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US20030130588A1 - Method and system for analyzing respiratory tract sounds - Google Patents

Method and system for analyzing respiratory tract sounds Download PDF

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Publication number
US20030130588A1
US20030130588A1 US10/041,494 US4149402A US2003130588A1 US 20030130588 A1 US20030130588 A1 US 20030130588A1 US 4149402 A US4149402 A US 4149402A US 2003130588 A1 US2003130588 A1 US 2003130588A1
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US
United States
Prior art keywords
tilde over
acoustic energy
over
determined
average acoustic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/041,494
Other languages
English (en)
Inventor
Igal Kushnir
Meir Botbol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DeepBreeze Ltd
Original Assignee
DeepBreeze Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DeepBreeze Ltd filed Critical DeepBreeze Ltd
Priority to US10/041,494 priority Critical patent/US20030130588A1/en
Assigned to DEEPBREEZE LTD. reassignment DEEPBREEZE LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BOTBOL, MEIR, KUSHNIR, IGAL
Priority to US10/338,742 priority patent/US6887208B2/en
Priority to DE60314225T priority patent/DE60314225T2/de
Priority to EP03729307A priority patent/EP1465527B1/fr
Priority to PCT/IL2003/000029 priority patent/WO2003057037A1/fr
Priority to KR1020047010760A priority patent/KR101020477B1/ko
Priority to IL16290103A priority patent/IL162901A0/xx
Priority to PT03729307T priority patent/PT1465527E/pt
Priority to JP2003557405A priority patent/JP4511188B2/ja
Priority to MXPA04006736A priority patent/MXPA04006736A/es
Priority to CNB03802120XA priority patent/CN100349547C/zh
Priority to RU2004124247/14A priority patent/RU2314751C2/ru
Priority to ES03729307T priority patent/ES2287480T3/es
Priority to AT03729307T priority patent/ATE363861T1/de
Priority to CA002472785A priority patent/CA2472785A1/fr
Priority to DK03729307T priority patent/DK1465527T3/da
Priority to HK05108079.2A priority patent/HK1076018B/xx
Priority to AU2003235813A priority patent/AU2003235813B2/en
Priority to BR0306845-5A priority patent/BR0306845A/pt
Priority to SI200330910T priority patent/SI1465527T1/sl
Publication of US20030130588A1 publication Critical patent/US20030130588A1/en
Priority to IL162901A priority patent/IL162901A/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B7/00—Instruments for auscultation
    • A61B7/02—Stethoscopes
    • A61B7/026—Stethoscopes comprising more than one sound collector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B7/00—Instruments for auscultation
    • A61B7/003—Detecting lung or respiration noise

Definitions

  • This invention relates to medical devices and methods, and more particularly to such devices and methods for analyzing body sounds.
  • Body sounds are routinely used by physicians in the diagnosis of various disorders.
  • a physician may place a stethoscope on a person's chest or back and monitor the patient's breathing in order to detect adventitious (i.e. abnormal or unexpected) lung sounds.
  • adventitious lung sounds often provides important information about pulmonary abnormalities.
  • U.S. Pat. No. 6,139,505 discloses a system in which a plurality of microphones are placed around a patient's chest. The recordings of the microphones during inhalation and expiration are displayed on a screen, or printed on paper. The recordings are then visually examined by a physician in order to detect a pulmonary disorder in the patent.
  • Kompis et al disclose a system in which M microphones are placed on a patient's chest, and lung sounds are recorded. The recordings generate M linear equations that are solved using a least-squares fit. The solution of the system is used to determine the location in the lungs of the source of a sound detected in the recordings.
  • the present invention provides a system and method for recording and analyzing sounds produced by the respiratory tract in order to produce an image that permits easy analysis of pathological conditions of the respiratory tract.
  • sounds are recorded in a plurality of locations over an individual's thorax (including locations in one or both of the individual's chest or back surfaces).
  • the sounds are recorded over a period of time, for example, over at least one respiratory cycle and preferably over several respiratory cycles, and the sounds recorded at each location are analyzed to produce a first analysis product.
  • the plurality of first analysis products are then combined in a manner so as to produce the desired image.
  • the first analysis product may be a function of a signal analysis in one or more of a variety of different parameters of the recorded signal, such as an analysis in the frequency domain, in the time domain, in the power domain or a combination of one or more of these domains.
  • the sounds are analyzed in the tine and frequency domains to produce said first analysis product said image therefrom.
  • a system for analyzing the respiratory tract of an individual comprising:
  • a signal analysis module for analyzing sound signals recorded by each of said transducers to produce a first analysis product
  • a display said display displaying an image produced by the analyzed sound recordings, which image includes a pattern with an overall shape corresponding to that of the respiratory system and an indication on said pattern of regions thereof that are suspected of having a pathological condition.
  • the present invention also provides a method for analyzing the condition of a respiratory tract of an individual, comprising:
  • pathological condition refers to any deviation from the normal, healthy condition of the respiratory tract. This includes infection, inflammation, tumor, narrowing of the airways, existence of a space occupying lesions in the respiratory tract, etc.
  • the first analysis product may be a function of one or more parameters of the recorded signal.
  • the first analysis product may be a function of an analysis made in a variety of different domains of the recorded signal, as pointed out above.
  • the transducers are typically embedded in a matrix that permits to affix them easily on the individual's skin.
  • a matrix may typically be in the form of a vest or garment for easily placing over the individual's thorax.
  • different matrices may be used for differently sized individual's; for different ages, sexes, etc.
  • the respiratory tract is displayed in a manner such as to resemble the general shape of the lung, typically shaped similar to that which can be viewed in an x-ray of the lung.
  • the term “similar” in this regard should be understood as meaning that a physician can generally recognize the shape of the lung from such a display although it is clear to any man of the art that the actual display of said image is different than that of an x-ray picture.
  • each region is identified as such by the existence of wheezes and crackles identified by an allowances of the recorded sound signal in the frequency domain, are identified and this may be in a number of ways, for example, by different colors, by different patterns, by way of a written text, and many other ways.
  • the present invention provides, by another embodiment, a system and method for recording and analyzing respiratory tract sounds produced in the respiratory tract.
  • the N signals P(x i , t) are processed by signal processing circuit.
  • the processing involves determining from the N signals an average acoustic energy, denoted herein by ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ), at least one position x in the region R over a time interval from t 1 to t 2 .
  • acoustic energy at a location is used herein to refer to a parameter indicative of or approximating the product of the pressure and the mass propagation velocity at that location.
  • an average acoustic energy ⁇ tilde over (P) ⁇ (x i ,t 1 ,t 2 ) over a time interval from t 1 , to t 2 is obtained at a plurality of positions x i of the microphones, for example using Equation (1), and then calculating ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) at other locations x by interpolation of the ⁇ tilde over (P) ⁇ (x i ,t 1 ,t 2 ) using any known interpolation method.
  • the kernal g ⁇ ( x , x i , ⁇ ) Exp - ( ( x 1 - x i 1 ⁇ ⁇ ) 2 2 ⁇ ⁇ ) ⁇ Exp - ( ( x 2 - x i 2 ⁇ ⁇ ) 2 2 ⁇ ⁇ ) ( 5 )
  • the system may optionally contain a display device for displaying the function ⁇ tilde over (P) ⁇ .
  • the function ⁇ tilde over (P) ⁇ may be displayed on the display, for example using a gray level scale, as demonstrated in the examples below.
  • a two dimensional graphical representation of the function ⁇ tilde over (P) ⁇ produces an image of the body region that may be analyzed for the detection of a disorder in the body region similar to the analysis of images obtained by other imaging methods such as X-ray or ultrasound imaging.
  • a time interval can be divided into a plurality of sub intervals, and an average acoustic energy ⁇ tilde over (P) ⁇ determined over the region R for two or more of the sub intervals.
  • An image of ⁇ tilde over (P) ⁇ for each of these sub intervals may then be determined and displayed sequentially on the display device. This generates a movie showing dynamic changes occurring in the acoustic energy in the body region, over the time interval.
  • transducers may be placed on a person's chest and an average acoustic energy ⁇ tilde over (P) ⁇ determined in accordance with the invention for a plurality of sub intervals over a breathing cycle.
  • An image can be obtained for each of these sub intervals and displayed sequentially so as to generate a movie showing changes in the acoustic energy of the lungs over the breathing cycle.
  • the signals P(x i ,t) may also be subjected to band pass filtering before being analyzed by the method of the invention, so that an average acoustic energy is produced for one or more frequency bands of interest.
  • the functions may be superimposed on the display device by representing each average acoustic energy function with a different color.
  • the present invention provides a system for analyzing sounds in at least a portion of an individual's respiratory tract comprising:
  • a processor configured to receive the signals P(x i ,t) and determine an average acoustic energy ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) at at least one position x over a time interval from a first time t 1 to a second time t 2 , ⁇ tilde over (P) ⁇ being determined in an algorithm involving at least one of the signals P(xi, t).
  • the present invention further provides a method for analyzing sounds in at least a portion of an individual's thorax, comprising:
  • the present invention also provides a program storage device readable by machine, tangibly embodying a program of instructions executable by the machine to perform method steps for determining for at least one time interval, an average acoustic energy function ⁇ tilde over (P) ⁇ using an algorithm involving at least one signal P(xi,t) indicative of pressure waves at a location x i on a body surface.
  • the present invention still further provides a computer program product comprising a computer useable medium having computer readable program code embodied therein analyzing sounds in at least a portion of an individual's body, the computer program product comprising:
  • FIG. 1 shows a system for obtaining an analyzing body sound in accordance with one embodiment of the invention
  • FIG. 2 shows a flow chart for carrying out a method of obtaining analyzing body sounds in accordance with one embodiment of the invention
  • FIG. 3 shows recording and analysis of signals over an inspiratory phase of a respiratory cycle
  • FIG. 4 shows recording and analysis of signals over an expiratory phase of a respiratory cycle.
  • FIG. 1 shows a system generally indicated by 100 for analyzing body sounds in a three-dimensional region of an individual's body in accordance with one embodiment of the invention.
  • a plurality of N sound transducers 105 are applied to a planar region of the chest or back skin of individual 110 .
  • the transducers 105 may be applied to the subject by any means is known in the art, for example using an adhesive, suction, or fastening straps.
  • Each transducer 105 produces an analog voltage signal 115 indicative of pressure waves arriving to the transducer.
  • the analog signals 115 are digitized by a multichannel analog to digital converter 120 .
  • the data signals 125 are input to a memory 130 .
  • Data input to the memory 130 are accessed by a processor 135 configured to process the data signals 125 .
  • the signals 125 may be denoised by filtering components such having frequencies outside of the range of body sounds in the body region, for example, vibrations due to movement of the individual. Each signal 125 may also be subject to band pass filtering so that only components in the signal within a range of interest are analyzed.
  • An input device such as a computer keyboard 140 or mouse 145 is used to input relevant information relating to the examination such as personal details of the individual 110 .
  • the input device 140 may also be used to input values of the times t 1 and t 2 .
  • the times t 1 and t 2 may be determined automatically times t 1 and t 2 .
  • the times t 1 and t 2 may be determined automatically in a respiratory phase analysis of the signals P(x i ,t) performed by the processor 135 .
  • the processor 135 determines an average acoustic energy ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) over the time interval from t 1 to t 2 at least one location x in the region R in a calculation involving at least one of the signals P(x i ,t).
  • the average acoustic energies are stored in the memory 130 and may be displayed on a display device 150 such as a CRT screen for diagnosis by a physician.
  • the processor 135 may also perform an automatic differential diagnosis by comparing the function ⁇ tilde over (P) ⁇ to functions stored in the memory and known to be indicative of various disorders in the body region.
  • FIG. 2 shows a flow chart diagram for carrying out the method of the invention in accordance with one embodiment.
  • the signals P(xi,t) are obtained from N transducers placed at predetermined locations x i for i from 1 to N in a region R on the body surface.
  • values of t 1 and t 2 are either input to the processor 135 using the input devices 140 or 145 , or are detrmined by the processor.
  • an average acoustic energy ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) is determined at least one location x in the region R over the time interval t 1 to t 2 .
  • step 220 the average acoustic energy is displayed on the display 150 for at least one value of x.
  • step 230 it is determined whether a function ⁇ tilde over (P) ⁇ is to be determined over another time interval. If yes, the process returns to step 205 . If not, the process terminates.
  • system may be a suitably programmed computer.
  • the invention contemplates a computer program being readable by a computer for executing the method of the invention.
  • the invention further contemplates a machine-readable memory tangibly embodying a program of instructions executable by the machine for executing the method of the invention.
  • FIG. 3 shows recording and analysis of signals over an inspiratory phase of a respiratory cycle in an individual.
  • a two-dimensional coordinate system was defined on the individual's back.
  • 48 transducers were placed on the individual's back over the lungs at the locations indicated by the circles 300 .
  • the curves 305 show the presumed contours of the lungs.
  • the transducers were arranged in a regular orthogonal lattice with a spacing between the transducers in the horizontal and vertical directions of 5 cm.
  • the signals P(xi,t) were then recorded over one inspiratory phase of a breathing cycle (t 1 and t 2 are the beginning and end respectively of the inspiratory phase).
  • each signal was filtered using a low-pass filter having a cut-off of 150 Hz.
  • the average value of each filtered function P(xi,t) over the inspiratory phase is indicated in FIG. 3 a by means of gray level shading of each circle 300 with reference to the gray level scale 310 .
  • FIG. 3 b shows a 512 pixel ⁇ 512 pixel pixel graphical representation of the function ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) over the inspiratory phase also in reference to the gray level scale 310 .
  • the contours of the lungs and heart are easily perceived.
  • FIG. 4 shows recording and analysis of signals over an expiratory phase of a respiratory cycle.
  • 48 transducers were placed on an individual's back at the same locations x i used in FIG. 3, as indicated by the circles 400 .
  • the curves 405 show the presumed contours of the individual's lungs.
  • the signals P(xi,t) were then recorded over one expiratory phase of a breathing cycle (t 1 and t 2 are the beginning and end respectively of the expiratory phase).
  • Each signal was filtered using a low-pass filter having a cut-off of 150 Hz.
  • the average value of each function P(xi,t) over the expiratory phase is indicated in FIG.
  • FIG. 4 a shows the function ⁇ tilde over (P) ⁇ (x,t 1 ,t 2 ) over the expiratory phase also in reference to the gray level scale 410 .
  • FIGS. 3 b and 4 b shows the volume change in acoustic energy between the inspiratory and expiratory phase of the respiratory cycle.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Acoustics & Sound (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Transplanting Machines (AREA)
US10/041,494 2002-01-10 2002-01-10 Method and system for analyzing respiratory tract sounds Abandoned US20030130588A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
US10/041,494 US20030130588A1 (en) 2002-01-10 2002-01-10 Method and system for analyzing respiratory tract sounds
US10/338,742 US6887208B2 (en) 2002-01-10 2003-01-09 Method and system for analyzing respiratory tract sounds
SI200330910T SI1465527T1 (sl) 2002-01-10 2003-01-12 Sistem za analiziranje in upodabljanje zvokov dihalnih poti
CNB03802120XA CN100349547C (zh) 2002-01-10 2003-01-12 呼吸道声音分析和成像系统
AT03729307T ATE363861T1 (de) 2002-01-10 2003-01-12 System zum analysieren und abbilden von geräuschen der atemwege
PCT/IL2003/000029 WO2003057037A1 (fr) 2002-01-10 2003-01-12 Systeme d'analyse et d'imagerie de bruits des voies respiratoires
KR1020047010760A KR101020477B1 (ko) 2002-01-10 2003-01-12 기도의 음향을 분석하고 이미지화하기 위한 시스템
IL16290103A IL162901A0 (en) 2002-01-10 2003-01-12 System for analyzing and imaging respiratory tractsounds
PT03729307T PT1465527E (pt) 2002-01-10 2003-01-12 Sistema para a análise e transformação em imagens dos sons do tracto respiratório
JP2003557405A JP4511188B2 (ja) 2002-01-10 2003-01-12 気道音響の解析及び画像形成用システム
MXPA04006736A MXPA04006736A (es) 2002-01-10 2003-01-12 Sistema para analisis y formacion de imagenes de sonidos del tracto respiratorio.
DE60314225T DE60314225T2 (de) 2002-01-10 2003-01-12 System zum analysieren und abbilden von geräuschen der atemwege
RU2004124247/14A RU2314751C2 (ru) 2002-01-10 2003-01-12 Система для анализа и формирования изображения шума дыхательных путей
ES03729307T ES2287480T3 (es) 2002-01-10 2003-01-12 Sistema de analisis y de representacion por imagen de sonidos del tracto respiratorio.
EP03729307A EP1465527B1 (fr) 2002-01-10 2003-01-12 Systeme d'analyse et d'imagerie de bruits des voies respiratoires
CA002472785A CA2472785A1 (fr) 2002-01-10 2003-01-12 Systeme d'analyse et d'imagerie de bruits des voies respiratoires
DK03729307T DK1465527T3 (da) 2002-01-10 2003-01-12 System til analyse og billeddannelse af lyde fra luftvejene
HK05108079.2A HK1076018B (en) 2002-01-10 2003-01-12 System for analyzing and imaging respiratory tract sounds
AU2003235813A AU2003235813B2 (en) 2002-01-10 2003-01-12 System for analyzing and imaging respiratory tract sounds
BR0306845-5A BR0306845A (pt) 2002-01-10 2003-01-12 Sistema para analisar sons em pelo menos uma parte do trato respiratório de um indivìduo, método para analisar sons em pelo menos uma parte do tórax de um indivìduo, imagem de uma representação bidimensional e programa de computador
IL162901A IL162901A (en) 2002-01-10 2004-07-07 System for analyzing and imaging respiratory tract sounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/041,494 US20030130588A1 (en) 2002-01-10 2002-01-10 Method and system for analyzing respiratory tract sounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/338,742 Continuation-In-Part US6887208B2 (en) 2002-01-10 2003-01-09 Method and system for analyzing respiratory tract sounds

Publications (1)

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US20030130588A1 true US20030130588A1 (en) 2003-07-10

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Family Applications (2)

Application Number Title Priority Date Filing Date
US10/041,494 Abandoned US20030130588A1 (en) 2002-01-10 2002-01-10 Method and system for analyzing respiratory tract sounds
US10/338,742 Expired - Fee Related US6887208B2 (en) 2002-01-10 2003-01-09 Method and system for analyzing respiratory tract sounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
US10/338,742 Expired - Fee Related US6887208B2 (en) 2002-01-10 2003-01-09 Method and system for analyzing respiratory tract sounds

Country Status (17)

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US (2) US20030130588A1 (fr)
EP (1) EP1465527B1 (fr)
JP (1) JP4511188B2 (fr)
KR (1) KR101020477B1 (fr)
CN (1) CN100349547C (fr)
AT (1) ATE363861T1 (fr)
AU (1) AU2003235813B2 (fr)
BR (1) BR0306845A (fr)
CA (1) CA2472785A1 (fr)
DE (1) DE60314225T2 (fr)
DK (1) DK1465527T3 (fr)
ES (1) ES2287480T3 (fr)
IL (1) IL162901A0 (fr)
MX (1) MXPA04006736A (fr)
PT (1) PT1465527E (fr)
RU (1) RU2314751C2 (fr)
WO (1) WO2003057037A1 (fr)

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WO2007060663A1 (fr) * 2005-11-25 2007-05-31 Deepbreeze Ltd. Méthode et système pour évaluer la physiologie pulmonaire régionale
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WO2008072233A1 (fr) * 2006-12-11 2008-06-19 Deepbreeze Ltd. Procédé et système pour analyser des bruits du corps
WO2008096349A1 (fr) * 2007-02-06 2008-08-14 Deepbreeze Ltd. Procédé et système pour l'évaluation régionale de la fonction pulmonaire
RU2346653C2 (ru) * 2003-06-02 2009-02-20 Дипбриз Лтд. Способ и система для анализа сердечно-сосудистых звуков
WO2009125407A1 (fr) * 2008-04-08 2009-10-15 Deepbreeze Ltd. Procédé et système de quantification de sons du tractus respiratoires
WO2015114285A1 (fr) * 2014-01-30 2015-08-06 Smiths Medical International Limited Systèmes de thérapie respiratoire, ensembles capteurs et procédés
WO2017194713A1 (fr) * 2016-05-11 2017-11-16 Koninklijke Philips N.V. Système d'oscillation de la paroi thoracique avec auscultation numérique
WO2021151172A1 (fr) * 2020-01-29 2021-08-05 Zira D.O.O. Système et procédé d'enregistrement multicanal et d'analyse numérique de sons respiratoires à différents niveaux de charge inspiratoire

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