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WO2011083381A1 - Réduction des bactéries par uv par l'intermédiaire de voies respiratoires artificielles - Google Patents

Réduction des bactéries par uv par l'intermédiaire de voies respiratoires artificielles Download PDF

Info

Publication number
WO2011083381A1
WO2011083381A1 PCT/IB2010/055691 IB2010055691W WO2011083381A1 WO 2011083381 A1 WO2011083381 A1 WO 2011083381A1 IB 2010055691 W IB2010055691 W IB 2010055691W WO 2011083381 A1 WO2011083381 A1 WO 2011083381A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultraviolet light
upper respiratory
optical fiber
artificial airway
respiratory assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2010/055691
Other languages
English (en)
Inventor
Richard James Mckenzie, Jr.
Lance Ranard Busch
Jason Good
Jason Paul Eaton
William Justin Kittridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of WO2011083381A1 publication Critical patent/WO2011083381A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0604—Lungs and/or airways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet

Definitions

  • the invention relates to a light therapy device and, more specifically, to an orally insertable device structured to project an ultraviolet light to a portion of anatomy through which an artificial airway passes.
  • VAP Ventilator associated pneumonia
  • a protective shell i.e. a glycocalyx, that protects the bacteria from antimicrobial agents and the patient's own defenses.
  • UV-C ultraviolet light
  • UV-C short wave ultraviolet light
  • UV-C has, for example, been used to sanitize air, water and surfaces.
  • UV-C has also been used as a curing agent for dental epoxies. That is, UV-C has been approved for use within a human mouth.
  • an artificial airway structured to project an ultraviolet light. That is, an artificial airway includes an ultraviolet light source and is structured to project the ultraviolet light within the mouth and airway of a patient. Such ultraviolet light therapy may reduce the number of bacteria which contribute to VAP. As such, the instances of VAP may be reduced. It is noted that the ultraviolet light provided may be less intense than the ultraviolet light used with dental epoxies. Generally, the weaker the ultraviolet light, the longer the light must be applied to achieve the desired result.
  • an ultraviolet light device includes an "ultraviolet light source” and an “ultraviolet light emitter.”
  • an "ultraviolet light source” creates an ultraviolet light.
  • a “ultraviolet light emitter” is the surface of the ultraviolet light device from which the ultraviolet light emerges.
  • the ultraviolet light artificial airway utilizes an ultraviolet light emitting diode (LED).
  • LED ultraviolet light emitting diode
  • the light is created by passing electricity from an anode to a cathode.
  • the emitter may be the LED lens.
  • the ultraviolet light source, LED or otherwise may be coupled to one or more optic fibers, or a similar means of light transmission.
  • the optic fibers transmit the ultraviolet light from the source to the distal ends of the fibers. That is, in this configuration, the optic fibers act as the emitter.
  • the ultraviolet light artificial airway may either incorporate ultraviolet LEDs or have ultraviolet light transmitted into, or from, the artificial airway by optic fibers.
  • the artificial airway includes: a body structured to be partially disposed in an upper respiratory passage, an ultraviolet light assembly having at least one ultraviolet light source with at least one associated ultraviolet light emitter, the ultraviolet light source structured to create and project ultraviolet light, the ultraviolet light emitter in light communication with the ultraviolet light source and structured to allow ultraviolet light to pass from the ultraviolet light emitter, and wherein the ultraviolet light emitter is structured to project ultraviolet light from the body.
  • Figure 1 is an isometric view of an ultraviolet light artificial airway.
  • Figure 2 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 3 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 4 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 5 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 6 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 7 an isometric view of an alternate embodiment of the ultraviolet light artificial airway.
  • Figure 7A is a detail view of an abraded optical fiber.
  • upper respiratory relates to any passage to the lungs including the oral cavity, the nasal cavity, or an artificial passage such as, but not limited to, a tracheotomy tube.
  • an “ultraviolet light source” may be, but is not limited to, an LED, OLED, or incandescent bulb.
  • an "optical fiber” may be a solid or tubular member, i.e. a light pipe.
  • an ultraviolet light artificial airway 10 includes a body 12 and as well as an ultraviolet light assembly 40.
  • the artificial airway 10 may perform one, or several, function(s) associated with the upper respiratory passage.
  • the artificial airway 10 may be, but is not limited to an endotracheal tube, an oropharyngeal tube, a nasopharyngeal tube or a tracheotomy tube.
  • the body 12, is structured to be partially disposed in an upper respiratory passage and extend, at least partially, into the trachea or lower airway.
  • the body 12 includes an external portion 14 and an upper respiratory assembly 16.
  • the external portion 14 is structured to assist a user in gripping the body 12.
  • the external portion 14 is further structured to assist the user in guiding the upper respiratory assembly 16 into the upper respiratory passage and positioning the upper respiratory assembly 16 in the upper respiratory passage.
  • the external portion 14 may include a collar 18 and may include a mouth shield 20.
  • the collar 18 is adapted to serve a function related to the function of the artificial airway 10.
  • the upper respiratory assembly 16 has, typically, an elongated body 26 with a proximal portion 28 and a distal portion 30.
  • the upper respiratory assembly body 26 may be solid or hollow.
  • the collar 18 is coupled to the upper respiratory assembly body proximal portion 28.
  • the ultraviolet light assembly 40 has at least one ultraviolet light source 42 with at least one associated ultraviolet light emitter 44.
  • the ultraviolet light source 42 is structured to create and project ultraviolet light.
  • the ultraviolet light emitter 44 is in light communication with the ultraviolet light source 42 and is structured to allow ultraviolet light to pass from the ultraviolet light emitter 44.
  • the ultraviolet light emitter 44 is further structured to project ultraviolet light from the upper respiratory assembly 16.
  • the ultraviolet light assembly 40 includes a source of power 48 structured to provide power to the ultraviolet light source 42.
  • the source of power 48 may be a stored energy device, typically a battery, that may be disposed at a remote location and coupled to the ultraviolet light source 42 by a wire or other conductor.
  • the source of power 48 may be a power grid (not shown) that is coupled to the ultraviolet light source 42 by a power cord.
  • the source of power 48 transmits power wirelessly. That is, it is known to transmit power via a radio frequency which is converted into a current.
  • the at least one ultraviolet light source 42 is at least one ultraviolet light emitting diode 50 which has a shell or lens 52 that acts as an ultraviolet light emitter 44.
  • the at least one ultraviolet light emitting diode 50 may be disposed within the upper respiratory assembly 16. Alternately, as shown in Figure 4, the at least one ultraviolet light emitting diode 50 may be disposed within the collar 18 and structured to project ultraviolet light into the upper respiratory assembly 16, discussed below.
  • the at least one ultraviolet light emitting diode 50, and more specifically the lens 52 may be structured to focus the ultraviolet light at a point or area.
  • the at least one ultraviolet light emitting diode 50 may be disposed at any location within the upper respiratory assembly 16.
  • the upper respiratory assembly 16 is preferably made from a material that is substantially transparent to ultraviolet light and/or structured to refract ultraviolet light. Thus, when a user utilizes the artificial airway, ultraviolet light is projected from the upper respiratory assembly 16 and into the mouth and airway.
  • the at least one ultraviolet light source 42 may be disposed at various locations within the upper respiratory assembly 16. As shown in Figure 1, the at least one ultraviolet light source 42 is disposed within the upper respiratory assembly body 26, preferably within the upper respiratory assembly body proximal portion 28. With this configuration of the at least one ultraviolet light source 42, the light transmission properties of the upper respiratory assembly body 26 may be adapted for specific purposes. For example, if it is desirable for the ultraviolet light to be projected throughout the oral cavity, the upper respiratory assembly body 26 is, preferably, made from a material that is substantially transparent to ultraviolet light and structured to refract a majority of the ultraviolet light. Thus, the upper respiratory assembly body 26 is structured to scatter the ultraviolet light along the length of the upper respiratory assembly 16.
  • the upper respiratory assembly body 26 is, preferably, made from a material that is substantially transparent to ultraviolet light and structured to refract a minimal amount of the ultraviolet light.
  • the upper respiratory assembly body 26 is structured to channel the ultraviolet light along the length of the upper respiratory assembly 16 and project the ultraviolet light from the upper respiratory assembly body distal portion 30. That is, the upper respiratory assembly body 26 is structured to act as a light pipe.
  • the at least one ultraviolet light source 42 may be disposed within, or on the surface of, the upper respiratory assembly body 26.
  • the at least one ultraviolet light source 42 may be a plurality of ultraviolet light emitting diodes 50A disposed over the length of the upper respiratory assembly body 26 and structured to project ultraviolet light throughout the oral cavity.
  • the at least one ultraviolet light source 42 may be disposed at a specific location on the upper respiratory assembly body 26, such as, but not limited to, the upper respiratory assembly body distal portion 30. Further, the at least one ultraviolet light source 42, i.e. the at least one ultraviolet light emitting diode 50, may be structured to focus the ultraviolet light at a selected point or area. Thus, for example, the upper respiratory assembly 16 may have a light emitting diode 50 at the tip projecting ultraviolet light which is focused, generally, in single direction. [0029] Alternately, as shown in Figure 4, the at least one ultraviolet light emitting diode 50 may be disposed adjacent the collar 18 and structured to project ultraviolet light into the upper respiratory assembly 16. There may be a plurality of ultraviolet light emitting diodes 50. As discussed above, the upper respiratory assembly body 26 may be made of a material having selected characteristics such as, but not limited to, being structured to scatter light or to channel/focus light as discussed above.
  • LEDs are several millimeters in diameter. The greatest diameter is typically associated with the shell/lens 52. It is, however, foreseeable that LEDs may be made without a shell/lens 52. In this configuration, the ultraviolet light emitting diode 50 may be embedded within the material that forms the upper respiratory assembly 16. Thus, the upper respiratory assembly 16 would become the ultraviolet light emitter 44.
  • each optical fiber 60 has an elongated body 61 with a first end 62 and a second end 64 and is structured to transmit light therethrough.
  • Each optical fiber first end 62 is disposed in light communication with the at least one ultraviolet light source 42.
  • Each optical fiber second end 64 is disposed in the upper respiratory assembly 16.
  • ultraviolet light is transmitted from the at least one ultraviolet light source 42 from the upper respiratory assembly body 26 via the at least one optical fiber 60 and each optical fiber second end 64 acts as an ultraviolet light emitter 44.
  • the external portion 14 may include an ultraviolet light assembly housing 69 having a base unit 70 and a flexible neck 72.
  • the base unit 70 has a housing 74 structured to enclose the ultraviolet light source 42 and which may enclose other elements typically associated with the operation of a portable light, such as, but not limited to, a power source 48, a control/switch and various conductors (non shown).
  • the flexible neck 72 acts as a protective tube for the optical fibers 60.
  • the flexible neck 72 further allows for the user to position the artificial airway as desired without having to move the base unit 70.
  • the base unit 70 is typically larger than the artificial airway collar 18 and, as such, may
  • the ultraviolet light source 42 may, however, be one or more LEDs disposed in the base unit 70.
  • the optical fibers 60 may be configured in a variety of ways.
  • all the optical fiber second ends 64 may terminate within the upper respiratory assembly body proximal portion 28 (Fig. 6). In this configuration, the bundle of optical fibers second ends 64 appears, and functions, similar to an LED disposed in the upper respiratory assembly 16.
  • the optical fibers second ends 64 may be disposed throughout the upper respiratory assembly body 26, preferably close to, but not extending beyond, the outer surface.
  • the longitudinal axis of each optical fiber second end 64 is preferably oriented generally normal to the surface of the upper respiratory assembly body 26 (Fig. 5). This has the effect of generally distributing the ultraviolet light evenly.
  • the optical fiber second ends 64 may be oriented so that the longitudinal axis of a group of optical fiber second ends 64 point in a similar direction, as shown in Figure 6. That is, at least one group 68 of optical fibers 60 may be associated and the longitudinal axis of each optical fiber second end 64 in the at least one group 68 is oriented generally parallel to the other optical fibers 60 in the at least one group 68. This has the effect of projecting the ultraviolet light to a selected location of the interior of the mouth.
  • the optical fiber second ends 64 may be positioned so as to project the ultraviolet light towards the back of the throat.
  • a smooth optical fiber 60 light projected into a first end 62 is substantially emitted from a second end 64. That is, there is an insubstantial leakage of light over the length of the optical fiber body 61.
  • an abraded optical fiber 60A i.e. wherein the outer surface of the optical fiber body 61 has deformations
  • light may escape the abraded optical fiber 60A at the deformations.
  • the deformations are also ultraviolet light emitters 44.
  • the upper respiratory assembly body 26 may have one or more abraded optical fiber 60A disposed within, or at the surface of, the upper respiratory assembly body 26.
  • the abraded optical fiber 60A preferably, extend longitudinally over the length of the upper respiratory assembly body 26. In this configuration, the abraded optical fibers 60A scatter the ultraviolet light throughout the oral cavity.
  • optical fibers 60 may also be used with the embodiment shown in Figure 2. That is, the optical fibers 60, and abraded optical fibers 60A, may be used as, for example, a device to disperse the ultraviolet light within the upper respiratory assembly body 26.
  • the optical fibers may have one end disposed immediately adjacent to the at least one ultraviolet light emitting diode 50 disposed within the collar 18, and the other ends disposed in the upper respiratory assembly body 26.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention a pour objet des voies respiratoires artificielles par voie orale utilisant de la lumière ultraviolette. A savoir, la présente invention concerne des voies respiratoires artificielles comprenant un corps conçu pour être au moins en partie disposé dans la bouche et s'étendant dans les voies respiratoires et une source de lumière ultraviolette. La source de lumière ultraviolette est conçue pour projeter de la lumière ultraviolette à l'intérieur de la bouche et des voies respiratoires d'un patient par l'intermédiaire du corps.
PCT/IB2010/055691 2010-01-08 2010-12-09 Réduction des bactéries par uv par l'intermédiaire de voies respiratoires artificielles Ceased WO2011083381A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29329210P 2010-01-08 2010-01-08
US61/293,292 2010-01-08

Publications (1)

Publication Number Publication Date
WO2011083381A1 true WO2011083381A1 (fr) 2011-07-14

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10180248B2 (en) 2015-09-02 2019-01-15 ProPhotonix Limited LED lamp with sensing capabilities
JP2019517305A (ja) * 2016-05-31 2019-06-24 シーダーズ−サイナイ メディカル センター 内部の紫外線治療法
US11147984B2 (en) 2020-03-19 2021-10-19 Know Bio, Llc Illumination devices for inducing biological effects
US20210353959A1 (en) * 2020-05-18 2021-11-18 Pathy Medical, Llc Devices and methods for applying therapeutic light to reduce hazard to health care providers of contracting infectious disease
WO2022132057A1 (fr) * 2020-12-18 2022-06-23 Kochan Peter Système de traitement d'un flux d'air par ultraviolet
US11524173B2 (en) 2015-07-28 2022-12-13 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
CN115666362A (zh) * 2020-03-20 2023-01-31 西达-赛奈医疗中心 内部紫外线治疗
US11654294B2 (en) 2021-03-15 2023-05-23 Know Bio, Llc Intranasal illumination devices
US11986666B2 (en) 2020-03-19 2024-05-21 Know Bio, Llc Illumination devices for inducing biological effects
US11992699B2 (en) 2019-10-15 2024-05-28 Cedars-Sinai Medical Center Internal ultraviolet therapy
US12011611B2 (en) 2020-03-19 2024-06-18 Know Bio, Llc Illumination devices for inducing biological effects
US12029914B2 (en) 2015-07-28 2024-07-09 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12115384B2 (en) 2021-03-15 2024-10-15 Know Bio, Llc Devices and methods for illuminating tissue to induce biological effects
US12347337B2 (en) 2020-12-10 2025-07-01 Know Bio, Llc Enhanced testing and characterization techniques for phototherapeutic light treatments
US12409339B2 (en) 2020-08-13 2025-09-09 Cedars-Sinai Medical Center Internal ultraviolet therapy
US12447354B2 (en) 2020-03-19 2025-10-21 Know Bio, Llc Illumination devices for inducing biological effects

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WO2003084601A2 (fr) * 2002-04-02 2003-10-16 Lumerx, Inc. Dispositifs et procedes utilisant la lumiere visible pour affaiblir et/ou tuer des micro-organismes dans le corps
US20060130846A1 (en) * 2004-12-20 2006-06-22 Rife Robert W Trachea tube with germicidal light source
US20060167531A1 (en) * 2005-01-25 2006-07-27 Michael Gertner Optical therapies and devices
WO2008030824A2 (fr) * 2006-09-05 2008-03-13 Morgan Robert D Conducteur de lumière et traitement d'affections associées à la gorge

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084601A2 (fr) * 2002-04-02 2003-10-16 Lumerx, Inc. Dispositifs et procedes utilisant la lumiere visible pour affaiblir et/ou tuer des micro-organismes dans le corps
US20060130846A1 (en) * 2004-12-20 2006-06-22 Rife Robert W Trachea tube with germicidal light source
US20060167531A1 (en) * 2005-01-25 2006-07-27 Michael Gertner Optical therapies and devices
WO2008030824A2 (fr) * 2006-09-05 2008-03-13 Morgan Robert D Conducteur de lumière et traitement d'affections associées à la gorge

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12109429B2 (en) 2015-07-28 2024-10-08 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12029914B2 (en) 2015-07-28 2024-07-09 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12440697B2 (en) 2015-07-28 2025-10-14 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US12397169B2 (en) 2015-07-28 2025-08-26 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US11524173B2 (en) 2015-07-28 2022-12-13 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US11617895B2 (en) 2015-07-28 2023-04-04 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US12179035B2 (en) 2015-07-28 2024-12-31 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US10180248B2 (en) 2015-09-02 2019-01-15 ProPhotonix Limited LED lamp with sensing capabilities
US12390660B2 (en) 2016-05-31 2025-08-19 Cedars-Sinai Medical Center Internal ultraviolet therapy
JP2019517305A (ja) * 2016-05-31 2019-06-24 シーダーズ−サイナイ メディカル センター 内部の紫外線治療法
JP2023106524A (ja) * 2016-05-31 2023-08-01 シーダーズ－サイナイ メディカル センター 内部の紫外線治療法
US11992699B2 (en) 2019-10-15 2024-05-28 Cedars-Sinai Medical Center Internal ultraviolet therapy
US11684798B2 (en) 2020-03-19 2023-06-27 Know Bio, Llc Illumination devices for inducing biological effects
US11752359B2 (en) 2020-03-19 2023-09-12 Know Bio, Llc Illumination devices for inducing biological effects
US12390657B2 (en) 2020-03-19 2025-08-19 Know Bio, Llc Illumination devices for inducing biological effects
US11986666B2 (en) 2020-03-19 2024-05-21 Know Bio, Llc Illumination devices for inducing biological effects
US12011611B2 (en) 2020-03-19 2024-06-18 Know Bio, Llc Illumination devices for inducing biological effects
US12447354B2 (en) 2020-03-19 2025-10-21 Know Bio, Llc Illumination devices for inducing biological effects
US11147984B2 (en) 2020-03-19 2021-10-19 Know Bio, Llc Illumination devices for inducing biological effects
CN115666362A (zh) * 2020-03-20 2023-01-31 西达-赛奈医疗中心 内部紫外线治疗
EP4117773A4 (fr) * 2020-05-18 2024-04-10 Pathy Medical, LLC Dispositifs et procédés d'application d'une lumière thérapeutique pour réduire le risque de contracter une maladie infectieuse pour du personnel soignant
US12121744B2 (en) * 2020-05-18 2024-10-22 Pathy Medical, Llc Devices and methods for applying therapeutic light to reduce hazard to health care providers of contracting infectious disease
WO2021236635A1 (fr) 2020-05-18 2021-11-25 Pathy Medical, Inc. Dispositifs et procédés d'application d'une lumière thérapeutique pour réduire le risque de contracter une maladie infectieuse pour du personnel soignant
US20210353959A1 (en) * 2020-05-18 2021-11-18 Pathy Medical, Llc Devices and methods for applying therapeutic light to reduce hazard to health care providers of contracting infectious disease
US12409339B2 (en) 2020-08-13 2025-09-09 Cedars-Sinai Medical Center Internal ultraviolet therapy
US12347337B2 (en) 2020-12-10 2025-07-01 Know Bio, Llc Enhanced testing and characterization techniques for phototherapeutic light treatments
JP2024500574A (ja) * 2020-12-18 2024-01-09 コチャン，ペーター 紫外線気流処理システム
WO2022132057A1 (fr) * 2020-12-18 2022-06-23 Kochan Peter Système de traitement d'un flux d'air par ultraviolet
US12115384B2 (en) 2021-03-15 2024-10-15 Know Bio, Llc Devices and methods for illuminating tissue to induce biological effects
US11654294B2 (en) 2021-03-15 2023-05-23 Know Bio, Llc Intranasal illumination devices

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