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US20190175938A1 - Internal ultraviolet therapy - Google Patents

Internal ultraviolet therapy Download PDF

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Publication number
US20190175938A1
US20190175938A1 US16/300,500 US201716300500A US2019175938A1 US 20190175938 A1 US20190175938 A1 US 20190175938A1 US 201716300500 A US201716300500 A US 201716300500A US 2019175938 A1 US2019175938 A1 US 2019175938A1
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United States
Prior art keywords
light source
delivery tube
capsule
light
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US16/300,500
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English (en)
Inventor
Ali REZAIE
Mark Pimentel
Gil Y. Melmed
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Cedars Sinai Medical Center
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Cedars Sinai Medical Center
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Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Priority to US16/300,500 priority Critical patent/US20190175938A1/en
Assigned to CEDARS-SINAI MEDICAL CENTER reassignment CEDARS-SINAI MEDICAL CENTER ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MELMED, GIL Y., PIMENTEL, MARK, REZAIE, Ali
Publication of US20190175938A1 publication Critical patent/US20190175938A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0684—Endoscope light sources using light emitting diodes [LED]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N2005/0602—Apparatus for use inside the body for treatment of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0608—Rectum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0609—Stomach and/or esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/061—Bladder and/or urethra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0611—Vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details
    • A61N2005/0667—Filters

Definitions

  • the present invention is directed to a device, a method, and a system for ultraviolet therapy. More particularly, the present disclosure relates to a device, a method, and a system for intra-corporeal ultraviolet therapy.
  • UV-A 320 to 400 nm
  • UV-B 280 to 320 nm
  • UV-C 110 to 280 nm
  • All these components are present in sunlight but UV-C is almost fully absorbed by ozone layer and does not reach the earth surface.
  • UV-A and UV-B are involved in the formation of Vitamin D in human skin.
  • UV-C light is traditionally used for disinfection of non-organic surfaces (e.g. hospital rooms, aquariums, air vents, and the like), UV-A and UV-B light have significant anti-inflammatory and antibiotic effects as well.
  • UV-A and UV-B light are induced via damage to haploid DNA/RNA of microorganisms such as bacteria, archaea, fungi, yeast and viruses within minutes. UV light is even capable of stopping the disease process in prion-related diseases that currently has no cure.
  • UV phototherapy is widely being used in management of skin diseases, such as, for example, psoriasis, vitiligo, atopic dermatitis, eczema, Kaposi sarcoma, lichen planus, skin lymphoma, neonatal jaundice, and the like.
  • skin diseases such as, for example, psoriasis, vitiligo, atopic dermatitis, eczema, Kaposi sarcoma, lichen planus, skin lymphoma, neonatal jaundice, and the like.
  • Such process has been proposed and used as adenomatous polyp detection tool on colonoscopy and also has been proposed in conjunction with a super glue for closing patent foramen ovale.
  • UV-A and UV-B light Considering the anti-inflammatory and antibiotic effects of UV-A and UV-B light, it has the potential to revolutionize the management of non-dermatologic (i.e., internal organs) infections and inflammatory diseases. While UV light has traditionally been used to treat skin disorders, it has not yet been developed for broader infection or inflammation treatment in vivo.
  • a system has been developed as described herein for emission of therapeutic doses of UV light using vehicles, such as, for example, a catheter, capsule, endoscope, tube or port, for treating or managing internal infections and/or inflammatory conditions inside a patient.
  • vehicles such as, for example, a catheter, capsule, endoscope, tube or port
  • the inventors developed devices that can deliver therapeutic doses of UV light in the UV-AB range from a catheter, endoscope, capsule, or other device to treat infections and inflammatory conditions inside the patient.
  • a system utilizing LEDs or a cold cathode emission that can emit light to cover a broad area inside the body has been developed. Accordingly, these systems may emit UV-A and/or UV-B light emitted from a catheter, endoscope, or other device inside the body to treat or manage infections or inflammatory conditions.
  • a system for performing intra-corporeal ultraviolet therapy including: a delivery tube, wherein the delivery tube includes an electrical connecting means; at least one UV light source inside the delivery tube that is configured to emit wavelengths, wherein the at least one UV light source is positioned to deliver radiation directed outwardly around the circumference of the delivery tube for a substantial length of the delivery tube; and a power supply connected to the UV light source via the electrical connecting means inside the delivery tube.
  • Embodiment 1 wherein the light source is a string of LEDs.
  • Embodiment 1 wherein the light source is a cold cathode tube.
  • Embodiment 1 The system of Embodiment 1, wherein the light source is a neon filled tube.
  • a system for performing intra-corporeal ultraviolet therapy including:
  • the delivery tube includes an electrical connecting means
  • a UV light source inside the delivery tube positioned to emit UV wavelengths outward from the tube and around the circumference of the tube;
  • a power supply connected to the UV light source by the electrical connection means inside the delivery tube.
  • the delivery tube is a catheter that includes a lumen that is configured to pass over a guide wire.
  • a capsule for performing intra-corporeal ultraviolet therapy including:
  • a UV light source connected to the battery inside the capsule positioned to emit UV wavelengths outward from the capsule and in all directions outside of the capsule;
  • a system for performing intra-corporeal ultraviolet therapy including:
  • the delivery rod includes a borosilicate segment and a silica segment
  • UV light source configured to emit wavelengths including at least one of: UV-A and UV-B;
  • the light source attachment is configured to be placed between the delivery rod and the UV light source.
  • Embodiment 16 wherein the system further includes a power source that is connected to the UV light source.
  • the body includes a front-end aperture that is configured to connect to the light source, and a back-end aperture, wherein the back-end aperture is configured to connect to a rod; and a fastening mechanism, wherein the fastening mechanism includes at least one of: a screw, flat-ended stopper screw, and a nail, wherein the fastening mechanism is configured to connect the body to the rod and stabilize position of the rod in relation to the light source.
  • the light source attachment further includes a convex lens that is configured to be placed between the front-end aperture and the back-end aperture in order to decrease light loss from the UV light source.
  • Embodiment 17 wherein the borosilicate segment is closer to the UV light source than the silica segment.
  • a method of treating a patient for an inflammatory or infectious condition inside the patient's body including:
  • a system for performing intra-corporeal ultraviolet therapy including:
  • a delivery rod including a UV-C filtering segment and a UV transmission segment;
  • Embodiment 24 wherein the delivery rod is configured to transmit UV-A and UV-B light.
  • FIG. 1 illustrates a cross sectional view of UV emitting device inserted into the rectum of a patient that is constructed in accordance with the principles of the present disclosure
  • FIG. 2 illustrates a schematic view of UV emitting device that incorporate LEDs that is constructed in accordance with the principles of the present disclosure
  • FIG. 3 illustrates a schematic view of UV emitting device that incorporates a cold cathode that is constructed in accordance with the principles of the present disclosure
  • FIG. 4 illustrates an example of a schematic of the UV spectrum
  • FIG. 5 illustrates a cross sectional view of UV emitting device inserted into the rectum of a patient that is constructed in accordance with the principles of the present disclosure
  • FIG. 6 illustrates a cross sectional view of UV emitting device inserted into the colon of a patient that is constructed in accordance with the principles of the present disclosure
  • FIG. 7 illustrates a cross sectional view of UV emitting device inserted in the esophagus and stomach of a patient that is constructed in accordance with the principles of the present disclosure
  • FIG. 8 illustrates a cross sectional view of UV emitting devices swallowed and traveling through the digestive system of a patient that is constructed in accordance with the principles of the present disclosure
  • FIG. 9A illustrates a side view of an example of a light source attachment that is constructed in accordance with the principles of the present disclosure
  • FIG. 9B illustrates a bottom view of an example of a light source attachment that is constructed in accordance with the principles of the present disclosure
  • FIG. 9C illustrates a top view of an example of a light source attachment that is constructed in accordance with the principles of the present disclosure
  • FIG. 9D illustrates a side view of an example of a light source attachment that is constructed in accordance with the principles of the present disclosure
  • FIG. 9E illustrates a side view of an example of a light source attachment being uses in accordance with the principles of the present disclosure.
  • FIG. 10 illustrates an example of a UV emitting device that is constructed in accordance with the principles of the present disclosure
  • FIG. 11 illustrates an example of method for using the UV emitting device on foley catheter in accordance with the principles of the present disclosure.
  • FIG. 12 illustrates an experimental data showing an example of a UV emitting device of the present disclosure being used to prevent of E. coli from proliferating.
  • FIG. 13 illustrates another experimental data showing an example of a UV emitting device of the present disclosure being used to prevent of E. coli from proliferating.
  • FIG. 14 illustrates an example of a UV emitting device of the present disclosure being used on a colonoscopy on a mouse.
  • FIGS. 15A and 15B illustrate an example of a UV emitting device of the present disclosure being used on a vaginal treatment on a mouse.
  • FIG. 16A illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIG. 16B illustrates an example of a UV emitting device of the present disclosure being used on a liquid culture containing E. coli.
  • FIG. 17 illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIGS. 18A and 18B illustrate an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIG. 19 illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIG. 20 illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIG. 21 illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • FIG. 22 illustrates an experimental data showing a use of an example of a UV emitting device of the present disclosure on a liquid culture containing E. coli.
  • UV light in the UV-A and UV-B range has traditionally been used to treat dermatologic disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection or inflammation treatment inside the human body.
  • the present disclosure describes a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube, or port that can be used to manage internal infections and inflammatory conditions inside a patient. Delivery of the UV light can be with or without a concomitant photosensitizer.
  • FIG. 1 illustrates an example of a UV light administrative system that includes a delivery tube 100 and several UV light sources 150 , and a power source 120 to power the system. Accordingly, as illustrated, a caregiver (e.g., physician) has navigated the delivery tube 100 to the colon and turned on the power source 120 to emit therapeutic light (e.g., UV light) into the colon region.
  • a caregiver e.g., physician
  • therapeutic light e.g., UV light
  • FIGS. 9A-9E illustrates an example of a UV light administrative system that includes a light source attachment 900 , wherein the light source attachment 900 is configured to be attached between the UV light source 950 and the delivery rod 940 .
  • Various delivery tubes 100 or other delivery vehicles may be utilized to delivery therapeutic UV light to various portions of the inside of the body.
  • the delivery tube 100 may be a suitable catheter, endoscope, capsule (for swallowing or suppository), or other device capable of housing one or more UV light sources 150 .
  • the UV delivery tube 100 may include various scopes such as endoscopes that may be inserted rectally or orally and navigated to the appropriate regions to deliver effective amounts of anti-inflammatory or other therapeutic doses of UV light.
  • the UV delivery tube 100 may include a catheter that is suitable for insertion into the arteries, urethra, vagina and urinary tract, ear canal, etc.
  • the UV delivery tube 100 may include an indwelling urinary catheter that can be inserted into a patient's bladder.
  • UV light can be emitted via a light source inside an inflatable balloon catheter to internal organs such as, e.g., vagina, rectum, gastroesophageal junction, stomach, biliary tract, or the like.
  • the UV light can be emitted via a light source inside a glove or cot that can be worn by a patient or a doctor.
  • the UV light can be inserted digitally and into a patient's orifice, e.g., a mouth, a rectum, a vagina, and the like.
  • the delivery tube 100 may be configured to include features that accommodate the light sources 150 that are placed inside the tube 100 .
  • the LED light sources 150 may be placed inside a hollow canal inside the tube 100 and wired together in the middle.
  • the delivery tube 100 may include a hollow canal for a guide wire to be inserted through and the light sources 150 and associated wiring may instead be embedded in the shell.
  • the light sources 150 may be distributed along the entire portion of the delivery tube 100 , an end portion of the delivery tube 100 or other suitable layouts so a broader application of the light sources 150 can be achieved.
  • the delivery tube (or rod) 100 may be constructed in a way that the entire delivery tube glow and transmit UV light homogenously throughout the entirety of the delivery tube as shown in, e.g., FIG. 10 .
  • the delivery tube 100 may be configured to conduct lights in UV-A and/or UV-B ranges only, and not in UV-C range.
  • the delivery tube 100 may be configured to limit thermoconduction to 10 mm.
  • the delivery tube may be configured to carry out thermoconduction beyond 10 mm.
  • the light may be incorporated in continuous and pulse therapy depending on efficacy and treatment variables as determined by a physician.
  • the delivery tube (or rod) 100 may be made of any suitable construction (e.g., rigid or flexible), including various polymers that are biocompatible or have a biocompatible coating.
  • the delivery tube 100 may include at least an outer layer of transparent material to allow the UV light from the light sources 150 to radiate out to the internal cavities.
  • the delivery tube 100 may be made from, e.g., silicon, silica, borosilicate, polyurethane, polyethylene, Teflon/PTFE, borosilicate, or other suitable materials.
  • the delivery vehicle may include a capsule instead of a delivery tube 100 .
  • the capsule may be inserted orally or anally and the capsule may emit light for a certain period of time.
  • a capsule may include a clear or semi-transparent polymer or other biocompatible coating that may be smooth to allow for passage of the capsule.
  • the capsule may include the light source 150 and a power supple 120 such as a small battery. The capsule may be deployed and pinned to an internal organ for prolonged light exposure.
  • the capsule a smooth coating, internal batteries that power UV lights 150 such as LEDs that are positioned to emit light in all direction from the capsule. Accordingly, as the capsule passes through the digestive system it may deliver the therapeutic light until it is excreted.
  • UV lights 150 such as LEDs that are positioned to emit light in all direction from the capsule. Accordingly, as the capsule passes through the digestive system it may deliver the therapeutic light until it is excreted.
  • FIG. 2 illustrates an embodiments of a flexible delivery tube 100 (e.g., catheter, endoscope, or the like) that includes a string of LED light sources 150 that are distributed along the tube 100 .
  • Each of the light sources 150 are attached together with electrical connections and connected to a power supply 120 .
  • the light sources 150 may be advantageous, since their small size and low power requirements enable them to be placed along the delivery tube 100 .
  • the light sources 150 may deliver a UV light to a large delivery area inside the patient. Accordingly, the therapeutic target area may be relatively large, to treat inflammatory diseases that may affect a large portion of the colon.
  • FIG. 3 illustrates an example of where a delivery tube 100 includes a light source 150 that is a cold cathode powered by a power supply 120 .
  • the cold cathode light source 150 delivers light through a transparent, flexible delivery tube 100 .
  • This embodiment may include an inert gas that fills the delivery tube (or a vacuum tube) 100 .
  • the delivery tube 100 may include, e.g., a cold cathode tube.
  • the delivery tube 100 may include any cathode light emitter that is not electrically heated by a filament.
  • a cold cathode fluorescent lamp may utilize a discharge in mercury vapor to emit ultra violet light.
  • the gases utilized in the tube should be inert for safety.
  • neon gas vapor may be energized with a 12 volt power supply 120 to generate sufficient UV light.
  • other power supplies with various voltages and/or currents will be utilized to develop sufficiently intense light at the current wavelength.
  • the light sources 150 may emit x-rays.
  • the system may include vacuum tubes or x-ray tubes.
  • the power supply 120 may include an on/off switch or other controls to turn on and off the light sources 150 .
  • the power supply will include the ability to turn on the UV light source at various intensities, or to modulate the intensity over time depending on the therapeutic application.
  • the power supply may be different for different types of UV light sources 150 . For instance, the power requirements for an LED implementation may be less than for a cold cathode implementation.
  • a UV light administrative system may include a delivery rod 900 , UV light source 950 , and a light source attachment 920 , wherein the light source attachment 920 is configured to be attached between the UV light source 950 and the delivery rod 900 .
  • the delivery rod 900 may include a borosilicate segment 950 which omits UVC from the light spectrum followed by a segment made out of pure silica (quartz) 900 to extent transmission distance of UV AB with minimal loss.
  • UV-C light emission e.g., 4,300 microWatt/cm 2 UV-C
  • pure quartz rod with a short segment of borosilicate in between the UV light source 950 and the delivery rod 900 results in above level of detection of UV-A and UV-B (e.g., over 30 cm) and only 10 microwatt/cm 2 of UVC light at the tip of the delivery rod 900 , which means that the UV light is reflected back to the body of the delivery rod 900 for a uniform delivery of the UV light throughout the delivery rod 900 .
  • the UV light source 950 may be configured to be connected to a power source (not shown) that powers the UV light source 950 .
  • the delivery rod 940 may be made by scoring using industrial diamond, whereby the glass cutter oil is used and bilateral pressure to snap clearly (rather than opaque) is applied.
  • the tip of the delivery rod 940 may be rounded by a drill (e.g., 500 RPM drill) wherein the drill uses a premium diamond polish pad (e.g., 120-200 grit premium diamond polish pad) and sandpaper (e.g., 400 sandpaper).
  • a body of the delivery rod 900 may be sanded with a 120-200 grit premium diamond polish pad so that the UV-C free light (e.g., UV-A and UV-B) can emit throughout the body of the delivery rod 900 .
  • the UV-C free light e.g., UV-A and UV-B
  • each of the UV light administrative device may include a light source attachment 900 that is placed between a delivery rod 940 (or delivery tube 100 ) and a light source 950 (or a power source 120 ).
  • the light source attachment 900 may include a body 920 and a fastening mechanism 910 (e.g., a screw, a stopper screw, a fastener, a nail, and the like) that attaches the body 920 to an enclosure (e.g., a rod, a catheter, a handle, or the like).
  • the body 920 may include a front-end aperture 970 that is configured to connect to a light source (or power supply) and a back-end aperture 980 that is configured to connect to a rod (or catheter).
  • a diameter of the front-end aperture 970 may be around 10.1 mm and a diameter of the back-end aperture 980 may be around 5 mm.
  • the fastening mechanism 910 may be around 3 mm in length.
  • the light source attachment 900 may be made of aluminum for heat conduction and for decreasing light intensity deterioration.
  • the diameter of both the front-end aperture 970 and the back-end aperture 980 may vary in order to fit, e.g., a particular catheter, tube, rod, or the like.
  • the light source attachment 900 may also include a convex lens 930 between the front-end aperture 970 and the back-end aperture 980 that is configured to decrease the light loss.
  • the convex lens may include semi-convex heat resistant lens that decreases light loss and focuses the light.
  • FIG. 4 illustrates UV ranges that may be implemented by the disclosed devices and methods.
  • the light sources may deliver light only the UV-A and UV-B ranges, and not in the UV-C ranges.
  • the systems and methods may deliver light in all three UV ranges, or also deliver light in the visible spectrum.
  • only UV-A light or only UV-B light may be emitted for certain indications and treatments.
  • the ranges that may be emitted also includes x-ray wavelengths.
  • X-ray wavelengths have wavelengths that are just shorter than UV-C range light.
  • FIGS. 5-6 illustrate example applications to treat disorders in the colon and/or rectum.
  • FIG. 5 illustrates a delivery tube 100 that includes light sources 150 may be inserted by the caregiver into the colon through the anus. Then, the delivery tube 100 may be navigated to the therapeutic site for instance the colon, a portion or most of the intestines (see, e.g., FIG. 6 ), or the stomach via mouth (see, e.g., FIG. 7 ). Then, the power supply (or light source) 120 may be turned on to illuminate the therapeutic site with UV light 150 .
  • the delivery tube 100 may include varying amounts of light sources 150 that may be embedded or contained in certain portions or lengths of the delivery tub 100 .
  • FIG. 7 illustrates an embodiment where an endoscope or other delivery tube 100 is inserted through the oral cavity through the esophagus into the stomach.
  • an infection or inflammatory disease in the stomach may be treated with the UV light sources 150 .
  • FIG. 8 illustrates an example of a system that utilized a capsule 800 for a delivery device that may be swallowed by the patient.
  • the capsule 800 may contain a light source 150 and a power supply 120 for powering the light source 150 .
  • the capsule will be made, or portions of it will be made of transparent material to allow the light to radiate through the capsule.
  • Capsule may contain a tracking device to assess the location of the capsule inside the gastrointestinal tract.
  • Capsule delivery system may be clipped in a hollow organ for continuous or intermittent controlled delivery.
  • the capsule may be the size of a pill or smaller, and may be orally ingestible.
  • the capsule may include a timer for turning on and off the UV light source when the capsule reaches or is most likely to reach a certain portion of the digestive tract.
  • the capsule may contain a simple timer to turn on the capsule after 30 minutes, an hour or two hours.
  • the capsule may not turn on the light source 150 until the capsule has reached the digestive tract to treat IBS or other infectious or inflammatory conditions.
  • the delivery device may be a catheter tube 100 that may be insertable into the arteries, urethra or other parts of a patient's body.
  • the catheter tube 100 may include a hollow portion that allows for a guide wire to pass through. Accordingly, a caregiver may navigate a guide wire to the treatment site and then pass the catheter over the guide wire to navigate the catheter to or beyond the treatment site.
  • the catheter tube 100 may then contain any variety of light sources 150 suitable for administering UV treatment to the inside of an artery.
  • this implementation may use smaller light sources 150 such as LEDs.
  • the delivery device may be a catheter tube 100 that may be inserted into a bladder as an indwelling urinary catheter (as shown in, e.g., FIG. 11 ), so that it disinfects the urinary tract infection with UV lights.
  • the delivery device may be a part of a balloon inserted into a rectum to treat the rectum with UV lights.
  • the delivery device may be incorporated into a vaginal rod to treat infection in a patient's vagina.
  • the blood from the patient may be routed extracorporeal and the blood radiated with UV light (e.g., UV-A and UV-B).
  • the blood may be passed through a machine that radiates the blood with UV light before routing the blood back to the patient.
  • UV-A and UV-B light may be utilized because there would be less risk to the bodily tissues other than the cells inside the blood.
  • UV radiation may be administered depending on the following: (1) type of disease, (2) type of light source, (3) light source power, (4) light source UV range, and (5) severity of the infection or inflammation.
  • the time of administration will be determined by the capsule digestion rate, and other factors (e.g., light source power, UV range, and the like) can be manipulated to vary the dosage.
  • the endoscope may be delivered by the physician/surgeon for an hour, 30 minutes, two hours, or other suitable times.
  • IBD ulcerative colitis and Crohn's disease and acute/chronic pouchitis and other chronic inflammatory bowel diseases
  • IBD chronic inflammatory bowel diseases
  • non-IBD related proctitis Treatment of IBD or non-IBD related fistula 4.
  • Treatment of inflammatory strictures 5.
  • Treatment of microscopic colitis Treating infectious diarrhea using UV light emitting capsules 7.
  • Treating refractory Helicobacter pylori and MALT lymphoma Treatment of esophageal lichen planus and pemphigus vulgaris 9.
  • Treatment of chronic sinusitis 1. Treatment of chronic sinusitis. 2. Treatment of chronic otitis. 3. Treatment of acute otitis media in patients requiring tympanostomy. 4. Treatment of nasal polyps (there is evidence that UV light shrinks them, see attached paper). 5. Treatment of halitosis. 6. Treatment of recurrent tonsillitis/pharyngitis. 7. Treatment of cancers limited to mucosa and submucosa
  • Intrathecal fibro-optic delivery of UV light in treatment of refractory meningitis 2. Treatment of refractory shunt infections. 3. Treatment of prion diseases with intrathecal or subarachnoid UV therapy. 4—Treating JC virus related Progressive multifocal leukoencephalopathy by decreasing viral load.
  • Intraarticular ILT for treatment of inflammatory and infectious large joint arthritis.
  • FIG. 14 illustrates an example of a UV emitting device being used on a colonoscopy on a mouse.
  • the colonoscopy has been carried out safely.
  • the parameters have included a normal colonoscopy 72 hours after 10 minutes and 30 minutes of UV exposure with 1,100 micoWatt/cm 2 intensity.
  • FIGS. 15A and 15B illustrate an example of a UV emitting device being used on a vaginal treatment of a mouse.
  • FIGS. 12 and 13 illustrate an experimental data showing an example of a UV emitting device of the present disclosure being used to prevent of E. coli from proliferating.
  • the control group where the UV light was not applied continued to grow, whereas the test group that had UV light applied through the UV emitting device showed continuous decrease in E. coli over time.
  • the UV light is shown to both prevent E. coli from proliferating and also kill the bacteria over time.
  • FIG. 16B illustrates an example of a UV emitting device of the present disclosure being used on a liquid culture containing E. coli .
  • the results of the experiment are shown in, e.g., FIGS. 16A, and 17-22 . All of the results illustrate a significant reduction in the growth of E. coli in liquid samples where UV-A and UV-B lights were emitted by the UV emitting device of the present disclosure onto the liquid samples.
  • FIG. 16A illustrates results of an experiment carried out in accordance with conditions as shown in Table 1 below.
  • FIG. 17 illustrates results of an experiment carried out in accordance with conditions as shown in Table 2 below.
  • FIG. 18A illustrates results of an experiment carried out in accordance with conditions as shown in Table 3 below.
  • FIG. 18B illustrates results of an experiment carried out in accordance with conditions as shown in Table 4 below.
  • FIG. 19 illustrates results of an experiment carried out in accordance with conditions as shown in Table 5 below.
  • FIG. 20 illustrates results of an experiment carried out in accordance with conditions as shown in Table 6 below.
  • FIG. 21 illustrates results of an experiment carried out in accordance with conditions as shown in Table 7 below.
  • FIG. 22 illustrates results of an experiment carried out in accordance with conditions as shown in Table 8 below.

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CN109414591B (zh) 2022-08-05
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WO2017210366A1 (fr) 2017-12-07
CA3024711A1 (fr) 2017-12-07
NZ748479A (en) 2021-10-29
AU2017273699A1 (en) 2018-12-06
US12390660B2 (en) 2025-08-19
US20200346032A1 (en) 2020-11-05
CN109414591A (zh) 2019-03-01
JP2023106524A (ja) 2023-08-01
EP3463570A4 (fr) 2020-07-29
SG11201810515TA (en) 2018-12-28
MX2023006353A (es) 2023-06-12
CN115282494A (zh) 2022-11-04
MX2018014694A (es) 2019-05-16
KR20190015357A (ko) 2019-02-13
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JP2019517305A (ja) 2019-06-24
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EP3463570A1 (fr) 2019-04-10
US20250339707A1 (en) 2025-11-06

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