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US20070129687A1 - Injection method and apparatus - Google Patents

Injection method and apparatus Download PDF

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Publication number
US20070129687A1
US20070129687A1 US11/598,969 US59896906A US2007129687A1 US 20070129687 A1 US20070129687 A1 US 20070129687A1 US 59896906 A US59896906 A US 59896906A US 2007129687 A1 US2007129687 A1 US 2007129687A1
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US
United States
Prior art keywords
housing
spring
dose
button
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/598,969
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English (en)
Inventor
Jeremy Marshall
Mark Eaton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Owen Mumford Ltd
Original Assignee
Owen Mumford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owen Mumford Ltd filed Critical Owen Mumford Ltd
Assigned to OWEN MUMFORD, LTD. reassignment OWEN MUMFORD, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EATON, MARK, MARSHALL, JEREMY
Publication of US20070129687A1 publication Critical patent/US20070129687A1/en
Priority to US12/561,320 priority Critical patent/US8905971B2/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6081—Colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals

Definitions

  • the present invention relates to an injection method and apparatus, and more particularly to an injection method and apparatus which provides for automatic medication delivery and for variable dose setting.
  • U.S. Pat. No. 5,104,380 describes a generally pen-like syringe which incorporates a dose metering device provided by a cap or “dose knob” which is rotatable with respect to the pen body to a position related to the dose of medication to be injected.
  • Rotation loads (by twisting) a coil spring which is prevented from unwinding by cooperating teeth.
  • the user disengages the ratchet teeth by means of a sliding trigger coupled to the outside of the pen body, resulting in the unwinding of the spring.
  • This causes rotation of a drive gear which is coupled to a syringe plunger via a quick pitch screw thread. Rotation of the gear results in axial movement of the plunger through the pen body.
  • the plunger acts on a “bung” of a medicament containing cartridge, driving medicament from the cartridge as it travels.
  • the structure of the syringe of U.S. Pat. No. 5,104,380 is such that, once a dose has been set by a user dialing the dose knob to a given position, the user cannot reduce the setting by winding the dose knob in the reverse direction. If the dose has been overset, the user must activate the trigger to expel the set dose, and redial the correct dose.
  • WO02/053214 describes a syringe comprising a similar dose setting mechanism. The design described in this document is claimed to allow the dose knob to be rotated in the reverse direction to allow an overset dose to be reduced.
  • medication delivery apparatus comprising:
  • actuation of said button causes said spring to unwind or expand in discrete steps with each press of the button
  • the apparatus further comprises a drive shaft extending through the housing, the drive shaft being coupled via a ratchet mechanism to a drive element, and the drive element being coupled to said drive member, whereby rotation of the drive element gives rise to axial movement of the drive member.
  • Said dose setting knob is coupled to the drive shaft for rotation therewith when the user actuable button is in a released position, and is decoupled from the drive shaft when the button is in a depressed position whereupon the dose knob is able to rotate relative to the drive shaft.
  • Said user actuable trigger is configured to release said drive element for rotation by the spring when the trigger is actuated, and to secure the drive element when the trigger is in its resting state.
  • Said ratchet mechanism preferably comprises two complimentary sets of teeth, a first set formed on an end of the drive shaft and a second formed on the drive element.
  • said user actuable button is coupled to the drive shaft for rotation therewith.
  • the drive shaft comprises means for locking the drive shaft to the dose knob, which means is released when the button is depressed by a user.
  • the locking means may comprise one or more teeth for engaging with teeth of a rack provided around a surface of the dose knob, which teeth are free to flex inwardly when the button is depressed.
  • the button may further comprise means for inducing rotation of the dose knob in a dose reducing direction when the button is depressed, and means for defining the dose reducing steps. These means may be provided by an indexing finger depending from the user actuable button and which engages a rack formed around a surface of the dose knob.
  • the apparatus may further comprise an annular member that is removably attachable to an outer surface of the main body, the annular member being used to identify a medicament.
  • medication delivery apparatus for receiving a medication containing member, the apparatus comprising:
  • the apparatus comprises a drive means for engaging a medication containing chamber, and a drive shaft coupled between the drive means and said spring means.
  • the dose knob In a resting state, the dose knob is coupled to the drive shaft for rotation therewith.
  • the dose knob is at least temporarily uncoupled from the drive shaft to allow the dose knob to rotate relative to the drive shaft.
  • a dose delivery apparatus comprising:
  • medication delivery apparatus comprising:
  • the or each spring mounted tooth has a one piece moulded construction, with a tooth element mounted on an end of a moulded spring.
  • the apparatus comprises an elongate drive shaft coupling said spring to said drive member.
  • An end of the drive shaft is coupled to the dose knob for rotation therewith.
  • the other end of the drive shaft provides part of said spring retaining means, either said at least one sprung tooth or said toothed rack.
  • the other of said at least one sprung tooth and said toothed rack is provided on a drive element which is coupled to the housing via said user actuable trigger.
  • the drive element is in turn coupled to the drive member. Actuation of the trigger releases the drive element to rotate within the housing under the action of the spring via the drive shaft. Rotation of the drive element produces axial movement of the drive member through the housing.
  • medication delivery apparatus comprising:
  • medication delivery apparatus comprising:
  • FIG. 1 shows schematically a pen-type injector
  • FIG. 2 shows a horizontal cross-section through the injector of FIG. 1 ;
  • FIG. 2A shows an enlarged view of a retaining and trigger portion of the injector taken at A of FIG. 2 ;
  • FIG. 3 shows a vertical cross-section through the injector of FIG. 1 ;
  • FIG. 4 is a perspective exploded view of the injector of FIG. 1 ;
  • FIG. 5 shows a dose knob of the injector of FIG. 1 ;
  • FIG. 6 shows a clutch collet of the injector of FIG. 1 ;
  • FIG. 7 shows in partial cross-section of an end of the injector of FIG. 1 ;
  • FIG. 8 illustrates an operating sequence of the injector of FIG. 1 ;
  • FIG. 9 shows a horizontal side elevation view of a dose knob
  • FIG. 10 is a perspective view of a locking bush and a leadscrew
  • FIG. 11 shows a horizontal cross-section through an alternative internal construction of the injector
  • FIG. 11A shows an enlarged view of a retaining and trigger portion of the injector taken at A of FIG. 11 ;
  • FIG. 12 shows a vertical cross-section through the alternative injector of FIG. 9 ;
  • FIG. 13 is a perspective exploded view of the injector of FIG. 9 ;
  • FIG. 14 shows perspective views of an end of a drive shaft of the injector of FIG. 9 .
  • FIG. 1 a pen-type injector having a user operable dose setting mechanism.
  • the injector comprises a main body 1 and a cap 20 which snap fit together.
  • Identity ring 19 is colour coded to indicate the type of medicament to be delivered by the injector.
  • a screw thread is provided on an inner surface of the main body 1 at its upper end. This internal screw thread is engaged by an external screw thread 2 a provided on an outer surface of a dose knob 2 .
  • the dose knob 2 is illustrated in detail in FIG. 5 . Longitudinal movement of the dose knob 2 within the pen body 1 is limited in both directions.
  • a cartridge housing 18 is secured to a lower end of the main body 1 and is arranged to receive a disposable medication filled cartridge (not shown).
  • a disposable medication filled cartridge (not shown).
  • Such a cartridge has a rubber bung sealing one end of the cartridge, with the other end being arranged to receive a disposable needle.
  • the cartridge is typically multi-use, with a user attaching a new needle for each injection.
  • a torsion spring 4 is located coaxially within the main body 1 and is arranged to provide the drive force for ejecting medication from a loaded cartridge.
  • the spring 4 is fixed at its upper end to the dose knob 5 .
  • the spring 4 is fixed to the housing via a retaining ring moulded integrally with the housing 1 .
  • a generally cylindrical ratchet drive shaft 3 extends through the centre of the spring 4 .
  • An enlarged end portion 3 a of the shaft 3 has three sprung legs 3 b formed around its periphery, the legs being spaced equiangularly around the shaft.
  • a tooth 3 c is provided at the outermost end of each leg.
  • the teeth 3 c engage teeth of a rack 11 a (not visible in FIG. 4 ) formed around the inner surface of a generally cylindrical drive gear component 11 which sits within the main body 1 at a fixed axial position.
  • the drive gear 11 has a second toothed rack 11 b formed around a lower outer surface portion. This rack sits within a correspondingly sized rack 12 a formed on an inner surface of a retaining ring 12 .
  • the ring 12 is formed integrally with a trigger 12 b , with the component being slidably mounted within a slot formed in the main body 1 , separated from the body by a pair of thrust washers 10 .
  • a spring 13 urges the trigger 12 b in an upward direction, maintaining the racks 11 b , 12 a in locking engagement in the absence of a user force applied to the trigger.
  • the dose knob 2 and the trigger 12 b may be provided with a soft rubber overmolding. This provides the user with a more comfortable and better grip.
  • the clutch collet illustrated in FIG. 6 (viewed from above A and below B) rotates with the drive shaft 3 and is provided with a pair of sprung fingers 5 a .
  • the sprung fingers are shaped in cross-section to provide respective teeth for engaging teeth of a rack 2 c formed around an inner surface of the dose knob 2 .
  • the fingers 5 a are biased outwardly.
  • a rewind button 6 is located within the dose knob 2 , projecting therefrom.
  • the button 6 is coupled to the ratchet drive shaft 3 , rotating with the drive shaft but being able to slide longitudinally within the drive shaft.
  • a spring 7 is coupled between the button 6 and the drive shaft 3 and biases the button outwardly relative to the main body 1 .
  • the lower portion of the button 6 is generally cross-shaped, with two opposed arms of the cross opposing the sprung fingers 5 a of the clutch collet 5 . These arms taper inwardly such that they prevent any radially inward flexing of the sprung fingers 5 a when the button is in its outer position, whilst allowing inward flexing when the button is fully depressed against the bias of the button spring 7 .
  • FIG. 7 illustrates the button 6 in situ whilst FIG. 7B illustrates the end of the injector with a cross-section taken through the button 6 .
  • a leadscrew 8 has a screw thread formed along the length of its outer surface.
  • the leadscrew is located within the ratchet drive shaft 3 , and engages a complimentary screw thread formed on the inner surface of the drive gear 11 .
  • the end portion of the leadscrew 8 projecting from the ratchet drive shaft 3 has a leadscrew cap secured thereto. Rotational movement of the leadscrew relative to the drive shaft is prevented by the engagement of recesses formed along the length of the leadscrew with complimentary splines provided on an inner surface of a locking bush 14 .
  • the locking bush is held within a mid-body compartment 17 which itself is secured to the end of the main body 1 via a pair of complimentary screw threads.
  • the cartridge compression cup 16 On coupling with a medicament containing cartridge, the cartridge compression cup 16 will compress the spring 15 and transmit the loading onto the locking bush 14 .
  • the serrated edge of the locking bush engages with the mating features of the body 1 preventing the locking bush from rotating and ensuring that the leadscrew 8 moves forward when subjected to rotation following release of the drive gear 11 .
  • An indexing finger 6 a depends from an inner surface of the button 6 .
  • the finger is provided at its end with a ramp shaped tooth 6 b having a vertical, blocking surface and a sloping drive surface.
  • the tooth 6 b engages teeth of an indexing rack 2 b formed around an inner surface of the dose knob 2 , when the button is pressed into the dose knob 2 .
  • the dose knob 2 has a barrel 2 d formed integrally with the dose knob 2 .
  • the barrel 2 d has a series of numbers printed around its circumference, so that as the dose knob 2 is rotated, the barrel 2 d also rotates.
  • a window in the main body 1 allows the user to see one of the printed numbers, and the printed number relates to the amount of medicament that will be delivered.
  • screw thread 2 d ensures that the dose knob moves linearly with respect to the longitudinal axis of the main body 1 , and allows the dose knob to be rotated over more than one revolution. This allows both higher loading of the torsion spring, and also allows the barrel 2 d to indicate doses over more than one revolution of the barrel, provided that the printed numbers relating to a medicament dose setting are printed in a helical pattern around the outer surface of the barrel 2 d , as shown in FIG. 13 .
  • the leadscrew 8 comprises a pair of channels 21 running along its longitudinal axis. At one end of each channel is a ramp 22 .
  • the locking bush 14 comprises a pair of fingers 23 that engage with a corresponding leadscrew channel 21 . This ensures that when the device is assembled, the leadscrew 8 and the locking bush 14 are located correctly together.
  • the fingers 23 are flexible such that when the leadscrew is passed through the centre of the locking bush 14 , the fingers ride up the corresponding ramps 22 and flex outwards. Once the fingers 23 have passed over the ramps 22 , they snap into engagement with the channels 21 . During resetting, the fingers 23 abut against the corresponding ramps 22 to ensure that the locking bush 14 does not move out of engagement with the leadscrew 8 .
  • a user sets a dose by rotating the dose knob 2 in a clockwise direction.
  • the top of the spring 4 rotates with it creating torsion of the spring.
  • Engagement of the sprung fingers 5 a at the top of the ratchet drive shaft 3 with the rack 2 c formed on the inner surface of the dose knob 2 also causes the ratchet drive shaft 3 to rotate.
  • the teeth of the sprung legs 5 a “click” around the teeth of the rack 11 a. The engagement of the teeth with the rack 11 a prevents the spring 4 unwinding after each click.
  • Each click corresponds to a predefined angular rotation of the spring and therefore to a predefined ejection dose. It will be readily appreciated that, during the dose setting action, the drive gear 11 is not rotated so no axial movement of the leadscrew 8 is induced. No medication is therefore ejected from the cartridge during the dose setting operation (or indeed air introduced due to back filling).
  • the downward movement of the cross-arms of the button 6 results in the sprung fingers 5 a being free to flex inwardly, freeing the dose knob 2 and the spring 4 to rotate under one or both of the force stored in the spring and the force induced by the tooth.
  • the dose knob 2 is able to rotate until the blocking surface of the tooth engages the next stop surface of the upper rack.
  • Neither the ratchet drive shaft 3 nor the drive gear 11 rotate during this resetting operation. No axial movement of the leadscrew 8 is therefore induced and no medication ejected from the cartridge.
  • the dose resetting mechanism operates by temporarily decoupling the dose knob and the torsion spring from the ratchet drive shaft allowing the former to rotate relative to the drive shaft.
  • the rewind button spring 7 Upon removal of the pressure from the button 6 , the rewind button spring 7 returns the button to its outermost position, whereupon the teeth of the sprung fingers 5 a reengage with the teeth of the rack 2 c.
  • FIGS. 11 to 14 An alternative pen-type injector will now be described with reference to FIGS. 11 to 14 . Externally, this injector has a similar external appearance to the injector illustrated in FIG. 1 .
  • the operating principle of the alternative injector is similar to that of the injector of FIGS. 2 to 10 in terms of both the dose setting and firing functionality. However, the dose resetting mechanism differs.
  • the injector comprises a dose setting knob 2 ′ which is coupled to the main body 1 ′ via complimentary screw threads.
  • the end of the dose knob 2 ′ is closed by a dose knob cap 7 ′ which rotates with the dose knob.
  • this has an end collar 3 a ′ having three radial extending slots formed therein ( FIG. 14 , where FIG. 14A shows the knob 2 with a ratchet retainer removed, FIG. 14B shows the knob with the retainer in situ, and FIG. 14C shows the knob with the retainer in place but shown transparent).
  • These slots receive respective arms (also referred to as a dial key) 5 a ′ of a ratchet plunger component 5 ′ having a cylindrical body.
  • Each arm 5 a ′ comprises a moulded spring body and an end tooth, the surfaces of the tooth sloping at the same angle.
  • a ratchet retainer 6 ′ snaps over the end of the collar 3 a ′ to secure the ratchet plungers in place.
  • the teeth of the ratchet plunger project from the ends of their respective slots by approximately 0.5 mm, and can be deflected radially inwards (by approximately 0.25 mm) as a result of the moulded springs.
  • the teeth of the ratchet plunger 5 ′ engage the rack (also referred to as a dial cam) formed around the inner surface of the drive gear 11 ′.
  • the teeth surfaces of the rack are also equiangular, corresponding to the teeth of the ratchet plunger.
  • a user dials up a dose by rotating the dose knob 2 ′ in a clockwise direction.
  • the user applied force is sufficient to overcome the resistance between the teeth of the ratchet plunger 11 ′ and those of the rack of the drive gear 11 ′, the drive gear being held in place against rotation by the trigger 12 ′.
  • the teeth of the ratchet plunger are pushed inward into the end collar of the ratchet drive shaft to allow them to ride over the teeth of the rack within the drive gear.
  • a user wishes to reduce a set dose, he or she rotates the dose knob in an anti-clockwise direction.
  • the shape of the ratchet plunger teeth permits this.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US11/598,969 2005-12-02 2006-11-14 Injection method and apparatus Abandoned US20070129687A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/561,320 US8905971B2 (en) 2005-12-02 2009-09-17 Injection method and apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0524604.6 2005-12-02
GBGB0524604.6A GB0524604D0 (en) 2005-12-02 2005-12-02 Injection method and apparatus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/561,320 Continuation US8905971B2 (en) 2005-12-02 2009-09-17 Injection method and apparatus

Publications (1)

Publication Number Publication Date
US20070129687A1 true US20070129687A1 (en) 2007-06-07

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ID=35685947

Family Applications (2)

Application Number Title Priority Date Filing Date
US11/598,969 Abandoned US20070129687A1 (en) 2005-12-02 2006-11-14 Injection method and apparatus
US12/561,320 Expired - Fee Related US8905971B2 (en) 2005-12-02 2009-09-17 Injection method and apparatus

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/561,320 Expired - Fee Related US8905971B2 (en) 2005-12-02 2009-09-17 Injection method and apparatus

Country Status (10)

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US (2) US20070129687A1 (fr)
EP (3) EP2198906B1 (fr)
JP (2) JP5119164B2 (fr)
CN (1) CN101321550B (fr)
DE (1) DE602006019900D1 (fr)
DK (1) DK1954337T3 (fr)
GB (1) GB0524604D0 (fr)
PL (1) PL1954337T4 (fr)
RU (1) RU2395306C2 (fr)
WO (1) WO2007063342A1 (fr)

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EP2198906A3 (fr) 2011-02-09
US20100069845A1 (en) 2010-03-18
DK1954337T3 (da) 2011-05-16
EP2198906B1 (fr) 2016-01-06
RU2008125049A (ru) 2010-01-10
GB0524604D0 (en) 2006-01-11
CN101321550A (zh) 2008-12-10
JP2009517157A (ja) 2009-04-30
US8905971B2 (en) 2014-12-09
EP1954337A1 (fr) 2008-08-13
RU2395306C2 (ru) 2010-07-27
JP2012148198A (ja) 2012-08-09
EP1954337B1 (fr) 2011-01-26
PL1954337T4 (pl) 2012-02-29
EP3020433A1 (fr) 2016-05-18
CN101321550B (zh) 2013-03-13
EP3020433B1 (fr) 2017-01-25
WO2007063342A1 (fr) 2007-06-07
PL1954337T3 (pl) 2011-06-30
EP2198906A2 (fr) 2010-06-23
DE602006019900D1 (de) 2011-03-10
JP5119164B2 (ja) 2013-01-16

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