increased or a dissolved substance may crystallise out.
  • Such substances escape primarily in gaseous form: these substances, which by their nature have an increased vapour pressure, are rapidly partially converted into the gaseous phase, even inside the container, particularly when there are climatic changes.
  • even very small increases in temperature or drops in pressure in the environment of the container may lead to an increased gas formation in the container and this gas may partially escape through a seal which is primarily designed to be liquidtight.
  • a mechanical miniaturised high pressure nebuliser with which liquid medicament formulations for inhalation can be nebulised from a container holding a number of units of the formulation and inside which the liquid pathway is sealed off statically and dynamically is known from WO97/12687A1 and WO2009/047173A2.
  • a liquid medicament formulation is conveyed from a rigid container with a collapsible inner bag inserted in the nebuliser, as disclosed in WO00/49988A2, out of the inner bag by means of a piston pump driven by a helical thrust gear and, by means of a spring-operated pressure pump, nebulised through a microstructured nozzle to form an inhalable aerosol.
  • WO2004/053362A1 describes a piston pump system that can be inserted in nebulisers of this kind, in which a predetermined amount of liquid is aspirated from the storage vessel into a pumping cylinder, by means of the axial movement of a hollow piston with non-return valve, and from there it is expelled through a liquid outlet.
  • the hollow piston and chamber are sealed by an elastomeric O-ring seal in the guide tube of the hollow piston close to its entry into the pump cylinder; the geometric installation status of this seal is described more extensively in WO2007/051536A1.
  • WO00/49988A2 shows a liquid-filled cartridge closed off with a stopper, connected to the attachment part of a removal device or a nebuliser.
  • the stopper comprises an immersion connector having a funnel-shaped centred guide for attaching a tubular removal connection belonging to the attachment part.
  • the stopper forms a press fit with the inserted removal connector (see WO96/06011 A1 for variants of this stopper in the form of a closure cap for a container).
  • the cartridge and attachment part are connected via a plug-in connection in which a plurality of snap-in hooks on the attachment part engage in an encircling groove in the upper part of the cartridge.
  • the cartridge or the upper open end of the immersion connector Before being connected to the removal device, the cartridge or the upper open end of the immersion connector is sealed off with a sealing film, while the end of the immersion connector facing the inside of the cartridge is provided with a membrane which is pierced or folded open as the removal connector is inserted.
  • WO2006/087516A1 shows a sealing arrangement for attaching the valve stem of a pressurised container to a nebuliser or to a switching device for a nebuliser.
  • This sealing arrangement comprises a first sealing portion which abuts directly on the outlet of the container, i.e. on the end face of the valve stem, and a second sealing portion at a spacing therefrom which seals off the side wall of the valve stem.
  • the first sealing portion is a flat seal with a through-hole and the second is an O-ring seal.
  • the two seals are redundant with respect to one another regarding their sealing function. The two are held together with a spacer by a solid cap and thus form a multi-part sealing arrangement.
  • the problem on which the present invention is based is to provide a device which is an improvement on the prior art, particularly a hand-held device such as a nebuliser or injector, for administering medicinal formulations from a container, in which the junction between the container and device is sealed off in liquidtight and gastight manner in accordance with the formulation used.
  • the sealing system should have no permeability with respect to the liquid and gaseous substances of the formulation or should not allow any diffusion leaks, particularly if the formulations contain substances with a high vapour pressure such as ethanol, for example.
  • the device with a sealing system at the junction of the container and device is intended in particular to be suitable for supplying measured amounts of liquid.
  • the devices equipped with these sealing systems should be as independent as possible from their subsequent use, i.e. particularly independent of climatic conditions and more especially independent of climatic fluctuations or the use or therapy which is individually determined for the user under the circumstances.
  • the number of actuations per day envisaged for the device may vary from one device to another depending on the active substance formulation and the dosage.
  • the device with sealing system should be suitable for mass production.
  • the sealing system should be particularly inexpensive with regard to the number and type of components and should be suitable for reliable assembly by mass production without suffering damage.
  • a device for administering a liquid medicinal formulation contained in a container inserted in the device The container is pushed onto a rigid tube within the device, the tube being connected to a holder which receives the container in the device, for example by clamping.
  • the container has an insertion point at which there is a first seal in the form of a fitting seal between the container and a section of the rigid tube which serves for removing liquid from the container.
  • a second seal Between the holder and the container is a second seal which seals off the space between the first seal, the container and the tube to prevent the escape of liquid and gases and/or the penetration of gases.
  • the second seal additionally seals off the fluidic connection between the device and container from the environment.
  • the two successive seals prevent the unwanted escape of liquid and gas from the container and/or the penetration of gas into the container more satisfactorily than the first seal on its own.
  • first seal is substantially leaktight against the liquid components of the medicinal formulation in the container and the second seal is essentially leaktight against gases.
  • the demands of the leaktightness of the system as a whole are divided into different requirements imposed on two separate seals.
  • This has the advantage that the individual requirements can be specifically met without any obligation to use a single solution which may be expensive or technically complex or defective in some respects.
  • a first seal at the container end may be designed primarily to hold back the liquid located within the container while fully respecting the requirements of the material compatibilities of the liquid and sealing material.
  • the requirement that the fluidic connection between the device and the container should be gastight can be specifically met by means of the second seal.
  • the material may be selected, for example, primarily from the point of view of its permeability to gas, without the materials used necessarily having to be chemically compatible with the liquid in the container.
  • the container holds substances that are highly volatile such as ethanol, for example.
  • Highly volatile substances exhibit both a high diffusion through very fine channels as a result of their vapour pressure and also, with lasting fluidic contact, significant diffusion through a plurality of plastics materials.
  • a further feature of the present invention is that whereas the first seal is formed by a fitting seal or press-fit between the container—preferably a partial region of an insertion funnel integrated in a container cap—and the tube that serves for the removal of liquid, the second seal is formed by only an additional component or an additional sealing layer between the container or the container cap and the holder for the container in the device.
  • the sealing layer the material of which is preferably softer than that of the container cap and holder, may for example be applied by moulding on, either on the side of the holder facing the container, or on the inner edge of the insertion point on the container or in the upper part of the container cap.
  • both seals, both the first and second act by direct contact with the container cap.
  • a seal formed by an additional component is preferably mounted on the device. It consists only of an elastomeric component which is compressed by the container cap and the device when the container is docked.
  • This seal on the device side may be a cap-like or cup-like or sleeve-like or cone-like shape with a through-opening for the tube or it may be an O-ring seal, flat seal or ring seal.
  • both seals may be formed by the direct contact of the container cap with hard components of the device.
  • they may be formed by press-fits between the container cap and the rigid tube serving to form the fluidic connection between the container and device, on the one hand, and a holder forming the container receptacle on the device on the other hand.
  • This measure provides an additional sealing of the junction between the container and the device with no or only one additional component.
  • This sealing system is inexpensive and suitable for mass production.
  • the double seal additionally has the advantage that occasional leaks cannot affect the leaktightness of the system as a whole. Such leakiness may be caused by sporadically occurring unevenness on a hard surface belonging to the sealing system, such as for example the surface of the tube in the region of the press-fit with the container cap.
  • a second seal catches any leaks occurring at the first. As a result, demands made of the production process and possibly production costs may be reduced in some cases.
  • the devices shown here for administering medicinal formulations are preferably hand-held devices such as nebulisers or injectors, by means of which liquids are nebulised or injected in predetermined volumes or defined amounts.
  • liquid additionally encompasses dispersions, suspensions, suslutions (mixtures of solutions and suspensions) or the like.
  • medicament formulation or “medicament formulation” in the present invention, in addition to medicaments, refers to therapeutic agents or the like, i.e. in particular any kind of agent for inhalation or other types of application to humans and animals.
  • FIG. 1 shows a schematic longitudinal section through a nebuliser in the “untensioned” state
  • FIG. 2 shows a schematic longitudinal section through the nebuliser of FIG. 1 , rotated through 90° compared with FIG. 1 , in the “tensioned” state
  • FIG. 3 shows a schematic longitudinal section through the nebuliser components of nozzle, filter, pump chamber, hollow piston and holder for the container (not shown).
  • FIG. 4 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump with a seal according to the invention
  • FIG. 5 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump according to a second embodiment of the invention
  • FIG. 6 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump according to a third embodiment of the invention
  • FIG. 7 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump according to a fourth embodiment of the invention
  • FIG. 8 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump according to a fifth embodiment of the invention
  • FIG. 9 shows a schematic longitudinal section through the point of attachment of a container to a delivery pump according to a sixth embodiment of the invention
  • FIGS. 1 and 2 diagrammatically show a manually operated medical device in which the sealing system according to the invention can be used.
  • the device shown in FIGS. 1 and 2 is a propellant-free nebuliser ( 1 ), which, on each actuating cycle, delivers the predetermined amount of a liquid ( 2 ) or a liquid medicinal formulation as a preferably lung-bound or inhalable aerosol ( 14 ) by means of a purely mechanical high pressure pump from the nozzle ( 12 ).
  • This aerosol ( 14 ) with droplets having aerodynamic diameters of preferably 3-10 microns can be breathed in by a user (not shown).
  • nozzle ( 12 ) of this device used for nebulisation is exchanged for the head of a liquid dispenser or an injection nozzle or a cannula or other injection device, all the operating principles independent of the nozzle remain unchanged.
  • the correlations described hereinafter apply analogously to injectors or other liquid-delivery systems, even though only nebulisers are mentioned in the interests of simplicity.
  • tensioning of the nebuliser ( 1 )
  • its upper housing part ( 16 ) is rotated relative to the inner housing part ( 17 ) and lower housing ( 18 ) by a fixed rotation angle, e.g. 180°.
  • a helical thrust gear mounted inside drives a piston pump by relative rotation, so that a predetermined, optionally adjustable amount of liquid ( 2 ) is conveyed from the container ( 3 ) into the pressure chamber and at the same time the drive spring ( 7 ) acting on the hollow piston ( 9 ) is tensioned.
  • FIG. 2 The final state of the tensioning process is shown in FIG. 2 .
  • the nebuliser ( 1 ) When the nebuliser ( 1 ) is actuated by the operation of the locking ring ( 8 ) using the button ( 40 ) the energy stored in the drive spring ( 7 ) is released.
  • the hollow piston ( 9 ) previously used for delivering liquid which is also part of the high pressure pump of the device, now presses into the pressure chamber ( 11 ) with its non-return valve ( 10 ) closed, so that the quantity of liquid predetermined by the lifting movement of the hollow piston ( 9 ) is expelled from there through the nozzle ( 12 ).
  • the device is now in the released state again ( FIG. 1 ).
  • FIG. 3 schematically shows the pressure generator ( 5 ) of the nebuliser ( 1 ) which, in the embodiment shown, is suitable both for nebulising aqueous liquid formulations and also, in particular, for nebulising formulations that contain a substance with a high vapour pressure or, more particularly, an alcohol compound, for example, as the solvent.
  • the hollow piston ( 9 ) belonging to the piston pump system projects into the pressure chamber ( 11 ) on the container side.
  • the hollow piston ( 9 ) is also the connecting element between the pressure chamber ( 11 ) and the interior of the container ( 3 ).
  • the hollow piston ( 9 ) or a similar rigid tube or tubular component such as a capillary or cannula thus creates the fluidic connection between the device and container ( 3 ) when inserted in the container ( 3 ). If the hollow piston ( 9 ) is partly withdrawn from the pressure chamber ( 11 ) during the tensioning of the drive spring ( 7 ), a reduced pressure is produced by means of which liquid ( 2 ) is aspirated out of the container ( 3 ) into the pressure chamber ( 11 ) via the non-return valve ( 10 ) in the hollow piston ( 9 ), which is open in this position.
  • the non-return valve ( 10 ) is closed by the abutment of its sealing surfaces on the seat in the hollow piston, and the liquid in the pressure chamber ( 11 ) is expelled under pressure through a filter system and the nozzle ( 12 ).
  • the hollow piston ( 9 ) and pressure chamber ( 11 ) are sealed off to the outside by an elastomeric seal ( 24 ) which is, more particularly, in the form of an O-ring and is located in the guide tube of the piston close to its entry into the pressure chamber ( 11 ) or the metering chamber of the nebuliser ( 1 ).
  • this seal ( 24 ) seals off a space from a moving part—the hollow piston ( 9 )—it may be referred to as a dynamic seal.
  • the high pressure pump is sealed off from the hollow piston ( 9 ) by a seal which is separate from the attachment of the hollow piston ( 9 ) to the container ( 3 ), more particularly a dynamic seal.
  • the seal ( 24 ) is compressed by a support ring ( 25 ) which is held in position by a check nut ( 26 ).
  • the geometric position of installation of the seal ( 24 ) corresponds, for example, to that described in WO2007/051536A1.
  • a filter system ( 27 , 28 ) which is located in front of the preferably microstructured nozzle ( 12 ) in the direction of flow and protects it from the depositing of particles.
  • a high deposition rate is achieved by the combination of different kinds of filters ( 27 , 28 ) and filtering techniques.
  • the nozzle ( 12 ) is preferably formed by a microstructured component consisting of a glass-silicon composite which itself contains a very fine filter designed as a flow filter in front of the actual nozzle channel. The nebulisation of the liquid through these nozzle channels preferably depends on the high speed impact between two microscopic liquid streams from nozzle channels only a few microns in diameter.
  • the central part ( 23 ) forms the lateral limit of the pressure chamber ( 11 ), the liquid inlet in the form of the passage for the liquid-carrying hollow piston ( 9 ), the installation space for the seal ( 24 ) that seals off from the hollow piston ( 9 ), and the fluidic attachment to the nozzle assembly ( 29 ), which contains the nozzle ( 12 ) and various associated holder or sealing components.
  • the central part ( 23 ) accommodates, in a central bore, one or more filter components attached to the pressure chamber ( 11 ).
  • the filter components are a preliminary filter ( 27 ), preferably made of a plastic material, and a fine filter ( 28 ), preferably made of metal. Further downstream is connected the microstructured component described above which contains very fine filters and nozzle channels.
  • the nebuliser ( 1 ) or its pressure generator ( 5 ) comprises a holder ( 6 ) for the container ( 3 ).
  • This holder ( 6 ) is fixedly connected to the hollow piston ( 9 ), preferably moulded on, for example also adhesively bonded or snap-fitted.
  • the drive spring ( 7 ) the holder ( 6 ), together with the container ( 3 ) and the hollow piston ( 9 ), is moved downwards, in the drawings.
  • the container ( 3 ) is fixed in the nebuliser ( 1 ) by means of the holder ( 6 ), particularly by a clamping or latching action, such that the hollow piston ( 9 ) projects into the fluid chamber of the container ( 3 ) and/or is fluidically connected to the liquid ( 2 ) in the container ( 3 ) and the liquid is aspirated through the hollow piston.
  • the hollow piston ( 9 ) and container ( 3 ) are thus no longer moved relative to one another during the operation of the nebuliser ( 1 ) after the container ( 3 ) has been connected to the holder ( 6 ), i.e. after the container ( 3 ) has been docked on the device there is no relative movement of the components involved in sealing the junction between the device and container.
  • the container ( 3 ) and holder ( 6 ) form a plug-in connection in which, in particular, a plurality of snap-in hooks ( 6 a ) of the holder ( 6 ) engage in an encircling contour in the upper part of the container ( 3 ).
  • This contour may be, for example, an encircling groove or, as in the embodiment shown, the lower collar edge of a container cap ( 31 ) that closes off the container ( 3 ).
  • the holder comprises 4 to 12, preferably 6 or 12 snap-in hooks or ribs. If the container ( 3 ) together with its container cap ( 31 ) is pushed forwards along the hollow piston ( 9 ) into the holder ( 6 ), the container cap ( 31 ) first makes contact with the insertion slopes ( 6 b ) on the snap-in hooks ( 6 a ). The inwardly sloping insertion slopes ( 6 b ) cause the snap-in hooks ( 6 a ) to be spread outwards by the container cap ( 31 ) until the container cap ( 31 ) is able to slide past the inwardly directed beads ( 6 c ) of the snap-in hooks ( 6 a ).
  • the snap-in hooks ( 6 a ) spring back inwardly, so that the beads ( 6 c ) secure the container ( 3 ) at the lower edge of the container cap ( 31 ).
  • the holder ( 6 ) may be configured such that the container ( 3 ) is exchangeable. This exchangeability is achieved by means of the springy properties of the snap-in hooks ( 6 a ). The length, width and, above all, thickness and material of the holder ( 6 ) are selected accordingly.
  • the holder ( 6 ) preferably consists of a plastic selected from among the thermoplasts such as, for example PPO (polyphenylene oxide) or PPE (polyphenylene ether) or PBT (polybutylene terephthalate).
  • the geometry of the beads ( 6 c ) and the proportion of the beads ( 6 c ) on the inner circumferential circle of the holder ( 6 ) are matched to one another. For fine adjustment of the forces needed for the insertion or removal of the container ( 3 ) into or out of the holder ( 6 ) it is useful to equip only some of the ribs on the holder with beads ( 6 c ) to form snap-in hooks ( 6 a ).
  • the holder ( 6 ) in the embodiment shown in FIG. 3 has a total of three ribs without a bead ( 6 c ). These ribs without a bead ( 6 c ) serve merely for radial guidance of the container ( 3 ) inserted into the holder ( 6 ).
  • the exchangeability of the container is determined not only by the properties of the holder ( 6 ) but also by its accessibility: in the embodiment shown in FIGS. 1 and 2 , a nebuliser is shown, the cap-like lower housing part ( 18 ) of which envelops the free end region of the container ( 3 ) inserted in the nebuliser.
  • the lower housing part ( 18 ) is releasably attached by means of a retaining element or safety closure ( 19 ), and in particular is fitted onto the inner housing part ( 17 ).
  • the retaining element or safety closure ( 19 ) is configured so as to prevent accidental opening of the nebuliser ( 1 ) or removal of the lower housing part ( 18 ).
  • the safety closure ( 19 ) In order to release the lower housing part ( 18 ), in particular, the safety closure ( 19 ) has to be pressed in counter to spring force.
  • the safety closure ( 19 ) is preferably a form that belongs to the inner housing part ( 17 ) and/or is moulded onto it, and configured in the form of a spring hook, for example.
  • the nebuliser ( 1 ) may also be configured such that the container ( 3 ) is pre-installed in the nebuliser.
  • the container ( 3 ) is inserted at the factory in the nebuliser ( 1 ) or in an additional retaining or securing element in the lower housing part ( 18 ) which is only partially pushed onto the inner housing part ( 17 ) when supplied.
  • the lower housing part ( 18 ) slides, for example, over a ratchet pathway which is designed to slide only in one direction of movement or, after being pushed fully on, hooks permanently into a latching mechanism of variable configuration.
  • the container ( 3 ) is pushed into its holder ( 6 ) and connected to the hollow piston ( 9 ). Further details of the configuration of such systems with a pre-installed container ( 3 ) can be found in WO2006/125577A2.
  • the medicinal devices under consideration here are designed for delivering a number of dosage units of the liquid medicinal formulation.
  • the nebuliser ( 1 ) in FIG. 1 has a counter ( 41 )—in this specific embodiment a spindle/cursor counter driven by the rotation of the housing, by means of which the user (not shown) can read off the quantity of dosage units taken or those remaining in the device.
  • the container inserted in the device contains a quantity of liquid ( 2 ) which is sufficient for the removal of numerous—e.g. 30 to 180—dosage units.
  • the container ( 3 ) inserted in the nebuliser ( 1 ) must be such that the internal pressure remains substantially unchanged even when liquid is being removed, so that the same amount of liquid ( 2 ) is always removed on aspiration.
  • This can basically be achieved using both a container ( 3 ) with a rigid container wall, the internal pressure of which is kept constant by means of a vent, as described for example in WO2006/136426A1, and also a container ( 3 ) with a flexible inner wall which moves at least partly into the interior of the container as liquid is withdrawn and thus keeps the internal pressure constant at the storage location for the liquid by reducing the internal volume.
  • Containers ( 3 ) in which the flexible wall is formed by a bag ( 32 ) or inner bag or foil bag which is substantially deformable, compressible and/or collapsible are preferred. Containers of this kind are described in various embodiments in the publications WO00/49988A2, WO01/076849A1, WO99/43571A1, WO2009/11500A1 and WO2009/103510A1.
  • a container is preferred in which the liquid ( 2 ) is located in a flexible, deformable and/or collapsible bag ( 32 ) or tube.
  • the internal pressure at the storage site of the liquid can be kept constant as liquid is withdrawn without any regular exchange of gases taking place with the environment of the nebuliser ( 1 ).
  • Such an exchange of gas would have the disadvantage, particularly when using liquid medicinal formulations with highly volatile solvents such as ethanol, that a solvent fraction could escape through the gaseous phase in each venting process.
  • a multilayered film or the like is used as the flexible wall material for the bag ( 32 ) that holds the liquid ( 2 ).
  • the film comprises a plastics layer compatible with the medicinal liquid and a metal layer such as a layer of aluminium or the like. This minimises the diffusion or permeation of gas through the wall of the bag.
  • the container ( 3 ) selected for the embodiments shown comprises an inner bag ( 32 ), a flange ( 32 a ), a container cap ( 31 ) and a rigid sleeve ( 34 ).
  • the flexible multilayer bag ( 32 ) which is closed at the bottom is directly connected at its upper part to a flange ( 32 a ), preferably made of plastics, that provides a grip.
  • the rigid sleeve ( 34 ) surrounds the bag ( 32 ) and protects it outwardly from mechanical damage.
  • the container cap ( 31 ) is preferably made of plastics, most preferably of HD-PE, and particularly a material that is the same as or similar to the flange ( 32 a ).
  • the container cap ( 31 ) comprises as the insertion point an insertion funnel ( 31 a ) projecting into the interior of the bag ( 32 ), which forms a centred guide for the hollow piston ( 9 ) when the container is attached to the nebuliser ( 1 ), and thus prevents the container ( 3 ) from being pierced by the hollow piston ( 9 ) in an uncontrolled manner with respect to the junction.
  • the container or the end of the insertion funnel ( 31 a ) facing the interior of the container ( 3 ) is closed off with a membrane ( 31 b ) which is pierced or flipped open when the hollow piston ( 9 ) is inserted.
  • the membrane ( 31 b ) protects the un-pierced container from the escape of liquid.
  • a top seal which may consist for example, of a metal foil, preferably aluminium, and closes off the upper open end of the insertion funnel ( 31 a ).
  • a seal of this kind may serve as a guarantee of origin and protect the insertion funnel ( 31 a ) from contamination during the transporting of individual cartridges. Gases that may possibly pass through the membrane ( 31 b ) are held back by a metallic top seal.
  • the top seal can be removed, e.g. by pulling it off using a protruding tab.
  • the hollow piston ( 9 ) is made of metal, preferably stainless steel.
  • the container cap ( 31 ) consists of a plastics material which is softer than the hollow piston ( 9 ), preferably PE or HD-PE.
  • the material of the container cap ( 31 ) cannot be of unlimited softness as the inherent stability is important to the operational reliability of the system.
  • the press-fit between the hollow piston ( 9 ) and the insertion funnel ( 31 a ) may be designed to be sealed against the passage of liquid but not necessarily against permeability to gases.
  • FIGS. 4 to 9 show different embodiments of the second seal ( 30 ).
  • the holder ( 6 ) and hollow piston ( 9 ) are only shown in their lower part, in the interests of simplicity (a complete representation of these components can be found in FIGS. 1 to 3 ).
  • FIG. 4 shows an example of the second seal ( 30 ) which is mounted as an additional sealing component on the outside of a tube such as the hollow piston ( 9 ) or on the holder ( 6 ) that forms the receptacle for the container and is provided on the device.
  • a radially symmetrical seal ( 30 ) is shown here which seals off the container cap ( 31 ) and hollow piston ( 9 ) from one another in the upper part of the insertion funnel ( 31 a ), i.e. in its widened portion above the press-fit with the hollow piston ( 9 ).
  • This second seal ( 30 ) which is located on the device side compared with the first seal, surrounds the hollow piston ( 9 ) radially in the region of the holder ( 6 )—either directly or at a spacing produced by the inner guide ( 6 d ).
  • the seal ( 30 ) here abuts with its upper side on the holder ( 6 ), particularly on the inner guide ( 6 d ), which is pulled downwards a little way along the hollow piston ( 9 ) towards the container ( 3 ).
  • the seal ( 30 ) embodied as a component has on the inside a circular cylindrical recess for guiding the hollow piston ( 9 ), in the upper part a configuration which is funnel shaped in this embodiment and adapted to the shape of the inner guide ( 6 d ) of the holder ( 6 ) and on the outside a conical configuration tapering towards the container ( 3 ).
  • This conical configuration forms a counterpart to the inner contour of the insertion funnel ( 31 a ) of the container cap ( 31 ).
  • the second seal ( 30 ) provides a seal in the conical wall portion of the insertion funnel ( 31 a ) of the container cap ( 31 ).
  • the seal ( 30 ) is pre-assembled on the holder ( 6 ), surrounding the hollow piston ( 9 ) and supported by the inner guide ( 6 d ). If the container ( 3 ) is then inserted in the nebuliser ( 1 ) and pushed axially onto the hollow piston ( 9 ), the seal ( 30 ) is axially compressed between the inner guide ( 6 d ) and the inner wall of the insertion funnel ( 31 a ) on the container cap ( 31 ). Looking at the attachment of the container ( 3 ) to the device as a whole, a sealing action is obtained by axial compression, particularly parallel to the tubular component or hollow piston ( 9 ) and by radial compression, particularly perpendicular to the hollow piston ( 9 ).
  • the system is provided with a double-acting seal.
  • the seal ( 30 ) preferably consists of an elastomer such as silicon and/or carbon-based elastomeric polymers.
  • Suitable materials include natural and synthetic elastomers, for example nitrile rubber, butadiene rubber, styrene-butadiene rubber, isoprene rubber, styrene-isoprene copolymers, butyl rubber such as isobutene-isoprene rubber, polyurethane, fluorine rubber, siloxans such as in particular silicones and diene such as in particular EPDM (ethylene-propylene-diene rubber) or other elastomers suitable for use in the medical field.
  • the seal may additionally be coated.
  • sealing components coated with PTFE (polytetrafluoroethylene) consisting of fluorine rubber are advantageous against the background of improved separability on assembly machines for mass production.
  • the use of a soft elastomer, particularly one with a Shore hardness in the range from 40 to 70 Shore, for the seal ( 30 ) has the advantage that a hard-soft seal is formed both relative to the insertion funnel ( 31 a ) and relative to the hollow piston ( 9 ). Unevennesses in the comparatively hard surface of the insertion funnel ( 31 a ) and hollow piston ( 9 ) can thus be evened out by the seal ( 30 ), so that the transitional area between the components is also leaktight in respect of volatile substances.
  • the seal ( 30 ) can thus also be termed a gas phase seal as the permeation of gases along the hollow piston ( 9 ) is prevented here.
  • the dead volume i.e. the unused free space between the second seal ( 30 ), the hollow piston ( 9 ) and the first seal (press-fit between the hollow piston ( 9 ) and container cap ( 31 )) is kept comparatively small.
  • the dead volume is constant as long as the container ( 3 ) is installed in the device.
  • the components involved in the seal are not moved towards one another during the operation of the device or nebuliser ( 1 ).
  • equilibrium is rapidly established during the permeation of gas from the bag ( 32 ) through the press-fit, so that the total quantity of substances lost by the escape of gases can be kept very small.
  • the substance with the highest vapour pressure is usually the solvent of the medicinal formulation in the bag ( 32 ).
  • the resulting minimising of the loss of solvent prevents concentration of the active substance in the solution.
  • Tests have shown good long-term stability of the effect of the second seal ( 30 ).
  • the gravimetrically determined evaporation values of containers ( 3 ) installed in devices using the seal ( 30 ) were just as low, depending on their material, as the unpierced containers ( 3 ) with an intact membrane ( 31 b ).
  • the sealing system formed by the two seals between the container cap and device had an ethanol permeability of less than 0.3 milligrams per day.
  • the results achieved were on average between 0.005 and 0.04 milligrams per day. Even when an elastomer such as silicon was used, which is known per se for its partial permeability for ethanol, the highest individual value measured was less than 0.15 milligrams per day.
  • FIG. 5 shows another embodiment of the second seal ( 30 ), embodied as a component, in the installed state.
  • the material of the seal ( 30 ) corresponds to that used in the embodiment in FIG. 4 .
  • a material should be used for the special application which is, in particular, diffusion-proof to the substances contained in the medicinal formulation, i.e. does not allow any gas permeation of the solvent, for example.
  • the component shown in FIG. 5 that forms the seal ( 30 ) is also radially symmetrical and is in the shape of a cup that has been opened at the bottom or a cap. The opening in the cup is the passage for the hollow piston ( 9 ).
  • the inner shape of the sealing component or the inner contour of the cup is the counterpart to the shape of the inner guide ( 6 d ) of the holder ( 6 ) in the region of the hollow piston ( 9 ).
  • the sealing component has an upper circular cylindrical region which merges into a region that tapers conically downwards.
  • the bottom of the cup is funnel shaped. Sealing is carried out by a purely radially acting compression of the seal ( 30 ) between the inner guide ( 6 a ) of the holder ( 6 ) and a circular cylindrical opening region ( 31 c ) of the container cap ( 31 ). This circular cylindrical opening region ( 31 c ) adjoins the insertion funnel ( 31 a ) in the upward direction on the container cap ( 31 ).
  • the two seals are formed by radial compression between the container ( 3 ) or container cap ( 31 ) and the hollow piston ( 9 ) or holder ( 6 ).
  • the radial action of the seal ( 30 ) has the advantage that no additional axial forces have to be applied when inserting the container ( 3 ) in the device.
  • the component forming the second seal ( 30 ) is shaped here so as to have a support region which in the axial direction abuts on another component of the device, particularly on the holder ( 6 ).
  • the cap-shaped or cup-shaped configuration of the sealing component is adapted to the lower edge of the inner guide ( 6 d ) of the holder ( 6 ) and the inner base of the cup which forms the support region for the sealing component abuts at the bottom on the inner guide ( 6 d ).
  • the support region of the component that forms the seal ( 30 ) thus abuts on the region of the holder ( 6 ) that projects into the container ( 3 ). Even if very soft sealing materials are used, the sealing component is held in position by this support and during docking, i.e. when the container ( 3 ) is inserted in the holder ( 6 ), it is not moved along by the axially acting forces in the upper axial space between the container cap ( 31 ) and the holder ( 6 ).
  • the non-sealing supported lower region of the sealing component can be expanded.
  • this lower region of the component that forms the seal ( 30 ) has no direct wall contact with the insertion funnel ( 31 a ) of the container cap ( 31 ), so that during the docking of the container ( 3 ) no additional axial forces come into play.
  • FIGS. 6 and 7 show two further embodiments of the seal ( 30 ) in the installed state.
  • the seal acts radially between the inner guide ( 6 d ) of the holder ( 6 ) and the inner wall of the container cap ( 31 ), or specifically in the cylindrical opening region ( 31 c ) above the insertion funnel ( 31 a ).
  • the seal is a hard-soft seal on both sides, in which the superficially soft material of the seal ( 30 ) evens out the surface unevenness of the container cap or of the inner guide ( 6 d ) of the holder ( 6 ) in the sealing region.
  • the seal ( 30 ) may take the form of a flat ring seal which is fitted over the inner guide ( 6 d ) of the holder ( 6 ) ( FIG. 6 ), or it may be in the shape of a flat or O-ring-shaped seal ( 30 ) set into the inner guide ( 6 d ) ( FIG. 7 ) which is held in position by a radial depression on the inner guide ( 6 d ).
  • the inner guide itself may converge conically downwards and the seal ( 30 )—adapted to the shape of the inner guide—may be a ring that expands downwardly and inwardly, which is inwardly supported on the inner guide ( 6 d ) (a variant not shown in the drawings).
  • a preferred assembly process for the seal ( 30 ) according to the embodiments in FIGS. 4 to 7 is as follows:
  • the hollow piston ( 9 ) is fixedly connected to the holder ( 6 ), preferably by moulding the plastic material of the holder ( 6 ) to the hollow piston ( 9 ) directly in an inlay injection moulding process. Then the holder ( 6 ) with the hollow piston ( 9 ) is mounted in the nebuliser ( 1 ) which is open on the container side (i.e. at the bottom in this case) but otherwise fully assembled.
  • the radially symmetrical component that forms the seal ( 30 ) is pushed along the hollow piston ( 9 ) from below, in a centred manner, into its position on the holder ( 6 ) or on the inner guide ( 6 d ).
  • This process is preferably carried out without any contact so as not to cause any damage to the hollow piston such as, for example, striations or other unevenness which could weaken the effectiveness of the first seal, in this embodiment the seal produced by the press-fit between the hollow piston ( 9 ) and the container cap ( 31 ).
  • a material with an elongation at break of at least 200%, preferably with an elongation at break of between 300% and 500% is used for the seal ( 30 ).
  • the material must also be selected so that the component undergoes purely elastic deformation during this loading and then returns to its original shape.
  • the assembly of the component that forms the seal ( 30 ) is preferably carried out by means of a device in which at least three gripper arms project into the circular passage in the component and spread it out from the inside outwards.
  • the spread-out component is pushed over the hollow piston ( 9 ) into its position on the holder ( 6 ).
  • a plastic sleeve located on the inside between the grippers may additionally serve to protect the hollow piston.
  • a further fine adjustment of the position of the component that forms the seal ( 30 ) may also take place while the container ( 3 ) is being docked on the nebuliser ( 1 ) if the container cap ( 31 ), the seal ( 30 ) and the holder ( 6 ) are optionally pushed axially further together.
  • the latter may be closed off with a lower housing part ( 18 ) without a container, if desired, or preferably completed with a partially docked container ( 3 ) and lower housing part ( 18 ) to form a pre-assembled system.
  • FIG. 8 shows another embodiment of the second seal ( 30 ) in which the sealing action is achieved by the fit of the holder ( 6 ) and container cap ( 31 ).
  • the holder ( 6 ) or its inner guide ( 6 d ) is shaped so that it forms the seal ( 30 ) itself by abutting directly on the container cap ( 31 ). This is particularly advantageous in terms of production costs and assembly methods as the seal ( 30 ) can be formed without the installation of an additional component.
  • the holder ( 6 ) encloses the hollow piston ( 9 ) along a central portion and is permanently attached thereto, particularly by moulding on.
  • the inner guide ( 6 d ) abutting on the hollow piston is significantly narrower by comparison with the total diameter of the holder ( 6 ) in all the embodiments and after the attachment of the container ( 3 ) to the holder ( 6 ) it projects into said container.
  • the lower edge of the inner guide ( 6 d ) is then located lower than the upper edge of the container ( 3 ).
  • the inner guide projects somewhat into the insertion funnel ( 31 a ) of the container cap ( 31 ).
  • this second seal ( 30 ) is a hard-hard seal since, due to the requirement for retaining properties in the holder ( 6 ) and container cap ( 31 ), in particular, both components have to have a certain rigidity.
  • a superficially softer material may indeed be used than is used for the holder ( 6 ) in this context, but the container cap ( 31 ) must have a certain rigidity.
  • the inner guide ( 6 d ) is configured so as to abut on the container cap ( 31 ) in the upper opening region. Analogously to the example in FIGS. 6 and 7 it may form the seal in the cylindrical opening region ( 31 c ) or, as shown in FIG.
  • the inner guide ( 6 d ) may also abut directly in the upper region of the insertion funnel ( 31 a ). In this case, it preferably forms an encircling pointed edge which presses into the surface of the insertion funnel ( 31 a ), i.e. into the inwardly convergent slope, to form a better seal. This edge comes to a point preferably not only in the radial direction but also in the axial direction, i.e.
  • the outer lower edge of the inner guide ( 6 d ) projects further in the direction of the container ( 3 ) then the material contact between the inner guide ( 6 d ) and the hollow pistons ( 9 ) formed by the moulding of material.
  • the inner guide ( 6 d ) thus comprises an undercut in this embodiment that is not shown.
  • These seals ( 30 ) formed by the inner guide ( 6 d ) preferably act axially, so that, as in the embodiment shown in FIG. 4 , they form a suitable combination for the radially acting, sealing press fit between the hollow piston ( 9 ) and container cap ( 31 ).
  • FIG. 9 shows another embodiment of the second seal ( 30 ) in the installed position.
  • the seal ( 30 ) is recessed or inset in the holder ( 6 ), as an independent component at the top end of the container.
  • the seal ( 30 ) is in the form of a radially symmetrical flat seal, preferably a flat ring seal, which is optionally provided with internal insertion slopes.
  • the material of the seal ( 30 ) corresponds to that in the embodiment in FIG. 4 .
  • the seal ( 30 ) by its compression, acts predominantly axially (parallel to the tube or hollow piston ( 9 )), and thus forms a suitable combination for the radially acting, sealing press fit between the hollow piston ( 9 ) and the container cap ( 31 ).
  • the seal is formed during the compression between the holder ( 6 ) and top edge of the container cap ( 31 ) as the container ( 3 ) is docked in the holder ( 6 ). On the inside, the component that forms the seal ( 30 ) abuts on the inner guide ( 6 d ).
  • the second seal may also be formed by a sealing layer—a region that is additionally moulded onto the holder ( 6 ), the material of which differs from that of the holder ( 6 ).
  • This additional material region may consist of an elastomeric material and may fill similar regions on the holder ( 6 ) to the independent elastomeric components in the embodiments according to FIGS. 9 and 4-7 .
  • the material is softer than that of the container cap and holder.
  • This sealing layer may be formed from one of the above-mentioned elastomeric materials but particularly from a thermoplastic elastomer (TPE) such as, for example, one based on urethane or olefins.
  • TPE thermoplastic elastomer
  • the sealing layer may also be a region consisting of one of the elastomeric materials mentioned, which is additionally moulded onto the container ( 3 ) or onto the container cap ( 31 ).
  • the sealing layer is located either on the inner edge of the insertion point or on the inner wall of the insertion funnel ( 31 a ) or in the upper region of the container cap ( 31 ).
  • the sealing layer may be configured for example as one or more moulded-on tabs protruding upwards before the insertion of the container ( 3 ) into the holder ( 6 ) and then pressed inwards into the gap between the container cap ( 31 ) and the inner guide ( 6 d ) as the contours of the holder ( 6 ) are inserted.
  • a sealing layer mounted on the container cap ( 31 ) in this way has the advantage, particularly in reusable devices, i.e. a nebuliser ( 1 ) which is operated with numerous containers ( 3 ) one after the other, that each seal ( 30 ) is used only once and cannot therefore be damaged in advance.
  • Each container ( 3 ) introduces into the device a new unused sealing system consisting of a first and second seal.
  • the holder ( 6 ) comprises an additional material region which is harder than the material of the container cap ( 31 ).
  • this additional material region may be an insert in multi-component injection moulding.
  • This insert preferably made of hard metal, could press into the material of the container cap ( 31 ) in the insertion funnel ( 31 a ) axially better at the lower end of the inner guide ( 6 d ) or—in the case of a single pairing of device and container—could cut in better than the plastic used for the moulding of the hollow piston ( 9 ) for the holder ( 6 ), which has to have a certain elasticity with regard to the nature of the snap-in hooks ( 6 a ).
  • the propellant-free nebuliser shown here serves to deliver a liquid medicinal formulation as an inhalable aerosol and is suitable for delivering both aqueous and also, preferably, alcoholic, particularly ethanolic, medicinal formulations.
  • a liquid medicinal formulation which is to be administered and which contains a substance with a high vapour pressure or an alcohol compound is used here.
  • Preferred ingredients of the preferably liquid medicinal formulation are listed in particular in the publications WO09/047173A2 and WO09/115200A1, in which the lists of substances and formulation recipes given (WO09/115200A1, pages 25 to 40 and WO09/047173A2, pages 15 to 21) are incorporated by reference in their entirety.
  • the fluids described in these publications may be aqueous or non-aqueous solutions, mixtures, formulations with and without solvent, such as ethanol or the like.
  • the proposal to equip the junction of a container with a device for delivering liquid with a dual seal against the loss of liquid and gas can be applied to numerous devices in which liquids are conveyed or transported.
  • the invention is directed to all kinds of dosage withdrawal means, i.e. devices from which a predefined quantity of liquid is drawn from a container on each actuation.
  • the proposed nebuliser ( 1 ) operates mechanically, although the sealing system envisaged here is not restricted to use in purely mechanical devices for delivering a liquid. It may, for example, also be used in systems in which the liquid is delivered by electrical, hydraulic or other pumps or by propulsion means. Terms such as “pressure generator” should thus be understood in general terms. In this sense the present invention may also be used across different sectors; even applications beyond the medicinal or medical sector are possible.

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JP6164694B2 (ja) 2017-07-19
US20120325204A1 (en) 2012-12-27

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