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US20080241502A1 - Molded Body, Method For Producing the Body and Use Thereof - Google Patents

Molded Body, Method For Producing the Body and Use Thereof Download PDF

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Publication number
US20080241502A1
US20080241502A1 US11/632,849 US63284905A US2008241502A1 US 20080241502 A1 US20080241502 A1 US 20080241502A1 US 63284905 A US63284905 A US 63284905A US 2008241502 A1 US2008241502 A1 US 2008241502A1
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US
United States
Prior art keywords
molded body
film
hollow structure
body according
pores
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/632,849
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English (en)
Inventor
Stefan Giselbrecht
Roman Truckenmuller
Christina Trautmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karlsruher Institut fuer Technologie KIT
Original Assignee
Forschungszentrum Karlsruhe GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Karlsruhe GmbH filed Critical Forschungszentrum Karlsruhe GmbH
Assigned to FORSCHUNGSZENTRUM KARLSRUHE GMBH reassignment FORSCHUNGSZENTRUM KARLSRUHE GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GISELBRECHT, STEFAN, TRAUTMANN, CHRISTIAN, TRUCKENMULLER, ROMAN
Publication of US20080241502A1 publication Critical patent/US20080241502A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0023—Organic membrane manufacture by inducing porosity into non porous precursor membranes
    • B01D67/0032—Organic membrane manufacture by inducing porosity into non porous precursor membranes by elimination of segments of the precursor, e.g. nucleation-track membranes, lithography or laser methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/50—Polycarbonates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/26—Perforating by non-mechanical means, e.g. by fluid jet
    • B26F1/31—Perforating by non-mechanical means, e.g. by fluid jet by radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/34—Use of radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
    • B29C2035/0872—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation using ion-radiation, e.g. alpha-rays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B29C2059/023—Microembossing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2793/00—Shaping techniques involving a cutting or machining operation
    • B29C2793/0045—Perforating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/755—Membranes, diaphragms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249971—Preformed hollow element-containing
    • Y10T428/249972—Resin or rubber element

Definitions

  • the invention relates to a molded body into which at least one hollow structure is configured, wherein the film and the at least one hollow structure contain a plurality of pores.
  • the invention furthermore relates to a method for producing the molded body and the use thereof.
  • micro-perforated films are based either on directed physical processes such as the ion-trace technology, the laser micro-perforation, or the lithography, on special precipitation methods such as the phase inversion, or on drawing processes. Whereas the latter two processes are primarily used for producing flat micro-filtration and ultra-filtration membranes, the directed physical processes are generally used for the micro-perforation of micro-structures. In combination with technical micro-structuring processes, such as the micro injection-molding or the hot stamping, however, these processes can be used only with already existing three-dimensional microstructures.
  • a molded body a method for producing said body and the use thereof, which do not have the aforementioned disadvantages and limitations.
  • a molded body according to the invention consists of a film (membrane) having a film thickness D ranging from 1 ⁇ m to 1000 ⁇ m, preferably from 10 ⁇ m to 100 ⁇ m, wherein the film thickness advantageously remains nearly constant over large areas (several square meters).
  • the film itself advantageously consists of a thermoplastic plastic material, preferably polymethylmethacrylate (PMMA), polycarbonate (PC), polyethyleneterephthalate (PET), polystyrene (PS), polyimide (PI), polypropylene (PP), polyvinylidenefluoride (PVDF), or cycloolefin copolymer (COC).
  • PMMA polymethylmethacrylate
  • PC polycarbonate
  • PET polyethyleneterephthalate
  • PS polystyrene
  • PI polyimide
  • PP polypropylene
  • PVDF polyvinylidenefluoride
  • COC cycloolefin copolymer
  • At least one hollow structure is configured into the film, wherein the geometric dimensions of said structure are expressed with the following values:
  • the hollow structure is provided with an undercut and consequently assumes the cross-sectional form of a ⁇ structure.
  • the values for the film thickness D, the outside diameter d of the hollow structure, and the height h of the hollow structure is the same—wherein the equation (1) must still be met—this results in a ⁇ structure with distinctive distribution function for the wall thickness b.
  • hollow structures preferably a plurality of hollow structures, are configured into the film, wherein the respective value for the distance g between these structures corresponds at least to the outside diameter d of the respective hollow structures:
  • This lower limit for the spacing essentially follows from the mechanical resistance of the reshaping tool for the film.
  • extremely narrow webs having a width of a few micrometers, which are still stable with respect to the shaping operation, can thus be produced.
  • the molded body meaning the film and the hollow structures, contains a plurality of pores for which the respective diameter ⁇ preferably has a value between 10 nm and 10 ⁇ m. It is preferable if the pores are distributed statistically across the complete molded body, meaning the film as well as the hollow structures, wherein it is possible for individual pores to overlap. According to one alternative embodiment, the pores are distributed in an orderly arrangement and with a spacing ⁇ across the film and the hollow structures.
  • a molded body according to the invention can be produced with the following method steps.
  • a film is initially provided with a thickness between 1 ⁇ m and 1000 ⁇ m, preferably between 10 ⁇ m and 100 ⁇ m, wherein this film advantageously consists of polymethylmethacrylate (PMMA), polycarbonate (PC), polyethyleneterephthalate (PET), polystyrene (PS), polyimide (PI), polypropylene (PP), polyvinylidenefluoride (PVDF), or cycloolefin copolymer (COC).
  • PMMA polymethylmethacrylate
  • PC polycarbonate
  • PET polyethyleneterephthalate
  • PS polystyrene
  • PI polyimide
  • PP polypropylene
  • PVDF polyvinylidenefluoride
  • COC cycloolefin copolymer
  • the film is subsequently irradiated with ionizing radiation, as specified in method step b), such that irradiated regions are created within the film.
  • Heavy ions are preferably used for irradiating the film, for example ions of the type 132 Xe 21+ .
  • the specific energy should be selected at least high enough to ensure the penetration of the film.
  • the fluence of the heavy ions is selected such that it can be used to adjust the average pore density per surface area.
  • the heavy ions preferably have a specific energy above 0.1 MeV/nucleon.
  • An approximately 90° angle is advantageously used for irradiating the film surface, meaning the film is positioned substantially perpendicular to the direction of the heavy ion beam.
  • Any other type of ionizing radiation which allows configuring regions in the film that are removed during a later processing step as pores of a suitable size, can be used in place of the heavy ions.
  • masks can also be used for irradiating the film, so as to produce locally delimited areas and/or regions of perforation, which are to be dissolved out completely.
  • the film is reshaped thermally into a molded body during the following method step c), for example by using the process known as micro-thermoforming.
  • the film is reshaped in an entropy-elastic phase and not in a melting phase of the plastic, so that the correlation between the radiation dose and the irradiated location is not lost.
  • the temperature remains in the range of softening temperature (glass-transition temperature) for the thermoplastic plastic, meaning below its melting temperature, to avoid a healing of the traces and/or a blurring of the locally deposited dose. This goal is reached with the comparably low reshaping temperature and the short reshaping duration.
  • the method according to the invention is based on inserting the intermediate technical step of reshaping through micro-structuring between the step of irradiating the polymer substrate and the processing step that would normally follow it.
  • Critical for the proposed method is the thermoforming of a locally modified polymer material with the aid of ionizing radiation to allow a later removal of these regions to generate perforated or net-type thin-walled three-dimensional hollow structures.
  • a flat semi-finished technical film is subjected to an ionizing radiation, preferably with ionizing particles.
  • an ionizing radiation preferably with ionizing particles.
  • the irradiated film with the existing latent traces is therefore micro-structured before (!) the pores are generated by means of etching and then dissolving.
  • micro-technical processes can be used for which the polymer does not transition to a liquid-melt phase since all traces are otherwise healed and/or a blurring of the locally deposited dose occurs.
  • Micro-thermoforming is a micro-technical process with an entropy-elastic state during the forming process, so that the material cohesion of the polymer is ensured since the thermoplastic material is deformed only in the range immediately surrounding its plasticizing temperature.
  • thermoplastic semi-finished products are spatially drawn in a negative form in order to thin the wall thickness.
  • the applied traces are retained per se, but change their position relative to each other, corresponding to the respective local drawing, meaning the trace density per surface unit decreases with increasing drawing.
  • the irradiated regions can then be freely etched and/or dissolved with a suitable substance because of their changed physical properties, as disclosed in method step d).
  • pores are formed in the molded body, which preferably have a diameter ⁇ between 10 nm and 10 ⁇ m.
  • the irradiated regions in the molded body are removed (dissolved) with the aid of wet chemical etching, for example by using a strong alkaline solution. The desired pore diameter is adjusted via the parameters (duration, temperature) for the etching step.
  • the molded body produced according to the invention is removed from the mold.
  • This molded body represents a three-dimensional hollow structure with thin walls, provided with pores of a defined size in all regions of the side walls and the bottom, wherein these are furthermore aligned in all regions mostly perpendicular to the wall.
  • a molded body comprising a single or several hollow structures can be used as housing for micro-structured parts (components) or for collecting micro-particles and/or nano-particles.
  • the surfaces of the aforementioned particles can be functionalized, for example, through perfusion of various reaction means.
  • Molded bodies with hollow structures that have an inside diameter d i , obtained by using the outside diameter d minus double the wall thickness b, as well as a height h in the range of 10-50 ⁇ m, can furthermore be used for individual biological or pharmaceutical analyses of bio-molecules, as well as prokaryotic or eukaryotic cells.
  • Molded bodies with hollow structures that have an inside diameter d i as well as a height h in the range of 50-500 ⁇ m, for which the dimensions are consequently in the range of standard spheroids, can be used for the three-dimensional cultivation of prokaryotic or eukaryotic cells. Examples for this are the cultivation of cells for studying angiogenesis, invasiveness (tumor research), or cell-to-cell communication.
  • hollow structures are arranged in a single plane, wherein it is possible to arrange the hollow structures in a row or to have a planar distribution across the complete film or parts of the film.
  • the hollow structures are preferably arranged in rows and columns and/or are in a staggered arrangement.
  • Molded bodies of this type can be used as addressable cavities for immobilizing and/or magazining micro-particles or nano-particles, for which the surfaces can be functionalized through perfusion of reaction media.
  • One preferred use of the molded bodies according to the invention is in the form of a micro-structured cell culture carrier for the three-dimensional cultivation of prokaryotic or eukaryotic cells, for example as disclosed in reference DE 41 32 379 A1. This allows the immobilizing of cells supplied by perfusing media, wherein the preferred parameters are:
  • Molded bodies according to the invention are furthermore suitable for immobilizing enzymes or surface-active catalysts because of their increased surface area. Immobilized enzymes on the increased surface area make it possible to configure a biosensor, with the medium (fluid) flowing directly through it and not just around it.
  • Molded bodies according to the invention can be used with mechanical, thermal, electric, magnetic or chemical separation processes.
  • molded bodies of this type can be used for the filtering out of micro-organisms, including viruses, bacterio-phages and/or or bacteria, or bio-molecules such as soluble proteins from a medium that is flowing through.
  • Molded bodies according to the invention are furthermore suitable for use as atomizers. Substances which do not mix while in the liquid phase are transferred from the pores of adjacent hollow structures in the form of finely-distributed drops (aerosols) and are mixed in this way.
  • a molded body according to the invention is rolled up simply or spirally, wherein the hollow structures are oriented either toward the inside or the outside.
  • a molded body according to the invention can also be folded or have a corrugated shape.
  • several molded bodies with the same or different parameters can be arranged side-by-side, one above the other, or can be nestled into each other and can be used, for example, for the membrane filtration.
  • micro-particles or nano-particles can be separated serially according to their size, by means of several layers with a graduated pore size. Molded bodies of this type are also suitable for use as three-dimensional filters with defined pore size, for example for the material separation in the pharmaceutical industry, the biotechnical industry, and the like.
  • One or several molded bodies according to the invention in the form of a tube represent a module, having a considerably larger surface area as compared to a standard hollow fiber.
  • a module of this type can be used, for example, for producing monoclonal antibodies or as extra-corporeal organ support system.
  • these bodies can be used as thin-walled microscopic channel structures and reservoir structures with defined localized openings and/or pores of a defined size, which are used for taking samples, for the ventilation, for the material separation, and the like. Molded bodies of this type are also used, for example, in ⁇ capillary electrophoresis chips or in lab-on-a-chip systems.
  • FIG. 1 A schematic cross section through a molded body with perforated hollow structures.
  • FIG. 2 A schematic cross section through a molded body with a hollow structure that is provided with an undercut ( ⁇ structure).
  • FIG. 3 A schematic cross section through an arrangement of several hollow structures in a single plane:
  • FIG. 4 Schematic cross-sections through three-dimensional arrangements of hollow structures:
  • FIG. 5 Schematic cross sections through three-dimensional arrangements of two molded bodies.
  • FIG. 6 Scanning electron microscope image of the section through a hollow structure, prior to the method step d).
  • FIG. 7 Scanning electron microscope image of a section through the hollow structure shown in FIG. 6 , following the method step d).
  • FIG. 8 Scanning electron microscope image of a different section through a hollow structure, following the method step d).
  • FIG. 9 A section through the outside region of the molded body shown in FIGS. 6 to 8 (single structure).
  • FIG. 10 A detail from FIG. 9 for further demonstrating the interconnectedness of the pores.
  • FIG. 1 shows a schematic cross section through a molded body with perforated hollow structures.
  • the individual parameters included with this Figure are:
  • FIG. 2 shows a schematic cross section through a molded body comprising a hollow structure with a real undercut, meaning a so-called ⁇ structure.
  • the distinctive distribution function of the wall thickness b is visible in this view.
  • FIG. 3 shows several options for arranged hollow structures in a single plane
  • FIG. 4 shows possible spatial arrangements of molded bodies according to the invention
  • FIG. 5 shows several options for arranging two molded bodies in stacked or sandwich-type arrangements.
  • the hollow structures of the individual molded bodies in this case can be oriented in the same (a, d) or in opposing directions (b, c, e, f), either in a row (a-c) or staggered (d-f) and/or can be directed toward the inside or the outside (c versus b; f versus e).
  • the method according to the invention was realized with a cast film of poly carbonate (PC), having a thickness of 50 ⁇ m.
  • PC poly carbonate
  • the film was irradiated at the linear accelerator UNILAC by the “GESELLSCHAFT FÜR SCHWERIONEN-FORSCHUNG” [Company for Heavy Ion Research] (GSI) in Darmstadt, Germany, using heavy ions of the type 132 Xe 21+ with a specific energy of 11.4 MeV/nucleon and a fluence of 10 6 ions/cm 2 .
  • the angle of irradiation relative to the surface of the film was 90°.
  • the film was subsequently dried in a vacuum for 45 minutes at 80° C. to prepare for the following micro thermoforming step.
  • a mechanical pressure of 80 000N was applied, given a forming temperature of 164° C. and a gas pressure of 5 MPa (50 bar).
  • the form release temperature was approximately 70° C. Obtained were hollow structures with a depth of approximately 240 ⁇ m to 250 ⁇ m.
  • a solution of 5N NaOH with 10% methanol was used as etching medium for the pore formation.
  • the etching occurred over a period of 6 hours, at a temperature of 50° C., and result in pores ranging in size from 4 ⁇ m to 5 ⁇ m.
  • FIG. 6 shows the scanning electron microscope image of a section through a hollow structure (cavity) configured in a micro thermoformed 50 ⁇ m thick film of polycarbonate (PC).
  • the maximum depth of the structure is approximately 250 ⁇ m while the depth in the cutting plane is somewhat lower.
  • the film was irradiated with heavy ions prior to the thermoforming operation.
  • FIG. 7 shows a scanning electron microscope image of the section through the hollow structure in the micro thermoformed film of polycarbonate (PC), previously shown in FIG. 6 , following the etching step.
  • PC polycarbonate
  • FIG. 8 illustrates the scanning electron microscope image of a different section through a hollow structure in the micro thermoformed film of polycarbonate (PC) that is already shown in FIG. 6 , following the method step d). The interconnectedness of the pores is again clearly visible in some areas.
  • PC polycarbonate
  • FIG. 9 contains a section through the outside region of the micro thermoformed film of polycarbonate (single structure), already shown in FIGS. 5 to 8 .
  • FIG. 10 contains an enlarged detail from FIG. 9 , which also shows the interconnectedness of the pores.

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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Toxicology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Forests & Forestry (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Filtering Materials (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
US11/632,849 2004-07-21 2005-06-30 Molded Body, Method For Producing the Body and Use Thereof Abandoned US20080241502A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE200410035267 DE102004035267B3 (de) 2004-07-21 2004-07-21 Formkörper, Verfahren zu seiner Herstellung und seine Verwendung
DE102004035267.4 2004-07-21
PCT/EP2005/007043 WO2006007948A1 (fr) 2004-07-21 2005-06-30 Element moule, procedes de fabrication associes et utilisation

Related Parent Applications (1)

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PCT/EP2005/007043 A-371-Of-International WO2006007948A1 (fr) 2004-07-21 2005-06-30 Element moule, procedes de fabrication associes et utilisation

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US12/695,653 Division US8506833B2 (en) 2004-07-21 2010-01-28 Molded body, method for producing the body and use thereof

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US20080241502A1 true US20080241502A1 (en) 2008-10-02

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US12/695,653 Expired - Fee Related US8506833B2 (en) 2004-07-21 2010-01-28 Molded body, method for producing the body and use thereof

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US (2) US20080241502A1 (fr)
EP (1) EP1768833B1 (fr)
JP (1) JP4773437B2 (fr)
CA (1) CA2574233C (fr)
DE (1) DE102004035267B3 (fr)
DK (1) DK1768833T3 (fr)
WO (1) WO2006007948A1 (fr)

Cited By (7)

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US20130270225A1 (en) * 2012-04-12 2013-10-17 Technische Universitaet Ilmenau Method for production of a microstructured molded object
US8875356B2 (en) 2011-10-06 2014-11-04 Intercontinental Great Brands Llc Mechanical and adhesive based reclosable fasteners
US9480931B1 (en) * 2012-11-16 2016-11-01 Mattel, Inc. Building components
USD813318S1 (en) 2017-03-30 2018-03-20 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD813317S1 (en) * 2017-03-30 2018-03-20 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD815216S1 (en) * 2017-03-30 2018-04-10 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD897451S1 (en) 2017-07-06 2020-09-29 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base

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DE102006050023B4 (de) * 2006-10-19 2008-11-13 Ist - Ionen Strahl Technologie - Gmbh Verfahren zur Bearbeitung von Material durch Schwerionenbestrahlung und nachfolgenden Ätzprozess
DE102007007718A1 (de) 2007-02-16 2008-08-21 Forschungszentrum Karlsruhe Gmbh Bioreaktor, Anordnung aus Bioreaktoren, Verfahren zu ihrer Herstellung und ihre Verwendung
DE102007023286B4 (de) 2007-05-18 2010-11-04 Karlsruher Institut für Technologie Verfahren zur Herstellung einer Membran in einem Rahmen
DE102007050976B4 (de) 2007-10-25 2010-02-11 Forschungszentrum Karlsruhe Gmbh Verfahren zur Umformung einer Folie
DE102008014113B4 (de) * 2008-03-13 2014-04-03 Semikron Elektronik Gmbh & Co. Kg Leistungshalbleitermodul in Druckkontaktausführung
DE102009044113A1 (de) 2009-09-27 2011-04-07 Technische Universität Ilmenau Teilweise perforierter mikrostrukturierter Formkörper und Verfahren zu dessen Herstellung
DE102009044115A1 (de) 2009-09-27 2011-04-07 Technische Universität Ilmenau Mikrostrukturierter Formkörper mit perforierten Teilen und Verfahren zu dessen Herstellung
EP2985343A1 (fr) 2014-08-11 2016-02-17 Karlsruher Institut für Technologie Système de co-culture in vitro
CN105564813A (zh) * 2016-02-23 2016-05-11 郑景文 包扎带
RU2637230C1 (ru) * 2016-10-26 2017-12-01 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" Способ формования полимерной трековой мембраны с полостью заданной кривизны и устройство для его осуществления
DE102022115584A1 (de) 2022-06-22 2023-12-28 Karlsruher Institut für Technologie, Körperschaft des öffentlichen Rechts Dreidimensional strukturierte Sensorfolien

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067585A1 (en) * 2002-10-07 2004-04-08 Yu-Chi Wang Cell cultivation surface and method of making the same
US7261950B2 (en) * 2002-08-17 2007-08-28 3M Innovative Properties Company Flexible, formable conductive films

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364723A (en) * 1979-05-04 1982-12-21 The Procter & Gamble Company Apparatus for texturing a thermoplastic film
US4259286A (en) * 1979-05-04 1981-03-31 The Procter & Gamble Company Method and apparatus for texturing a thermoplastic film
ES2040348T3 (es) * 1987-08-24 1993-10-16 The Procter & Gamble Company Lamina de polimero con microburbujas, substancialmente impermeable a los fluidos, y metodo y aparato para producirla.
US5637925A (en) * 1988-02-05 1997-06-10 Raychem Ltd Uses of uniaxially electrically conductive articles
DE3816078A1 (de) * 1988-05-11 1989-11-23 Brandt Reinhard Verfahren zur herstellung hitzebestaendiger und chemikalienresistenter feinstporiger mikrosiebe (lichgroessen d > 10 nano-m) aus der polyimid-folie "kapton" (handelsname von du pont)
SU1763452A1 (ru) * 1990-08-27 1992-09-23 Объединенный Институт Ядерных Исследований Способ получени полипропиленовой микрофильтрационной мембраны
DE4132379A1 (de) * 1991-09-28 1993-04-08 Kernforschungsz Karlsruhe Substrat fuer zellkulturen und kultur von zellen oder zellaggregaten
JP3510136B2 (ja) * 1999-03-03 2004-03-22 ユニ・チャーム株式会社 体液処理用品の不透液性裏面シート
FR2803237A1 (fr) * 1999-12-29 2001-07-06 Iniversite Catholique De Louva Procede de creation de pores dans un materiau polymere en feuilles ou une couche polymere telle qu'un film mince d'epaisseur egale a une centaine de nanometres, prealablement deposee sur un support metallique
JP2003222422A (ja) * 2001-11-02 2003-08-08 Sharp Corp 再生器、再生器の製造方法および再生器の製造装置ならびにスターリング冷凍機
DE10203250C1 (de) * 2001-12-20 2003-07-24 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Strukturierung, insbesondere Mikrostrukturierung, von Polymerfolien
DE10201640A1 (de) * 2002-01-17 2003-08-07 Fraunhofer Ges Forschung Verfahren zur Herstellung einer Folie mit Oberflächenstrukturen im Mikro- und Nanometerbereich sowie eine diesbezügliche Folie
US6908552B2 (en) * 2002-02-26 2005-06-21 Gesellschaft Fuer Schwerionenforschung Mbh Method of producing nanostructures in membrances, and asymmetrical membrane
DE10229118A1 (de) * 2002-06-28 2004-01-29 Infineon Technologies Ag Verfahren zur kostengünstigen Strukturierung von leitfähigen Polymeren mittels Definition von hydrophilen und hydrophoben Bereichen
EP1580497B1 (fr) * 2002-10-31 2008-04-30 Sharp Kabushiki Kaisha Regenerateur, procede de fabrication d'un regenerateur, systeme destine a la fabrication d'un regenerateur et appareil de refrigeration a cycle de stirling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261950B2 (en) * 2002-08-17 2007-08-28 3M Innovative Properties Company Flexible, formable conductive films
US20040067585A1 (en) * 2002-10-07 2004-04-08 Yu-Chi Wang Cell cultivation surface and method of making the same

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8875356B2 (en) 2011-10-06 2014-11-04 Intercontinental Great Brands Llc Mechanical and adhesive based reclosable fasteners
US20130270225A1 (en) * 2012-04-12 2013-10-17 Technische Universitaet Ilmenau Method for production of a microstructured molded object
US8845911B2 (en) * 2012-04-12 2014-09-30 Technische Universität Ilmenau Method for production of a microstructured molded object
US9480931B1 (en) * 2012-11-16 2016-11-01 Mattel, Inc. Building components
US10596480B1 (en) * 2012-11-16 2020-03-24 Mattel, Inc. Building components
USD813318S1 (en) 2017-03-30 2018-03-20 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD813317S1 (en) * 2017-03-30 2018-03-20 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD815216S1 (en) * 2017-03-30 2018-04-10 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD928890S1 (en) 2017-03-30 2021-08-24 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base
USD897451S1 (en) 2017-07-06 2020-09-29 Chrome Cherry Design Studio (Pty) Ltd Tape forming a toy building block base

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EP1768833A1 (fr) 2007-04-04
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JP2008507424A (ja) 2008-03-13
CA2574233A1 (fr) 2006-01-26
DK1768833T3 (da) 2014-06-30
CA2574233C (fr) 2012-10-02
DE102004035267B3 (de) 2006-02-09
WO2006007948A1 (fr) 2006-01-26
EP1768833B1 (fr) 2014-04-23
US20100126965A1 (en) 2010-05-27

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