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US20080255069A1 - Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease - Google Patents

Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease Download PDF

Info

Publication number
US20080255069A1
US20080255069A1 US12/065,099 US6509906A US2008255069A1 US 20080255069 A1 US20080255069 A1 US 20080255069A1 US 6509906 A US6509906 A US 6509906A US 2008255069 A1 US2008255069 A1 US 2008255069A1
Authority
US
United States
Prior art keywords
retinoid
group
medicament
bowel disease
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/065,099
Other languages
English (en)
Inventor
Koichi Shudo
Hiroyuki Kagechika
Hiroshi Fukasawa
Tetsuro MATSUISHI
Naoko Katsumura
Miwako ISHIDO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KEMPHYS Ltd
Original Assignee
R and R Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R and R Inc filed Critical R and R Inc
Assigned to R & R INC. reassignment R & R INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FUKASAWA, HIROSHI, ISHIDO, MIWAKO, KAGECHIKA, HIROYUKI, KATSUMURA, NAOKO, MATSUISHI, TETSURO, SHUDO, KOICHI
Publication of US20080255069A1 publication Critical patent/US20080255069A1/en
Assigned to KEMPHYS LTD. reassignment KEMPHYS LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: R & R INC.
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Definitions

  • 1 Localized hyperemia, no ulcers
  • 2 Ulceration without hyperemia or colonic wall thickening
  • 3 Inflammation and ulceration at one site
  • 4 Ulcers and Inflammations at two or more sites
  • 5 A major damaged site extending in 1 cm or longer along the direction of the colon length
  • 6-10 When a major damaged site extends in 2 cm or longer along the direction of the colon length, a score is increased by one for each additional 1 cm over 2 cm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US12/065,099 2005-09-09 2006-09-07 Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease Abandoned US20080255069A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005-261775 2005-09-09
JP2005261775 2005-09-09
PCT/JP2006/317720 WO2007029760A1 (ja) 2005-09-09 2006-09-07 腸疾患の予防及び／又は治療のための医薬

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/317720 A-371-Of-International WO2007029760A1 (ja) 2005-09-09 2006-09-07 腸疾患の予防及び／又は治療のための医薬

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/559,268 Continuation US8168677B2 (en) 2005-09-09 2009-09-14 Method for treatment of inflammatory bowel disease

Publications (1)

Publication Number Publication Date
US20080255069A1 true US20080255069A1 (en) 2008-10-16

Family

ID=37835875

Family Applications (3)

Application Number Title Priority Date Filing Date
US12/065,099 Abandoned US20080255069A1 (en) 2005-09-09 2006-09-07 Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease
US12/559,268 Expired - Fee Related US8168677B2 (en) 2005-09-09 2009-09-14 Method for treatment of inflammatory bowel disease
US12/872,171 Expired - Fee Related US8071647B2 (en) 2005-09-09 2010-08-31 Method for treatment of adhesion of the intestines

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/559,268 Expired - Fee Related US8168677B2 (en) 2005-09-09 2009-09-14 Method for treatment of inflammatory bowel disease
US12/872,171 Expired - Fee Related US8071647B2 (en) 2005-09-09 2010-08-31 Method for treatment of adhesion of the intestines

Country Status (5)

Country Link
US (3) US20080255069A1 (ja)
EP (2) EP2286807A3 (ja)
JP (2) JP5042839B2 (ja)
CN (2) CN101262861B (ja)
WO (1) WO2007029760A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021108A1 (en) * 2004-03-10 2008-01-24 Research Foundation Itsuu Laboratory Memory Fixation Accelerator
US20100004203A1 (en) * 2005-09-09 2010-01-07 Kemphys Ltd. Medicament for preventive and/or therapeutic treatment of bowel disease
US20180166165A1 (en) * 2016-12-14 2018-06-14 Tracy Warren System and methods for developing and using a microbiome-based action component for patient health
US11039995B2 (en) 2013-03-15 2021-06-22 Samson Pharma, Llc Topical compositions for reducing the effects of aging
US11978543B2 (en) 2016-12-14 2024-05-07 Astarte Medical Partners Inc. System and methods for developing and using a microbiome-based action component

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009101684A1 (ja) * 2008-02-14 2009-08-20 Kemphys Ltd. 内臓癒着の予防及び／又は治療のための医薬
US20140323550A1 (en) * 2011-11-18 2014-10-30 Nitto Denko Corporation Intestinal fibrosis treatment agent
RU2015106915A (ru) * 2012-08-01 2016-09-20 Мерк Шарп И Доум Корп. МОДУЛЯТОРЫ α7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И ИХ ПРИМЕНЕНИЕ
CN104162167A (zh) * 2014-07-18 2014-11-26 山东大学 他米巴罗汀环糊精或环糊精衍生物包合物及其制备方法
DE102014011699B4 (de) * 2014-08-07 2023-11-02 Fresenius Medical Care Deutschland Gmbh Vorrichtung zur Ermittlung eines optimalen Dialysatflusses für eine extrakorporale Blutbehandlung mit einer extrakorporalen Blutbehandlungsvorrichtung
LT3433234T (lt) 2016-03-22 2021-12-10 Merck Sharp & Dohme Corp. Nikotino acetilcholino receptorių alosteriniai moduliatoriai

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703110A (en) * 1984-07-07 1987-10-27 Koichi Shudo Benzoic acid derivatives having a para substituent which is a substituted phenyl group connected by a linking radical; useful in neoplastic cell differentiation and diagnosis
US5929069A (en) * 1995-09-21 1999-07-27 Institute Of Medicinal Molecular Design, Inc. Compounds activating pharmacological effects of retinoids
US20080021108A1 (en) * 2004-03-10 2008-01-24 Research Foundation Itsuu Laboratory Memory Fixation Accelerator
US20080139842A1 (en) * 2006-09-27 2008-06-12 R&R Inc. Medicament for preventive and/or therapeutic treatment of diseases with secretory disorder
US20080182905A1 (en) * 2007-01-29 2008-07-31 St. Marianna University School Of Medicine Medicament for preventive and therapeutic treatment of physical dysfunction caused by nerve damage
US20080207768A1 (en) * 2007-02-28 2008-08-28 R&R Inc. Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6122047A (ja) 1984-07-07 1986-01-30 Koichi Shiyudo 安息香酸誘導体
JPS6176440A (ja) 1984-09-19 1986-04-18 Koichi Shiyudo 安息香酸誘導体
JPH07101857A (ja) * 1993-10-04 1995-04-18 Kuraray Co Ltd ビタミンａ酸亜鉛塩を有効成分とする抗潰瘍剤
US5601579A (en) * 1994-12-29 1997-02-11 Medex, Inc. Method for the treatment of bowel adhesions
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same
JP3865829B2 (ja) 1995-09-21 2007-01-10 株式会社医薬分子設計研究所 レチノイド作用増強性化合物
CA2295807A1 (en) * 1997-07-29 1999-02-11 Bristol-Myers Squibb Company Use of selective rxr agonists to prevent surgical adhesions
US5776915A (en) * 1997-08-12 1998-07-07 Clarion Pharmaceuticals Inc. Phosphocholines of retinoids
EP0908179A1 (en) * 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
ZA200408744B (en) * 2002-04-22 2005-11-10 Res Found Itsuu Lab Drugs for treating vascular diseases.
US20050205086A1 (en) * 2002-10-25 2005-09-22 Foamix Ltd. Retinoid immunomodulating kit and composition and uses thereof
CA2559849C (en) 2004-03-08 2013-06-18 Dentsply International Inc. Energy assisted delivery of dental materials from a cartridge
CN101262861B (zh) * 2005-09-09 2011-04-06 有限会社肯菲思 用于预防及/或治疗肠疾病的药物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703110A (en) * 1984-07-07 1987-10-27 Koichi Shudo Benzoic acid derivatives having a para substituent which is a substituted phenyl group connected by a linking radical; useful in neoplastic cell differentiation and diagnosis
US5929069A (en) * 1995-09-21 1999-07-27 Institute Of Medicinal Molecular Design, Inc. Compounds activating pharmacological effects of retinoids
US20080021108A1 (en) * 2004-03-10 2008-01-24 Research Foundation Itsuu Laboratory Memory Fixation Accelerator
US20080139842A1 (en) * 2006-09-27 2008-06-12 R&R Inc. Medicament for preventive and/or therapeutic treatment of diseases with secretory disorder
US20080182905A1 (en) * 2007-01-29 2008-07-31 St. Marianna University School Of Medicine Medicament for preventive and therapeutic treatment of physical dysfunction caused by nerve damage
US20080207768A1 (en) * 2007-02-28 2008-08-28 R&R Inc. Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080021108A1 (en) * 2004-03-10 2008-01-24 Research Foundation Itsuu Laboratory Memory Fixation Accelerator
US8198329B2 (en) 2004-03-10 2012-06-12 Research Foundation Itsuu Laboratory Memory consolidation promoting agent and method of use
US8431613B2 (en) 2004-03-10 2013-04-30 Research Foundation Itsuu Laboratory Memory fixation accelerator
US20100004203A1 (en) * 2005-09-09 2010-01-07 Kemphys Ltd. Medicament for preventive and/or therapeutic treatment of bowel disease
US8071647B2 (en) 2005-09-09 2011-12-06 Kemphys Ltd. Method for treatment of adhesion of the intestines
US8168677B2 (en) 2005-09-09 2012-05-01 Kemphys Ltd. Method for treatment of inflammatory bowel disease
US11039995B2 (en) 2013-03-15 2021-06-22 Samson Pharma, Llc Topical compositions for reducing the effects of aging
US20180166165A1 (en) * 2016-12-14 2018-06-14 Tracy Warren System and methods for developing and using a microbiome-based action component for patient health
US10811126B2 (en) * 2016-12-14 2020-10-20 Tracy Warren System and methods for developing and using a microbiome-based action component for patient health
US11978543B2 (en) 2016-12-14 2024-05-07 Astarte Medical Partners Inc. System and methods for developing and using a microbiome-based action component

Also Published As

Publication number Publication date
US20100324134A1 (en) 2010-12-23
CN102058571A (zh) 2011-05-18
CN101262861A (zh) 2008-09-10
JPWO2007029760A1 (ja) 2009-03-19
EP2286807A2 (en) 2011-02-23
JP5172911B2 (ja) 2013-03-27
WO2007029760A1 (ja) 2007-03-15
CN101262861B (zh) 2011-04-06
CN102058571B (zh) 2012-09-19
US8168677B2 (en) 2012-05-01
JP2010265315A (ja) 2010-11-25
EP2286807A3 (en) 2012-08-29
US8071647B2 (en) 2011-12-06
JP5042839B2 (ja) 2012-10-03
EP1930001A1 (en) 2008-06-11
EP1930001A4 (en) 2010-07-21
US20100004203A1 (en) 2010-01-07

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Legal Events

Date Code Title Description
AS Assignment

Owner name: R & R INC., JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SHUDO, KOICHI;KAGECHIKA, HIROYUKI;FUKASAWA, HIROSHI;AND OTHERS;REEL/FRAME:021074/0067

Effective date: 20080520

AS Assignment

Owner name: KEMPHYS LTD., JAPAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:R & R INC.;REEL/FRAME:023371/0719

Effective date: 20090924

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION