US20050061339A1 - Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity - Google Patents
Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity Download PDFInfo
- Publication number
- US20050061339A1 US20050061339A1 US10/499,552 US49955204A US2005061339A1 US 20050061339 A1 US20050061339 A1 US 20050061339A1 US 49955204 A US49955204 A US 49955204A US 2005061339 A1 US2005061339 A1 US 2005061339A1
- Authority
- US
- United States
- Prior art keywords
- nicotine
- tobacco
- composition according
- release
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 133
- 241000208125 Nicotiana Species 0.000 title claims abstract description 110
- 235000002637 Nicotiana tabacum Nutrition 0.000 title claims abstract description 110
- 210000000214 mouth Anatomy 0.000 title claims abstract description 25
- 239000012528 membrane Substances 0.000 claims abstract description 194
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 158
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 139
- 229960002715 nicotine Drugs 0.000 claims abstract description 139
- 239000000463 material Substances 0.000 claims abstract description 46
- 239000000126 substance Substances 0.000 claims abstract description 42
- 230000000694 effects Effects 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000000391 smoking effect Effects 0.000 claims abstract description 12
- 206010057852 Nicotine dependence Diseases 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- 150000003839 salts Chemical class 0.000 claims description 33
- 239000012453 solvate Substances 0.000 claims description 33
- -1 propylcellulose Polymers 0.000 claims description 32
- 230000002209 hydrophobic effect Effects 0.000 claims description 18
- 229920002678 cellulose Chemical class 0.000 claims description 10
- 239000001913 cellulose Chemical class 0.000 claims description 10
- 229920002301 cellulose acetate Polymers 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 8
- 239000004698 Polyethylene Substances 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 7
- 229920000573 polyethylene Polymers 0.000 claims description 7
- 239000000872 buffer Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000035699 permeability Effects 0.000 claims description 5
- MXYUKLILVYORSK-UHFFFAOYSA-N (+/-)-allo-lobeline Natural products C1CCC(CC(=O)C=2C=CC=CC=2)N(C)C1CC(O)C1=CC=CC=C1 MXYUKLILVYORSK-UHFFFAOYSA-N 0.000 claims description 3
- MXYUKLILVYORSK-HBMCJLEFSA-N (-)-lobeline Chemical compound C1([C@@H](O)C[C@H]2N([C@H](CCC2)CC(=O)C=2C=CC=CC=2)C)=CC=CC=C1 MXYUKLILVYORSK-HBMCJLEFSA-N 0.000 claims description 3
- MTXSIJUGVMTTMU-JTQLQIEISA-N (S)-anabasine Chemical compound N1CCCC[C@H]1C1=CC=CN=C1 MTXSIJUGVMTTMU-JTQLQIEISA-N 0.000 claims description 3
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical compound C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 claims description 3
- QLDPCHZQQIASHX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 QLDPCHZQQIASHX-UHFFFAOYSA-N 0.000 claims description 3
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims description 3
- WHAIHNKQZOMXJJ-NSHDSACASA-N 3-[(2s)-1-methylpiperidin-2-yl]pyridine Chemical compound CN1CCCC[C@H]1C1=CC=CN=C1 WHAIHNKQZOMXJJ-NSHDSACASA-N 0.000 claims description 3
- MQWJVKLIBZWVEL-XRIOVQLTSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;dihydrochloride Chemical compound Cl.Cl.CN1CCC[C@H]1C1=CC=CN=C1 MQWJVKLIBZWVEL-XRIOVQLTSA-N 0.000 claims description 3
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 claims description 3
- IECQULMJVNSKDB-RCWTXCDDSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;sulfuric acid Chemical compound OS(O)(=O)=O.CN1CCC[C@H]1C1=CC=CN=C1.CN1CCC[C@H]1C1=CC=CN=C1 IECQULMJVNSKDB-RCWTXCDDSA-N 0.000 claims description 3
- 244000043261 Hevea brasiliensis Species 0.000 claims description 3
- 244000061176 Nicotiana tabacum Species 0.000 claims description 3
- MYKUKUCHPMASKF-UHFFFAOYSA-N Nornicotine Natural products C1CCNC1C1=CC=CN=C1 MYKUKUCHPMASKF-UHFFFAOYSA-N 0.000 claims description 3
- 229930014345 anabasine Natural products 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 229960002339 lobeline Drugs 0.000 claims description 3
- 229930013610 lobeline Natural products 0.000 claims description 3
- 229920003052 natural elastomer Polymers 0.000 claims description 3
- 229920001194 natural rubber Polymers 0.000 claims description 3
- 229940069688 nicotine bitartrate Drugs 0.000 claims description 3
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 claims description 3
- 239000000779 smoke Substances 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 claims description 3
- BRTHFWPGJMGHIV-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride;hydrate Chemical compound O.[Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 BRTHFWPGJMGHIV-UHFFFAOYSA-L 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 241000208134 Nicotiana rustica Species 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 241000208292 Solanaceae Species 0.000 claims description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 239000012676 herbal extract Substances 0.000 claims description 2
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims 1
- 229920003266 Leaf® Polymers 0.000 claims 1
- 235000019568 aromas Nutrition 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 abstract description 7
- 235000019505 tobacco product Nutrition 0.000 abstract description 6
- 235000019506 cigar Nutrition 0.000 abstract description 4
- 210000004379 membrane Anatomy 0.000 description 170
- 238000009792 diffusion process Methods 0.000 description 15
- 230000004907 flux Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 239000011148 porous material Substances 0.000 description 7
- 239000004627 regenerated cellulose Substances 0.000 description 7
- 230000003247 decreasing effect Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 230000035807 sensation Effects 0.000 description 5
- 235000019615 sensations Nutrition 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 238000002211 ultraviolet spectrum Methods 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 150000004005 nitrosamines Chemical class 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229920000148 Polycarbophil calcium Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
Definitions
- the present invention relates to a novel composition for the use as snuff in the oral cavity, the composition comprising tobacco and/or a tobacco substitute encapsulated in a membrane material comprising one or more membranes at least one of which being water permeable and water-insoluble.
- a novel composition enables a selective release of e.g. nicotine while it at the same time reduces the release of substances, which normally lead to unwanted side effects.
- the novel compositions may be used as a healthier alternative to snuff and other tobacco products such as, e.g., cigarettes, cigars and pipe.
- the invention also relates to methods for giving up smoking, reducing nicotine craving, reducing side effects normally related to smoking and snuffing of tobacco as well to a method for the preparation of a composition according to the invention.
- various buffer systems may be added, e.g. carbonates.
- the moist snuff is either packed loosely, as bulk in a box or as single doses in small non-woven bags. A number of the filled and sealed bags are then packed in a box.
- the moist snuff as a single dose has become popular due to the ease of use compared to the bulk product.
- the popularity of moist snuff is most probably due to its pharmacological nicotine absorption profile.
- the dose of nicotine and speed of absorption is approximately 10 ng per ml over 10 minutes.
- Plasma nicotine concentrations rapidly increase within the first few minutes of the use of snuff and reach levels comparable to those obtained from smoking cigarettes within 30 min of use. Measurements of plasma nicotine concentrations after a single day of moist snuff consumption also yielded levels similar to cigarette use.
- the kinetics is slightly slower compared to the kinetics when smoking tobacco, such as e.g. cigarettes and cigars; however, the overall amount of nicotine absorbed is higher when snuff is employed.
- snuff is the vast number of compounds, more or less harmful to the body, e.g. different tobacco-specific nitrosamines, which are compounds known to cause different diseases such as, e.g., gastrointestinal disorders and cancer.
- U.S. Pat. No. 4,141,369 describes a method of inhaling the nicotine from tobacco without combustion of the tobacco.
- Another way of avoiding the harmful substances contained in tobacco is to substitute tobacco with nicotine.
- Various devices have also be constructed in order to deliver nicotine from a tobacco composition placed in the oral cavity:
- U.S. Pat. No. 5,346,734 describes a perforated latex oral pouch for loose, moist snuff, the pouch serving as a barrier to avoid direct physical contact between the tobacco product and the gum.
- the pouch has to be filled by the user, cut to fit the mouth cavity of the user and is re-usable.
- U.S. Pat. No. 6,162,516 describes a shield, which also has to be filled with snuff by the user, the shield acting as a barrier to reduce tobacco contact with the sensitive inner cheek lining and gum surfaces while using snuff.
- the present invention provides a composition wherein the release of nicotine from snuff can be designed freely, even though the release of unwanted and harmful substances from the tobacco is dramatically reduced.
- the present invention provides a composition for use in the oral cavity comprising tobacco and/or a tobacco substitute encapsulated in a membrane material comprising one or more membranes at least one of which being water permeable and water-insoluble.
- the gist of the invention is the employment of a membrane material which makes it possible to deliver nicotine and/or a nicotine derivative, analog, salt, solvate or a mixture thereof in a predetermined manner and—at the same time—has the properties of withholding the substances which are unwanted to such a degree that the side-effects normally observed in connection with the use of snuff in the oral cavity are dramatically reduced.
- the tobacco used in the novel snuff composition according to the invention may be natural tobacco leaves in order to preserve the authentic taste and feeling of tobacco.
- the tobacco plant belongs to the family Solanaceae and the genus Nicotiana . More than 60 tobacco species exists, the most commonly used in smoking or snuffing tobacco products being Nicotiana tabacum and Nicotiana rustica .
- To manufacture moist snuff the tobacco, which typically has a content of from about 1% to 8% nicotine, is dried, milled and mixed with a fermentative solution. The mixture is then fermented, typically for 5 days to 4 weeks at elevated temperature. After this the tobacco mass is mixed with a suitable buffer, such as e.g. carbonate, so a pH of about 6 to 8 for the moist snuff mixture is obtained, to enable and enhance the release of nicotine or a derivative thereof from the tobacco.
- the water content in the final product may lie in the range from about 10% to about 60%.
- additional compounds may be added, such as e.g. sweeteners, aroma substances and other taste additives, detergents and preservative, release modifying agents, and other liquids such as oil, organic solvents and herbal extracts.
- the natural fermented tobacco may be partly or fully substituted with a tobacco substitute, such as, e.g., nicotine and/or a nicotine derivative, analog, salt, solvate or a mixture thereof selected from the group consisting of nor-nicotine, lobeline, methylanabasine, anabasine, nicotine hydrochloride, nicotine dihydrochloride, nicotine sulphate, nicotine monotartrate, nicotine bitartrate, nicotine salicylate or nicotine zinc chloride monohydrate.
- a tobacco substitute such as, e.g., nicotine and/or a nicotine derivative, analog, salt, solvate or a mixture thereof selected from the group consisting of nor-nicotine, lobeline, methylanabasine, anabasine, nicotine hydrochloride, nicotine dihydrochloride, nicotine sulphate, nicotine monotartrate, nicotine bitartrate, nicotine salicylate or nicotine zinc chloride monohydrate.
- some additional filler may be added, such as, e.g., non-digestible fiber
- the tobacco and/or tobacco substitute may preferably have a content of nicotine and/or a nicotine derivative, analog, salt, solvate or a mixture thereof, from about 0% w/w to about 30% w/w such as, e.g., from about 0.5% w/w to about 25% w/w, from about 0.1% w/w to about 20% w/w, from about 0.1% w/w to about 15% w/w, from about 0.1% w/w to about 10% w/w, from about 0.1% w/w to about 9% w/w or from about 0.1% w/w to about 8% w/w.
- a content of nicotine and/or a nicotine derivative, analog, salt, solvate or a mixture thereof from about 0% w/w to about 30% w/w such as, e.g., from about 0.5% w/w to about 25% w/w, from about 0.1% w/w to about 20% w/w, from about 0.1% w/w to about 15%
- the tobacco and/or tobacco substitute is enclosed in a membrane material.
- the membrane material may comprise one or more membranes.
- membrane describes a thin polymeric film having natural pores and acting as a selective permeability barrier. The term does not include papermade material or polymeric materials in which not-naturally occurring openings have been made.
- At least one of the membranes may be water-insoluble to prevent spreading of the snuff in the oral cavity, and to maintain the beneficial properties of the selective membrane material during use, with respect to the withholding of unwanted substances
- At least one of the membranes may be water permeable in order to allow water to diffuse into the encapsulated tobacco and/or tobacco substitute and to allow e.g. nicotine to diffuse through the polymeric membrane material and thus becoming available for absorption.
- the membranes may have a predominantly hydrophilic or hydrophobic nature.
- the hydrophilic or hydrophobic nature of the membrane has an effect on the release of substances such as, e.g., nicotine through the membrane, since the flow of substances through the membrane is dependent on the ability of the membrane to hydrate, e.g. create hydro-channels through the membrane. These hydro-channels are a prerequisite for molecular transport when dry polymeric membranes are used.
- the flow of hydrophilic substances through a hydrophobic membrane is slower compared to a hydrophilic membrane. This is probably due to less swelling of the hydrophobic membrane pores, i.e. in the hydrophobic membranes nicotine diffusion occurs through well-organized polymeric material and hydrophobic organized water.
- One or more of the membranes used for making the composition may be a synthetic or semi-synthetic membrane.
- a synthetic or semi-synthetic membrane As is given some examples of natural, synthetic and semi-synthetic hydrophilic and hydrophobic membranes, which may be used in a novel snuff composition according to the invention.
- membranes are membranes made of cellulose acetate and derivates thereof, carboxymethyl cellulose membranes, polycellulose ester membranes, other cellulose derivatives such as, e.g., ethylcellulose, propylcellulose, polyethylene membranes, polypropylene membranes, polystyrene membranes, polyvinyl chloride membranes, polyvinyl acetate membranes, membranes made of polymers of methacrylates and acrylates, natural rubber membranes, polycarbonate membranes, polyethylene terephthalate membranes, polyester membranes, polyamide membranes and nylon membranes.
- cellulose acetate and derivates thereof such as, e.g., ethylcellulose, propylcellulose, polyethylene membranes, polypropylene membranes, polystyrene membranes, polyvinyl chloride membranes, polyvinyl acetate membranes, membranes made of polymers of methacrylates and acrylates, natural rubber membranes, polycarbonate membranes, polyethylene tere
- At least the outer membrane in the membrane material enclosing the tobacco and/or tobacco substitute may be made from a biocompatible and physiologically acceptable polymeric material, since the novel snuff composition has to be placed close to or in contact with the mucous membrane in the oral cavity during use.
- At least one of the membranes in a membrane material may be surface treated with e.g. polycarbophils to obtain a bioadhesiveness of the novel snuff composition in the oral cavity.
- the molecular weight cut off of the membrane material used in the novel snuff composition may be varied to obtain a desired release of nicotine and other substances through the membrane material.
- the molecular weight cut-off of a membrane is defined as the molecular weight of the smallest molecule of which 90% will be prevented from permeating the membrane.
- the exact permeability of a molecule is dependent on the shape, the degree of hydration and the charge of the molecule.
- At least one of the membranes comprising the membrane material may have a molecular weight cut-off from about 500 to about 40,000 such as, e.g., from about 500 to about 5,000, from about 800 to about 4,000, from about 1,000 to about 3,500; or from about 2,000 to about 40,000, from about 3,000 to about 30,000, from about 5,000 to about 25,000, from about 7,500 to about 20,000 or from about 10,000 to about 20,000.
- a molecular weight cut-off from about 500 to about 40,000 such as, e.g., from about 500 to about 5,000, from about 800 to about 4,000, from about 1,000 to about 3,500; or from about 2,000 to about 40,000, from about 3,000 to about 30,000, from about 5,000 to about 25,000, from about 7,500 to about 20,000 or from about 10,000 to about 20,000.
- the release of nicotine and/or other substances through the membrane material is also dependent on the thickness of the membrane materiel.
- the diffusion process of molecules through the membrane is decreased when the membrane thickness is increased and vice versa.
- the thickness of the membrane material may be varied in respect of obtaining a desired release of nicotine and other substances through the membrane material.
- the lower limit for the membrane material thickness is determined by what is possible from a practical point of view, and the upper value is restricted by what will allow a comfortable fit of the novel snuff composition in the oral cavity of the user.
- At least one of the membranes comprising the membrane material may have a thickness of from 2 to about 200 ⁇ m such as, e.g., from about 5 to about 100 ⁇ m, from about 7.5 to about 50 ⁇ m, from about 7.5 to about 40 ⁇ m, from about 7.5 to about 35 ⁇ m, from about 7.5 to about 30 ⁇ m or from about 7.5 to about 25 ⁇ m.
- nicotine or a nicotine derivative, analog, salt, solvate or a mixture thereof, selected from the group consisting of nor-nicotine, lobeline, methylanabasine, anabasine, nicotine hydrochloride, nicotine dihydrochloride, nicotine sulphate, nicotine monotartrate, nicotine bitartrate, nicotine salicylate or nicotine zinc chloride monohydrate, has to be released from the composition.
- the release profile may be designed with respect to the rate and amount of nicotine and unwanted substances released by the membrane.
- the release of nicotine and/or a derivative, analog, salt, solvate or a mixture thereof from a novel snuff composition may be designed to be released in a sufficient amount and/or a sufficient rate to enable a desired effect and on the other hand be designed to retain substances, which normally give rise to side-effects, such as, e.g., nitrosamines, and/or to release such substances in a substantially low amount and/or at a substantially slow rate.
- Impurity Index As a measure of the selective release of nicotine or a derivative, analog, salt, solvate or a mixture thereof, the Impurity Index —IPI—is introduced.
- the IPI is calculated from the UV-spectra recorded from 200 nm to 900 nm as described in Example 2, and is defined as the ratio of the sum of peak heights other than that of nicotine (i.e. thus including unwanted and harmful substances) to the peak height of nicotine. In other words, a low IPI reflects that a large amount of nicotine is released through the membrane compared to the amount of unwanted substances.
- the impurity index IPI is at the most 3.0 such as, e.g. at the most 2.75, at the most 2.5, at the most 2.0, at the most 1.75, at the most 1.5, at the most 1.5 or at the most 1.4 when measured after 90 min.
- the release profile of nicotine and/or a derivative, analog, salt, solvate or a mixture thereof from the invention could e.g., be fast and equivalent to the release of nicotine from the commercially available moist snuff, while maintaining a low IPI value, i.e. limiting the release of unwanted substances.
- a composition according to the invention can be designed to release nicotine and/or a derivative, analog, salt, solvate or mixture thereof in a controlled manner such as, e.g., fast (faster than from the reference product employed in the examples herein), relatively fast (i.e. similar or almost similar to the reference product employed in the examples herein), delayed (i.e. with a lag time in which period no nicotine is released followed by a release of nicotine), prolonged or sustained (i.e. a relatively slower release than the reference product to avoid any peak concentration and to obtain a relatively constant plasma concentration of nicotine after application).
- fast fast
- relatively fast i.e. similar or almost similar to the reference product employed in the examples herein
- delayed i.e. with a lag time in which period no nicotine is released followed by a release of nicotine
- prolonged or sustained i.e. a relatively slower release than the reference product to avoid any peak concentration and to obtain a relatively constant plasma concentration of nicotine after application.
- the release of nicotine or a derivative, analog, salt, solvate or a mixture thereof may be delayed compared to the commercially available moist snuff, to mimic the effect of nicotine replacement products such as, e.g., patches.
- the release of nicotine or a derivative, analog, salt, solvate or a mixture thereof may be determined by the release test described in Example 1, but other suitable methods for determining the release of nicotine may also be used, i.e. the embodiments of the invention described below referrer to Example 1 without limiting the relevant release tests to the one described in Example 1.
- the tobacco and/or tobacco substitute composition may be designed so that at least about 50% w/w of the total content of nicotine and/or a derivative, analog, salt, solvate or a mixture thereof is released within at the most 60 min when subject to the release test described in Example 1 below.
- the tobacco and/or tobacco substitute composition may be designed so that at the most 25% w/w of the total content of nicotine and/or a derivative, analog, salt, solvate or a mixture thereof is released within at the most 60 min when subject to the release test described in Example 1 below.
- the tobacco and/or tobacco substitute composition may be designed so that at least about 50% w/w of the total content of nicotine and/or a derivative, analog, salt, solvate or a mixture thereof is released within at the most 120 min when subject to the release test described in Example 1 below.
- release profiles for compositions according to the invention are described as % w/w released of total nicotine content as a function of time, measured at 0, 3, 30, 90 and 180 minutes.
- the release profiles according to the invention also includes profiles described by only one or any combination of the values below, i.e. a release profile according to the invention could be defined by e.g. the % w/w release of nicotine at 3 minutes and 90 min, or at 3 and 90 and 180 minutes, or at 90 and 180 minutes or any possible combination of the values shown below.
- a composition according to the invention is suitable designed to release nicotine and/or a derivative, analog, salt, solvate or a mixture thereof from the tobacco or the tobacco substitute with the following characteristics: time (min) % w/w released of total nicotine content 0 from about 0 to about 20 such as, e.g., from about 0 to about 15 or from about 0 to about 10, 3 from about 0 to about 40 such as, e.g., from about 0 to about 35, from about 0 to about 30, from about 0 to about 25, from about 0 to about 20, 30 from about 2 to about 100, such as, e.g., from about 2 to about 90, from about 2 to about 80, from about 2 to about 70, from about 2 to about 65, from about 2 to about 60, from about 5 to about 60, from about 5 to about 55, from about 7.5 to about 55 or from about 10 to about 50, op til 100 90 from about 10 to about 100 such as, e.g., from about 10 to about 95, from about 15 to about 90
- a composition according to the invention releases nicotine and/or a derivative, analog, salt, solvate or a mixture thereof from the tobacco or the tobacco substitute with the following release profile characteristics: time (min) % w/w released of total nicotine content 0 from about 0 to about 15 3 from about 1 to about 25 30 from about 7.5 to about 55 90 from about 35 to about 80 180 from about 65 to about 100 and the release is determined as described herein in Example 1.
- a composition according to the invention releases nicotine and/or derivative, analog, salt or solvate thereof from the tobacco or the tobacco substitute with the following release profile characteristics: time (min) % w/w released of total nicotine content 0 from about 0 to about 10 3 from about 1 to about 20 30 from about 10 to about 50 90 from about 40 to about 90 180 from about 70 to about 100 and the release is determined as described herein in Example 1.
- a composition according to the invention releases nicotine and/or a derivative, analog, salt, solvate or a mixture thereof from the tobacco or the tobacco substitute with the following release profile characteristics: time (min) % w/w released of total nicotine content 0 from about 0 to about 10 3 from about 1 to about 20 30 from about 30 to about 50 90 from about 65 to about 90 and the release is determined as described herein in Example 1.
- release profile characteristics time (min) % w/w released of total nicotine content 0 from about 0 to about 10 3 from about 1 to about 20 30 from about 30 to about 50 90 from about 65 to about 90 and the release is determined as described herein in Example 1.
- membrane material properties such as hydrophobicity, hydrophilicity, molecular weight cut-off and membrane thickness may be used in designing a desired release profile for nicotine or a derivative, analog, salt, solvate or mixture thereof.
- a multilayer membrane is e.g. designed to contain one membrane material being hydrophilic and a second membrane material being lipophilic. Both membrane components are chosen in such a manner that the membrane material has a molecular cut off large enough for the relatively small nicotine molecule to pass through with ease.
- amphiphilic nature of nicotine enables it to pass both hydrophilic and hydrophobic materials while a majority of both hydrophilic and lipophilic unwanted and harmful substances are excluded from permeation through the membrane material.
- Many other combinations of different types of membranes are of course possible and based on the disclosure herein a skilled person will know how to chose different membranes in order to obtain a suitable release.
- compositions according to the invention are a composition wherein the membrane material is a bi-layer membrane with one membrane being preferentially hydrophilic and one membrane being predominantly hydrophobic. Both membranes possess high permeability to nicotine while maintaining low aqueous pore diffusion.
- the release profile of nicotine could either be identical to the release profile of original snuff or it could be designed to have a prolonged or sustained release. The unwanted and harmful substances from the tobacco should substantially be maintained inside the membrane.
- a composition according to the invention may attain all possible sizes and shapes, such as, e.g. round, circular, oblong, elliptical, square, rectangular or trapezoidal.
- the shape and/or size chosen may be such as to allow a comfortable fit in the oral cavity.
- the location in the oral cavity of a composition according to the invention may be centered or to the sides under the upper front lip, centered or to the sides under the lower front lip, under the tongue or in the cheeks.
- the invention also relates to use of a composition according to the invention as a smoke substitute and it can be used by persons who suffer from nicotine craving or who want to give up or reduce smoking.
- the content of tobacco and/or a tobacco substitute is adjusted to the individual purposes and it is possible to design a kit comprising compositions according to the invention with different concentrations of tobacco and/or a tobacco substitute.
- Such compositions in a kit could e.g. contain compositions with a decreasing content of tobacco or nicotine.
- FIG. 1 shows the release profile from moist tobacco using side-by-side diffusion cells equipped with specific membranes having different physical properties.
- FIG. 2 shows the impurity index (IPI) for various hydrophilic membranes with different thickness and molecular weight cut-offs.
- the reference is filter paper.
- FIG. 3 shows the maximum flux of nicotine as a function of membranes thickness for a hydrophilic membrane with a molecular weight cut-off of 13,000.
- the reference flux illustrates the flux through filter paper.
- Membranes made of regenerated cellulose acetate dialysis tubing with varying MW cut-off together with vinyl and polyethylene membranes with various thicknesses were tested with respect to the diffusion profiles over the membranes of nicotine released from tobacco.
- snuff tobacco SVENSKT SNUS, GOTHIATEK, General
- PBS phosphate buffered saline according to Ph. Eur.
- PBS with a pH of 6.6 was placed in the receiver chamber.
- the cells of the diffusion chamber were kept at a temperature of 37° C. ⁇ 0.5° C. by attachment to a water bath. The temperature control was made in order to simulate the environment of the oral cavity.
- Diffusion profiles were constructed by sampling from the receiver chamber at 0, 3, 30, 60, 90, 120, (110 min for the polyethylene membrane) and 180 min after the start of the diffusion experiment.
- the concentration of nicotine in the receiver chamber was measured by HPLC, using a C-18, 5 ⁇ , 4.5 mm ⁇ 15 cm column, employing a mobile phase consisting of 70% v/v 0.1 M phosphate buffer (pH 4.5), 30% acetonitrile, and 2.3 g sodium dodecyl sulphate/liter at a flow rate of 1 ml/min and a temperature of 40° C.
- the sample volume was 10 ⁇ l and detection was carried out using a UV-detector running at 260 nm.
- the membranes used were regenerated cellulose acetate dialysis tubing with varying MW cut-off and vinyl and polyethylene membranes with varying thickness.
- Table 1 shows a comparison of the release profile of nicotine for a commercial non-woven snuff-bag, and a piece of filter paper used as reference in the experiments. The measurements were performed as described above, and the results are the mean of 2 single runs. TABLE 1 Comparison of the nicotine release profile for a commercial non-woven filter and a reference paper filter Nicotine released (mg/ml) Filter type 15 sec. 30 min. 60 min. 90 min. Reference paper 11.5 64.4 92.0 202.4 filter Commercial non- 9.4 65.8 90.1 205.5 woven filter
- Hydrophobic membranes e.g. vinyl and polyethylene membranes
- the slower profile is probably due to less swelling of the hydrophobic membrane pores, i.e. in the hydrophobic membranes nicotine diffusion occurs through well-organized polymeric material and hydrophobic organized water rather than through aqueous pores.
- FIG. 1 shows that the release of nicotine over a hydrophilic membrane made of regenerated cellulose acetate dialysis tubing is high and close to the nicotine release over the reference filter paper.
- FIG. 1 also shows that the physical properties, i.e. the molecular weight cut-off and thickness of the hydrophilic membrane, affect the permeability of nicotine as stated below.
- a membrane with a relatively small molecular weight cut-off tends to have a sigmoid release profile for nicotine.
- a considerable lag time is expected before the nicotine starts to permeate the membrane, even though the size of a nicotine molecule is significantly smaller than the molecular weight cut-off of 3,500.
- a membrane with a higher molecular weight cut-off e.g. a molecular weight cut-off of 13,000, seems to have a release profile for nicotine that is very close to the release profile for nicotine of the reference filter paper.
- This difference may be due to a much lower aqueous mobility of nicotine in the membrane with a molecular weight cut-off of 3,500, compared to the membrane with a molecular weight cut-off of 13,000.
- FIG. 1 also shows that when the thickness of a membrane increases, then the flux of nicotine through the membrane decreases.
- Example 1 shows that it is possible to design a polymeric membrane which gives rise to a release profile of nicotine from moist tobacco through the membrane very similar to the release profile through a commercial non-woven snuff-bag, i.e. with respect to the shape of the profile and the individual release data (time, percentage released). Especially, it seems that a hydrophilic membrane material is suitable. Furthermore, the release profile is dependent of the molecular weight cut-off of the membrane, the thickness of the membrane and of the membrane material itself.
- Example 1 also shows that some hydrophobic membranes, e.g. vinyl and polyethylene membranes, have a slower nicotine release profile compared to the hydrophilic membranes.
- hydrophobic membranes e.g. vinyl and polyethylene membranes
- membranes which enable a specific release of nicotine, i.e. it is possible to design membranes having desired release characteristics e.g. a quick or a slow release of nicotine dependent on the purpose of the composition.
- desired release characteristics e.g. a quick or a slow release of nicotine dependent on the purpose of the composition.
- the specific features of a membrane or a membrane material can be used to design a controlled and well-defined release profile for the release of nicotine from a composition according to the invention.
- Membranes made from regenerated cellulose acetate dialysis tubing with varying thickness and molecular weight cut-off were tested for their selectivity in transporting nicotine across the membrane, while unwanted and potentially harmful substances are retained in the tobacco.
- the IPI is calculated from the UV-spectra recorded from 200 nm to 900 nm, and is defined as the ratio of the sum of peak heights other than that of nicotine (i.e. thus including unwanted and harmful substances) to the peak height of nicotine. All measurements are performed in the receiver chamber, i.e. after permeation through the membrane in question. The IPI is measured 3, 30 and 90 min after start of the experiment, cf. above. In those cases where any additionally substances are added to the tobacco composition such as, e.g., sweeteners, flavors, detergents, buffers, etc. the peak heights of these are normally not included when calculating the sum of peak height as described above.
- Impurity index (IPI) calculated for the reference filter paper membrane and hydrophilic regenerated cellulose acetate membranes with different physical properties
- Impurity index (IPI) Membrane 1 Membrane 2 Membrane 3 Time Thick: 25.2 ⁇ m Thick: 23.2 ⁇ m Thick 46.4 ⁇ m (min) MWCO 3,500 MWCO 13,000 MWCO 13,000 Reference 3 0.9 0.75 1.05 1.64 30 1.17 1.24 1.17 2.91 90 1.26 1.35 1.25 3.35
- the decrease in IPI is not merely a result of a decrease in the overall release rate. Accordingly, the release profiles relating to nicotine and employing cellulose membranes with a molecular weight cut-off of 13,000 are only a few percent lower than the release profile for the reference filter paper. Thus, employment of such membranes enables a release, which permits release of wanted substances (i.e. nicotine) while retaining unwanted substances.
- Example 2 shows that no significant loss in membrane selectivity ⁇ s observed as the membrane thickness is being decreased. Therefore, further studies to investigate the relationship between membrane thickness, molecular weight cut-off of the membrane and amount of nicotine transferred over the membrane were performed by analyzing selected data from Example 1.
- the maximum slope for each release profile has been deduced.
- the maximum slope i.e. percentage nicotine release per time unit, dR/dt represents the maximum flux of nicotine through the membranes (see Table 4).
- Maximum flux Molecular weight Thickness Lag time of nicotine cut-off ( ⁇ m) (min) (dR/dt) ⁇ 0 1.250 (reference pouch) 13,000 MW CO 23.2 0 1.205 membrane 46.4 0 1.144 92.8 0 0.637 3,500 MW CO 25.2 ⁇ 50 1.250 membrane 50.4 ⁇ 50 1.204
- FIG. 3 shows a plot of the maximum flux as a function of membrane thickness for the cellulose membrane with a molecular weight cut-off of 13,000.
- the Figure shows that the flux of nicotine through a membrane is approaching the flux through a reference filter paper, which practically has no barrier to the nicotine diffusion, at a membrane thickness of about 10 ⁇ m.
- a hydrophilic membrane with a molecular cut off about 13,000 does not seem to give rise to any boundary layer/membrane effects or any major diffusion limitations for nicotine.
- a thickness of approx. 10 ⁇ m will give a release profile equal to the original commercially available non-woven moist snuff pouches.
- the sensation of taking up nicotine into the blood stream from the oral cavity was scored using a scale rating from zero to five, with zero indicating no feeling and 5 indicating a very strong feeling of uptake, leading to dizziness and nausea.
- the results show that the effect of nicotine uptake from the novel snuff composition is slightly delayed compared to the sensation of nicotine uptake from the commercially available bag snuff.
- the volunteers feel an effect rated 5 after 8 to 10 minutes.
- the volunteers feel the maximum effect between 12 to 16 minutes.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101945 | 2001-12-21 | ||
| DKPA200101945 | 2001-12-21 | ||
| PCT/EP2002/014853 WO2003053175A2 (fr) | 2001-12-21 | 2002-12-17 | Composition de substitut de tabac et/ou de tabac ameliore s'utilisant comme tabac a priser dans la cavite buccale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20050061339A1 true US20050061339A1 (en) | 2005-03-24 |
Family
ID=8160931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/499,552 Abandoned US20050061339A1 (en) | 2001-12-21 | 2002-12-17 | Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050061339A1 (fr) |
| EP (1) | EP1458252B1 (fr) |
| AT (1) | ATE384450T1 (fr) |
| AU (1) | AU2002360097A1 (fr) |
| DE (1) | DE60224832T2 (fr) |
| DK (1) | DK1458252T3 (fr) |
| WO (1) | WO2003053175A2 (fr) |
Cited By (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060147498A1 (en) * | 2003-01-24 | 2006-07-06 | Ingemar Jonsson | Composition material for transmucosal delivery |
| US20070012328A1 (en) * | 2005-04-29 | 2007-01-18 | Philip Morris Usa Inc. | Tobacco pouch product |
| US20070062549A1 (en) * | 2005-09-22 | 2007-03-22 | Holton Darrell E Jr | Smokeless tobacco composition |
| US20070186941A1 (en) * | 2006-02-10 | 2007-08-16 | Holton Darrell E Jr | Smokeless tobacco composition |
| US20070207239A1 (en) * | 2005-11-21 | 2007-09-06 | Philip Morris Usa Inc. | Flavor pouch |
| US20070261707A1 (en) * | 2005-04-29 | 2007-11-15 | Philip Morris Usa Inc. | Tobacco pouch product |
| WO2007144687A1 (fr) * | 2006-06-12 | 2007-12-21 | Philip Morris Products S.A. | Produit autre que du tabac conditionné en poche |
| US20080021072A1 (en) * | 2006-07-21 | 2008-01-24 | Luzenberg Robert S | Porous plastic smoking cessation devices |
| US20080029117A1 (en) * | 2006-08-01 | 2008-02-07 | John-Paul Mua | Smokeless Tobacco |
| US20080029116A1 (en) * | 2006-08-01 | 2008-02-07 | John Howard Robinson | Smokeless tobacco |
| US20080029110A1 (en) * | 2006-02-10 | 2008-02-07 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US20080173317A1 (en) * | 2006-08-01 | 2008-07-24 | John Howard Robinson | Smokeless tobacco |
| US20080202536A1 (en) * | 2007-02-28 | 2008-08-28 | Philip Morris Usa Inc. | Oral pouch product with flavored wrapper |
| US20080202533A1 (en) * | 2006-11-15 | 2008-08-28 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US20080210249A1 (en) * | 2007-03-02 | 2008-09-04 | Luzenberg Robert S | Systems, devices and methods for delivering one or more additives to smokeless tobacco |
| US20080305216A1 (en) * | 2007-06-08 | 2008-12-11 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US20080317911A1 (en) * | 2007-06-08 | 2008-12-25 | Philip Morris Usa Inc. | Oral pouch product including soluble dietary fibers |
| US20090004329A1 (en) * | 2007-06-08 | 2009-01-01 | Philip Morris Usa Inc. | Chewable pouch for flavored product delivery |
| US20090014018A1 (en) * | 2007-06-01 | 2009-01-15 | Philip Morris Usa Inc. | Coated colloidal ground plant materials |
| US20090022856A1 (en) * | 2007-07-16 | 2009-01-22 | Philip Morris Usa Inc. | Oral pouch products with immobilized flavorant particles |
| US20090022917A1 (en) * | 2007-07-16 | 2009-01-22 | Philip Morris Usa Inc. | Oral delivery pouch product with coated seam |
| US20090025741A1 (en) * | 2007-07-16 | 2009-01-29 | Philip Morris Usa Inc. | Tobacco-free oral flavor delivery pouch product |
| US20090025739A1 (en) * | 2007-07-23 | 2009-01-29 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US20090025738A1 (en) * | 2007-07-23 | 2009-01-29 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US20090025740A1 (en) * | 2007-07-16 | 2009-01-29 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| US20090035414A1 (en) * | 2007-07-16 | 2009-02-05 | Philip Morris Usa Inc. | Method of flavor encapsulation through the use of a drum coater |
| US20090032040A1 (en) * | 2007-03-30 | 2009-02-05 | Luzenberg Jr Robert S | Porous plastic smokeless tobacco substitutes |
| US20090038631A1 (en) * | 2007-08-09 | 2009-02-12 | Philip Morris Usa Inc. | Oral tobacco product having a hydrated membrane coating and a high surface area |
| US20090065013A1 (en) * | 2006-04-28 | 2009-03-12 | Swedish Match North Europe Ab | moist snuff non-tobacco composition and a method for producing thereof |
| US20090095313A1 (en) * | 2007-10-11 | 2009-04-16 | Fuisz Richard C | Smokeless Tobacco Product, Smokeless Tobacco Product in the Form of a Sheet, Extrudable Tobacco Composition, Method for Manufacturing a Smokeless Tobacco Product, Method for Delivering Super Bioavailable Nicotine Contained in Tobacco to a User, and Packaged Smokeless Tobacco Product Sheet |
| US20090301505A1 (en) * | 2008-02-08 | 2009-12-10 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
| JP2009545315A (ja) * | 2006-08-01 | 2009-12-24 | アール・ジェイ・レノルズ・タバコ・カンパニー | 無煙たばこ |
| US20100018539A1 (en) * | 2008-07-28 | 2010-01-28 | Paul Andrew Brinkley | Smokeless tobacco products and processes |
| US20100018882A1 (en) * | 2008-07-28 | 2010-01-28 | St Charles Frank K | Smokeless tobacco products and processes |
| US20100018540A1 (en) * | 2008-07-28 | 2010-01-28 | David James Doolittle | Smokeless tobacco products and processes |
| US20100018541A1 (en) * | 2008-07-28 | 2010-01-28 | Anthony Richard Gerardi | Smokeless tobacco products and processes |
| EP2179666A2 (fr) | 2007-07-23 | 2010-04-28 | R.J.Reynolds Tobacco Company | Composition de tabac sans fumée et procédé pour le traitement du tabac pour de tels usages |
| US20100116281A1 (en) * | 2008-11-07 | 2010-05-13 | Jerry Wayne Marshall | Tobacco products and processes |
| US20100170522A1 (en) * | 2008-12-19 | 2010-07-08 | U.S. Smokeless Tobacco Company | Tobacco Granules and Method of Producing Tobacco Granules |
| US20100187143A1 (en) * | 2007-04-26 | 2010-07-29 | Swedish Match North Europe Ab | Moist non-tobacco snuff product |
| US20100218779A1 (en) * | 2009-02-27 | 2010-09-02 | Philip Morris Usa Inc. | Controlled flavor release tobacco pouch products and methods of making |
| US20100242978A1 (en) * | 2007-10-11 | 2010-09-30 | Fuisz Richard C | Smokeless tobacco product |
| US20100294292A1 (en) * | 2007-12-21 | 2010-11-25 | Swedish Match North Europe Ab | Tobacco or non-tobacco product comprising magnesium carbonate |
| US20100300465A1 (en) * | 2007-06-08 | 2010-12-02 | Zimmermann Stephen G | Oral Pouch Products Including a Liner and Tobacco Beads |
| US20100300464A1 (en) * | 2008-12-18 | 2010-12-02 | Philip Morris Usa Inc. | Moist botanical pouch processing and moist oral botanical pouch products |
| US20110005536A1 (en) * | 2004-08-23 | 2011-01-13 | Us Smokeless Tobacco Co. | Nicotiana diversity |
| US20110083680A1 (en) * | 2009-10-09 | 2011-04-14 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
| US20110083688A1 (en) * | 2009-10-09 | 2011-04-14 | Philip Morris Usa Inc. | Moist smokeless tobacco product with textured coating |
| US20110083681A1 (en) * | 2009-03-16 | 2011-04-14 | Philip Morris Usa Inc. | Colloidal plant powder/extract encapsulation with pectin-protein coacervate gels |
| US20110100382A1 (en) * | 2009-10-13 | 2011-05-05 | Philip Morris Usa Inc. | Oral moist smokeless tobacco products with net-structured gel coating and methods of making |
| US20110180087A1 (en) * | 2008-12-30 | 2011-07-28 | Philip Morris Usa Inc. | Oral pouch product with multi-layered pouch wrapper |
| US20110232657A1 (en) * | 2010-03-26 | 2011-09-29 | Philip Morris Usa Inc. | Controlled release mentholated tobacco beads |
| RU2430635C1 (ru) * | 2010-10-20 | 2011-10-10 | Олег Иванович Квасенков | Способ выработки некурительного изделия из махорки |
| WO2012030946A1 (fr) | 2010-09-02 | 2012-03-08 | R. J. Reynolds Tobacco Company | Appareil de fabrication d'un produit de tabac sans fumée et procédé associé |
| WO2012061192A1 (fr) | 2010-11-01 | 2012-05-10 | R.J. Reynolds Tobacco Company | Produits du tabac sans fumée et processus associés |
| WO2012106237A1 (fr) | 2011-01-31 | 2012-08-09 | American Snuff Company, Llc | Contenant pour produits de tabac sans fumée |
| US8241680B2 (en) | 2010-06-30 | 2012-08-14 | Rock Creek Pharmaceuticals, Inc. | Nutraceutical product containing anatabine and yerba maté |
| US20120298124A1 (en) * | 2010-01-28 | 2012-11-29 | Hiroki Shikata | Portion tobacco product |
| WO2013090366A2 (fr) | 2011-12-14 | 2013-06-20 | R. J. Reynolds Tobacco Company | Produits à base de tabac sans fumée comprenant une composition effervescente |
| WO2013122948A1 (fr) | 2012-02-13 | 2013-08-22 | R. J. Reynolds Tobacco Company | Composition de tabac blanchi |
| WO2013166285A1 (fr) | 2012-05-04 | 2013-11-07 | R. J. Reynolds Tobacco Company | Revêtements de barrière contre l'humidité transparents pour conteneurs |
| WO2013192519A1 (fr) | 2012-06-22 | 2013-12-27 | R. J. Reynolds Tobacco Company | Matériaux composites contenant du tabac |
| US20140017286A1 (en) * | 2011-03-29 | 2014-01-16 | Chill Of Sweden Ab | Pouch containing nicotine in free salt form |
| US20140026912A1 (en) * | 2012-07-30 | 2014-01-30 | British American Tobacco (Investments) Limited | Fleece for Smokeless Tobacco |
| WO2014164509A1 (fr) | 2013-03-11 | 2014-10-09 | Niconovum Usa, Inc. | Procédé et appareil pour différentier des produits oraux en sachet |
| US20160000140A1 (en) * | 2014-07-02 | 2016-01-07 | R.J. Reynolds Tobacco Company | Oral pouch products |
| WO2016040754A1 (fr) | 2014-09-12 | 2016-03-17 | R. J. Reynolds Tobacco Company | Sachet non tissé comprenant des fibres liantes thermoscellables |
| WO2016090075A1 (fr) | 2014-12-05 | 2016-06-09 | R. J. Reynolds Tobacco Company | Sachet de tabac sans fumée |
| US20160192703A1 (en) * | 2015-01-07 | 2016-07-07 | R.J. Reynolds Tobacco Company | Oral pouch products |
| US9387201B2 (en) | 2011-08-29 | 2016-07-12 | Rcp Development, Inc. | Methods of providing anti-inflammation support |
| US9386800B2 (en) | 2012-09-21 | 2016-07-12 | R.J. Reynolds Tobacco Company | Fibrous composite tobacco-containing materials |
| WO2016182833A1 (fr) | 2015-05-14 | 2016-11-17 | R. J. Reynolds Tobacco Company | Traitement du tabac |
| WO2016200804A1 (fr) | 2015-06-10 | 2016-12-15 | R. J. Reynolds Tobacco Company | Récipient pour produits de tabac sans fumée comprenant une matière de pâte, et ensemble produit emballé et procédé associés |
| US9591875B2 (en) | 2012-09-21 | 2017-03-14 | R. J. Reynolds Tobacco Company | Fibrous composite tobacco-containing materials |
| US9629832B2 (en) | 2002-12-20 | 2017-04-25 | Niconovum Usa, Inc. | Physically and chemically stable nicotine-containing particulate material |
| US9635881B2 (en) | 2012-04-10 | 2017-05-02 | Swedish Match North Europe Ab | Smokeless tobacco composition comprising non-tobacco fibers and a method for its manufacture |
| WO2017130161A1 (fr) | 2016-01-28 | 2017-08-03 | R. J. Reynolds Tobacco Company | Agents aromatisants dérivés du tabac |
| WO2017134586A1 (fr) | 2016-02-02 | 2017-08-10 | R. J. Reynolds Tobacco Company | Procédé de préparation de composés savoureux isolés à partir de liqueur noire et produits incorporant les composés savoureux |
| WO2018172995A1 (fr) | 2017-03-24 | 2018-09-27 | R. J. Reynolds Tobacco Company | Procédés de formation sélective de pyrazines substituées |
| WO2018185708A1 (fr) | 2017-04-06 | 2018-10-11 | R. J. Reynolds Tobacco Company | Traitement à la fumée |
| US10219999B2 (en) | 2006-03-16 | 2019-03-05 | Niconovum Usa, Inc. | Snuff composition |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| WO2019162903A1 (fr) | 2018-02-23 | 2019-08-29 | American Snuff Company, Llc | Contenant destiné à des produits de tabac sans fumée |
| WO2019198055A2 (fr) | 2018-04-13 | 2019-10-17 | R. J. Reynolds Tobacco Company | Couvercle pour récipient pour produits de tabac sans fumée |
| CN110384700A (zh) * | 2019-09-03 | 2019-10-29 | 云南喜科科技有限公司 | 一种合成尼古丁的组合物 |
| US10568338B2 (en) | 2008-12-30 | 2020-02-25 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
| WO2020128971A1 (fr) | 2018-12-20 | 2020-06-25 | R. J. Reynolds Tobacco Company | Procédé de blanchiment de tabac |
| WO2020225768A1 (fr) | 2019-05-09 | 2020-11-12 | American Snuff Company, Llc | Stabilisateur pour tabac à sucer |
| US20200383373A1 (en) * | 2019-06-07 | 2020-12-10 | Fertin Pharma A/S | Nicotine pouch product |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| WO2021048768A1 (fr) | 2019-09-11 | 2021-03-18 | Nicoventures Trading Limited | Procédé de blanchiment de tabac |
| WO2021048769A1 (fr) | 2019-09-13 | 2021-03-18 | Nicoventures Trading Limited | Procédé de blanchiment de tabac |
| WO2021048770A1 (fr) | 2019-09-11 | 2021-03-18 | Nicoventures Trading Limited | Procédés alternatifs de blanchiment du tabac |
| WO2021116853A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Matériau de toison fibreux |
| WO2021116852A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Produit oral à composant soluble |
| WO2021116894A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Produits en sachet avec liant thermoscellable |
| WO2022049536A1 (fr) | 2020-09-04 | 2022-03-10 | Nicoventures Trading Limited | Procédé de blanchissement de tabac |
| US20220202071A1 (en) * | 2019-09-19 | 2022-06-30 | Nerudia Limited | Smokeless article |
| WO2022162558A1 (fr) | 2021-01-28 | 2022-08-04 | Nicoventures Trading Limited | Procédé de fermeture hermétique de sachets |
| US11503853B2 (en) | 2013-09-09 | 2022-11-22 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition incorporating a botanical material |
| WO2023084499A1 (fr) | 2021-11-15 | 2023-05-19 | Nicoventures Trading Limited | Produits présentant des caractéristiques sensorielles améliorées |
| WO2023194959A1 (fr) | 2022-04-06 | 2023-10-12 | Nicoventures Trading Limited | Produits en sachet avec liant thermoscellable |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| WO2024074942A1 (fr) | 2022-10-03 | 2024-04-11 | Nicoventures Trading Limited | Élément d'étanchéité pour emballage |
| WO2024074988A1 (fr) | 2022-10-04 | 2024-04-11 | R. J. Reynolds Tobacco Company | Agencement empilable de contenants de produit et procédé d'empilement associé |
| WO2024079696A1 (fr) | 2022-10-14 | 2024-04-18 | Nicoventures Trading Limited | Appareil et procédé de fabrication et d'inspection d'un produit en sachet ou d'au moins un objet associé à celui-ci |
| WO2024079697A1 (fr) | 2022-10-14 | 2024-04-18 | Nicoventures Trading Limited | Appareil et procédé de fabrication d'un produit en sachet |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US12064424B2 (en) | 2019-12-09 | 2024-08-20 | Nicoventures Trading Limited | Moist oral compositions |
| RU2829343C2 (ru) * | 2019-06-07 | 2024-10-30 | Филип Моррис Продактс С.А. | Композиция никотинового пакетика |
| US12138342B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Fleece for oral product with releasable component |
| US12178905B2 (en) | 2019-12-09 | 2024-12-31 | Nicoventures Trading Limited | Fleece for pouched product with controlled basis weight |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12382982B2 (en) | 2021-06-25 | 2025-08-12 | Nicoventures Trading Limited | Oral products and method of manufacture |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US12471618B2 (en) | 2019-12-09 | 2025-11-18 | Nicoventures Trading Limited | Stimulus-responsive pouch |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0500006L (sv) * | 2005-01-04 | 2006-07-05 | Peter Stigsson | Anordning för intagande av koffein i en munhåla |
| EP1926401B1 (fr) | 2005-09-22 | 2014-01-15 | R. J. Reynolds Tobacco Company | Composition de tabac qui ne se fume pas |
| WO2008148603A1 (fr) * | 2007-06-04 | 2008-12-11 | British American Tobacco (Investments) Limited | Conditionnement pour des produits à base de tabac |
| DE102008038556A1 (de) * | 2008-06-26 | 2009-12-31 | Eswegee Vliesstoff Gmbh | Vliesstoff zur Verwendung als feuchtedurchlässiges, mikroporöses Genussmittelverpackungsmaterial |
| US8833378B2 (en) | 2008-09-17 | 2014-09-16 | Niconovum Ab | Process for preparing snuff composition |
| JP6093693B2 (ja) | 2010-04-12 | 2017-03-08 | アルトリア クライアント サービシーズ エルエルシー | 改良したシールを有する袋製品及びその製造方法 |
| GB201220280D0 (en) * | 2012-11-12 | 2012-12-26 | British American Tobacco Co | Products including capsules, uses and preparation thereof |
| CN102920013B (zh) * | 2012-11-19 | 2015-02-11 | 湖南中烟工业有限责任公司 | 一种烟草提取物微胶囊及其制备方法 |
| CN103783648B (zh) * | 2014-02-21 | 2015-08-19 | 安徽中烟工业有限责任公司 | 一种打叶复烤工序中的过程样品的取样方法 |
| CN105116837B (zh) * | 2015-07-13 | 2018-03-16 | 河北白沙烟草有限责任公司 | 一种基于物料容重累积算法的切丝机自动调速控制方法及设备 |
| KR102642690B1 (ko) * | 2019-06-05 | 2024-03-04 | 필립모리스 프로덕츠 에스.에이. | 니코틴 조성물, 제조 방법, 및 이를 포함하는 에어로졸 발생 물품 |
| CA3159297A1 (fr) * | 2019-12-09 | 2021-06-17 | Jr. Darrell Eugene Holton | Produits a usage oral a liberation controlee |
| WO2021116842A1 (fr) * | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Produits à usage oral à libération contrôlée |
| GB202006143D0 (en) | 2020-04-27 | 2020-06-10 | Nonwovenn Ltd | Nonwoven fabric for oral pounched product, and methods of manufacturing a nonwoven fabric |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3617553A (en) * | 1968-03-13 | 1971-11-02 | British Petroleum Co | Catalyst ultrafiltration process |
| US3757798A (en) * | 1972-01-03 | 1973-09-11 | W Lambert | Method of reducing dependence on tobacco |
| US4666991A (en) * | 1984-11-05 | 1987-05-19 | Sagami Chemical Research Center | Fluorine-containing graft copolymer and adhesive and composite membrane made thereof |
| US4941484A (en) * | 1989-05-30 | 1990-07-17 | R. J. Reynolds Tobacco Company | Tobacco processing |
| US5069231A (en) * | 1989-07-12 | 1991-12-03 | International Flavors & Fragrances Inc. | Method for imparting functional ingredients, functional ingredient-imparting articles and methods for preparation and use thereof |
| US5091086A (en) * | 1986-08-27 | 1992-02-25 | Danisco A/S | Permeable, porous polymeric membrane with hydrophilic character, methods for preparing said membranes and their use |
| US5346734A (en) * | 1993-04-16 | 1994-09-13 | Bethanie K. Wydick | Perforated latex oral pouch for loose snuff |
| US5372149A (en) * | 1992-03-25 | 1994-12-13 | Roth; David S. | Sterilization process in the manufacturing of snuff |
| US5387416A (en) * | 1993-07-23 | 1995-02-07 | R. J. Reynolds Tobacco Company | Tobacco composition |
| US5403595A (en) * | 1991-05-07 | 1995-04-04 | Dynagen, Inc. | Controlled, sustained release delivery system for smoking cessation |
| US5465739A (en) * | 1992-04-15 | 1995-11-14 | R. J. Reynolds Tobacco Company | Cigarette and cigarette filter element therefor |
| US5799663A (en) * | 1994-03-10 | 1998-09-01 | Elan Medical Technologies Limited | Nicotine oral delivery device |
| US5824334A (en) * | 1989-09-05 | 1998-10-20 | University Of Utah Research Foundation | Tobacco substitute |
| US6162516A (en) * | 1995-10-11 | 2000-12-19 | Derr; Dedric M. | System and method for protecting oral tissues from smokeless tobacco |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975270A (en) * | 1987-04-21 | 1990-12-04 | Nabisco Brands, Inc. | Elastomer encased active ingredients |
| JPH01108966A (ja) * | 1987-10-22 | 1989-04-26 | Kowa Display:Kk | かぎタバコ |
| ATE111351T1 (de) * | 1990-07-23 | 1994-09-15 | Alza Corp | Oral anzuwendende osmotische vorrichtung zur abgabe von nicotin. |
-
2002
- 2002-12-17 DE DE60224832T patent/DE60224832T2/de not_active Expired - Lifetime
- 2002-12-17 EP EP02795287A patent/EP1458252B1/fr not_active Expired - Lifetime
- 2002-12-17 US US10/499,552 patent/US20050061339A1/en not_active Abandoned
- 2002-12-17 DK DK02795287T patent/DK1458252T3/da active
- 2002-12-17 AT AT02795287T patent/ATE384450T1/de not_active IP Right Cessation
- 2002-12-17 AU AU2002360097A patent/AU2002360097A1/en not_active Abandoned
- 2002-12-17 WO PCT/EP2002/014853 patent/WO2003053175A2/fr not_active Ceased
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3617553A (en) * | 1968-03-13 | 1971-11-02 | British Petroleum Co | Catalyst ultrafiltration process |
| US3757798A (en) * | 1972-01-03 | 1973-09-11 | W Lambert | Method of reducing dependence on tobacco |
| US4666991A (en) * | 1984-11-05 | 1987-05-19 | Sagami Chemical Research Center | Fluorine-containing graft copolymer and adhesive and composite membrane made thereof |
| US5091086A (en) * | 1986-08-27 | 1992-02-25 | Danisco A/S | Permeable, porous polymeric membrane with hydrophilic character, methods for preparing said membranes and their use |
| US4941484A (en) * | 1989-05-30 | 1990-07-17 | R. J. Reynolds Tobacco Company | Tobacco processing |
| US5069231A (en) * | 1989-07-12 | 1991-12-03 | International Flavors & Fragrances Inc. | Method for imparting functional ingredients, functional ingredient-imparting articles and methods for preparation and use thereof |
| US5824334A (en) * | 1989-09-05 | 1998-10-20 | University Of Utah Research Foundation | Tobacco substitute |
| US5403595A (en) * | 1991-05-07 | 1995-04-04 | Dynagen, Inc. | Controlled, sustained release delivery system for smoking cessation |
| US5372149A (en) * | 1992-03-25 | 1994-12-13 | Roth; David S. | Sterilization process in the manufacturing of snuff |
| US5465739A (en) * | 1992-04-15 | 1995-11-14 | R. J. Reynolds Tobacco Company | Cigarette and cigarette filter element therefor |
| US5346734A (en) * | 1993-04-16 | 1994-09-13 | Bethanie K. Wydick | Perforated latex oral pouch for loose snuff |
| US5387416A (en) * | 1993-07-23 | 1995-02-07 | R. J. Reynolds Tobacco Company | Tobacco composition |
| US5799663A (en) * | 1994-03-10 | 1998-09-01 | Elan Medical Technologies Limited | Nicotine oral delivery device |
| US6162516A (en) * | 1995-10-11 | 2000-12-19 | Derr; Dedric M. | System and method for protecting oral tissues from smokeless tobacco |
Cited By (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9629832B2 (en) | 2002-12-20 | 2017-04-25 | Niconovum Usa, Inc. | Physically and chemically stable nicotine-containing particulate material |
| US20060147498A1 (en) * | 2003-01-24 | 2006-07-06 | Ingemar Jonsson | Composition material for transmucosal delivery |
| US8846075B2 (en) | 2003-01-24 | 2014-09-30 | Magle Holding Ab | Composition material for transmucosal delivery |
| US20110005536A1 (en) * | 2004-08-23 | 2011-01-13 | Us Smokeless Tobacco Co. | Nicotiana diversity |
| KR101301325B1 (ko) * | 2005-04-29 | 2013-08-29 | 필립모리스 프로덕츠 에스.에이. | 담배 쌈지 제품 |
| AU2006245434B2 (en) * | 2005-04-29 | 2012-02-02 | Philip Morris Products S.A. | Tobacco pouch product |
| US7980251B2 (en) | 2005-04-29 | 2011-07-19 | Philip Morris Usa Inc. | Method of making pouched tobacco product |
| US20070261707A1 (en) * | 2005-04-29 | 2007-11-15 | Philip Morris Usa Inc. | Tobacco pouch product |
| EA012674B1 (ru) * | 2005-04-29 | 2009-12-30 | Филип Моррис Продактс С.А. | Табачный продукт в пакетиках |
| US8671952B2 (en) | 2005-04-29 | 2014-03-18 | Philip Morris Usa Inc. | Tobacco pouch product |
| US8678015B2 (en) | 2005-04-29 | 2014-03-25 | Philip Morris Usa Inc. | Non-tobacco pouch product |
| US7950399B2 (en) | 2005-04-29 | 2011-05-31 | Philip Morris Usa Inc. | Non-tobacco pouch product |
| US20070012328A1 (en) * | 2005-04-29 | 2007-01-18 | Philip Morris Usa Inc. | Tobacco pouch product |
| US9044049B2 (en) | 2005-04-29 | 2015-06-02 | Philip Morris Usa Inc. | Tobacco pouch product |
| US20070095356A1 (en) * | 2005-04-29 | 2007-05-03 | Philip Morris Usa Inc. | Non-tobacco pouch product |
| WO2006120570A3 (fr) * | 2005-04-29 | 2007-04-19 | Philip Morris Prod | Produit a base de tabac avec poche |
| JP2008538911A (ja) * | 2005-04-29 | 2008-11-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | タバコポーチ製品 |
| US20070062549A1 (en) * | 2005-09-22 | 2007-03-22 | Holton Darrell E Jr | Smokeless tobacco composition |
| US9643773B2 (en) | 2005-11-21 | 2017-05-09 | Philip Morris Usa Inc. | Flavor pouch |
| US10065794B2 (en) | 2005-11-21 | 2018-09-04 | Philip Morris Usa Inc. | Flavor pouch |
| US9139360B2 (en) | 2005-11-21 | 2015-09-22 | Philip Morris Usa Inc. | Flavor pouch |
| US8685478B2 (en) | 2005-11-21 | 2014-04-01 | Philip Morris Usa Inc. | Flavor pouch |
| US20070207239A1 (en) * | 2005-11-21 | 2007-09-06 | Philip Morris Usa Inc. | Flavor pouch |
| US8695609B2 (en) * | 2006-02-10 | 2014-04-15 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US7810507B2 (en) | 2006-02-10 | 2010-10-12 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US20110061666A1 (en) * | 2006-02-10 | 2011-03-17 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US7861728B2 (en) | 2006-02-10 | 2011-01-04 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition having an outer and inner pouch |
| US20070186941A1 (en) * | 2006-02-10 | 2007-08-16 | Holton Darrell E Jr | Smokeless tobacco composition |
| US20080029110A1 (en) * | 2006-02-10 | 2008-02-07 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US10219999B2 (en) | 2006-03-16 | 2019-03-05 | Niconovum Usa, Inc. | Snuff composition |
| US20110041860A1 (en) * | 2006-04-28 | 2011-02-24 | Swedish Match North Europe Ab | Moist snuff non-tobacco composition and a method for producing thereof |
| US20090065013A1 (en) * | 2006-04-28 | 2009-03-12 | Swedish Match North Europe Ab | moist snuff non-tobacco composition and a method for producing thereof |
| WO2007144687A1 (fr) * | 2006-06-12 | 2007-12-21 | Philip Morris Products S.A. | Produit autre que du tabac conditionné en poche |
| US20080021072A1 (en) * | 2006-07-21 | 2008-01-24 | Luzenberg Robert S | Porous plastic smoking cessation devices |
| US7766019B2 (en) | 2006-07-21 | 2010-08-03 | Gp Technologies, Inc. | Porous plastic smoking cessation devices |
| US20080029117A1 (en) * | 2006-08-01 | 2008-02-07 | John-Paul Mua | Smokeless Tobacco |
| JP2009545315A (ja) * | 2006-08-01 | 2009-12-24 | アール・ジェイ・レノルズ・タバコ・カンパニー | 無煙たばこ |
| US20100294291A1 (en) * | 2006-08-01 | 2010-11-25 | John Howard Robinson | Smokeless Tobacco |
| US20080029116A1 (en) * | 2006-08-01 | 2008-02-07 | John Howard Robinson | Smokeless tobacco |
| US20080173317A1 (en) * | 2006-08-01 | 2008-07-24 | John Howard Robinson | Smokeless tobacco |
| US20080202533A1 (en) * | 2006-11-15 | 2008-08-28 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US11278049B2 (en) | 2006-11-15 | 2022-03-22 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US9924739B2 (en) | 2006-11-15 | 2018-03-27 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US10426190B2 (en) | 2006-11-15 | 2019-10-01 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US12053014B2 (en) | 2006-11-15 | 2024-08-06 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US9032971B2 (en) | 2006-11-15 | 2015-05-19 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
| US20080202536A1 (en) * | 2007-02-28 | 2008-08-28 | Philip Morris Usa Inc. | Oral pouch product with flavored wrapper |
| US8616221B2 (en) | 2007-02-28 | 2013-12-31 | Philip Morris Usa Inc. | Oral pouch product with flavored wrapper |
| US9345267B2 (en) | 2007-02-28 | 2016-05-24 | Philip Morris Usa Inc. | Oral pouch product with flavored wrapper |
| US9061824B2 (en) | 2007-02-28 | 2015-06-23 | Philip Morris Usa Inc. | Oral pouch product with flavored wrapper |
| US20080210249A1 (en) * | 2007-03-02 | 2008-09-04 | Luzenberg Robert S | Systems, devices and methods for delivering one or more additives to smokeless tobacco |
| US20090032040A1 (en) * | 2007-03-30 | 2009-02-05 | Luzenberg Jr Robert S | Porous plastic smokeless tobacco substitutes |
| US20100187143A1 (en) * | 2007-04-26 | 2010-07-29 | Swedish Match North Europe Ab | Moist non-tobacco snuff product |
| US20090014018A1 (en) * | 2007-06-01 | 2009-01-15 | Philip Morris Usa Inc. | Coated colloidal ground plant materials |
| US9532592B2 (en) | 2007-06-01 | 2017-01-03 | Philip Morris Usa Inc. | Coated colloidal ground plant materials |
| US8356606B2 (en) | 2007-06-01 | 2013-01-22 | Philip Morris Usa Inc. | Production of micronized encapsulated tobacco particles for tobacco flavor delivery from an oral pouch |
| US11785973B2 (en) | 2007-06-08 | 2023-10-17 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US8067046B2 (en) | 2007-06-08 | 2011-11-29 | Philip Morris Usa Inc. | Oral pouch product including soluble dietary fibers |
| US9265272B2 (en) | 2007-06-08 | 2016-02-23 | Philip Morris Usa Inc. | Chewable pouch for flavored product delivery |
| US20080305216A1 (en) * | 2007-06-08 | 2008-12-11 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US20080317911A1 (en) * | 2007-06-08 | 2008-12-25 | Philip Morris Usa Inc. | Oral pouch product including soluble dietary fibers |
| US20100300465A1 (en) * | 2007-06-08 | 2010-12-02 | Zimmermann Stephen G | Oral Pouch Products Including a Liner and Tobacco Beads |
| US20090004329A1 (en) * | 2007-06-08 | 2009-01-01 | Philip Morris Usa Inc. | Chewable pouch for flavored product delivery |
| US8940344B2 (en) | 2007-06-08 | 2015-01-27 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US9668503B2 (en) | 2007-06-08 | 2017-06-06 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US10779560B2 (en) | 2007-06-08 | 2020-09-22 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US9888712B2 (en) | 2007-06-08 | 2018-02-13 | Philip Morris Usa Inc. | Oral pouch products including a liner and tobacco beads |
| US8029837B2 (en) | 2007-06-08 | 2011-10-04 | Philip Morris Usa Inc. | Chewable pouch for flavored product delivery |
| US9974325B2 (en) | 2007-06-08 | 2018-05-22 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
| US8389034B2 (en) | 2007-06-08 | 2013-03-05 | Philip Morris Usa Inc. | Chewable pouch for flavored product delivery |
| US20090025740A1 (en) * | 2007-07-16 | 2009-01-29 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| US8424541B2 (en) | 2007-07-16 | 2013-04-23 | Philip Morris Usa Inc. | Tobacco-free oral flavor delivery pouch product |
| US11542049B2 (en) | 2007-07-16 | 2023-01-03 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| US8119173B2 (en) | 2007-07-16 | 2012-02-21 | Philip Morris Usa Inc. | Method of flavor encapsulation through the use of a drum coater |
| US8124147B2 (en) | 2007-07-16 | 2012-02-28 | Philip Morris Usa Inc. | Oral pouch products with immobilized flavorant particles |
| US20090022856A1 (en) * | 2007-07-16 | 2009-01-22 | Philip Morris Usa Inc. | Oral pouch products with immobilized flavorant particles |
| US12116154B2 (en) | 2007-07-16 | 2024-10-15 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| US8202589B2 (en) | 2007-07-16 | 2012-06-19 | Philip Morris Usa Inc. | Oral delivery pouch product with coated seam |
| US20090022917A1 (en) * | 2007-07-16 | 2009-01-22 | Philip Morris Usa Inc. | Oral delivery pouch product with coated seam |
| US20090025741A1 (en) * | 2007-07-16 | 2009-01-29 | Philip Morris Usa Inc. | Tobacco-free oral flavor delivery pouch product |
| US8950408B2 (en) | 2007-07-16 | 2015-02-10 | Philip Morris Usa Inc. | Oral pouch product having soft edge |
| US20090035414A1 (en) * | 2007-07-16 | 2009-02-05 | Philip Morris Usa Inc. | Method of flavor encapsulation through the use of a drum coater |
| US8701679B2 (en) | 2007-07-16 | 2014-04-22 | Philip Morris Usa Inc. | Tobacco-free oral flavor delivery pouch product |
| US10640246B2 (en) | 2007-07-16 | 2020-05-05 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| US9889956B2 (en) | 2007-07-16 | 2018-02-13 | Philip Morris Usa Inc. | Oral pouch product having soft edge and method of making |
| EP2377413A1 (fr) | 2007-07-23 | 2011-10-19 | R.J. Reynolds Tobacco Company | Composition de tabac sans fumée et procédé pour le traitement du tabac pour de tels usages |
| US20090025739A1 (en) * | 2007-07-23 | 2009-01-29 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| US9237769B2 (en) | 2007-07-23 | 2016-01-19 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US7946295B2 (en) | 2007-07-23 | 2011-05-24 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US10219537B2 (en) | 2007-07-23 | 2019-03-05 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US20090025738A1 (en) * | 2007-07-23 | 2009-01-29 | R. J. Reynolds Tobacco Company | Smokeless Tobacco Composition |
| EP2179666A2 (fr) | 2007-07-23 | 2010-04-28 | R.J.Reynolds Tobacco Company | Composition de tabac sans fumée et procédé pour le traitement du tabac pour de tels usages |
| US8061362B2 (en) | 2007-07-23 | 2011-11-22 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| US8869804B2 (en) | 2007-08-09 | 2014-10-28 | Philip Morris Usa Inc. | Oral tobacco product having a hydrated membrane coating and a high surface area |
| WO2009022233A3 (fr) * | 2007-08-09 | 2009-05-28 | Philip Morris Prod | Produit de tabac utilisé par voie orale doté d'un revêtement de membrane hydratée et d'une zone de surface importante |
| US20090038631A1 (en) * | 2007-08-09 | 2009-02-12 | Philip Morris Usa Inc. | Oral tobacco product having a hydrated membrane coating and a high surface area |
| US8312886B2 (en) | 2007-08-09 | 2012-11-20 | Philip Morris Usa Inc. | Oral tobacco product having a hydrated membrane coating and a high surface area |
| US20100242978A1 (en) * | 2007-10-11 | 2010-09-30 | Fuisz Richard C | Smokeless tobacco product |
| US9125434B2 (en) * | 2007-10-11 | 2015-09-08 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
| US10334872B2 (en) | 2007-10-11 | 2019-07-02 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
| US20090095313A1 (en) * | 2007-10-11 | 2009-04-16 | Fuisz Richard C | Smokeless Tobacco Product, Smokeless Tobacco Product in the Form of a Sheet, Extrudable Tobacco Composition, Method for Manufacturing a Smokeless Tobacco Product, Method for Delivering Super Bioavailable Nicotine Contained in Tobacco to a User, and Packaged Smokeless Tobacco Product Sheet |
| CN107048483A (zh) * | 2007-10-11 | 2017-08-18 | 菲利普莫里斯生产公司 | 无烟烟草产品 |
| CN101877975A (zh) * | 2007-10-11 | 2010-11-03 | 菲利普莫里斯生产公司 | 无烟烟草产品 |
| US10609949B2 (en) * | 2007-12-21 | 2020-04-07 | Swedish Match North Europe Ab | Tobacco or non-tobacco product comprising magnesium carbonate |
| US20100294292A1 (en) * | 2007-12-21 | 2010-11-25 | Swedish Match North Europe Ab | Tobacco or non-tobacco product comprising magnesium carbonate |
| US9072318B2 (en) | 2008-02-08 | 2015-07-07 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
| US20090301505A1 (en) * | 2008-02-08 | 2009-12-10 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
| US8469037B2 (en) | 2008-02-08 | 2013-06-25 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
| US8746256B2 (en) | 2008-02-08 | 2014-06-10 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
| US20100018540A1 (en) * | 2008-07-28 | 2010-01-28 | David James Doolittle | Smokeless tobacco products and processes |
| US20100018539A1 (en) * | 2008-07-28 | 2010-01-28 | Paul Andrew Brinkley | Smokeless tobacco products and processes |
| US20100018541A1 (en) * | 2008-07-28 | 2010-01-28 | Anthony Richard Gerardi | Smokeless tobacco products and processes |
| US20100018882A1 (en) * | 2008-07-28 | 2010-01-28 | St Charles Frank K | Smokeless tobacco products and processes |
| US20100116281A1 (en) * | 2008-11-07 | 2010-05-13 | Jerry Wayne Marshall | Tobacco products and processes |
| EP3479704A1 (fr) | 2008-11-07 | 2019-05-08 | R. J. Reynolds Tobacco Company | Procédés et produits de tabac |
| US10039312B2 (en) | 2008-11-07 | 2018-08-07 | R. J. Reynolds Tobacco Company | Tobacco products and processes |
| US10492523B2 (en) | 2008-12-17 | 2019-12-03 | Philip Morris Usa Inc. | Moist botanical pouch processing and moist oral botanical pouch products |
| US20100300464A1 (en) * | 2008-12-18 | 2010-12-02 | Philip Morris Usa Inc. | Moist botanical pouch processing and moist oral botanical pouch products |
| US8377215B2 (en) | 2008-12-18 | 2013-02-19 | Philip Morris Usa Inc. | Moist botanical pouch processing |
| US9516894B2 (en) | 2008-12-18 | 2016-12-13 | Philip Morris Usa Inc. | Moist botanical pouch processing and moist oral botanical pouch products |
| US11963545B2 (en) | 2008-12-18 | 2024-04-23 | Philip Morris Usa Inc. | Moist botanical pouch processing and moist oral botanical pouch products |
| US9307787B2 (en) * | 2008-12-19 | 2016-04-12 | U.S. Smokeless Tobacco Company Llc | Tobacco granules and method of producing tobacco granules |
| US10820622B2 (en) | 2008-12-19 | 2020-11-03 | U.S. Smokeless Tobacco Company Llc | Tobacco granules and method of producing tobacco granules |
| US20100170522A1 (en) * | 2008-12-19 | 2010-07-08 | U.S. Smokeless Tobacco Company | Tobacco Granules and Method of Producing Tobacco Granules |
| US12396476B2 (en) | 2008-12-19 | 2025-08-26 | U.S. Smokeless Tobacco Company Llc | Tobacco granules and method of producing tobacco granules |
| US10568338B2 (en) | 2008-12-30 | 2020-02-25 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
| US12121040B2 (en) | 2008-12-30 | 2024-10-22 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
| US20110180087A1 (en) * | 2008-12-30 | 2011-07-28 | Philip Morris Usa Inc. | Oral pouch product with multi-layered pouch wrapper |
| US10952452B2 (en) | 2008-12-30 | 2021-03-23 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
| US9027567B2 (en) | 2008-12-30 | 2015-05-12 | Philip Morris Usa Inc. | Oral pouch product with multi-layered pouch wrapper |
| US20100218779A1 (en) * | 2009-02-27 | 2010-09-02 | Philip Morris Usa Inc. | Controlled flavor release tobacco pouch products and methods of making |
| US8863755B2 (en) | 2009-02-27 | 2014-10-21 | Philip Morris Usa Inc. | Controlled flavor release tobacco pouch products and methods of making |
| US11224247B2 (en) | 2009-03-16 | 2022-01-18 | Philip Morris Usa Inc. | Coated tobacco particles suitable for usage in a smokeless tobacco product |
| US20110083681A1 (en) * | 2009-03-16 | 2011-04-14 | Philip Morris Usa Inc. | Colloidal plant powder/extract encapsulation with pectin-protein coacervate gels |
| US9167847B2 (en) | 2009-03-16 | 2015-10-27 | Philip Morris Usa Inc. | Production of coated tobacco particles suitable for usage in a smokeless tobacoo product |
| US8747562B2 (en) | 2009-10-09 | 2014-06-10 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
| US9687023B2 (en) | 2009-10-09 | 2017-06-27 | Philip Morris Usa Inc. | Moist smokeless tobacco product for oral usage having on a portion of the outer surface at least one friction reducing strip that provides texture during use |
| US12041958B2 (en) | 2009-10-09 | 2024-07-23 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
| US10143230B2 (en) | 2009-10-09 | 2018-12-04 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
| US20110083688A1 (en) * | 2009-10-09 | 2011-04-14 | Philip Morris Usa Inc. | Moist smokeless tobacco product with textured coating |
| US20110083680A1 (en) * | 2009-10-09 | 2011-04-14 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
| US9648903B2 (en) | 2009-10-13 | 2017-05-16 | Philip Morris Usa Inc. | Oral moist smokeless tobacco products with net-structured gel coating and methods of making |
| US20110100382A1 (en) * | 2009-10-13 | 2011-05-05 | Philip Morris Usa Inc. | Oral moist smokeless tobacco products with net-structured gel coating and methods of making |
| US8539958B2 (en) | 2009-10-13 | 2013-09-24 | Philip Morris Usa Inc. | Oral moist smokeless tobacco products with net-structured gel coating and methods of making |
| EP2529634A4 (fr) * | 2010-01-28 | 2017-04-05 | Japan Tobacco, Inc. | Produit de tabac unitaire |
| US20120298124A1 (en) * | 2010-01-28 | 2012-11-29 | Hiroki Shikata | Portion tobacco product |
| US9161567B2 (en) * | 2010-01-28 | 2015-10-20 | Japan Tobacco Inc. | Portion tobacco product |
| US11723395B2 (en) | 2010-03-26 | 2023-08-15 | Philip Morris Usa Inc. | Controlled release mentholated tobacco beads |
| US10051884B2 (en) | 2010-03-26 | 2018-08-21 | Philip Morris Usa Inc. | Controlled release mentholated tobacco beads |
| US12295402B2 (en) | 2010-03-26 | 2025-05-13 | Philip Morris Usa Inc. | Controlled release mentholated tobacco beads |
| US20110232657A1 (en) * | 2010-03-26 | 2011-09-29 | Philip Morris Usa Inc. | Controlled release mentholated tobacco beads |
| US8241680B2 (en) | 2010-06-30 | 2012-08-14 | Rock Creek Pharmaceuticals, Inc. | Nutraceutical product containing anatabine and yerba maté |
| US10028520B2 (en) | 2010-09-02 | 2018-07-24 | R.J. Reynolds Tobacco Company | Apparatus for manufacturing a smokeless tobacco product incorporating an object, and associated method |
| US12433319B2 (en) | 2010-09-02 | 2025-10-07 | R.J. Reynolds Tobacco Company | Apparatus for manufacturing a smokeless tobacco product incorporating an object, and associated method |
| US11172702B2 (en) | 2010-09-02 | 2021-11-16 | R. J. Reynolds Tobacco Company | Apparatus for manufacturing a smokeless tobacco product incorporating an object, and associated method |
| WO2012030946A1 (fr) | 2010-09-02 | 2012-03-08 | R. J. Reynolds Tobacco Company | Appareil de fabrication d'un produit de tabac sans fumée et procédé associé |
| RU2430635C1 (ru) * | 2010-10-20 | 2011-10-10 | Олег Иванович Квасенков | Способ выработки некурительного изделия из махорки |
| US8931493B2 (en) | 2010-11-01 | 2015-01-13 | R.J. Reynolds Tobacco Co. | Smokeless tobacco products |
| WO2012061192A1 (fr) | 2010-11-01 | 2012-05-10 | R.J. Reynolds Tobacco Company | Produits du tabac sans fumée et processus associés |
| WO2012106237A1 (fr) | 2011-01-31 | 2012-08-09 | American Snuff Company, Llc | Contenant pour produits de tabac sans fumée |
| US20140017286A1 (en) * | 2011-03-29 | 2014-01-16 | Chill Of Sweden Ab | Pouch containing nicotine in free salt form |
| US9161908B2 (en) * | 2011-03-29 | 2015-10-20 | Tillce Ab | Pouch containing nicotine in free salt form |
| US9402810B2 (en) | 2011-03-29 | 2016-08-02 | Nyz Ab | Pouch containing nicotine in free salt form |
| US9387201B2 (en) | 2011-08-29 | 2016-07-12 | Rcp Development, Inc. | Methods of providing anti-inflammation support |
| WO2013090366A2 (fr) | 2011-12-14 | 2013-06-20 | R. J. Reynolds Tobacco Company | Produits à base de tabac sans fumée comprenant une composition effervescente |
| EP3461351A1 (fr) | 2012-02-13 | 2019-04-03 | R. J. Reynolds Tobacco Company | Composition de tabac blanchi |
| WO2013122948A1 (fr) | 2012-02-13 | 2013-08-22 | R. J. Reynolds Tobacco Company | Composition de tabac blanchi |
| EP4445751A2 (fr) | 2012-02-13 | 2024-10-16 | R. J. Reynolds Tobacco Company | Composition de tabac blanchi |
| US9635881B2 (en) | 2012-04-10 | 2017-05-02 | Swedish Match North Europe Ab | Smokeless tobacco composition comprising non-tobacco fibers and a method for its manufacture |
| WO2013166285A1 (fr) | 2012-05-04 | 2013-11-07 | R. J. Reynolds Tobacco Company | Revêtements de barrière contre l'humidité transparents pour conteneurs |
| US11490650B2 (en) | 2012-06-22 | 2022-11-08 | R.J. Reynolds Tobacco Company | Composite tobacco-containing materials |
| WO2013192519A1 (fr) | 2012-06-22 | 2013-12-27 | R. J. Reynolds Tobacco Company | Matériaux composites contenant du tabac |
| US10973256B2 (en) | 2012-07-30 | 2021-04-13 | British American Tobacco (Investments) Limited | Fleece for smokeless tobacco |
| US20140026912A1 (en) * | 2012-07-30 | 2014-01-30 | British American Tobacco (Investments) Limited | Fleece for Smokeless Tobacco |
| US9913491B2 (en) * | 2012-07-30 | 2018-03-13 | British American Tobacco (Investments) Limited | Fleece for smokeless tobacco |
| US9591875B2 (en) | 2012-09-21 | 2017-03-14 | R. J. Reynolds Tobacco Company | Fibrous composite tobacco-containing materials |
| US9386800B2 (en) | 2012-09-21 | 2016-07-12 | R.J. Reynolds Tobacco Company | Fibrous composite tobacco-containing materials |
| WO2014164509A1 (fr) | 2013-03-11 | 2014-10-09 | Niconovum Usa, Inc. | Procédé et appareil pour différentier des produits oraux en sachet |
| EP4410290A2 (fr) | 2013-09-09 | 2024-08-07 | R.J. Reynolds Tobacco Company | Composition de tabac sans fumée incorporant une matière botanique |
| US11503853B2 (en) | 2013-09-09 | 2022-11-22 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition incorporating a botanical material |
| US12408692B2 (en) | 2013-10-16 | 2025-09-09 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US12048321B2 (en) | 2013-10-16 | 2024-07-30 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US10568355B2 (en) | 2013-10-16 | 2020-02-25 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US11540555B2 (en) | 2013-10-16 | 2023-01-03 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US10980271B2 (en) | 2013-10-16 | 2021-04-20 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US20160000140A1 (en) * | 2014-07-02 | 2016-01-07 | R.J. Reynolds Tobacco Company | Oral pouch products |
| US11019840B2 (en) * | 2014-07-02 | 2021-06-01 | R.J. Reynolds Tobacco Company | Oral pouch products |
| WO2016040754A1 (fr) | 2014-09-12 | 2016-03-17 | R. J. Reynolds Tobacco Company | Sachet non tissé comprenant des fibres liantes thermoscellables |
| US10959456B2 (en) | 2014-09-12 | 2021-03-30 | R.J. Reynolds Tobacco Company | Nonwoven pouch comprising heat sealable binder fiber |
| US11793235B2 (en) | 2014-09-12 | 2023-10-24 | R.J. Reynolds Tobacco Company | Nonwoven pouch comprising heat sealable binder fiber |
| WO2016090075A1 (fr) | 2014-12-05 | 2016-06-09 | R. J. Reynolds Tobacco Company | Sachet de tabac sans fumée |
| EP4442128A1 (fr) | 2014-12-05 | 2024-10-09 | R. J. Reynolds Tobacco Company | Sachet de tabac sans fumée |
| US11832640B2 (en) | 2014-12-05 | 2023-12-05 | R.J. Reynolds Tobacco Company | Capsule-containing pouched product for oral use |
| US20160192703A1 (en) * | 2015-01-07 | 2016-07-07 | R.J. Reynolds Tobacco Company | Oral pouch products |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| US10321708B2 (en) | 2015-05-14 | 2019-06-18 | R.J. Reynolds Tobacco Company | Treatment of tobacco |
| WO2016182833A1 (fr) | 2015-05-14 | 2016-11-17 | R. J. Reynolds Tobacco Company | Traitement du tabac |
| US9918492B2 (en) | 2015-05-14 | 2018-03-20 | R.J. Reynolds Tobacco Company | Treatment of tobacco |
| WO2016200804A1 (fr) | 2015-06-10 | 2016-12-15 | R. J. Reynolds Tobacco Company | Récipient pour produits de tabac sans fumée comprenant une matière de pâte, et ensemble produit emballé et procédé associés |
| WO2017130161A1 (fr) | 2016-01-28 | 2017-08-03 | R. J. Reynolds Tobacco Company | Agents aromatisants dérivés du tabac |
| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
| WO2017134586A1 (fr) | 2016-02-02 | 2017-08-10 | R. J. Reynolds Tobacco Company | Procédé de préparation de composés savoureux isolés à partir de liqueur noire et produits incorporant les composés savoureux |
| US11091446B2 (en) | 2017-03-24 | 2021-08-17 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| WO2018172995A1 (fr) | 2017-03-24 | 2018-09-27 | R. J. Reynolds Tobacco Company | Procédés de formation sélective de pyrazines substituées |
| US11891364B2 (en) | 2017-03-24 | 2024-02-06 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| US10470487B2 (en) | 2017-04-06 | 2019-11-12 | R.J. Reynolds Tobacco Company | Smoke treatment |
| WO2018185708A1 (fr) | 2017-04-06 | 2018-10-11 | R. J. Reynolds Tobacco Company | Traitement à la fumée |
| WO2019162903A1 (fr) | 2018-02-23 | 2019-08-29 | American Snuff Company, Llc | Contenant destiné à des produits de tabac sans fumée |
| WO2019198055A2 (fr) | 2018-04-13 | 2019-10-17 | R. J. Reynolds Tobacco Company | Couvercle pour récipient pour produits de tabac sans fumée |
| WO2020128971A1 (fr) | 2018-12-20 | 2020-06-25 | R. J. Reynolds Tobacco Company | Procédé de blanchiment de tabac |
| WO2020225768A1 (fr) | 2019-05-09 | 2020-11-12 | American Snuff Company, Llc | Stabilisateur pour tabac à sucer |
| US11213062B2 (en) | 2019-05-09 | 2022-01-04 | American Snuff Company | Stabilizer for moist snuff |
| JP2022535909A (ja) * | 2019-06-07 | 2022-08-10 | エヌシーピー ネクストジェン アクティーゼルスカブ | ニコチンパウチ製品 |
| US20200383373A1 (en) * | 2019-06-07 | 2020-12-10 | Fertin Pharma A/S | Nicotine pouch product |
| JP2025031723A (ja) * | 2019-06-07 | 2025-03-07 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチンパウチ製品 |
| JP7597742B2 (ja) | 2019-06-07 | 2024-12-10 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチンパウチ製品 |
| RU2829343C2 (ru) * | 2019-06-07 | 2024-10-30 | Филип Моррис Продактс С.А. | Композиция никотинового пакетика |
| US11540557B2 (en) * | 2019-06-07 | 2023-01-03 | Philip Morris Products S.A. | Nicotine pouch product |
| CN110384700A (zh) * | 2019-09-03 | 2019-10-29 | 云南喜科科技有限公司 | 一种合成尼古丁的组合物 |
| WO2021048770A1 (fr) | 2019-09-11 | 2021-03-18 | Nicoventures Trading Limited | Procédés alternatifs de blanchiment du tabac |
| WO2021048768A1 (fr) | 2019-09-11 | 2021-03-18 | Nicoventures Trading Limited | Procédé de blanchiment de tabac |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| WO2021048769A1 (fr) | 2019-09-13 | 2021-03-18 | Nicoventures Trading Limited | Procédé de blanchiment de tabac |
| US20220202071A1 (en) * | 2019-09-19 | 2022-06-30 | Nerudia Limited | Smokeless article |
| WO2021116853A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Matériau de toison fibreux |
| US12138342B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Fleece for oral product with releasable component |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US12064424B2 (en) | 2019-12-09 | 2024-08-20 | Nicoventures Trading Limited | Moist oral compositions |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US12471618B2 (en) | 2019-12-09 | 2025-11-18 | Nicoventures Trading Limited | Stimulus-responsive pouch |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12178905B2 (en) | 2019-12-09 | 2024-12-31 | Nicoventures Trading Limited | Fleece for pouched product with controlled basis weight |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| WO2021116894A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Produits en sachet avec liant thermoscellable |
| WO2021116852A1 (fr) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Produit oral à composant soluble |
| WO2022049536A1 (fr) | 2020-09-04 | 2022-03-10 | Nicoventures Trading Limited | Procédé de blanchissement de tabac |
| WO2022162558A1 (fr) | 2021-01-28 | 2022-08-04 | Nicoventures Trading Limited | Procédé de fermeture hermétique de sachets |
| US12382982B2 (en) | 2021-06-25 | 2025-08-12 | Nicoventures Trading Limited | Oral products and method of manufacture |
| WO2023084499A1 (fr) | 2021-11-15 | 2023-05-19 | Nicoventures Trading Limited | Produits présentant des caractéristiques sensorielles améliorées |
| WO2023194959A1 (fr) | 2022-04-06 | 2023-10-12 | Nicoventures Trading Limited | Produits en sachet avec liant thermoscellable |
| WO2024074942A1 (fr) | 2022-10-03 | 2024-04-11 | Nicoventures Trading Limited | Élément d'étanchéité pour emballage |
| WO2024074988A1 (fr) | 2022-10-04 | 2024-04-11 | R. J. Reynolds Tobacco Company | Agencement empilable de contenants de produit et procédé d'empilement associé |
| WO2024079697A1 (fr) | 2022-10-14 | 2024-04-18 | Nicoventures Trading Limited | Appareil et procédé de fabrication d'un produit en sachet |
| WO2024079696A1 (fr) | 2022-10-14 | 2024-04-18 | Nicoventures Trading Limited | Appareil et procédé de fabrication et d'inspection d'un produit en sachet ou d'au moins un objet associé à celui-ci |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002360097A1 (en) | 2003-07-09 |
| ATE384450T1 (de) | 2008-02-15 |
| DE60224832T2 (de) | 2009-01-22 |
| EP1458252B1 (fr) | 2008-01-23 |
| DK1458252T3 (da) | 2008-05-13 |
| WO2003053175A2 (fr) | 2003-07-03 |
| DE60224832D1 (de) | 2008-03-13 |
| AU2002360097A8 (en) | 2003-07-09 |
| EP1458252A2 (fr) | 2004-09-22 |
| WO2003053175A3 (fr) | 2003-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1458252B1 (fr) | Tabac et/ou substitut de tabac en combinaison avec du tabac s'utilisant comme tabac a priser dans la cavite buccale | |
| JP7600232B2 (ja) | ニコチン粒子を含有する充填材を含む経口袋状ニコチン製品 | |
| US12219983B1 (en) | Compositions for buccal administration | |
| US11957165B2 (en) | Oral pouched nicotine product including a filling material comprising nicotine-containing particles | |
| US8846075B2 (en) | Composition material for transmucosal delivery | |
| EP3868222A1 (fr) | Article sans fumée | |
| CA2868445C (fr) | Formulation de nicotine | |
| EP3833315B1 (fr) | Produit en sachet approprié pour une application dans une cavité buccale | |
| WO2021165418A1 (fr) | Article sans fumée | |
| EP3868221A1 (fr) | Article sans fumée | |
| FR2873584A1 (fr) | Systeme de sevrage tabagique | |
| US20060112965A1 (en) | Chewing tobacco substitute containing cotinine | |
| EP3868223A1 (fr) | Article sans fumée | |
| EP4505883A1 (fr) | Procédé de fabrication d'un article sans fumée | |
| RU2832481C1 (ru) | Бездымное изделие, содержащее бамбуковые волокна с дозированным количеством никотина, применение таких волокон, способ изготовления указанного изделия и комплект, содержащий бездымное изделие | |
| RU2779390C1 (ru) | Пакетированный продукт, подходящий для применения в ротовой полости | |
| EP4631366A1 (fr) | Article sans fumée | |
| US20220386685A1 (en) | Smokeless article | |
| EP4505884A1 (fr) | Article sans fumée | |
| DK1998748T3 (en) | Improved snuff composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: GALENICA AB, SWEDEN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HANSSON, HENRI;HOVGAARD, LARS;SPEGEL, CHRISTER;REEL/FRAME:015391/0075 Effective date: 20040829 |
|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |